Correction of hyponatremia and osmotic demyelinating syndrome: have we neglected to think intracellularly? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Phuong-Mai T. Pham, Phuong-Anh T. Pham, Son V. Pham, Phuong-Truc T. Pham, Phuong-Thu T. Pham, Phuong-Chi T. Pham

ABSTRACT

BACKGROUND: Osmotic demyelination syndrome (ODS) is a complication generally associated with overly rapid correction of hyponatremia. Traditionally, nephrologists have been trained to focus solely on limiting the correction rate. However, there is accumulating evidence to suggest that the prevention of ODS is beyond achieving slow correction rates. METHODS: We (1) reviewed the literature for glial intracellular protective alterations during hyperosmolar stress, a state presumed equivalent to the rapid correction of hyponatremia, and (2) analyzed all available hyponatremia-associated ODS cases from PubMed for possible contributing factors including correction rates and concurrent metabolic disturbances involving hypokalemia, hypophosphatemia, hypomagnesemia, and/or hypoglycemia. RESULTS: In response to acute hyperosmolar stress, glial cells undergo immediate extracellular free water shift, followed by active intracellular Na(+), K(+) and amino acid uptake, and eventual idiogenic osmoles synthesis. At minimum, protective mechanisms require K(+), Mg(2+), phosphate, amino acids, and glucose. There were 158 cases of hyponatremia-associated ODS where both correction rates and other metabolic factors were documented. Compared with the rapid correction group (>0.5 mmol/L/h), the slow correction group (≤0.5 mmol/L/h) had a greater number of cases with concurrent hypokalemia (49.4 vs. 33.3 %, p = 0.04), and a greater number of cases with any concurrent metabolic derangements (55.8 vs. 38.3 %, p = 0.03). CONCLUSION: Glial cell minimizes volume changes and injury in response to hyperosmolar stress via mobilization and/or utilization of various electrolytes and metabolic factors. The prevention of ODS likely requires both minimization of correction rate and optimization of intracellular response during the correction phase when a sufficient supply of various factors is necessary. More... »

PAGES

489-495

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-014-1021-y

DOI

http://dx.doi.org/10.1007/s10157-014-1021-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031460785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25150510


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Demyelinating Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypokalemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyponatremia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnesium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osmolar Concentration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Water-Electrolyte Balance", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Greater Los Angeles Veterans Administration, 91343, Sepulveda, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Phuong-Mai T.", 
        "id": "sg:person.013042171342.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013042171342.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Veterans Affairs Central California Health Care System, 93703, Fresno, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Phuong-Anh T.", 
        "id": "sg:person.012244610742.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012244610742.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "South Texas Veterans Health Care System", 
          "id": "https://www.grid.ac/institutes/grid.280682.6", 
          "name": [
            "South Texas Veterans Health Care System and University of Texas Health Science Center, 78229, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Son V.", 
        "id": "sg:person.01320452060.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320452060.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Penn State Worthington Scranton", 
          "id": "https://www.grid.ac/institutes/grid.457009.f", 
          "name": [
            "Penn State Worthington Scranton, 18512, Dunmore, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Phuong-Truc T.", 
        "id": "sg:person.0606135332.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606135332.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Phuong-Thu T.", 
        "id": "sg:person.011401115142.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011401115142.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Olive View-UCLA Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.429879.9", 
          "name": [
            "Olive View-UCLA Medical Center, Division of Nephrology and Hypertension, 14445 Olive View Drive, 2B-182, 91342, Sylmar, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Phuong-Chi T.", 
        "id": "sg:person.012774056142.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012774056142.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1978.tb10467.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000295323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00999383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001441631", 
          "https://doi.org/10.1007/bf00999383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/410971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004791282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(84)80002-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006604774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.74.6.820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006812904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/cclm.1999.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008277230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2169/internalmedicine.51.7498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009649728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2008.02465.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009695040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneurpsyc.1959.02340140020004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009754713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010643245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000192733.00535.b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010731271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000192733.00535.b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010731271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000192733.00535.b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010731271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000192733.00535.b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010731271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004310000631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010799049", 
          "https://doi.org/10.1007/s004310000631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.2006.01552.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014176909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1996.sp021305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017061776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1972.sp009755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018852379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(79)90070-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019767860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(79)90070-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019767860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2125.1999.00872.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020288667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2125.1999.00872.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020288667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ajkd.2000.9013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022128079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/maj.0b013e3181d3cd78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022816139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/maj.0b013e3181d3cd78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022816139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clineuro.2013.07.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024975264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci30077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025217547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci30077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025217547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annfar.2008.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029693306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.292.6521.684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030016151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci102952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034961356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03256181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036847356", 
          "https://doi.org/10.1007/bf03256181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(94)90166-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037371122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043358686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apa.12143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044946261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci103712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051334929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2169/internalmedicine.49.3069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052944453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1468-1331.2001.00176.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053000571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-973686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057505953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.27.9.1648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063342090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074802828", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1955.180.3.545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076469480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1989.256.1.f113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078996935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1989.257.6.f1108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079097900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1980.239.3.f195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082353011"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "BACKGROUND: Osmotic demyelination syndrome (ODS) is a complication generally associated with overly rapid correction of hyponatremia. Traditionally, nephrologists have been trained to focus solely on limiting the correction rate. However, there is accumulating evidence to suggest that the prevention of ODS is beyond achieving slow correction rates.\nMETHODS: We (1) reviewed the literature for glial intracellular protective alterations during hyperosmolar stress, a state presumed equivalent to the rapid correction of hyponatremia, and (2) analyzed all available hyponatremia-associated ODS cases from PubMed for possible contributing factors including correction rates and concurrent metabolic disturbances involving hypokalemia, hypophosphatemia, hypomagnesemia, and/or hypoglycemia.\nRESULTS: In response to acute hyperosmolar stress, glial cells undergo immediate extracellular free water shift, followed by active intracellular Na(+), K(+) and amino acid uptake, and eventual idiogenic osmoles synthesis. At minimum, protective mechanisms require K(+), Mg(2+), phosphate, amino acids, and glucose. There were 158 cases of hyponatremia-associated ODS where both correction rates and other metabolic factors were documented. Compared with the rapid correction group (>0.5 mmol/L/h), the slow correction group (\u22640.5 mmol/L/h) had a greater number of cases with concurrent hypokalemia (49.4 vs. 33.3 %, p = 0.04), and a greater number of cases with any concurrent metabolic derangements (55.8 vs. 38.3 %, p = 0.03).\nCONCLUSION: Glial cell minimizes volume changes and injury in response to hyperosmolar stress via mobilization and/or utilization of various electrolytes and metabolic factors. The prevention of ODS likely requires both minimization of correction rate and optimization of intracellular response during the correction phase when a sufficient supply of various factors is necessary.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10157-014-1021-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1117096", 
        "issn": [
          "1342-1751", 
          "1437-7799"
        ], 
        "name": "Clinical and Experimental Nephrology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Correction of hyponatremia and osmotic demyelinating syndrome: have we neglected to think intracellularly?", 
    "pagination": "489-495", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "95df484a3e2582125c40d7d50869ac1da142baf69e6caebed0fb7018fcbde934"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25150510"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9709923"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10157-014-1021-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031460785"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10157-014-1021-y", 
      "https://app.dimensions.ai/details/publication/pub.1031460785"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000532.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10157-014-1021-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10157-014-1021-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10157-014-1021-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10157-014-1021-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10157-014-1021-y'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      81 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10157-014-1021-y schema:about N30facc9689af4db39c9545be9a7c9ad6
2 N3b7eacb3b42b40f394aaf9bd0b362c14
3 N41f2ef1ef9604715bff413b90052a387
4 N60caf13c492c4b358ed3b6c403b4ab2f
5 N64f525b7c9d746289ea8b05ef42c010e
6 N67a9764ba8eb42f2a739de2b16003f99
7 N6d0f538e42d14e7fa1944f2bd7efc0c0
8 N8feffbedf7be4f00b7e5474df37c694e
9 N91dd39923b9d4faea8c24018b5716e4d
10 N92eac1f761274762a57fe092658238f0
11 Na3e4a94c2c164e21b89d1179e7a14f73
12 Nd517377795784a84bdf27f62fa0ad019
13 Ndbce72173985455dae47eb2cbc022683
14 Nfad2ad7329ae4d1cbb46398a7dbad3fe
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N8f5639b813a1417a82025d1889acc752
18 schema:citation sg:pub.10.1007/bf00999383
19 sg:pub.10.1007/bf03256181
20 sg:pub.10.1007/s004310000631
21 https://app.dimensions.ai/details/publication/pub.1074802828
22 https://doi.org/10.1001/archneurpsyc.1959.02340140020004
23 https://doi.org/10.1016/0002-9343(94)90166-x
24 https://doi.org/10.1016/0006-8993(79)90070-2
25 https://doi.org/10.1016/j.annfar.2008.11.010
26 https://doi.org/10.1016/j.clineuro.2013.07.037
27 https://doi.org/10.1016/s0002-9343(84)80002-9
28 https://doi.org/10.1046/j.1365-2125.1999.00872.x
29 https://doi.org/10.1046/j.1468-1331.2001.00176.x
30 https://doi.org/10.1053/ajkd.2000.9013
31 https://doi.org/10.1055/s-2007-973686
32 https://doi.org/10.1056/nejmoa043901
33 https://doi.org/10.1097/01.wnr.0000192733.00535.b6
34 https://doi.org/10.1097/maj.0b013e3181d3cd78
35 https://doi.org/10.1111/apa.12143
36 https://doi.org/10.1111/j.1464-5491.2008.02465.x
37 https://doi.org/10.1111/j.1471-4159.1978.tb10467.x
38 https://doi.org/10.1111/j.1748-1716.2006.01552.x
39 https://doi.org/10.1113/jphysiol.1972.sp009755
40 https://doi.org/10.1113/jphysiol.1996.sp021305
41 https://doi.org/10.1136/bmj.292.6521.684
42 https://doi.org/10.1136/jnnp.74.6.820
43 https://doi.org/10.1152/ajplegacy.1955.180.3.545
44 https://doi.org/10.1152/ajprenal.1980.239.3.f195
45 https://doi.org/10.1152/ajprenal.1989.256.1.f113
46 https://doi.org/10.1152/ajprenal.1989.257.6.f1108
47 https://doi.org/10.1155/2011/410971
48 https://doi.org/10.1161/01.str.27.9.1648
49 https://doi.org/10.1172/jci102952
50 https://doi.org/10.1172/jci103712
51 https://doi.org/10.1172/jci114587
52 https://doi.org/10.1172/jci30077
53 https://doi.org/10.1515/cclm.1999.151
54 https://doi.org/10.2169/internalmedicine.49.3069
55 https://doi.org/10.2169/internalmedicine.51.7498
56 schema:datePublished 2015-06
57 schema:datePublishedReg 2015-06-01
58 schema:description BACKGROUND: Osmotic demyelination syndrome (ODS) is a complication generally associated with overly rapid correction of hyponatremia. Traditionally, nephrologists have been trained to focus solely on limiting the correction rate. However, there is accumulating evidence to suggest that the prevention of ODS is beyond achieving slow correction rates. METHODS: We (1) reviewed the literature for glial intracellular protective alterations during hyperosmolar stress, a state presumed equivalent to the rapid correction of hyponatremia, and (2) analyzed all available hyponatremia-associated ODS cases from PubMed for possible contributing factors including correction rates and concurrent metabolic disturbances involving hypokalemia, hypophosphatemia, hypomagnesemia, and/or hypoglycemia. RESULTS: In response to acute hyperosmolar stress, glial cells undergo immediate extracellular free water shift, followed by active intracellular Na(+), K(+) and amino acid uptake, and eventual idiogenic osmoles synthesis. At minimum, protective mechanisms require K(+), Mg(2+), phosphate, amino acids, and glucose. There were 158 cases of hyponatremia-associated ODS where both correction rates and other metabolic factors were documented. Compared with the rapid correction group (>0.5 mmol/L/h), the slow correction group (≤0.5 mmol/L/h) had a greater number of cases with concurrent hypokalemia (49.4 vs. 33.3 %, p = 0.04), and a greater number of cases with any concurrent metabolic derangements (55.8 vs. 38.3 %, p = 0.03). CONCLUSION: Glial cell minimizes volume changes and injury in response to hyperosmolar stress via mobilization and/or utilization of various electrolytes and metabolic factors. The prevention of ODS likely requires both minimization of correction rate and optimization of intracellular response during the correction phase when a sufficient supply of various factors is necessary.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N074a83c5ee6f4a2e9afd360b9841bbae
63 N414ae9edb8a1410bb1875673e0a15d58
64 sg:journal.1117096
65 schema:name Correction of hyponatremia and osmotic demyelinating syndrome: have we neglected to think intracellularly?
66 schema:pagination 489-495
67 schema:productId N05bee65cc9d64b319d96a1456f389b90
68 N31da04bab22f4e85b1f4531ed6dbca1c
69 N71e44e801d8646128c09671fa9e430e2
70 Nbf3f0e77ab6e46529df974daf3cf5e24
71 Nfb472d19b83846cbab160da5cf3103b1
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031460785
73 https://doi.org/10.1007/s10157-014-1021-y
74 schema:sdDatePublished 2019-04-11T00:20
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N229dfdfcfaf24ed09de98854632c0e3a
77 schema:url http://link.springer.com/10.1007%2Fs10157-014-1021-y
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N05bee65cc9d64b319d96a1456f389b90 schema:name pubmed_id
82 schema:value 25150510
83 rdf:type schema:PropertyValue
84 N074a83c5ee6f4a2e9afd360b9841bbae schema:issueNumber 3
85 rdf:type schema:PublicationIssue
86 N07e41bda82d747009907d65ac1b00621 rdf:first sg:person.012774056142.05
87 rdf:rest rdf:nil
88 N0b7bfc17b68647bb9ef97b4f20e26a6b rdf:first sg:person.0606135332.16
89 rdf:rest Nf837bb1d982b4f7c99077391947512e5
90 N229dfdfcfaf24ed09de98854632c0e3a schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N2922f4ef68f0453a8e99702e1fdcddba schema:name Greater Los Angeles Veterans Administration, 91343, Sepulveda, CA, USA
93 rdf:type schema:Organization
94 N30facc9689af4db39c9545be9a7c9ad6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Phosphates
96 rdf:type schema:DefinedTerm
97 N31da04bab22f4e85b1f4531ed6dbca1c schema:name readcube_id
98 schema:value 95df484a3e2582125c40d7d50869ac1da142baf69e6caebed0fb7018fcbde934
99 rdf:type schema:PropertyValue
100 N3b7eacb3b42b40f394aaf9bd0b362c14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Water-Electrolyte Balance
102 rdf:type schema:DefinedTerm
103 N414ae9edb8a1410bb1875673e0a15d58 schema:volumeNumber 19
104 rdf:type schema:PublicationVolume
105 N41f2ef1ef9604715bff413b90052a387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N60caf13c492c4b358ed3b6c403b4ab2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Sodium
110 rdf:type schema:DefinedTerm
111 N64f525b7c9d746289ea8b05ef42c010e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Osmolar Concentration
113 rdf:type schema:DefinedTerm
114 N67a9764ba8eb42f2a739de2b16003f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Hyponatremia
116 rdf:type schema:DefinedTerm
117 N698343a5b57842c694625fbfc6112ef4 rdf:first sg:person.012244610742.47
118 rdf:rest Nc7570f687de3428f86895c62b6e646b6
119 N6d0f538e42d14e7fa1944f2bd7efc0c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Magnesium
121 rdf:type schema:DefinedTerm
122 N71e44e801d8646128c09671fa9e430e2 schema:name doi
123 schema:value 10.1007/s10157-014-1021-y
124 rdf:type schema:PropertyValue
125 N8f5639b813a1417a82025d1889acc752 rdf:first sg:person.013042171342.42
126 rdf:rest N698343a5b57842c694625fbfc6112ef4
127 N8feffbedf7be4f00b7e5474df37c694e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Hypokalemia
129 rdf:type schema:DefinedTerm
130 N91dd39923b9d4faea8c24018b5716e4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Neuroglia
132 rdf:type schema:DefinedTerm
133 N92eac1f761274762a57fe092658238f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Potassium
135 rdf:type schema:DefinedTerm
136 Na3e4a94c2c164e21b89d1179e7a14f73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Glucose
138 rdf:type schema:DefinedTerm
139 Nbf3f0e77ab6e46529df974daf3cf5e24 schema:name nlm_unique_id
140 schema:value 9709923
141 rdf:type schema:PropertyValue
142 Nc7570f687de3428f86895c62b6e646b6 rdf:first sg:person.01320452060.02
143 rdf:rest N0b7bfc17b68647bb9ef97b4f20e26a6b
144 Nd517377795784a84bdf27f62fa0ad019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Demyelinating Diseases
146 rdf:type schema:DefinedTerm
147 Ndbce72173985455dae47eb2cbc022683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Amino Acids
149 rdf:type schema:DefinedTerm
150 Nf837bb1d982b4f7c99077391947512e5 rdf:first sg:person.011401115142.24
151 rdf:rest N07e41bda82d747009907d65ac1b00621
152 Nfa328d696dbb477a8dba0d9ab2203f3c schema:name Veterans Affairs Central California Health Care System, 93703, Fresno, CA, USA
153 rdf:type schema:Organization
154 Nfad2ad7329ae4d1cbb46398a7dbad3fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Syndrome
156 rdf:type schema:DefinedTerm
157 Nfb472d19b83846cbab160da5cf3103b1 schema:name dimensions_id
158 schema:value pub.1031460785
159 rdf:type schema:PropertyValue
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
164 schema:name Clinical Sciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1117096 schema:issn 1342-1751
167 1437-7799
168 schema:name Clinical and Experimental Nephrology
169 rdf:type schema:Periodical
170 sg:person.011401115142.24 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
171 schema:familyName Pham
172 schema:givenName Phuong-Thu T.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011401115142.24
174 rdf:type schema:Person
175 sg:person.012244610742.47 schema:affiliation Nfa328d696dbb477a8dba0d9ab2203f3c
176 schema:familyName Pham
177 schema:givenName Phuong-Anh T.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012244610742.47
179 rdf:type schema:Person
180 sg:person.012774056142.05 schema:affiliation https://www.grid.ac/institutes/grid.429879.9
181 schema:familyName Pham
182 schema:givenName Phuong-Chi T.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012774056142.05
184 rdf:type schema:Person
185 sg:person.013042171342.42 schema:affiliation N2922f4ef68f0453a8e99702e1fdcddba
186 schema:familyName Pham
187 schema:givenName Phuong-Mai T.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013042171342.42
189 rdf:type schema:Person
190 sg:person.01320452060.02 schema:affiliation https://www.grid.ac/institutes/grid.280682.6
191 schema:familyName Pham
192 schema:givenName Son V.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320452060.02
194 rdf:type schema:Person
195 sg:person.0606135332.16 schema:affiliation https://www.grid.ac/institutes/grid.457009.f
196 schema:familyName Pham
197 schema:givenName Phuong-Truc T.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606135332.16
199 rdf:type schema:Person
200 sg:pub.10.1007/bf00999383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001441631
201 https://doi.org/10.1007/bf00999383
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/bf03256181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036847356
204 https://doi.org/10.1007/bf03256181
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s004310000631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010799049
207 https://doi.org/10.1007/s004310000631
208 rdf:type schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1074802828 schema:CreativeWork
210 https://doi.org/10.1001/archneurpsyc.1959.02340140020004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009754713
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0002-9343(94)90166-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037371122
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/0006-8993(79)90070-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019767860
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.annfar.2008.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029693306
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.clineuro.2013.07.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024975264
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0002-9343(84)80002-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006604774
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1046/j.1365-2125.1999.00872.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020288667
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1046/j.1468-1331.2001.00176.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053000571
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1053/ajkd.2000.9013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022128079
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1055/s-2007-973686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057505953
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1056/nejmoa043901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010643245
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1097/01.wnr.0000192733.00535.b6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010731271
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/maj.0b013e3181d3cd78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022816139
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/apa.12143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044946261
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1464-5491.2008.02465.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009695040
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/j.1471-4159.1978.tb10467.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000295323
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1748-1716.2006.01552.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014176909
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1113/jphysiol.1972.sp009755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018852379
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1113/jphysiol.1996.sp021305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017061776
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1136/bmj.292.6521.684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030016151
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1136/jnnp.74.6.820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006812904
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1152/ajplegacy.1955.180.3.545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076469480
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1152/ajprenal.1980.239.3.f195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082353011
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1152/ajprenal.1989.256.1.f113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078996935
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1152/ajprenal.1989.257.6.f1108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079097900
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1155/2011/410971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004791282
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1161/01.str.27.9.1648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063342090
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1172/jci102952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034961356
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1172/jci103712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051334929
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci114587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043358686
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1172/jci30077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025217547
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1515/cclm.1999.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008277230
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2169/internalmedicine.49.3069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052944453
275 rdf:type schema:CreativeWork
276 https://doi.org/10.2169/internalmedicine.51.7498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009649728
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
279 schema:name David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.280682.6 schema:alternateName South Texas Veterans Health Care System
282 schema:name South Texas Veterans Health Care System and University of Texas Health Science Center, 78229, San Antonio, TX, USA
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.429879.9 schema:alternateName Olive View-UCLA Medical Center
285 schema:name Olive View-UCLA Medical Center, Division of Nephrology and Hypertension, 14445 Olive View Drive, 2B-182, 91342, Sylmar, CA, USA
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.457009.f schema:alternateName Penn State Worthington Scranton
288 schema:name Penn State Worthington Scranton, 18512, Dunmore, PA, USA
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...