Primary membranoproliferative glomerulonephritis on the decline: decreased rate from the 1970s to the 2000s in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09-13

AUTHORS

Tetsuya Kawamura, Joichi Usui, Koji Kaseda, Kenji Takada, Itaru Ebihara, Takashi Ishizu, Tadashi Iitsuka, Kentaro Sakai, Katsumi Takemura, Masaki Kobayashi, Akio Koyama, Katsuyoshi Kanemoto, Ryo Sumazaki, Noriko Uesugi, Masayuki Noguchi, Michio Nagata, Machi Suka, Kunihiro Yamagata

ABSTRACT

BackgroundA prolonged change in the rate of primary membranoproliferative glomerulonephritis (MPGN) was identified using a Japanese database of renal biopsies.MethodsWe retrospectively investigated 6,369 renal biopsies that were performed between 1976 and 2009. Primary MPGN patients were selected, and the clinical and pathological findings were examined. We also statistically analyzed the changing rate of the onset of primary MPGN according to each decade.ResultsSeventy-nine cases with primary MPGN (1.2 % of total biopsies) were diagnosed. The age of the patients ranged from 6–79 years (average 34.6 years). There were 24 children and 55 adults, including 37 male and 42 female patients. Thirty-six cases of primary MPGN (45.6 %) showed nephrotic syndrome—8 childhood and 28 adult cases. In the pathological classification of 44 samples using electron microscopy, 29 cases were MPGN type I, 1 case was MPGN type II, and 14 cases were MPGN type III. The secular change of the rate of primary MPGN onset showed a statistically significant reduction from the 1970s to the 2000s. The rate of primary MPGN onset in the child population also significantly decreased, but not in the adult population. Among the clinical parameters, disease severity and prognosis remained unchanged. Regarding treatment in recent years, steroid pulse therapy became more available but the administration of warfarin and anti-platelet drugs significantly decreased.ConclusionWe concluded that the rate of total primary MPGN and that of pediatric patients with primary MPGN decreased. More... »

PAGES

248-254

Journal

TITLE

Clinical and Experimental Nephrology

ISSUE

2

VOLUME

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10157-012-0690-7

DOI

http://dx.doi.org/10.1007/s10157-012-0690-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006829502

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22971963


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age of Onset", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Databases, Factual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis, Membranoproliferative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrotic Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Registries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawamura", 
        "givenName": "Tetsuya", 
        "id": "sg:person.0676043416.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676043416.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Usui", 
        "givenName": "Joichi", 
        "id": "sg:person.01007133200.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007133200.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaseda", 
        "givenName": "Koji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Tsukuba Gakuen Hospital, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Nephrology, Tsukuba Gakuen Hospital, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Kenji", 
        "id": "sg:person.0575700450.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575700450.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415975.b", 
          "name": [
            "Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ebihara", 
        "givenName": "Itaru", 
        "id": "sg:person.01371700030.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371700030.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Tsukuba Central Hospital, Ushiku, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Nephrology, Tsukuba Central Hospital, Ushiku, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishizu", 
        "givenName": "Takashi", 
        "id": "sg:person.0750446650.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750446650.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iitsuka", 
        "givenName": "Tadashi", 
        "id": "sg:person.01107711373.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107711373.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakai", 
        "givenName": "Kentaro", 
        "id": "sg:person.01271751213.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271751213.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Takemura Nephrology Clinic, Kanuma, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Takemura Nephrology Clinic, Kanuma, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takemura", 
        "givenName": "Katsumi", 
        "id": "sg:person.01224137773.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224137773.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412784.c", 
          "name": [
            "Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "Masaki", 
        "id": "sg:person.0601105423.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601105423.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Tsukuba Memorial Hospital, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410857.f", 
          "name": [
            "Department of Nephrology, Tsukuba Memorial Hospital, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koyama", 
        "givenName": "Akio", 
        "id": "sg:person.0727176563.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727176563.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, National Hospital Organization Chiba-East-Hospital, Chiba, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416586.8", 
          "name": [
            "Department of Pediatrics, National Hospital Organization Chiba-East-Hospital, Chiba, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanemoto", 
        "givenName": "Katsuyoshi", 
        "id": "sg:person.01137131372.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137131372.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sumazaki", 
        "givenName": "Ryo", 
        "id": "sg:person.01065541033.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065541033.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uesugi", 
        "givenName": "Noriko", 
        "id": "sg:person.0666651172.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666651172.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noguchi", 
        "givenName": "Masayuki", 
        "id": "sg:person.01334510511.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334510511.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Michio", 
        "id": "sg:person.01022702772.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suka", 
        "givenName": "Machi", 
        "id": "sg:person.01334664363.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334664363.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamagata", 
        "givenName": "Kunihiro", 
        "id": "sg:person.01315534513.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315534513.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00857674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038919563", 
          "https://doi.org/10.1007/bf00857674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00013438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000769917", 
          "https://doi.org/10.1007/pl00013438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00856851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024708268", 
          "https://doi.org/10.1007/bf00856851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00868295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041091259", 
          "https://doi.org/10.1007/bf00868295"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-09-13", 
    "datePublishedReg": "2012-09-13", 
    "description": "BackgroundA prolonged change in the rate of primary membranoproliferative glomerulonephritis (MPGN) was identified using a Japanese database of renal biopsies.MethodsWe retrospectively investigated 6,369 renal biopsies that were performed between 1976 and 2009. Primary MPGN patients were selected, and the clinical and pathological findings were examined. We also statistically analyzed the changing rate of the onset of primary MPGN according to each decade.ResultsSeventy-nine cases with primary MPGN (1.2\u00a0% of total biopsies) were diagnosed. The age of the patients ranged from 6\u201379\u00a0years (average 34.6 years). There were 24 children and 55 adults, including 37 male and 42 female patients. Thirty-six cases of primary MPGN (45.6\u00a0%) showed nephrotic syndrome\u20148 childhood and 28 adult cases. In the pathological classification of 44 samples using electron microscopy, 29 cases were MPGN type I, 1 case was MPGN type II, and 14 cases were MPGN type III. The secular change of the rate of primary MPGN onset showed a statistically significant reduction from the 1970s to the 2000s. The rate of primary MPGN onset in the child population also significantly decreased, but not in the adult population. Among the clinical parameters, disease severity and prognosis remained unchanged. Regarding treatment in recent years, steroid pulse therapy became more available but the administration of warfarin and anti-platelet drugs significantly decreased.ConclusionWe concluded that the rate of total primary MPGN and that of pediatric patients with primary MPGN decreased.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10157-012-0690-7", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1117096", 
        "issn": [
          "1342-1751", 
          "1437-7799"
        ], 
        "name": "Clinical and Experimental Nephrology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "primary membranoproliferative glomerulonephritis", 
      "membranoproliferative glomerulonephritis", 
      "renal biopsy", 
      "ResultsSeventy-nine cases", 
      "steroid pulse therapy", 
      "MPGN type I", 
      "administration of warfarin", 
      "anti-platelet drugs", 
      "MPGN type III", 
      "MPGN type II", 
      "MPGN patients", 
      "pulse therapy", 
      "pediatric patients", 
      "pathological findings", 
      "female patients", 
      "clinical parameters", 
      "adult cases", 
      "pathological classification", 
      "patients", 
      "disease severity", 
      "adult population", 
      "child population", 
      "Japanese database", 
      "glomerulonephritis", 
      "biopsy", 
      "type III", 
      "significant reduction", 
      "type I", 
      "onset", 
      "type II", 
      "prognosis", 
      "warfarin", 
      "cases", 
      "therapy", 
      "population", 
      "years", 
      "MethodsWe", 
      "administration", 
      "BackgroundA", 
      "ConclusionWe", 
      "severity", 
      "rate", 
      "drugs", 
      "age", 
      "adults", 
      "childhood", 
      "treatment", 
      "children", 
      "males", 
      "changes", 
      "findings", 
      "secular changes", 
      "decline", 
      "database", 
      "reduction", 
      "recent years", 
      "samples", 
      "classification", 
      "Japan", 
      "decades", 
      "electron microscopy", 
      "microscopy", 
      "parameters"
    ], 
    "name": "Primary membranoproliferative glomerulonephritis on the decline: decreased rate from the 1970s to the 2000s in Japan", 
    "pagination": "248-254", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006829502"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10157-012-0690-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22971963"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10157-012-0690-7", 
      "https://app.dimensions.ai/details/publication/pub.1006829502"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_570.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10157-012-0690-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10157-012-0690-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10157-012-0690-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10157-012-0690-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10157-012-0690-7'


 

This table displays all metadata directly associated to this object as RDF triples.

366 TRIPLES      21 PREDICATES      112 URIs      100 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10157-012-0690-7 schema:about N04dd6c8d5c5b4c1db067be72c90f0a6d
2 N055de995414148689eb552788f43e095
3 N191cfea8dc16482a8314ef2cf7c62eea
4 N1e72a2bb823c4e9fab45ab2c18457933
5 N1f320a59582e4e729e45cacf662abbd7
6 N218f4c0f722f463ea18ca0d20b053349
7 N2330c6a2438543bcaa02ca6cde835d25
8 N3408c1c97e7a4083b98dba8258fccffe
9 N55a81c110372413ca3a6458dbe78cfd7
10 N5b2e117b6fc24b7dadb89a99ad0c1452
11 N651cb3dcb4a24995a3ce5d80855a8282
12 N6bd847b1be584e068c884c130d124289
13 N7ca7e05e9ba9406ea8f45ebef83769ce
14 N985aa8ec83c14cdaae152b0fa97b9a19
15 N99349b62dd274570a54d5cbb13127a71
16 N9b79b9f9c5474a4bb1570ed0c3bbf769
17 N9ca3c6734afa476c9aec6c191732dee3
18 N9d4806e2a4d74c6aa070a7f4c8a6ee84
19 Na0d4f41d3f304200b609e3b3c1dbc718
20 Nd1acca29ca234962b75288774dc93556
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N4fc57a4623384f07b6338e9ff3fd2532
24 schema:citation sg:pub.10.1007/bf00856851
25 sg:pub.10.1007/bf00857674
26 sg:pub.10.1007/bf00868295
27 sg:pub.10.1007/pl00013438
28 schema:datePublished 2012-09-13
29 schema:datePublishedReg 2012-09-13
30 schema:description BackgroundA prolonged change in the rate of primary membranoproliferative glomerulonephritis (MPGN) was identified using a Japanese database of renal biopsies.MethodsWe retrospectively investigated 6,369 renal biopsies that were performed between 1976 and 2009. Primary MPGN patients were selected, and the clinical and pathological findings were examined. We also statistically analyzed the changing rate of the onset of primary MPGN according to each decade.ResultsSeventy-nine cases with primary MPGN (1.2 % of total biopsies) were diagnosed. The age of the patients ranged from 6–79 years (average 34.6 years). There were 24 children and 55 adults, including 37 male and 42 female patients. Thirty-six cases of primary MPGN (45.6 %) showed nephrotic syndrome—8 childhood and 28 adult cases. In the pathological classification of 44 samples using electron microscopy, 29 cases were MPGN type I, 1 case was MPGN type II, and 14 cases were MPGN type III. The secular change of the rate of primary MPGN onset showed a statistically significant reduction from the 1970s to the 2000s. The rate of primary MPGN onset in the child population also significantly decreased, but not in the adult population. Among the clinical parameters, disease severity and prognosis remained unchanged. Regarding treatment in recent years, steroid pulse therapy became more available but the administration of warfarin and anti-platelet drugs significantly decreased.ConclusionWe concluded that the rate of total primary MPGN and that of pediatric patients with primary MPGN decreased.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf Nc6205f6c4fb24421bd91ee8f2c30d02b
34 Nd55fd711baef41638637268d97733c94
35 sg:journal.1117096
36 schema:keywords BackgroundA
37 ConclusionWe
38 Japan
39 Japanese database
40 MPGN patients
41 MPGN type I
42 MPGN type II
43 MPGN type III
44 MethodsWe
45 ResultsSeventy-nine cases
46 administration
47 administration of warfarin
48 adult cases
49 adult population
50 adults
51 age
52 anti-platelet drugs
53 biopsy
54 cases
55 changes
56 child population
57 childhood
58 children
59 classification
60 clinical parameters
61 database
62 decades
63 decline
64 disease severity
65 drugs
66 electron microscopy
67 female patients
68 findings
69 glomerulonephritis
70 males
71 membranoproliferative glomerulonephritis
72 microscopy
73 onset
74 parameters
75 pathological classification
76 pathological findings
77 patients
78 pediatric patients
79 population
80 primary membranoproliferative glomerulonephritis
81 prognosis
82 pulse therapy
83 rate
84 recent years
85 reduction
86 renal biopsy
87 samples
88 secular changes
89 severity
90 significant reduction
91 steroid pulse therapy
92 therapy
93 treatment
94 type I
95 type II
96 type III
97 warfarin
98 years
99 schema:name Primary membranoproliferative glomerulonephritis on the decline: decreased rate from the 1970s to the 2000s in Japan
100 schema:pagination 248-254
101 schema:productId N2c74ef8728994caeb6bff96de7d838f9
102 N88e79df0fd544031aa72fe1ac0437fc8
103 Nc7334ee4cb914fcc95ce43f6370365fb
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006829502
105 https://doi.org/10.1007/s10157-012-0690-7
106 schema:sdDatePublished 2022-10-01T06:37
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher Na75e2e1bbe754fbd8d7db403af9abec4
109 schema:url https://doi.org/10.1007/s10157-012-0690-7
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N04dd6c8d5c5b4c1db067be72c90f0a6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Adolescent
115 rdf:type schema:DefinedTerm
116 N055de995414148689eb552788f43e095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Child
118 rdf:type schema:DefinedTerm
119 N138231bacab647a2898e7ab7bee56ed2 schema:affiliation grid-institutes:grid.20515.33
120 schema:familyName Kaseda
121 schema:givenName Koji
122 rdf:type schema:Person
123 N191cfea8dc16482a8314ef2cf7c62eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Middle Aged
125 rdf:type schema:DefinedTerm
126 N1e72a2bb823c4e9fab45ab2c18457933 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adult
128 rdf:type schema:DefinedTerm
129 N1f320a59582e4e729e45cacf662abbd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Young Adult
131 rdf:type schema:DefinedTerm
132 N218f4c0f722f463ea18ca0d20b053349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Biopsy
134 rdf:type schema:DefinedTerm
135 N2330c6a2438543bcaa02ca6cde835d25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Glomerulonephritis, Membranoproliferative
137 rdf:type schema:DefinedTerm
138 N2c74ef8728994caeb6bff96de7d838f9 schema:name doi
139 schema:value 10.1007/s10157-012-0690-7
140 rdf:type schema:PropertyValue
141 N2eafee16fdea4909ad8583b86caff4e9 rdf:first sg:person.0727176563.05
142 rdf:rest N47378769278140f4a465573c0de1a982
143 N3408c1c97e7a4083b98dba8258fccffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Nephrotic Syndrome
145 rdf:type schema:DefinedTerm
146 N355188eb25ec47cabfe50195c346e962 rdf:first sg:person.01007133200.05
147 rdf:rest Ne0bf18c6f88e4f1d909ce97cb3804afe
148 N4671e6fc656245538e7bd3c6dfa2a756 rdf:first sg:person.01065541033.84
149 rdf:rest Nc39fe0215769449caf1f77ca53aef1e0
150 N47378769278140f4a465573c0de1a982 rdf:first sg:person.01137131372.44
151 rdf:rest N4671e6fc656245538e7bd3c6dfa2a756
152 N4fc57a4623384f07b6338e9ff3fd2532 rdf:first sg:person.0676043416.38
153 rdf:rest N355188eb25ec47cabfe50195c346e962
154 N50b4da5997fe47db958091aa499c15de rdf:first sg:person.01022702772.51
155 rdf:rest N628149e8104b4a1788935976059a11bf
156 N55a81c110372413ca3a6458dbe78cfd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Treatment Outcome
158 rdf:type schema:DefinedTerm
159 N5b2e117b6fc24b7dadb89a99ad0c1452 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Male
161 rdf:type schema:DefinedTerm
162 N628149e8104b4a1788935976059a11bf rdf:first sg:person.01334664363.23
163 rdf:rest Nb16477e98c664af7afc1497741250ac7
164 N651cb3dcb4a24995a3ce5d80855a8282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N67108ca9897746c2bb33c32215e84b82 rdf:first sg:person.01371700030.71
168 rdf:rest N6cac3d14dd7f4fbaa0370f2fc9d273e0
169 N6bd847b1be584e068c884c130d124289 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Registries
171 rdf:type schema:DefinedTerm
172 N6cac3d14dd7f4fbaa0370f2fc9d273e0 rdf:first sg:person.0750446650.54
173 rdf:rest N8fb746f0947043febd0ca6427098ee76
174 N7ca7e05e9ba9406ea8f45ebef83769ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Age of Onset
176 rdf:type schema:DefinedTerm
177 N88e79df0fd544031aa72fe1ac0437fc8 schema:name pubmed_id
178 schema:value 22971963
179 rdf:type schema:PropertyValue
180 N8fb746f0947043febd0ca6427098ee76 rdf:first sg:person.01107711373.08
181 rdf:rest Nb49e8633c6994b1ca8007e2a421131e2
182 N950ec1afeafd4ed1843712a9d9746b09 rdf:first sg:person.01224137773.74
183 rdf:rest Nb9ddef6027a143d8aba643549062cf61
184 N985aa8ec83c14cdaae152b0fa97b9a19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Kaplan-Meier Estimate
186 rdf:type schema:DefinedTerm
187 N99349b62dd274570a54d5cbb13127a71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Female
189 rdf:type schema:DefinedTerm
190 N9b79b9f9c5474a4bb1570ed0c3bbf769 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Age Factors
192 rdf:type schema:DefinedTerm
193 N9ca3c6734afa476c9aec6c191732dee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Japan
195 rdf:type schema:DefinedTerm
196 N9d4806e2a4d74c6aa070a7f4c8a6ee84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Aged
198 rdf:type schema:DefinedTerm
199 Na0d4f41d3f304200b609e3b3c1dbc718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Prognosis
201 rdf:type schema:DefinedTerm
202 Na75e2e1bbe754fbd8d7db403af9abec4 schema:name Springer Nature - SN SciGraph project
203 rdf:type schema:Organization
204 Naa5f27a782384302b0a1ca1ed50e3a1f rdf:first sg:person.0575700450.97
205 rdf:rest N67108ca9897746c2bb33c32215e84b82
206 Nb16477e98c664af7afc1497741250ac7 rdf:first sg:person.01315534513.06
207 rdf:rest rdf:nil
208 Nb49e8633c6994b1ca8007e2a421131e2 rdf:first sg:person.01271751213.27
209 rdf:rest N950ec1afeafd4ed1843712a9d9746b09
210 Nb9ddef6027a143d8aba643549062cf61 rdf:first sg:person.0601105423.85
211 rdf:rest N2eafee16fdea4909ad8583b86caff4e9
212 Nc39fe0215769449caf1f77ca53aef1e0 rdf:first sg:person.0666651172.86
213 rdf:rest Ncedfe2e1e5594c1783cd325b39d44990
214 Nc6205f6c4fb24421bd91ee8f2c30d02b schema:issueNumber 2
215 rdf:type schema:PublicationIssue
216 Nc7334ee4cb914fcc95ce43f6370365fb schema:name dimensions_id
217 schema:value pub.1006829502
218 rdf:type schema:PropertyValue
219 Ncedfe2e1e5594c1783cd325b39d44990 rdf:first sg:person.01334510511.35
220 rdf:rest N50b4da5997fe47db958091aa499c15de
221 Nd1acca29ca234962b75288774dc93556 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Databases, Factual
223 rdf:type schema:DefinedTerm
224 Nd55fd711baef41638637268d97733c94 schema:volumeNumber 17
225 rdf:type schema:PublicationVolume
226 Ne0bf18c6f88e4f1d909ce97cb3804afe rdf:first N138231bacab647a2898e7ab7bee56ed2
227 rdf:rest Naa5f27a782384302b0a1ca1ed50e3a1f
228 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
229 schema:name Medical and Health Sciences
230 rdf:type schema:DefinedTerm
231 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
232 schema:name Clinical Sciences
233 rdf:type schema:DefinedTerm
234 sg:journal.1117096 schema:issn 1342-1751
235 1437-7799
236 schema:name Clinical and Experimental Nephrology
237 schema:publisher Springer Nature
238 rdf:type schema:Periodical
239 sg:person.01007133200.05 schema:affiliation grid-institutes:grid.20515.33
240 schema:familyName Usui
241 schema:givenName Joichi
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007133200.05
243 rdf:type schema:Person
244 sg:person.01022702772.51 schema:affiliation grid-institutes:grid.20515.33
245 schema:familyName Nagata
246 schema:givenName Michio
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51
248 rdf:type schema:Person
249 sg:person.01065541033.84 schema:affiliation grid-institutes:grid.20515.33
250 schema:familyName Sumazaki
251 schema:givenName Ryo
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065541033.84
253 rdf:type schema:Person
254 sg:person.01107711373.08 schema:affiliation grid-institutes:None
255 schema:familyName Iitsuka
256 schema:givenName Tadashi
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107711373.08
258 rdf:type schema:Person
259 sg:person.01137131372.44 schema:affiliation grid-institutes:grid.416586.8
260 schema:familyName Kanemoto
261 schema:givenName Katsuyoshi
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137131372.44
263 rdf:type schema:Person
264 sg:person.01224137773.74 schema:affiliation grid-institutes:None
265 schema:familyName Takemura
266 schema:givenName Katsumi
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224137773.74
268 rdf:type schema:Person
269 sg:person.01271751213.27 schema:affiliation grid-institutes:None
270 schema:familyName Sakai
271 schema:givenName Kentaro
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271751213.27
273 rdf:type schema:Person
274 sg:person.01315534513.06 schema:affiliation grid-institutes:grid.20515.33
275 schema:familyName Yamagata
276 schema:givenName Kunihiro
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315534513.06
278 rdf:type schema:Person
279 sg:person.01334510511.35 schema:affiliation grid-institutes:grid.20515.33
280 schema:familyName Noguchi
281 schema:givenName Masayuki
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334510511.35
283 rdf:type schema:Person
284 sg:person.01334664363.23 schema:affiliation grid-institutes:grid.411898.d
285 schema:familyName Suka
286 schema:givenName Machi
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334664363.23
288 rdf:type schema:Person
289 sg:person.01371700030.71 schema:affiliation grid-institutes:grid.415975.b
290 schema:familyName Ebihara
291 schema:givenName Itaru
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371700030.71
293 rdf:type schema:Person
294 sg:person.0575700450.97 schema:affiliation grid-institutes:None
295 schema:familyName Takada
296 schema:givenName Kenji
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575700450.97
298 rdf:type schema:Person
299 sg:person.0601105423.85 schema:affiliation grid-institutes:grid.412784.c
300 schema:familyName Kobayashi
301 schema:givenName Masaki
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601105423.85
303 rdf:type schema:Person
304 sg:person.0666651172.86 schema:affiliation grid-institutes:grid.20515.33
305 schema:familyName Uesugi
306 schema:givenName Noriko
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666651172.86
308 rdf:type schema:Person
309 sg:person.0676043416.38 schema:affiliation grid-institutes:grid.20515.33
310 schema:familyName Kawamura
311 schema:givenName Tetsuya
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676043416.38
313 rdf:type schema:Person
314 sg:person.0727176563.05 schema:affiliation grid-institutes:grid.410857.f
315 schema:familyName Koyama
316 schema:givenName Akio
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727176563.05
318 rdf:type schema:Person
319 sg:person.0750446650.54 schema:affiliation grid-institutes:None
320 schema:familyName Ishizu
321 schema:givenName Takashi
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750446650.54
323 rdf:type schema:Person
324 sg:pub.10.1007/bf00856851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024708268
325 https://doi.org/10.1007/bf00856851
326 rdf:type schema:CreativeWork
327 sg:pub.10.1007/bf00857674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038919563
328 https://doi.org/10.1007/bf00857674
329 rdf:type schema:CreativeWork
330 sg:pub.10.1007/bf00868295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041091259
331 https://doi.org/10.1007/bf00868295
332 rdf:type schema:CreativeWork
333 sg:pub.10.1007/pl00013438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000769917
334 https://doi.org/10.1007/pl00013438
335 rdf:type schema:CreativeWork
336 grid-institutes:None schema:alternateName Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan
337 Department of Nephrology, Tsukuba Central Hospital, Ushiku, Ibaraki, Japan
338 Department of Nephrology, Tsukuba Gakuen Hospital, Tsukuba, Ibaraki, Japan
339 Takemura Nephrology Clinic, Kanuma, Tochigi, Japan
340 schema:name Department of Nephrology, Ibaraki Seinan Medical Center Hospital, Sakai, Ibaraki, Japan
341 Department of Nephrology, Tsukuba Central Hospital, Ushiku, Ibaraki, Japan
342 Department of Nephrology, Tsukuba Gakuen Hospital, Tsukuba, Ibaraki, Japan
343 Takemura Nephrology Clinic, Kanuma, Tochigi, Japan
344 rdf:type schema:Organization
345 grid-institutes:grid.20515.33 schema:alternateName Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan
346 Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
347 Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
348 schema:name Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan
349 Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
350 Department of Pediatrics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
351 rdf:type schema:Organization
352 grid-institutes:grid.410857.f schema:alternateName Department of Nephrology, Tsukuba Memorial Hospital, Tsukuba, Ibaraki, Japan
353 schema:name Department of Nephrology, Tsukuba Memorial Hospital, Tsukuba, Ibaraki, Japan
354 rdf:type schema:Organization
355 grid-institutes:grid.411898.d schema:alternateName Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan
356 schema:name Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan
357 rdf:type schema:Organization
358 grid-institutes:grid.412784.c schema:alternateName Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
359 schema:name Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
360 rdf:type schema:Organization
361 grid-institutes:grid.415975.b schema:alternateName Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
362 schema:name Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
363 rdf:type schema:Organization
364 grid-institutes:grid.416586.8 schema:alternateName Department of Pediatrics, National Hospital Organization Chiba-East-Hospital, Chiba, Chiba, Japan
365 schema:name Department of Pediatrics, National Hospital Organization Chiba-East-Hospital, Chiba, Chiba, Japan
366 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...