Serum ferritin as an indicator of the development of encephalopathy in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

Masaki Shimizu, Natsumi Inoue, Mondo Kuroda, Hitoshi Irabu, Maiko Takakura, Hisashi Kaneda, Naotoshi Sugimoto, Kazuhide Ohta, Akihiro Yachie

ABSTRACT

OBJECTIVES: To investigate the diagnostic value of serum ferritin levels as a marker of disease activity and the development of encephalopathy in hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli. METHODS: Twenty patients with HUS were studied. Serum ferritin levels were compared with clinical features and serum soluble tumor necrosis factor receptor (sTNFR) I and sTNFRII levels. Serum sTNFRI and sTNFRII levels were quantified by enzyme-linked immunosorbent assays. RESULTS: Serum ferritin levels were significantly elevated at the time of the diagnosis of HUS. Serum ferritin levels were significantly elevated in patients with encephalopathy compared to patients without encephalopathy. HUS patients with serum ferritin levels of >687.5 ng/ml were at high risk of encephalopathy. Serum ferritin levels were significantly positively correlated with serum sTNFRI and sTNFRII levels. CONCLUSIONS: Serum ferritin levels are a promising indicator of the development of encephalopathy in HUS. More... »

PAGES

1083-1087

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-017-1391-z

DOI

http://dx.doi.org/10.1007/s10157-017-1391-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084024039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28283851


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45 schema:description OBJECTIVES: To investigate the diagnostic value of serum ferritin levels as a marker of disease activity and the development of encephalopathy in hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli. METHODS: Twenty patients with HUS were studied. Serum ferritin levels were compared with clinical features and serum soluble tumor necrosis factor receptor (sTNFR) I and sTNFRII levels. Serum sTNFRI and sTNFRII levels were quantified by enzyme-linked immunosorbent assays. RESULTS: Serum ferritin levels were significantly elevated at the time of the diagnosis of HUS. Serum ferritin levels were significantly elevated in patients with encephalopathy compared to patients without encephalopathy. HUS patients with serum ferritin levels of >687.5 ng/ml were at high risk of encephalopathy. Serum ferritin levels were significantly positively correlated with serum sTNFRI and sTNFRII levels. CONCLUSIONS: Serum ferritin levels are a promising indicator of the development of encephalopathy in HUS.
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