Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-30

AUTHORS

Yasunori Yoshino, Ayumi Taguchi, Maki Takao, Tomoko Kashiyama, Akiko Furusawa, Masaya Uno, Satoshi Okada, Nao Kino, Toshiharu Yasugi

ABSTRACT

BackgroundLymphopenia is associated with poor outcomes in patients with various cancers, but little is known about the prognostic impact of lymphopenia in patients with epithelial ovarian cancer (EOC) after induction chemotherapy (IC). This study investigated the prognostic significance of pre- and post-IC lymphopenia in patients with advanced EOC.MethodsWe reviewed medical records of 68 patients with stage III/IV ovarian, fallopian tube, or peritoneal cancer treated with IC at our institution between 2009 and 2017. We assessed the associations of pre- and post-IC inflammatory markers, including lymphocyte counts, with several oncological outcomes, such as the implementation of interval debulking surgery (IDS), complete resection, progression-free survival (PFS), and overall survival (OS).ResultsLymphocyte counts increased significantly post-IC compared with the pre-IC values (P = 0.009). Pre-IC lymphopenia was observed in 27 patients (40%), whereas only 16 patients (24%) displayed lymphopenia post-IC (P = 0.020). Among several inflammatory markers, only post-IC lymphopenia was significantly associated with incomplete resection outcome during IDS (P = 0.012). Moreover, post-IC lymphopenia was significantly associated with poor PFS (log-rank test, P = 0.009), whereas pre-IC lymphopenia was associated with neither PFS nor OS.ConclusionsPost-IC lymphopenia may predict incomplete resection during IDS and poor prognosis in patients with advanced EOC. More... »

PAGES

428-436

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-018-1374-4

DOI

http://dx.doi.org/10.1007/s10147-018-1374-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110281566

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30506281


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41 IC lymphopenia
42 IDS
43 III/IV ovarian
44 IV ovarian
45 MethodsWe
46 Pre-IC lymphopenia
47 ResultsLymphocyte counts
48 advanced epithelial ovarian cancer
49 advanced ovarian cancer
50 association
51 cancer
52 chemotherapy
53 complete resection
54 counts
55 epithelial ovarian cancer
56 fallopian tube
57 impact
58 implementation
59 implementation of interval
60 incomplete resection
61 incomplete resection outcome
62 incomplete surgical resection
63 induction chemotherapy
64 inflammatory markers
65 institutions
66 intervals
67 lymphocyte count
68 lymphopenia
69 lymphopenia post-IC
70 markers
71 medical records
72 oncological outcomes
73 outcomes
74 ovarian
75 ovarian cancer
76 overall survival
77 patients
78 peritoneal cancer
79 poor outcome
80 poor prognosis
81 poor progression-free survival
82 post-IC
83 post-IC inflammatory markers
84 post-IC lymphopenia
85 pre
86 pre-IC values
87 prognosis
88 prognostic impact
89 prognostic significance
90 progression-free survival
91 records
92 resection
93 resection outcomes
94 significance
95 stage III/IV ovarian
96 study
97 surgery
98 surgical resection
99 survival
100 tube
101 values
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