Heavy chain deposition disease: an overview View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05-08

AUTHORS

Yuji Oe, Jun Soma, Hiroshi Sato, Sadayoshi Ito

ABSTRACT

Heavy chain deposition disease (HCDD) is one of three entities of monoclonal immunoglobulin deposition disease, characterized histopathologically by the presence of nodular glomerulosclerosis and glomerular and tubular deposition of monoclonal heavy chains without associated light chains. Although HCDD is an extremely rare disease, >30 cases have been reported to date in the literature. Of these cases, only three cases have been reported in Japan. The majority of the patients presents with nephrotic syndrome, hematuria, and hypertension, and develop progressive renal failure with or without the complication of multiple myeloma. Some cases have been treated successfully using chemotherapy. Because of its rarity, a thorough understanding of HCDD is essential for both accurate diagnosis and adequate subsequent treatment. More... »

PAGES

771-778

References to SciGraph publications

  • 2003-09-24. Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease in JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10157-013-0812-x

    DOI

    http://dx.doi.org/10.1007/s10157-013-0812-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033528788

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23652830


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