Creatinine-based equations to estimate glomerular filtration rate in Japanese children aged between 2 and 11 years old with chronic kidney ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12

AUTHORS

Takuhito Nagai, Osamu Uemura, Kenji Ishikura, Shuichi Ito, Hiroshi Hataya, Yoshimitsu Gotoh, Naoya Fujita, Yuko Akioka, Tetsuji Kaneko, Masataka Honda

ABSTRACT

BACKGROUND: Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measuring serum Cr by enzymatic method. The updated Schwartz formulae were reported by enzymatic Cr instead of by the Jaffe method in American children aged 1-16 years old. We believe it would be better to determine serum Cr-based eGFR by the enzymatic method in Japanese children for evaluation of renal function. METHODS: Serum Cr-based eGFR was determined by measuring inulin clearance and serum Cr level in 76 pediatric chronic kidney disease (CKD) patients (49 males and 27 females) aged 2-11 years with no underlying disease that would affect renal function. RESULTS: We showed the inulin clearance by expression of the body length/serum Cr ratio in pediatric CKD patients, which resulted in the equation: [Formula: see text]. Additionally, we suggest the following serum Cr-based eGFR formula passing through the origin: [Formula: see text], because it is simple and easy to remember, thus making it clinically useful. CONCLUSION: The new eGFR formula derived from body length and serum Cr level is applicable for clinical screening of renal function in Asian as well as Japanese children aged between 2 and 11 years old. More... »

PAGES

877-881

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-013-0799-3

DOI

http://dx.doi.org/10.1007/s10157-013-0799-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020996220

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23564380


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