Ontology type: schema:ScholarlyArticle Open Access: True
2021-08-07
AUTHORSNaoko Hosono, Hisayuki Yokoyama, Nobuyuki Aotsuka, Kiyoshi Ando, Hiroatsu Iida, Takayuki Ishikawa, Kensuke Usuki, Masahiro Onozawa, Masahiro Kizaki, Kohmei Kubo, Junya Kuroda, Yukio Kobayashi, Takayuki Shimizu, Shigeru Chiba, Miho Nara, Tomoko Hata, Michihiro Hidaka, Shin-Ichiro Fujiwara, Yoshinobu Maeda, Yasuyoshi Morita, Mikiko Kusano, Qiaoyang Lu, Shuichi Miyawaki, Erhan Berrak, Nahla Hasabou, Tomoki Naoe
ABSTRACTBackgroundUntil recently, no effective targeted therapies for FLT3-mutated (FLT3mut+) relapsed/refractory (R/R) acute myeloid leukemia (AML) were available in Japan. The FLT3 inhibitor, gilteritinib, was approved in Japan for patients with FLT3mut+ R/R AML based on the phase 3 ADMIRAL trial, which demonstrated the superiority of gilteritinib over salvage chemotherapy (SC) with respect to overall survival (OS; median OS, 9.3 vs 5.6 months, respectively; hazard ratio, 0.64 [95% confidence interval 0.49, 0.83]; P < 0.001).MethodsWe evaluated the Japanese subgroup (n = 48) of the ADMIRAL trial, which included 33 patients randomized to 120-mg/day gilteritinib and 15 randomized to SC.ResultsMedian OS was 14.3 months in the gilteritinib arm and 9.6 months in the SC arm. The complete remission/complete remission with partial hematologic recovery rate was higher in the gilteritinib arm (48.5%) than in the SC arm (13.3%). After adjustment for drug exposure, fewer adverse events (AEs) occurred in the gilteritinib arm than in the SC arm. Common grade ≥ 3 AEs related to gilteritinib were febrile neutropenia (36%), decreased platelet count (27%), and anemia (24%).ConclusionFindings in Japanese patients are consistent with those of the overall ADMIRAL study population. More... »
PAGES2131-2141
http://scigraph.springernature.com/pub.10.1007/s10147-021-02006-7
DOIhttp://dx.doi.org/10.1007/s10147-021-02006-7
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34363558
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-021-02006-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-021-02006-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-021-02006-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-021-02006-7'
This table displays all metadata directly associated to this object as RDF triples.
420 TRIPLES
21 PREDICATES
94 URIs
74 LITERALS
14 BLANK NODES