Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Akihiro Tomida, Keisuke Uehara, Kazuhiro Hiramatsu, Atsuyuki Maeda, Eiji Sakamoto, Yoshito Okada, Yasuhiro Kurumiya, Goro Nakayama, Masanao Nakamura, Toshisada Aiba, Masato Nagino, Of the Nagoya Surgical Oncology Group

ABSTRACT

BACKGROUND: Neoadjuvant chemotherapy (NAC) alone for locally advanced rectal cancer (LARC) remains an experimental treatment, and the efficacy in terms of long-term outcome has not been fully elucidated. The N-SOG 03 trial examined the safety and efficacy of neoadjuvant CAPOX and bevacizumab (Bev) without radiotherapy in patients with poor-risk LARC. METHODS: Thirty-two patients with MRI-defined LARC received neoadjuvant CAPOX and Bev followed by curative resection between 2010 and 2011. The overall survival (OS), progression-free survival (PFS), and local-relapse rate (LRR) were calculated using the Kaplan-Meier method, and the risk factors were evaluated by multivariate analysis using the Cox proportional hazard models. This trial is registered with UMIN, number 000003507. RESULTS: In the entire cohort, the 5-year OS was 81.3%. Because of disease progression during chemotherapy, 3 patients ultimately did not undergo curative surgery. As a result, 29 patients underwent R0/1 resection. Among these 29 patients, the 5-year OS, PFS, and LRR were 89.7%, 72.4% and 13.9%, respectively. In multivariate analysis, cT4b tumor was an independent poor prognostic factor for OS and LRR, and ypT4b tumor and absence of N down-staging were independent poor prognostic factors for PFS. CONCLUSIONS: Patients with cT4b tumor were not suitable for NAC alone. However, the long-term outcomes of the other patients were satisfactory, and NAC alone might be an option for treatment of LARC. N down-staging was likely to bring favorable PFS, even in patients with cStage III. More... »

PAGES

403-410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-018-1372-6

DOI

http://dx.doi.org/10.1007/s10147-018-1372-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110152772

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30471067


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomida", 
        "givenName": "Akihiro", 
        "id": "sg:person.0770124226.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770124226.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uehara", 
        "givenName": "Keisuke", 
        "id": "sg:person.01235507706.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235507706.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyohashi Municipal Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417241.5", 
          "name": [
            "Department of Surgery, Toyohashi Municipal Hospital, Toyohashi, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiramatsu", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.016317476450.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016317476450.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ogaki Municipal Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416762.0", 
          "name": [
            "Department of Surgery, Ogaki Municipal Hospital, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maeda", 
        "givenName": "Atsuyuki", 
        "id": "sg:person.0674545423.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674545423.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japanese Red Cross Nagoya Daini Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413410.3", 
          "name": [
            "Department of Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Eiji", 
        "id": "sg:person.01320736632.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320736632.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Handa City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413634.7", 
          "name": [
            "Department of Surgery, Handa City Hospital, Handa, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Yoshito", 
        "id": "sg:person.010205067113.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010205067113.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Kosei Hospital", 
          "id": "https://www.grid.ac/institutes/grid.452852.c", 
          "name": [
            "Department of Surgery, Toyota Kosei Hospital, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurumiya", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.012231451625.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012231451625.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakayama", 
        "givenName": "Goro", 
        "id": "sg:person.01215473417.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215473417.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Masanao", 
        "id": "sg:person.01020107526.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020107526.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aiba", 
        "givenName": "Toshisada", 
        "id": "sg:person.016227265003.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016227265003.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagino", 
        "givenName": "Masato", 
        "id": "sg:person.01211606464.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211606464.55"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Of the Nagoya Surgical Oncology Group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2016.66.6198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002463380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70097-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004231899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2014.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004661589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-014-2417-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011044097", 
          "https://doi.org/10.1007/s00280-014-2417-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyt115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012695908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.4780110703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013470807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdv223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017544287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000257358.56863.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018072834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000257358.56863.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018072834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa060829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021609703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2016.02.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023794047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.51.7904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026958614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.40.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027178418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)70377-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029656099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031672074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034294500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2008.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041278170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00159-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045913562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.42.8771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046054332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.53.7753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048070532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa010580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052169957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdw062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059394687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-017-3243-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083403980", 
          "https://doi.org/10.1007/s00280-017-3243-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-017-3243-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083403980", 
          "https://doi.org/10.1007/s00280-017-3243-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-017-1101-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084024007", 
          "https://doi.org/10.1007/s10147-017-1101-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-017-1101-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084024007", 
          "https://doi.org/10.1007/s10147-017-1101-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clcc.2017.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086330786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clcc.2017.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086330786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-017-5967-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090369203", 
          "https://doi.org/10.1245/s10434-017-5967-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-017-5967-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090369203", 
          "https://doi.org/10.1245/s10434-017-5967-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "BACKGROUND: Neoadjuvant chemotherapy (NAC) alone for locally advanced rectal cancer (LARC) remains an experimental treatment, and the efficacy in terms of long-term outcome has not been fully elucidated. The N-SOG 03 trial examined the safety and efficacy of neoadjuvant CAPOX and bevacizumab (Bev) without radiotherapy in patients with poor-risk LARC.\nMETHODS: Thirty-two patients with MRI-defined LARC received neoadjuvant CAPOX and Bev followed by curative resection between 2010 and 2011. The overall survival (OS), progression-free survival (PFS), and local-relapse rate (LRR) were calculated using the Kaplan-Meier method, and the risk factors were evaluated by multivariate analysis using the Cox proportional hazard models. This trial is registered with UMIN, number 000003507.\nRESULTS: In the entire cohort, the 5-year OS was 81.3%. Because of disease progression during chemotherapy, 3 patients ultimately did not undergo curative surgery. As a result, 29 patients underwent R0/1 resection. Among these 29 patients, the 5-year OS, PFS, and LRR were 89.7%, 72.4% and 13.9%, respectively. In multivariate analysis, cT4b tumor was an independent poor prognostic factor for OS and LRR, and ypT4b tumor and absence of N down-staging were independent poor prognostic factors for PFS.\nCONCLUSIONS: Patients with cT4b tumor were not suitable for NAC alone. However, the long-term outcomes of the other patients were satisfactory, and NAC alone might be an option for treatment of LARC. N down-staging was likely to bring favorable PFS, even in patients with cStage III.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10147-018-1372-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312225", 
        "issn": [
          "1341-9625", 
          "1437-7772"
        ], 
        "name": "International Journal of Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial", 
    "pagination": "403-410", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f1be58afa64c35aec81f0553ef7021d88e7381062587a343ab7980aa9a80fda0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30471067"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9616295"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10147-018-1372-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110152772"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10147-018-1372-6", 
      "https://app.dimensions.ai/details/publication/pub.1110152772"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46738_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10147-018-1372-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1372-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1372-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1372-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1372-6'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10147-018-1372-6 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nb5e730ff4d364d27a3b93586dc32bb85
4 schema:citation sg:pub.10.1007/s00280-014-2417-9
5 sg:pub.10.1007/s00280-017-3243-7
6 sg:pub.10.1007/s10147-017-1101-6
7 sg:pub.10.1245/s10434-017-5967-3
8 https://doi.org/10.1002/sim.4780110703
9 https://doi.org/10.1016/j.clcc.2017.06.008
10 https://doi.org/10.1016/j.ejso.2016.02.014
11 https://doi.org/10.1016/j.ijrobp.2014.03.007
12 https://doi.org/10.1016/j.surg.2008.09.014
13 https://doi.org/10.1016/s1470-2045(11)70097-3
14 https://doi.org/10.1016/s1470-2045(14)70377-8
15 https://doi.org/10.1016/s1470-2045(15)00159-x
16 https://doi.org/10.1056/nejmoa010580
17 https://doi.org/10.1056/nejmoa040694
18 https://doi.org/10.1056/nejmoa060829
19 https://doi.org/10.1093/annonc/mds236
20 https://doi.org/10.1093/annonc/mdv223
21 https://doi.org/10.1093/annonc/mdw062
22 https://doi.org/10.1093/jjco/hyt115
23 https://doi.org/10.1097/01.sla.0000257358.56863.ce
24 https://doi.org/10.1200/jco.2011.40.1836
25 https://doi.org/10.1200/jco.2012.42.8771
26 https://doi.org/10.1200/jco.2013.51.7904
27 https://doi.org/10.1200/jco.2013.53.7753
28 https://doi.org/10.1200/jco.2016.66.6198
29 schema:datePublished 2019-04
30 schema:datePublishedReg 2019-04-01
31 schema:description BACKGROUND: Neoadjuvant chemotherapy (NAC) alone for locally advanced rectal cancer (LARC) remains an experimental treatment, and the efficacy in terms of long-term outcome has not been fully elucidated. The N-SOG 03 trial examined the safety and efficacy of neoadjuvant CAPOX and bevacizumab (Bev) without radiotherapy in patients with poor-risk LARC. METHODS: Thirty-two patients with MRI-defined LARC received neoadjuvant CAPOX and Bev followed by curative resection between 2010 and 2011. The overall survival (OS), progression-free survival (PFS), and local-relapse rate (LRR) were calculated using the Kaplan-Meier method, and the risk factors were evaluated by multivariate analysis using the Cox proportional hazard models. This trial is registered with UMIN, number 000003507. RESULTS: In the entire cohort, the 5-year OS was 81.3%. Because of disease progression during chemotherapy, 3 patients ultimately did not undergo curative surgery. As a result, 29 patients underwent R0/1 resection. Among these 29 patients, the 5-year OS, PFS, and LRR were 89.7%, 72.4% and 13.9%, respectively. In multivariate analysis, cT4b tumor was an independent poor prognostic factor for OS and LRR, and ypT4b tumor and absence of N down-staging were independent poor prognostic factors for PFS. CONCLUSIONS: Patients with cT4b tumor were not suitable for NAC alone. However, the long-term outcomes of the other patients were satisfactory, and NAC alone might be an option for treatment of LARC. N down-staging was likely to bring favorable PFS, even in patients with cStage III.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf Nad126833a00d4747a0f6323618eb17ec
36 Nb9705aea52a94a96b246e34ffc607fbe
37 sg:journal.1312225
38 schema:name Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial
39 schema:pagination 403-410
40 schema:productId N4c502721d3644d10b58c4c7cb133e3ae
41 N675ed4ac0131478b8151ac83c5602508
42 N887ceb0e979d4686a8715716470bf22a
43 Na5bb33d22f02459c983496593e8ea43a
44 Ne5ee1e37e1a348168c1b6691908ddd00
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110152772
46 https://doi.org/10.1007/s10147-018-1372-6
47 schema:sdDatePublished 2019-04-11T13:27
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N3822c5d8753a40229b89fb8012237bd7
50 schema:url https://link.springer.com/10.1007%2Fs10147-018-1372-6
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N01b9658f20484ef6833f2b837db8eead rdf:first sg:person.01235507706.37
55 rdf:rest N889093f5d2634786b13f3f65ca9cff0f
56 N36ed46bc7fce42338eec3ecbd555b007 rdf:first sg:person.01320736632.73
57 rdf:rest N636635c9d8af4fccb93d4d1317e13ebd
58 N3822c5d8753a40229b89fb8012237bd7 schema:name Springer Nature - SN SciGraph project
59 rdf:type schema:Organization
60 N3c640ec86bf049eb93fa0aae922110f7 rdf:first Nadf15c8a1ebe432fa06465125ea775ae
61 rdf:rest rdf:nil
62 N4c502721d3644d10b58c4c7cb133e3ae schema:name dimensions_id
63 schema:value pub.1110152772
64 rdf:type schema:PropertyValue
65 N53206cefaccc484c818ea3bbacdf27f7 rdf:first sg:person.01211606464.55
66 rdf:rest N3c640ec86bf049eb93fa0aae922110f7
67 N636635c9d8af4fccb93d4d1317e13ebd rdf:first sg:person.010205067113.16
68 rdf:rest Nf7c603330c144286b0654a56b154cc7d
69 N675ed4ac0131478b8151ac83c5602508 schema:name doi
70 schema:value 10.1007/s10147-018-1372-6
71 rdf:type schema:PropertyValue
72 N887ceb0e979d4686a8715716470bf22a schema:name nlm_unique_id
73 schema:value 9616295
74 rdf:type schema:PropertyValue
75 N889093f5d2634786b13f3f65ca9cff0f rdf:first sg:person.016317476450.30
76 rdf:rest Nadf93b49dc6c427d96e9db042b5fea2b
77 Na5bb33d22f02459c983496593e8ea43a schema:name pubmed_id
78 schema:value 30471067
79 rdf:type schema:PropertyValue
80 Nad126833a00d4747a0f6323618eb17ec schema:issueNumber 4
81 rdf:type schema:PublicationIssue
82 Nadf15c8a1ebe432fa06465125ea775ae schema:familyName Of the Nagoya Surgical Oncology Group
83 rdf:type schema:Person
84 Nadf93b49dc6c427d96e9db042b5fea2b rdf:first sg:person.0674545423.25
85 rdf:rest N36ed46bc7fce42338eec3ecbd555b007
86 Nb5e730ff4d364d27a3b93586dc32bb85 rdf:first sg:person.0770124226.13
87 rdf:rest N01b9658f20484ef6833f2b837db8eead
88 Nb9705aea52a94a96b246e34ffc607fbe schema:volumeNumber 24
89 rdf:type schema:PublicationVolume
90 Nba4ae36440d742eb956202d1c71153ee rdf:first sg:person.016227265003.05
91 rdf:rest N53206cefaccc484c818ea3bbacdf27f7
92 Nc54cc761c2fe4998a1f509ebfa334594 rdf:first sg:person.01215473417.11
93 rdf:rest Nd89c76b735f54c5d975e635f96938343
94 Nd89c76b735f54c5d975e635f96938343 rdf:first sg:person.01020107526.32
95 rdf:rest Nba4ae36440d742eb956202d1c71153ee
96 Ne5ee1e37e1a348168c1b6691908ddd00 schema:name readcube_id
97 schema:value f1be58afa64c35aec81f0553ef7021d88e7381062587a343ab7980aa9a80fda0
98 rdf:type schema:PropertyValue
99 Nf7c603330c144286b0654a56b154cc7d rdf:first sg:person.012231451625.42
100 rdf:rest Nc54cc761c2fe4998a1f509ebfa334594
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
105 schema:name Oncology and Carcinogenesis
106 rdf:type schema:DefinedTerm
107 sg:journal.1312225 schema:issn 1341-9625
108 1437-7772
109 schema:name International Journal of Clinical Oncology
110 rdf:type schema:Periodical
111 sg:person.01020107526.32 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
112 schema:familyName Nakamura
113 schema:givenName Masanao
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020107526.32
115 rdf:type schema:Person
116 sg:person.010205067113.16 schema:affiliation https://www.grid.ac/institutes/grid.413634.7
117 schema:familyName Okada
118 schema:givenName Yoshito
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010205067113.16
120 rdf:type schema:Person
121 sg:person.01211606464.55 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
122 schema:familyName Nagino
123 schema:givenName Masato
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211606464.55
125 rdf:type schema:Person
126 sg:person.01215473417.11 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
127 schema:familyName Nakayama
128 schema:givenName Goro
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215473417.11
130 rdf:type schema:Person
131 sg:person.012231451625.42 schema:affiliation https://www.grid.ac/institutes/grid.452852.c
132 schema:familyName Kurumiya
133 schema:givenName Yasuhiro
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012231451625.42
135 rdf:type schema:Person
136 sg:person.01235507706.37 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
137 schema:familyName Uehara
138 schema:givenName Keisuke
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235507706.37
140 rdf:type schema:Person
141 sg:person.01320736632.73 schema:affiliation https://www.grid.ac/institutes/grid.413410.3
142 schema:familyName Sakamoto
143 schema:givenName Eiji
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320736632.73
145 rdf:type schema:Person
146 sg:person.016227265003.05 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
147 schema:familyName Aiba
148 schema:givenName Toshisada
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016227265003.05
150 rdf:type schema:Person
151 sg:person.016317476450.30 schema:affiliation https://www.grid.ac/institutes/grid.417241.5
152 schema:familyName Hiramatsu
153 schema:givenName Kazuhiro
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016317476450.30
155 rdf:type schema:Person
156 sg:person.0674545423.25 schema:affiliation https://www.grid.ac/institutes/grid.416762.0
157 schema:familyName Maeda
158 schema:givenName Atsuyuki
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674545423.25
160 rdf:type schema:Person
161 sg:person.0770124226.13 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
162 schema:familyName Tomida
163 schema:givenName Akihiro
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770124226.13
165 rdf:type schema:Person
166 sg:pub.10.1007/s00280-014-2417-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011044097
167 https://doi.org/10.1007/s00280-014-2417-9
168 rdf:type schema:CreativeWork
169 sg:pub.10.1007/s00280-017-3243-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083403980
170 https://doi.org/10.1007/s00280-017-3243-7
171 rdf:type schema:CreativeWork
172 sg:pub.10.1007/s10147-017-1101-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084024007
173 https://doi.org/10.1007/s10147-017-1101-6
174 rdf:type schema:CreativeWork
175 sg:pub.10.1245/s10434-017-5967-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090369203
176 https://doi.org/10.1245/s10434-017-5967-3
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/sim.4780110703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013470807
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.clcc.2017.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086330786
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ejso.2016.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023794047
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.ijrobp.2014.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004661589
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.surg.2008.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041278170
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s1470-2045(11)70097-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004231899
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s1470-2045(14)70377-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029656099
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s1470-2045(15)00159-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045913562
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1056/nejmoa010580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052169957
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1056/nejmoa040694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031672074
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1056/nejmoa060829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021609703
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1093/annonc/mds236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294500
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1093/annonc/mdv223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017544287
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1093/annonc/mdw062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059394687
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1093/jjco/hyt115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012695908
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/01.sla.0000257358.56863.ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1018072834
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1200/jco.2011.40.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027178418
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1200/jco.2012.42.8771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046054332
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1200/jco.2013.51.7904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026958614
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1200/jco.2013.53.7753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048070532
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1200/jco.2016.66.6198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002463380
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
221 schema:name Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
222 Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
223 Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.413410.3 schema:alternateName Japanese Red Cross Nagoya Daini Hospital
226 schema:name Department of Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.413634.7 schema:alternateName Handa City Hospital
229 schema:name Department of Surgery, Handa City Hospital, Handa, Aichi, Japan
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.416762.0 schema:alternateName Ogaki Municipal Hospital
232 schema:name Department of Surgery, Ogaki Municipal Hospital, Gifu, Japan
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.417241.5 schema:alternateName Toyohashi Municipal Hospital
235 schema:name Department of Surgery, Toyohashi Municipal Hospital, Toyohashi, Aichi, Japan
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.452852.c schema:alternateName Toyota Kosei Hospital
238 schema:name Department of Surgery, Toyota Kosei Hospital, Toyota, Aichi, Japan
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...