Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-10

AUTHORS

Kunihiro Yamagata, Joichi Usui, Michio Nagata, Hitoshi Sugiyama, Ken-ei Sada, Eri Muso, Masayoshi Harigai, Koichi Amano, Tatsuya Atsumi, Shouichi Fujimoto, Yukio Yuzawa, Masaki Kobayashi, Takao Saito, Takafumi Ito, Nobuhito Hirawa, Sakae Homma, Hiroaki Dobashi, Naotaka Tsuboi, Akihiro Ishizu, Yoshihiro Arimura, Hirofumi Makino, Seiichi Matsuo

ABSTRACT

BackgroundThe prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.MethodsWe collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years.ResultsBased on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis.ConclusionThis histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis. More... »

PAGES

387-394

Journal

TITLE

Clinical and Experimental Nephrology

ISSUE

3

VOLUME

23

Author Affiliations

  • Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan
  • Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
  • Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
  • Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
  • Department of Pharmacovigilance, Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
  • Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
  • Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine, Hokkaido University, Sapporo, Japan
  • Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
  • Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan
  • Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan
  • Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
  • Division of Nephrology, Faculty of Medicine, Shimane University, Izumo, Japan
  • Department of Hemodialysis and Apheresis, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan
  • Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
  • Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan
  • Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
  • Kichijoji Asahi Hospital, Tokyo, Japan
  • Okayama University, Okayama, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10157-018-1656-1

    DOI

    http://dx.doi.org/10.1007/s10157-018-1656-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107537281

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30306344


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerular Filtration Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerulonephritis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.20515.33", 
              "name": [
                "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamagata", 
            "givenName": "Kunihiro", 
            "id": "sg:person.01315534513.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315534513.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.20515.33", 
              "name": [
                "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Usui", 
            "givenName": "Joichi", 
            "id": "sg:person.01007133200.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007133200.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.20515.33", 
              "name": [
                "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagata", 
            "givenName": "Michio", 
            "id": "sg:person.01022702772.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sugiyama", 
            "givenName": "Hitoshi", 
            "id": "sg:person.0767063345.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767063345.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sada", 
            "givenName": "Ken-ei", 
            "id": "sg:person.0705044575.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705044575.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415392.8", 
              "name": [
                "Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muso", 
            "givenName": "Eri", 
            "id": "sg:person.01042575643.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042575643.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacovigilance, Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Department of Pharmacovigilance, Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harigai", 
            "givenName": "Masayoshi", 
            "id": "sg:person.0670103754.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670103754.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amano", 
            "givenName": "Koichi", 
            "id": "sg:person.01023355176.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023355176.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine, Hokkaido University, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.39158.36", 
              "name": [
                "Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atsumi", 
            "givenName": "Tatsuya", 
            "id": "sg:person.01061766176.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061766176.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410849.0", 
              "name": [
                "Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujimoto", 
            "givenName": "Shouichi", 
            "id": "sg:person.012553625252.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012553625252.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan", 
              "id": "http://www.grid.ac/institutes/grid.256115.4", 
              "name": [
                "Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yuzawa", 
            "givenName": "Yukio", 
            "id": "sg:person.0605601010.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605601010.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412784.c", 
              "name": [
                "Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Masaki", 
            "id": "sg:person.0601105423.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601105423.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411497.e", 
              "name": [
                "Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Takao", 
            "id": "sg:person.014771011022.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014771011022.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Nephrology, Faculty of Medicine, Shimane University, Izumo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411621.1", 
              "name": [
                "Division of Nephrology, Faculty of Medicine, Shimane University, Izumo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "Takafumi", 
            "id": "sg:person.014560721422.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014560721422.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hemodialysis and Apheresis, Yokohama City University Medical Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413045.7", 
              "name": [
                "Department of Hemodialysis and Apheresis, Yokohama City University Medical Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirawa", 
            "givenName": "Nobuhito", 
            "id": "sg:person.0747013232.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747013232.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.452874.8", 
              "name": [
                "Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Homma", 
            "givenName": "Sakae", 
            "id": "sg:person.01323477112.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323477112.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258331.e", 
              "name": [
                "Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dobashi", 
            "givenName": "Hiroaki", 
            "id": "sg:person.0657013776.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657013776.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsuboi", 
            "givenName": "Naotaka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Faculty of Health Sciences, Hokkaido University, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.39158.36", 
              "name": [
                "Faculty of Health Sciences, Hokkaido University, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishizu", 
            "givenName": "Akihiro", 
            "id": "sg:person.01330245113.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330245113.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kichijoji Asahi Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413946.d", 
              "name": [
                "Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan", 
                "Kichijoji Asahi Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arimura", 
            "givenName": "Yoshihiro", 
            "id": "sg:person.01210261571.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210261571.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okayama University, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Okayama University, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Makino", 
            "givenName": "Hirofumi", 
            "id": "sg:person.01326213552.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326213552.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuo", 
            "givenName": "Seiichi", 
            "id": "sg:person.01024375011.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024375011.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10157-009-0201-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032020926", 
              "https://doi.org/10.1007/s10157-009-0201-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10157-012-0755-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046335331", 
              "https://doi.org/10.1007/s10157-012-0755-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10165-013-0877-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005312440", 
              "https://doi.org/10.1007/s10165-013-0877-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2369-14-125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003466137", 
              "https://doi.org/10.1186/1471-2369-14-125"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-10-10", 
        "datePublishedReg": "2018-10-10", 
        "description": "BackgroundThe prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.MethodsWe collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2\u00a0years.ResultsBased on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n\u2009=\u200930, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis.ConclusionThis histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10157-018-1656-1", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9337902", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8439134", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8439074", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9337427", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.12845786", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1117096", 
            "issn": [
              "1342-1751", 
              "1437-7799"
            ], 
            "name": "Clinical and Experimental Nephrology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "keywords": [
          "histopathological classification", 
          "renal function", 
          "renal survival", 
          "sclerotic class", 
          "cohort study", 
          "anti-neutrophil cytoplasmic antibody-associated glomerulonephritis", 
          "anti-neutrophil cytoplasmic antibodies", 
          "cytoplasmic antibody-associated glomerulonephritis", 
          "BackgroundThe prognostic value", 
          "renal survival rate", 
          "renal survival curves", 
          "glomerular filtration rate", 
          "renal biopsy material", 
          "cytoplasmic antibodies", 
          "renal prognosis", 
          "better prognosis", 
          "eGFR values", 
          "prognostic value", 
          "filtration rate", 
          "focal class", 
          "histological parameters", 
          "biopsy material", 
          "biopsy samples", 
          "glomerulonephritis", 
          "ANCA", 
          "prognosis", 
          "follow", 
          "survival", 
          "histology", 
          "MethodsWe", 
          "antibodies", 
          "number of events", 
          "study", 
          "association", 
          "rate", 
          "conclusion", 
          "function", 
          "stratification", 
          "years", 
          "classification", 
          "period", 
          "number", 
          "events", 
          "entry", 
          "large number", 
          "survey", 
          "samples", 
          "time", 
          "curves", 
          "comparison", 
          "mixed classes", 
          "results", 
          "class", 
          "values", 
          "materials", 
          "parameters", 
          "world", 
          "estimation"
        ], 
        "name": "Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study", 
        "pagination": "387-394", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107537281"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10157-018-1656-1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30306344"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10157-018-1656-1", 
          "https://app.dimensions.ai/details/publication/pub.1107537281"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_790.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10157-018-1656-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1656-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1656-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1656-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1656-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    389 TRIPLES      21 PREDICATES      98 URIs      86 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10157-018-1656-1 schema:about N165114ffc3b44bf2ac30ceab46f62b38
    2 N228e23ca880f4efca59ac9babf6636aa
    3 N28abc92839e143f3a1ac5bdb077ac298
    4 N386c39af9d644010a73c8c0bbe9260f8
    5 N3fed2d16377b4a0eabd95b3c7fa159c6
    6 N619ec1f381824b64a106252429b10892
    7 N8b5a785168f94ab19d4cff9e74fb1bd0
    8 Nb3c9e8ee22924910b38c2ed4fce6f56c
    9 Nda45731734924f6cae53ced09f71ce7b
    10 Ne96c5662752a41d695dab3f4c9cceda6
    11 Nf5b11ed3a60248a99943033674e2ec3e
    12 anzsrc-for:11
    13 anzsrc-for:1117
    14 schema:author N813239cc6a51452087cc80053f9d9d97
    15 schema:citation sg:pub.10.1007/s10157-009-0201-7
    16 sg:pub.10.1007/s10157-012-0755-7
    17 sg:pub.10.1007/s10165-013-0877-0
    18 sg:pub.10.1186/1471-2369-14-125
    19 schema:datePublished 2018-10-10
    20 schema:datePublishedReg 2018-10-10
    21 schema:description BackgroundThe prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.MethodsWe collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years.ResultsBased on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis.ConclusionThis histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.
    22 schema:genre article
    23 schema:isAccessibleForFree false
    24 schema:isPartOf N8054afab60aa4247b113357f0f0196ad
    25 N9c87c532fdef478bb9275c56c17c178a
    26 sg:journal.1117096
    27 schema:keywords ANCA
    28 BackgroundThe prognostic value
    29 MethodsWe
    30 anti-neutrophil cytoplasmic antibodies
    31 anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
    32 antibodies
    33 association
    34 better prognosis
    35 biopsy material
    36 biopsy samples
    37 class
    38 classification
    39 cohort study
    40 comparison
    41 conclusion
    42 curves
    43 cytoplasmic antibodies
    44 cytoplasmic antibody-associated glomerulonephritis
    45 eGFR values
    46 entry
    47 estimation
    48 events
    49 filtration rate
    50 focal class
    51 follow
    52 function
    53 glomerular filtration rate
    54 glomerulonephritis
    55 histological parameters
    56 histology
    57 histopathological classification
    58 large number
    59 materials
    60 mixed classes
    61 number
    62 number of events
    63 parameters
    64 period
    65 prognosis
    66 prognostic value
    67 rate
    68 renal biopsy material
    69 renal function
    70 renal prognosis
    71 renal survival
    72 renal survival curves
    73 renal survival rate
    74 results
    75 samples
    76 sclerotic class
    77 stratification
    78 study
    79 survey
    80 survival
    81 time
    82 values
    83 world
    84 years
    85 schema:name Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study
    86 schema:pagination 387-394
    87 schema:productId N2ecdce778a70419faf01f8b3d15acf3d
    88 N6b173c0bee7942fdad1217545ce12531
    89 N929515fc77c84bdaa7b95d42258a43b2
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107537281
    91 https://doi.org/10.1007/s10157-018-1656-1
    92 schema:sdDatePublished 2022-12-01T06:38
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N2bffc87e330c4fc9bc2e3f19e206d31d
    95 schema:url https://doi.org/10.1007/s10157-018-1656-1
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N019f602d02fc4a4aa11abb28880c11fc rdf:first sg:person.01210261571.66
    100 rdf:rest N3c699f4d40494c93b2cb7c2152a7e08d
    101 N01e10657913d4ec5a3922468396971bf rdf:first sg:person.01042575643.05
    102 rdf:rest N3a0c32ffd7f64d24b40d2d218d3a2956
    103 N04fe3b8291ac47f48aeef966e4cc46ff rdf:first sg:person.01023355176.35
    104 rdf:rest N282f1d5cb91143a9b901ae6f5778e406
    105 N073c41f9696b44198f6af8d55d030220 rdf:first sg:person.0705044575.68
    106 rdf:rest N01e10657913d4ec5a3922468396971bf
    107 N09ff80e86b3e4c389f7a126d0d1001bd rdf:first Nb44da1aa8fc74f5eb760f95522e23cf8
    108 rdf:rest N4e4ec8e6b0ac4e4da2a3a8838920db24
    109 N0d759a05915a468b945e7e3359ea1e1e rdf:first sg:person.0601105423.85
    110 rdf:rest N42548522b0cd40a9955a73283d2a44c8
    111 N165114ffc3b44bf2ac30ceab46f62b38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Glomerular Filtration Rate
    113 rdf:type schema:DefinedTerm
    114 N228e23ca880f4efca59ac9babf6636aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Aged, 80 and over
    116 rdf:type schema:DefinedTerm
    117 N282f1d5cb91143a9b901ae6f5778e406 rdf:first sg:person.01061766176.97
    118 rdf:rest N5c09c542af99453b867d8e608256f58a
    119 N28abc92839e143f3a1ac5bdb077ac298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Female
    121 rdf:type schema:DefinedTerm
    122 N2bffc87e330c4fc9bc2e3f19e206d31d schema:name Springer Nature - SN SciGraph project
    123 rdf:type schema:Organization
    124 N2ecdce778a70419faf01f8b3d15acf3d schema:name pubmed_id
    125 schema:value 30306344
    126 rdf:type schema:PropertyValue
    127 N386c39af9d644010a73c8c0bbe9260f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    129 rdf:type schema:DefinedTerm
    130 N389014c304f04a88a97e19dcf02b3150 rdf:first sg:person.01323477112.38
    131 rdf:rest N7963ce42ec8c4fe9a926d9c8b09a6e18
    132 N3a0c32ffd7f64d24b40d2d218d3a2956 rdf:first sg:person.0670103754.78
    133 rdf:rest N04fe3b8291ac47f48aeef966e4cc46ff
    134 N3c699f4d40494c93b2cb7c2152a7e08d rdf:first sg:person.01326213552.92
    135 rdf:rest Nf9ed9f0057754b7aa6d4c446399bfa20
    136 N3fed2d16377b4a0eabd95b3c7fa159c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Follow-Up Studies
    138 rdf:type schema:DefinedTerm
    139 N42548522b0cd40a9955a73283d2a44c8 rdf:first sg:person.014771011022.59
    140 rdf:rest N71664dd6f2c94cf5a2406cee47e8da8f
    141 N4e4ec8e6b0ac4e4da2a3a8838920db24 rdf:first sg:person.01330245113.27
    142 rdf:rest N019f602d02fc4a4aa11abb28880c11fc
    143 N5c09c542af99453b867d8e608256f58a rdf:first sg:person.012553625252.50
    144 rdf:rest N74e36892cb2141ce9ecce7fb6f751dd2
    145 N619ec1f381824b64a106252429b10892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Middle Aged
    147 rdf:type schema:DefinedTerm
    148 N6b173c0bee7942fdad1217545ce12531 schema:name dimensions_id
    149 schema:value pub.1107537281
    150 rdf:type schema:PropertyValue
    151 N71664dd6f2c94cf5a2406cee47e8da8f rdf:first sg:person.014560721422.39
    152 rdf:rest Nfb597a19e6dc476c985f8ca0cd0bc881
    153 N74e36892cb2141ce9ecce7fb6f751dd2 rdf:first sg:person.0605601010.43
    154 rdf:rest N0d759a05915a468b945e7e3359ea1e1e
    155 N7963ce42ec8c4fe9a926d9c8b09a6e18 rdf:first sg:person.0657013776.40
    156 rdf:rest N09ff80e86b3e4c389f7a126d0d1001bd
    157 N8054afab60aa4247b113357f0f0196ad schema:issueNumber 3
    158 rdf:type schema:PublicationIssue
    159 N813239cc6a51452087cc80053f9d9d97 rdf:first sg:person.01315534513.06
    160 rdf:rest Na5b18c446dca4317a0ac8ccafb665653
    161 N8b5a785168f94ab19d4cff9e74fb1bd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Humans
    163 rdf:type schema:DefinedTerm
    164 N8cee8bc416534c57ba615aa95d828266 rdf:first sg:person.0767063345.54
    165 rdf:rest N073c41f9696b44198f6af8d55d030220
    166 N929515fc77c84bdaa7b95d42258a43b2 schema:name doi
    167 schema:value 10.1007/s10157-018-1656-1
    168 rdf:type schema:PropertyValue
    169 N9c87c532fdef478bb9275c56c17c178a schema:volumeNumber 23
    170 rdf:type schema:PublicationVolume
    171 Na5b18c446dca4317a0ac8ccafb665653 rdf:first sg:person.01007133200.05
    172 rdf:rest Nadd1fd8220174dec8abb384389dad066
    173 Nadd1fd8220174dec8abb384389dad066 rdf:first sg:person.01022702772.51
    174 rdf:rest N8cee8bc416534c57ba615aa95d828266
    175 Nb3c9e8ee22924910b38c2ed4fce6f56c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Glomerulonephritis
    177 rdf:type schema:DefinedTerm
    178 Nb44da1aa8fc74f5eb760f95522e23cf8 schema:affiliation grid-institutes:grid.27476.30
    179 schema:familyName Tsuboi
    180 schema:givenName Naotaka
    181 rdf:type schema:Person
    182 Nda45731734924f6cae53ced09f71ce7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Aged
    184 rdf:type schema:DefinedTerm
    185 Ne96c5662752a41d695dab3f4c9cceda6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Prospective Studies
    187 rdf:type schema:DefinedTerm
    188 Nf5b11ed3a60248a99943033674e2ec3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Male
    190 rdf:type schema:DefinedTerm
    191 Nf9ed9f0057754b7aa6d4c446399bfa20 rdf:first sg:person.01024375011.44
    192 rdf:rest rdf:nil
    193 Nfb597a19e6dc476c985f8ca0cd0bc881 rdf:first sg:person.0747013232.68
    194 rdf:rest N389014c304f04a88a97e19dcf02b3150
    195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    196 schema:name Medical and Health Sciences
    197 rdf:type schema:DefinedTerm
    198 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Public Health and Health Services
    200 rdf:type schema:DefinedTerm
    201 sg:grant.12845786 http://pending.schema.org/fundedItem sg:pub.10.1007/s10157-018-1656-1
    202 rdf:type schema:MonetaryGrant
    203 sg:grant.8439074 http://pending.schema.org/fundedItem sg:pub.10.1007/s10157-018-1656-1
    204 rdf:type schema:MonetaryGrant
    205 sg:grant.8439134 http://pending.schema.org/fundedItem sg:pub.10.1007/s10157-018-1656-1
    206 rdf:type schema:MonetaryGrant
    207 sg:grant.9337427 http://pending.schema.org/fundedItem sg:pub.10.1007/s10157-018-1656-1
    208 rdf:type schema:MonetaryGrant
    209 sg:grant.9337902 http://pending.schema.org/fundedItem sg:pub.10.1007/s10157-018-1656-1
    210 rdf:type schema:MonetaryGrant
    211 sg:journal.1117096 schema:issn 1342-1751
    212 1437-7799
    213 schema:name Clinical and Experimental Nephrology
    214 schema:publisher Springer Nature
    215 rdf:type schema:Periodical
    216 sg:person.01007133200.05 schema:affiliation grid-institutes:grid.20515.33
    217 schema:familyName Usui
    218 schema:givenName Joichi
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007133200.05
    220 rdf:type schema:Person
    221 sg:person.01022702772.51 schema:affiliation grid-institutes:grid.20515.33
    222 schema:familyName Nagata
    223 schema:givenName Michio
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51
    225 rdf:type schema:Person
    226 sg:person.01023355176.35 schema:affiliation grid-institutes:None
    227 schema:familyName Amano
    228 schema:givenName Koichi
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023355176.35
    230 rdf:type schema:Person
    231 sg:person.01024375011.44 schema:affiliation grid-institutes:grid.27476.30
    232 schema:familyName Matsuo
    233 schema:givenName Seiichi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024375011.44
    235 rdf:type schema:Person
    236 sg:person.01042575643.05 schema:affiliation grid-institutes:grid.415392.8
    237 schema:familyName Muso
    238 schema:givenName Eri
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042575643.05
    240 rdf:type schema:Person
    241 sg:person.01061766176.97 schema:affiliation grid-institutes:grid.39158.36
    242 schema:familyName Atsumi
    243 schema:givenName Tatsuya
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061766176.97
    245 rdf:type schema:Person
    246 sg:person.01210261571.66 schema:affiliation grid-institutes:grid.413946.d
    247 schema:familyName Arimura
    248 schema:givenName Yoshihiro
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210261571.66
    250 rdf:type schema:Person
    251 sg:person.012553625252.50 schema:affiliation grid-institutes:grid.410849.0
    252 schema:familyName Fujimoto
    253 schema:givenName Shouichi
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012553625252.50
    255 rdf:type schema:Person
    256 sg:person.01315534513.06 schema:affiliation grid-institutes:grid.20515.33
    257 schema:familyName Yamagata
    258 schema:givenName Kunihiro
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315534513.06
    260 rdf:type schema:Person
    261 sg:person.01323477112.38 schema:affiliation grid-institutes:grid.452874.8
    262 schema:familyName Homma
    263 schema:givenName Sakae
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323477112.38
    265 rdf:type schema:Person
    266 sg:person.01326213552.92 schema:affiliation grid-institutes:grid.261356.5
    267 schema:familyName Makino
    268 schema:givenName Hirofumi
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326213552.92
    270 rdf:type schema:Person
    271 sg:person.01330245113.27 schema:affiliation grid-institutes:grid.39158.36
    272 schema:familyName Ishizu
    273 schema:givenName Akihiro
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330245113.27
    275 rdf:type schema:Person
    276 sg:person.014560721422.39 schema:affiliation grid-institutes:grid.411621.1
    277 schema:familyName Ito
    278 schema:givenName Takafumi
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014560721422.39
    280 rdf:type schema:Person
    281 sg:person.014771011022.59 schema:affiliation grid-institutes:grid.411497.e
    282 schema:familyName Saito
    283 schema:givenName Takao
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014771011022.59
    285 rdf:type schema:Person
    286 sg:person.0601105423.85 schema:affiliation grid-institutes:grid.412784.c
    287 schema:familyName Kobayashi
    288 schema:givenName Masaki
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601105423.85
    290 rdf:type schema:Person
    291 sg:person.0605601010.43 schema:affiliation grid-institutes:grid.256115.4
    292 schema:familyName Yuzawa
    293 schema:givenName Yukio
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605601010.43
    295 rdf:type schema:Person
    296 sg:person.0657013776.40 schema:affiliation grid-institutes:grid.258331.e
    297 schema:familyName Dobashi
    298 schema:givenName Hiroaki
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657013776.40
    300 rdf:type schema:Person
    301 sg:person.0670103754.78 schema:affiliation grid-institutes:grid.265073.5
    302 schema:familyName Harigai
    303 schema:givenName Masayoshi
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670103754.78
    305 rdf:type schema:Person
    306 sg:person.0705044575.68 schema:affiliation grid-institutes:grid.261356.5
    307 schema:familyName Sada
    308 schema:givenName Ken-ei
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705044575.68
    310 rdf:type schema:Person
    311 sg:person.0747013232.68 schema:affiliation grid-institutes:grid.413045.7
    312 schema:familyName Hirawa
    313 schema:givenName Nobuhito
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747013232.68
    315 rdf:type schema:Person
    316 sg:person.0767063345.54 schema:affiliation grid-institutes:grid.261356.5
    317 schema:familyName Sugiyama
    318 schema:givenName Hitoshi
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767063345.54
    320 rdf:type schema:Person
    321 sg:pub.10.1007/s10157-009-0201-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032020926
    322 https://doi.org/10.1007/s10157-009-0201-7
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/s10157-012-0755-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046335331
    325 https://doi.org/10.1007/s10157-012-0755-7
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s10165-013-0877-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005312440
    328 https://doi.org/10.1007/s10165-013-0877-0
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1186/1471-2369-14-125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003466137
    331 https://doi.org/10.1186/1471-2369-14-125
    332 rdf:type schema:CreativeWork
    333 grid-institutes:None schema:alternateName Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    334 schema:name Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    335 rdf:type schema:Organization
    336 grid-institutes:grid.20515.33 schema:alternateName Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan
    337 Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    338 schema:name Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan
    339 Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    340 rdf:type schema:Organization
    341 grid-institutes:grid.256115.4 schema:alternateName Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan
    342 schema:name Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan
    343 rdf:type schema:Organization
    344 grid-institutes:grid.258331.e schema:alternateName Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    345 schema:name Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    346 rdf:type schema:Organization
    347 grid-institutes:grid.261356.5 schema:alternateName Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
    348 Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
    349 Okayama University, Okayama, Japan
    350 schema:name Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
    351 Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
    352 Okayama University, Okayama, Japan
    353 rdf:type schema:Organization
    354 grid-institutes:grid.265073.5 schema:alternateName Department of Pharmacovigilance, Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    355 schema:name Department of Pharmacovigilance, Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    356 rdf:type schema:Organization
    357 grid-institutes:grid.27476.30 schema:alternateName Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan
    358 schema:name Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan
    359 rdf:type schema:Organization
    360 grid-institutes:grid.39158.36 schema:alternateName Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    361 Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
    362 schema:name Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    363 Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
    364 rdf:type schema:Organization
    365 grid-institutes:grid.410849.0 schema:alternateName Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    366 schema:name Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    367 rdf:type schema:Organization
    368 grid-institutes:grid.411497.e schema:alternateName Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
    369 schema:name Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
    370 rdf:type schema:Organization
    371 grid-institutes:grid.411621.1 schema:alternateName Division of Nephrology, Faculty of Medicine, Shimane University, Izumo, Japan
    372 schema:name Division of Nephrology, Faculty of Medicine, Shimane University, Izumo, Japan
    373 rdf:type schema:Organization
    374 grid-institutes:grid.412784.c schema:alternateName Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan
    375 schema:name Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan
    376 rdf:type schema:Organization
    377 grid-institutes:grid.413045.7 schema:alternateName Department of Hemodialysis and Apheresis, Yokohama City University Medical Center, Yokohama, Japan
    378 schema:name Department of Hemodialysis and Apheresis, Yokohama City University Medical Center, Yokohama, Japan
    379 rdf:type schema:Organization
    380 grid-institutes:grid.413946.d schema:alternateName Kichijoji Asahi Hospital, Tokyo, Japan
    381 schema:name Kichijoji Asahi Hospital, Tokyo, Japan
    382 Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan
    383 rdf:type schema:Organization
    384 grid-institutes:grid.415392.8 schema:alternateName Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    385 schema:name Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    386 rdf:type schema:Organization
    387 grid-institutes:grid.452874.8 schema:alternateName Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan
    388 schema:name Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan
    389 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...