Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-06

AUTHORS

Naoki Nakagawa, Naoyuki Hasebe, Motoshi Hattori, Michio Nagata, Hitoshi Yokoyama, Hiroshi Sato, Hitoshi Sugiyama, Akira Shimizu, Yoshitaka Isaka, Shoichi Maruyama, Ichiei Narita

ABSTRACT

BackgroundThe incidence and age distribution of membranoproliferative glomerulonephritis (MPGN) vary throughout the world by race and ethnicity. We sought to evaluate the clinical features, pathogenesis, and age distribution of MPGN among a large nationwide data from the Japan Renal Biopsy Registry (J-RBR).MethodsA cross-sectional survey of 593 patients with MPGN (types I and III) registered in the J-RBR between 2007 and 2015 was conducted. Clinical parameters, and laboratory findings at diagnosis were compared between children (< 20 years), adults (20–64 years), and elderly patients (≥ 65 years).ResultsThe median age of the patients was 59.0 years and mean proteinuria was 3.7 g/day. The rate of nephrotic syndrome was significantly higher in adults (40.4%) and elderly patients (54.0%) than in children (14.9%), whereas the rate of chronic glomerulonephritis was significantly higher in children (66.2%) than in adults (34.4%) and elderly patients (31.2%). According to the CGA risk classification, high-risk (red zone) cases accounted for 3.4% of children, 52.5% of adults and 84.1% of elderly patients with MPGN. As for pathogenesis, primary MPGN was most frequent (56.0%). Lupus nephritis was the most common disease among adult patients with secondary MPGN, whereas infectious disease was more common in elderly patients. Multiple regression analysis revealed that high systolic blood pressure and high proteinuria were independent factors associated with decreased estimated glomerular filtration rate (eGFR) in adults and elderly patients with MPGN.ConclusionsIn Japan, adults and elderly patients with MPGN had a lower eGFR and severer proteinuria than children. More... »

PAGES

797-807

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-017-1513-7

DOI

http://dx.doi.org/10.1007/s10157-017-1513-7

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https://app.dimensions.ai/details/publication/pub.1099698945

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29214407


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35 EGFR
36 J-RBR
37 Japan
38 Japan Renal Biopsy Registry
39 MethodsA cross-sectional survey
40 Renal Biopsy Registry
41 adult patients
42 adults
43 age
44 age distribution
45 analysis
46 blood pressure
47 cases
48 children
49 chronic glomerulonephritis
50 classification
51 clinical features
52 clinical parameters
53 common disease
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57 diagnosis
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61 ethnicity
62 factors
63 features
64 filtration rate
65 findings
66 glomerular filtration rate
67 glomerulonephritis
68 high-risk cases
69 higher proteinuria
70 higher systolic blood pressure
71 incidence
72 independent factors
73 infectious diseases
74 laboratory findings
75 large nationwide data
76 lower eGFR
77 lupus nephritis
78 median age
79 membranoproliferative glomerulonephritis
80 multiple regression analysis
81 nationwide analysis
82 nationwide data
83 nephritis
84 nephrotic syndrome
85 parameters
86 pathogenesis
87 patients
88 pressure
89 primary membranoproliferative glomerulonephritis
90 proteinuria
91 race
92 rate
93 registry
94 regression analysis
95 risk classification
96 secondary membranoproliferative glomerulonephritis
97 survey
98 syndrome
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