Long-term prognosis of AL and AA renal amyloidosis: a Japanese single-center experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04-26

AUTHORS

Masatoyo Ozawa, Atsushi Komatsuda, Hiroshi Ohtani, Mizuho Nara, Ryuta Sato, Masaru Togashi, Naoto Takahashi, Hideki Wakui

ABSTRACT

BackgroundFew studies have been conducted on the long-term prognosis of patients with amyloid light chain (AL) and amyloid A (AA) renal amyloidosis in the same cohort.MethodsWe retrospectively examined 68 patients with biopsy-proven renal amyloidosis (38 AL and 30 AA). Clinicopathological findings at the diagnosis and follow-up data were evaluated in each patient. We analyzed the relationship between clinicopathological parameters and survival data.ResultsSignificant differences were observed in several clinicopathological features, such as proteinuria levels, between the AL and AA groups. Among all patients, 84.2 % of the AL group and 93.3 % of the AA group received treatments for the underlying diseases of amyloidosis. During the follow-up period (median 18 months in AL and 61 months in AA), 36.8 % of the AL group and 36.7 % of the AA group developed end-stage renal failure requiring dialysis, while 71.1 % of the AL group and 56.7 % of the AA group died. Patient and renal survivals were significantly longer in the AA group than in the AL group. eGFR of >60 mL/min/1.73 m2 at biopsy and an early histological stage of glomerular amyloid deposition were identified as low-risk factors. A multivariate analysis showed that cardiac amyloidosis and steroid therapy significantly influenced patient and renal survivals.ConclusionsOur results showed that heart involvement was the major predictor of poor outcomes in renal amyloidosis, and that the prognosis of AA renal amyloidosis was markedly better than that in previously reported cohorts. Therapeutic advances in inflammatory diseases are expected to improve the prognosis of AA amyloidosis. More... »

PAGES

212-227

References to SciGraph publications

  • 2008-04-01. New advances in renal amyloidosis in CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s10157-016-1271-y

    DOI

    http://dx.doi.org/10.1007/s10157-016-1271-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038063658

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27116248


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