Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09-19

AUTHORS

Jungmin Son, Soo Bong Lee, Dong Won Lee, Il Young Kim, Su Jin Lee, Sun Min Lee, Sang Heon Song, Eun Young Seong, Ihm Soo Kwak

ABSTRACT

BackgroundIn response to the pandemic 2009 A/H1N1 virus, monovalent MF59-adjuvanted vaccines were prepared. Recently, single 3.75-μg doses of MF59-adjuvanted vaccines have shown good immunogenicity in young adults. However, the immunogenicity of these vaccines has not been evaluated in dialysis patients.MethodsDialysis patients received a single 3.75-μg dose of MF59-adjuvanted vaccine by intramuscular injection. For immunogenicity assays, serum samples were obtained before vaccination and 28 days after vaccination. All sera were tested by hemagglutination inhibition assays.ResultsOverall, 48 hemodialysis (HD) patients and 34 peritoneal dialysis (PD) patients were included in immunogenicity analysis. In HD patients, geometric mean titers (GMTs) were significantly increased compared with baseline GMTs in both young (aged 18–60 years) and elderly (aged ≥60 years) patients (51.2 ± 51.4 vs. 14.1 ± 20.7 in young patients, P = 0.012; 37.9 ± 73.9 vs. 6.8 ± 8.0 in elderly patients, P = 0.018, respectively). The rates of seroprotection and seroconversion were 27.6 and 17.2 % in young patients and 31.6 and 26.3 % in elderly patients, respectively. Among PD patients, GMTs were increased only in young patients (39.8 ± 51.4 vs. 6.8 ± 5.0, P = 0.001). The rates of seroprotection and seroconversion were 36.0 and 36.0 % in young patients and 11.1 and 0.0 % in elderly patients, respectively.ConclusionA single 3.75-μg dose of MF59-adjuvanted vaccine was suboptimal to elicit protective antibody response in dialysis patients. Antibody responses against vaccine were compromised especially in elderly PD patients. Trials of different vaccination protocols such as a two-dose schedule or a higher hemagglutinin antigen dose of MF59-adjuvanted vaccine are necessary for improving antibody response in dialysis patients. More... »

PAGES

275-283

References to SciGraph publications

  • 2011-02. Inactivated Influenza Vaccines in DRUGS & AGING
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    http://scigraph.springernature.com/pub.10.1007/s10157-012-0696-1

    DOI

    http://dx.doi.org/10.1007/s10157-012-0696-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014503153

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22990301


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    40 PD patients
    41 ResultsOverall
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    44 antibodies
    45 antibody response
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    49 days
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    63 immunogenicity
    64 immunogenicity analysis
    65 immunogenicity assays
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    67 inhibition assays
    68 injection
    69 intramuscular injection
    70 mean titers
    71 patients
    72 peritoneal dialysis patients
    73 protective antibody responses
    74 protocol
    75 rate
    76 rates of seroprotection
    77 response
    78 samples
    79 schedule
    80 seroconversion
    81 seroprotection
    82 serum
    83 serum samples
    84 titers
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    87 vaccination
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