Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02-23

AUTHORS

Hitoshi Yokoyama, Takashi Taguchi, Hitoshi Sugiyama, Hiroshi Sato, On behalf of the Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry in the Japanese Society of Nephrology

ABSTRACT

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults. The J-RBR/J-KDR registry developed by the Japanese Society of Nephrology provides nationwide cohort data for epidemiological studies of MN. MN was present in 36.8% of 1,203 primary nephrotic syndrome patients in Japan. In addition, 633 (77.9%) out of 813 MN patients were referred to as “idiopathic,” whereas 22.1% were classified as “secondary” and involved conditions such as systemic lupus erythematosus, drug exposure, infections, cancer, and various collagen diseases. The mean age of the MN patients was 62.2 (2–88) years old, their mean eGFR was 76.7 (7.6–154.6) ml/min/1.73 m2, and 63.3% had hypertension at the time of renal biopsy. On the basis of these findings, half of Japanese idiopathic MN patients have risk factors (age >60, male, or lower eGFR) for end-stage renal failure, and 10% belong to the high-risk group (daily proteinuria of over 8.0 g). Further studies with high-grade evidence should resolve the natural history and therapeutic problems of idiopathic MN in elderly Japanese. More... »

PAGES

557-563

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URI

http://scigraph.springernature.com/pub.10.1007/s10157-012-0593-7

DOI

http://dx.doi.org/10.1007/s10157-012-0593-7

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https://app.dimensions.ai/details/publication/pub.1035076317

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22358611


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