Ontology type: schema:ScholarlyArticle Open Access: True
2019-01
AUTHORSHideki Kato, Yoshitaka Miyakawa, Yoshihiko Hidaka, Norimitsu Inoue, Shuichi Ito, Shoji Kagami, Shinya Kaname, Masanori Matsumoto, Masashi Mizuno, Takahisa Matsuda, Akihiko Shimono, Shoichi Maruyama, Yoshihiro Fujimura, Masaomi Nangaku, Hirokazu Okada
ABSTRACTBACKGROUND: Eculizumab has been available for the treatment of atypical hemolytic-uremic syndrome (aHUS) in Japan since 2013. To assess safety and effectiveness of eculizumab in adult aHUS patients in the real-life setting, we performed interim analysis of a post-marketing surveillance mandated by Japanese regulations. METHODS: This study enrolled any patient who was diagnosed with TMA excluding Shiga toxin-producing Escherichia coli-HUS or thrombotic thrombocytopenic purpura based on Japanese clinical guide published in 2013 as inclusion criteria and treated with eculizumab. Although the term aHUS was redefined to denote only complement-mediated HUS in the guide revised in 2016, the patients with TMA caused by other causes (secondary TMA) were included. Patient outcomes and safety were evaluated at 6 months, 12 months, and annually thereafter. RESULTS: Thirty-three patients with aHUS and 27 patients with secondary TMA were enrolled. Median treatment duration of aHUS was 24weeks. Complement genes variants were detected in 11 of 18 patients with aHUS (61.1%). Among the 29 aHUS patients with available baseline data, platelet count (PLT), lactic dehydrogenase and serum creatinine (SCr) improved within 1-month after eculizumab initiation. TMA event-free status, complete TMA response, PLT normalization, and SCr decrease were achieved in 67.9% (19/28), 27.8% (5/18), 56.5% (13/23), and 57.1% (16/28) of patients, respectively. Thirty-three and 11 adverse reactions were observed in patients with aHUS (13/33 patients) and secondary TMA (6/27 patients), respectively. CONCLUSIONS: This interim analysis confirmed the acceptable safety profile and effectiveness of eculizumab for Japanese adult aHUS patients in real-world settings. More... »
PAGES1-11
http://scigraph.springernature.com/pub.10.1007/s10157-018-1609-8
DOIhttp://dx.doi.org/10.1007/s10157-018-1609-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105208689
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29959568
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Division of Nephrology and Endocrinology, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kato",
"givenName": "Hideki",
"id": "sg:person.01275753007.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275753007.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Saitama Medical University",
"id": "https://www.grid.ac/institutes/grid.410802.f",
"name": [
"Department of General Internal Medicine, Thrombosis and Hemostasis Center, Saitama Medical University, 38 Moroyama, Iruma-gun, 350-0495, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Miyakawa",
"givenName": "Yoshitaka",
"id": "sg:person.01317475506.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317475506.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shinshu University Hospital",
"id": "https://www.grid.ac/institutes/grid.412568.c",
"name": [
"Clinical Division of Pediatrics, Shinshu University Hospital, 3-1-1 Asahi, 390-8621, Matsumoto, Nagano, Japan"
],
"type": "Organization"
},
"familyName": "Hidaka",
"givenName": "Yoshihiko",
"id": "sg:person.01366756522.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366756522.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka International Cancer Institute",
"id": "https://www.grid.ac/institutes/grid.489169.b",
"name": [
"Department of Tumor Immunology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, 541-8567, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Inoue",
"givenName": "Norimitsu",
"id": "sg:person.010564733752.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010564733752.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Pediatrics, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanasawa-ku, 236-0004, Yokohama, Kanagawa, Japan"
],
"type": "Organization"
},
"familyName": "Ito",
"givenName": "Shuichi",
"id": "sg:person.012302533312.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012302533312.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokushima",
"id": "https://www.grid.ac/institutes/grid.267335.6",
"name": [
"Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto cho 3-chome, 770-8503, Tokushima, Japan"
],
"type": "Organization"
},
"familyName": "Kagami",
"givenName": "Shoji",
"id": "sg:person.01227336036.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227336036.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyorin University",
"id": "https://www.grid.ac/institutes/grid.411205.3",
"name": [
"Department of Nephrology and Rheumatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, 181-8611, Mitaka, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kaname",
"givenName": "Shinya",
"id": "sg:person.0632351573.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632351573.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nara Medical University",
"id": "https://www.grid.ac/institutes/grid.410814.8",
"name": [
"Department of Blood Transfusion Medicine, Nara Medical University, 840 Shijyo-cho, 634-8522, Kashihara, Nara, Japan"
],
"type": "Organization"
},
"familyName": "Matsumoto",
"givenName": "Masanori",
"id": "sg:person.013301731152.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013301731152.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Renal Replacement Therapy, Division of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan"
],
"type": "Organization"
},
"familyName": "Mizuno",
"givenName": "Masashi",
"id": "sg:person.01211430102.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211430102.94"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Alexion Pharma GK, 1-18-14 Ebisu, Shibuya-ku, 150-0013, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Matsuda",
"givenName": "Takahisa",
"id": "sg:person.014167142054.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014167142054.61"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Alexion Pharma GK, 1-18-14 Ebisu, Shibuya-ku, 150-0013, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Shimono",
"givenName": "Akihiko",
"id": "sg:person.014764522454.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014764522454.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan"
],
"type": "Organization"
},
"familyName": "Maruyama",
"givenName": "Shoichi",
"id": "sg:person.01106355134.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106355134.42"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Japanese Red Cross Kinki Block Blood Center, 7-5-17, Saitoasagi, 567-0085, Ibaraki, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Fujimura",
"givenName": "Yoshihiro",
"id": "sg:person.0724065021.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724065021.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Division of Nephrology and Endocrinology, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Nangaku",
"givenName": "Masaomi",
"id": "sg:person.01300062465.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300062465.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Saitama Medical University",
"id": "https://www.grid.ac/institutes/grid.410802.f",
"name": [
"Department of Nephrology, Saitama Medical University, 38 Moroyama, Iruma-gun, 350-0495, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Okada",
"givenName": "Hirokazu",
"id": "sg:person.0700630035.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700630035.01"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1053/j.ajkd.2008.12.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000437042"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.kint.2016.10.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001194540"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/kisup.2012.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004822134",
"https://doi.org/10.1038/kisup.2012.1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-013-0911-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015777021",
"https://doi.org/10.1007/s10157-013-0911-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2215/cjn.02210310",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015844186"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-6143.2008.02297.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016959283"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-016-1276-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023786470",
"https://doi.org/10.1007/s10157-016-1276-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-016-1276-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023786470",
"https://doi.org/10.1007/s10157-016-1276-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-016-1276-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023786470",
"https://doi.org/10.1007/s10157-016-1276-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2215/cjn.04760512",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031732423"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ki.2014.423",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034487753",
"https://doi.org/10.1038/ki.2014.423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1681/asn.2009070706",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037766154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1681/asn.2009070706",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037766154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2014-09-600411",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038634364"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1208981",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038836296"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ped.12274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041431327"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2015-08-663435",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045520489"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ped.13044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045648041"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ajt.12077",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046014554"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.ajkd.2015.12.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046980700"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ndt/gfw453",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059933581"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079365600",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.kint.2016.12.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083699939"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2215/cjn.00280117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085942289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2215/cjn.00280117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085942289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.kint.2017.06.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091576704"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci.insight.99128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101679438"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci.insight.99128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101679438"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci.insight.99128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101679438"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-01",
"datePublishedReg": "2019-01-01",
"description": "BACKGROUND: Eculizumab has been available for the treatment of atypical hemolytic-uremic syndrome (aHUS) in Japan since 2013. To assess safety and effectiveness of eculizumab in adult aHUS patients in the real-life setting, we performed interim analysis of a post-marketing surveillance mandated by Japanese regulations.\nMETHODS: This study enrolled any patient who was diagnosed with TMA excluding Shiga toxin-producing Escherichia coli-HUS or thrombotic thrombocytopenic purpura based on Japanese clinical guide published in 2013 as inclusion criteria and treated with eculizumab. Although the term aHUS was redefined to denote only complement-mediated HUS in the guide revised in 2016, the patients with TMA caused by other causes (secondary TMA) were included. Patient outcomes and safety were evaluated at 6 months, 12 months, and annually thereafter.\nRESULTS: Thirty-three patients with aHUS and 27 patients with secondary TMA were enrolled. Median treatment duration of aHUS was 24weeks. Complement genes variants were detected in 11 of 18 patients with aHUS (61.1%). Among the 29 aHUS patients with available baseline data, platelet count (PLT), lactic dehydrogenase and serum creatinine (SCr) improved within 1-month after eculizumab initiation. TMA event-free status, complete TMA response, PLT normalization, and SCr decrease were achieved in 67.9% (19/28), 27.8% (5/18), 56.5% (13/23), and 57.1% (16/28) of patients, respectively. Thirty-three and 11 adverse reactions were observed in patients with aHUS (13/33 patients) and secondary TMA (6/27 patients), respectively.\nCONCLUSIONS: This interim analysis confirmed the acceptable safety profile and effectiveness of eculizumab for Japanese adult aHUS patients in real-world settings.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10157-018-1609-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1117096",
"issn": [
"1342-1751",
"1437-7799"
],
"name": "Clinical and Experimental Nephrology",
"type": "Periodical"
}
],
"name": "Safety and effectiveness of eculizumab for adult patients with atypical hemolytic\u2013uremic syndrome in Japan: interim analysis of post-marketing surveillance",
"pagination": "1-11",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"097fa277641a8a6a8473816580d04c05f4b3820dcc4df87594e0231847aa3dfc"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29959568"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9709923"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10157-018-1609-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105208689"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10157-018-1609-8",
"https://app.dimensions.ai/details/publication/pub.1105208689"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000557.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs10157-018-1609-8"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1609-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1609-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1609-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10157-018-1609-8'
This table displays all metadata directly associated to this object as RDF triples.
265 TRIPLES
21 PREDICATES
50 URIs
19 LITERALS
7 BLANK NODES