Ontology type: schema:ScholarlyArticle
2019-04
AUTHORSShin Fujisawa, Yasunori Ueda, Kensuke Usuki, Hajime Kobayashi, Eisei Kondo, Noriko Doki, Takafumi Nakao, Yoshinobu Kanda, Nobuharu Kosugi, Hiroshi Kosugi, Takashi Kumagai, Hiroshi Harada, Masato Shikami, Yasuhiro Maeda, Toru Sakura, Koiti Inokuchi, Akio Saito, Yuichiro Nawa, Masahiro Ogasawara, Junji Nishida, Takeshi Kondo, Chikashi Yoshida, Hiroyuki Kuroda, Yoko Tabe, Yoshinobu Maeda, Kenji Imajo, Kensuke Kojima, Satoshi Morita, Sho Komukai, Atsushi Kawaguchi, Junichi Sakamoto, Shinya Kimura
ABSTRACTBACKGROUND: Treatment-free remission (TFR), the ability to maintain a molecular response (MR), occurs in approximately 50% of patients with chronic myelogenous leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). METHODS: A multicenter phase 2 trial (Delightedly Overcome CML Expert Stop TKI Trial: DOMEST Trial) was conducted to test the safety and efficacy of discontinuing imatinib. Patients with CML with a sustained MR of 4.0 or MR4.0-equivalent for at least 2 years and confirmed MR4.0 at the beginning of the study were enrolled. In the TFR phase, the international scale (IS) was regularly monitored by IS-PCR testing. Molecular recurrence was defined as the loss of MR4.0. Recurrent patients were immediately treated with dasatinib or other TKIs including imatinib. RESULTS: Of 110 enrolled patients, 99 were evaluable. The median time from diagnosis to discontinuation of imatinib was 103 months, and the median duration of imatinib therapy was 100 months. Molecular recurrence-free survival rates were 69.6%, 68.6% and 64.3% at 6, 12, and 24 months, respectively. After discontinuation of imatinib therapy, 26 patients showed molecular recurrence, and 25 re-achieved deep MR after dasatinib treatment. Molecular response MR4.0 was achieved in 23 patients within 6 months and 25 patients within 12 months. Multivariate analysis revealed that a longer time from diagnosis to discontinuation of imatinib therapy (p = 0.0002) and long duration of imatinib therapy (p = 0.0029) predicted a favorable prognosis. CONCLUSIONS: This DOMEST Trial showed the feasibility of TKI discontinuation in a Japanese clinical setting. More... »
PAGES445-453
http://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2
DOIhttp://dx.doi.org/10.1007/s10147-018-1368-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1109819873
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30421023
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Yokohama City University Medical Center",
"id": "https://www.grid.ac/institutes/grid.413045.7",
"name": [
"Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Fujisawa",
"givenName": "Shin",
"id": "sg:person.01145377314.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kurashiki Central Hospital",
"id": "https://www.grid.ac/institutes/grid.415565.6",
"name": [
"Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan"
],
"type": "Organization"
},
"familyName": "Ueda",
"givenName": "Yasunori",
"type": "Person"
},
{
"affiliation": {
"alternateName": "NTT Medical Center",
"id": "https://www.grid.ac/institutes/grid.414992.3",
"name": [
"Department of Hematology, NTT Medical Center, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Usuki",
"givenName": "Kensuke",
"id": "sg:person.0724116206.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Obihiro Kosei General Hospital",
"id": "https://www.grid.ac/institutes/grid.416691.d",
"name": [
"Department of Hematology, Obihiro Kosei Hospital, Obihiro, Japan"
],
"type": "Organization"
},
"familyName": "Kobayashi",
"givenName": "Hajime",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Okayama University",
"id": "https://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"
],
"type": "Organization"
},
"familyName": "Kondo",
"givenName": "Eisei",
"id": "sg:person.014450312452.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014450312452.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Metropolitan Komagome Hospital",
"id": "https://www.grid.ac/institutes/grid.415479.a",
"name": [
"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Doki",
"givenName": "Noriko",
"id": "sg:person.01240752436.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka City General Hospital",
"id": "https://www.grid.ac/institutes/grid.416948.6",
"name": [
"Department of Hematology, Osaka City General Hospital, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Nakao",
"givenName": "Takafumi",
"id": "sg:person.0655045363.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655045363.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jichi Medical University Saitama Medical Center",
"id": "https://www.grid.ac/institutes/grid.415020.2",
"name": [
"Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Kanda",
"givenName": "Yoshinobu",
"id": "sg:person.0617055140.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Numazu City Hospital",
"id": "https://www.grid.ac/institutes/grid.416627.0",
"name": [
"Department of Hematology, Numazu City Hospital, Numazu, Japan"
],
"type": "Organization"
},
"familyName": "Kosugi",
"givenName": "Nobuharu",
"id": "sg:person.01110574032.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110574032.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ogaki Municipal Hospital",
"id": "https://www.grid.ac/institutes/grid.416762.0",
"name": [
"Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan"
],
"type": "Organization"
},
"familyName": "Kosugi",
"givenName": "Hiroshi",
"id": "sg:person.0716070516.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716070516.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ome Municipal General Hospital",
"id": "https://www.grid.ac/institutes/grid.416773.0",
"name": [
"Department of Hematology, Ome Municipal General Hospital, Ome, Japan"
],
"type": "Organization"
},
"familyName": "Kumagai",
"givenName": "Takashi",
"id": "sg:person.0677442365.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677442365.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Showa University Fujigaoka Hospital",
"id": "https://www.grid.ac/institutes/grid.412808.7",
"name": [
"Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Harada",
"givenName": "Hiroshi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Daiy\u016bkaidaiichi Hospital",
"id": "https://www.grid.ac/institutes/grid.413416.5",
"name": [
"Department of Hematology, Daiyukai General Hospital, Ichinomiya, Japan"
],
"type": "Organization"
},
"familyName": "Shikami",
"givenName": "Masato",
"id": "sg:person.01212043506.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212043506.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka Minami Medical Center",
"id": "https://www.grid.ac/institutes/grid.471868.4",
"name": [
"Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Maeda",
"givenName": "Yasuhiro",
"id": "sg:person.014613660432.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014613660432.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gunma Saiseikai Maebashi Hospital",
"id": "https://www.grid.ac/institutes/grid.416616.2",
"name": [
"Department of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan"
],
"type": "Organization"
},
"familyName": "Sakura",
"givenName": "Toru",
"id": "sg:person.0620232746.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620232746.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nippon Medical School",
"id": "https://www.grid.ac/institutes/grid.410821.e",
"name": [
"Department of Hematology, Nippon Medical School, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Inokuchi",
"givenName": "Koiti",
"id": "sg:person.015546543462.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546543462.29"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, Fujioka General Hospital, Fujioka, Japan"
],
"type": "Organization"
},
"familyName": "Saito",
"givenName": "Akio",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime Prefectural Central Hospital",
"id": "https://www.grid.ac/institutes/grid.414413.7",
"name": [
"Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan"
],
"type": "Organization"
},
"familyName": "Nawa",
"givenName": "Yuichiro",
"id": "sg:person.01235232263.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235232263.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sapporo Hokuyu Hospital",
"id": "https://www.grid.ac/institutes/grid.415262.6",
"name": [
"Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Ogasawara",
"givenName": "Masahiro",
"id": "sg:person.01066317125.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066317125.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jichi Medical University Saitama Medical Center",
"id": "https://www.grid.ac/institutes/grid.415020.2",
"name": [
"Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Nishida",
"givenName": "Junji",
"id": "sg:person.01370167773.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370167773.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hokkaido University Hospital",
"id": "https://www.grid.ac/institutes/grid.412167.7",
"name": [
"Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
],
"type": "Organization"
},
"familyName": "Kondo",
"givenName": "Takeshi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mito Medical Center",
"id": "https://www.grid.ac/institutes/grid.410845.c",
"name": [
"Department of Hematology, National Hospital Organization Mito Medical Center, Mito, Japan"
],
"type": "Organization"
},
"familyName": "Yoshida",
"givenName": "Chikashi",
"id": "sg:person.01277156611.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277156611.63"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Gastroenterology and Hematology/Clinical Oncology, Steel Muroran Memorial Hospital, Muroran, Japan"
],
"type": "Organization"
},
"familyName": "Kuroda",
"givenName": "Hiroyuki",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Juntendo University",
"id": "https://www.grid.ac/institutes/grid.258269.2",
"name": [
"Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Tabe",
"givenName": "Yoko",
"id": "sg:person.01130154025.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130154025.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Okayama University Hospital",
"id": "https://www.grid.ac/institutes/grid.412342.2",
"name": [
"Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan"
],
"type": "Organization"
},
"familyName": "Maeda",
"givenName": "Yoshinobu",
"id": "sg:person.011371440332.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011371440332.50"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Internal Medicine, Okayama Municipal Hospital, Okayama, Japan"
],
"type": "Organization"
},
"familyName": "Imajo",
"givenName": "Kenji",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Saga University",
"id": "https://www.grid.ac/institutes/grid.412339.e",
"name": [
"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan"
],
"type": "Organization"
},
"familyName": "Kojima",
"givenName": "Kensuke",
"id": "sg:person.016662733302.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016662733302.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Morita",
"givenName": "Satoshi",
"id": "sg:person.01177506722.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177506722.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Komukai",
"givenName": "Sho",
"id": "sg:person.07743051405.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07743051405.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Osaka University",
"id": "https://www.grid.ac/institutes/grid.136593.b",
"name": [
"Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kawaguchi",
"givenName": "Atsushi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokai Central Hospital",
"id": "https://www.grid.ac/institutes/grid.460103.0",
"name": [
"Tokai Central Hospital, Kakamigahara, Japan"
],
"type": "Organization"
},
"familyName": "Sakamoto",
"givenName": "Junichi",
"id": "sg:person.0673305153.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673305153.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Saga University",
"id": "https://www.grid.ac/institutes/grid.412339.e",
"name": [
"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan"
],
"type": "Organization"
},
"familyName": "Kimura",
"givenName": "Shinya",
"id": "sg:person.016704032752.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704032752.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1182/blood-2010-12-326843",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001924846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2016.68.2914",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002282507"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-011-0328-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002300629",
"https://doi.org/10.1007/s10147-011-0328-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ajh.24120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003406138"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.48.5797",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008977093"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2016.360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009666759",
"https://doi.org/10.1038/leu.2016.360"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2015.139899",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010900381"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2012-10-462291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012037694"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2009.46",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012226579",
"https://doi.org/10.1038/leu.2009.46"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2015.64.8899",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015564810"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2016-01-694265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021246169"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2016.115",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022073613",
"https://doi.org/10.1038/leu.2016.115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(10)70233-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022333795"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2013-02-483750",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024310337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.13151",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030376624"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0023022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034885332"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s2352-3026(15)00196-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039925779"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2016.5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041273297",
"https://doi.org/10.1038/leu.2016.5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2015.66.2866",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047614403"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.6004/jnccn.2009.0065",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077978571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.6004/jnccn.2009.0065",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077978571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1609324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084149625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdx219",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085249344"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-017-2334-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091831187",
"https://doi.org/10.1007/s12185-017-2334-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/m17-1094",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101122445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(18)30192-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103814600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(18)30192-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103814600"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04",
"datePublishedReg": "2019-04-01",
"description": "BACKGROUND: Treatment-free remission (TFR), the ability to maintain a molecular response (MR), occurs in approximately 50% of patients with chronic myelogenous leukemia (CML) treated with tyrosine kinase inhibitors (TKIs).\nMETHODS: A multicenter phase 2 trial (Delightedly Overcome CML Expert Stop TKI Trial: DOMEST Trial) was conducted to test the safety and efficacy of discontinuing imatinib. Patients with CML with a sustained MR of 4.0 or MR4.0-equivalent for at least 2\u00a0years and confirmed MR4.0\u00a0at the beginning of the study were enrolled. In the TFR phase, the international scale (IS) was regularly monitored by IS-PCR testing. Molecular recurrence was defined as the loss of MR4.0. Recurrent patients were immediately treated with dasatinib or other TKIs including imatinib.\nRESULTS: Of 110 enrolled patients, 99 were evaluable. The median time from diagnosis to discontinuation of imatinib was 103 months, and the median duration of imatinib therapy was 100 months. Molecular recurrence-free survival rates were 69.6%, 68.6% and 64.3% at 6, 12, and 24 months, respectively. After discontinuation of imatinib therapy, 26 patients showed molecular recurrence, and 25 re-achieved deep MR after dasatinib treatment. Molecular response MR4.0 was achieved in 23 patients within 6 months and 25 patients within 12 months. Multivariate analysis revealed that a longer time from diagnosis to discontinuation of imatinib therapy (p\u2009=\u20090.0002) and long duration of imatinib therapy (p\u2009=\u20090.0029) predicted a favorable prognosis.\nCONCLUSIONS: This DOMEST Trial showed the feasibility of TKI discontinuation in a Japanese clinical setting.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10147-018-1368-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1312225",
"issn": [
"1341-9625",
"1437-7772"
],
"name": "International Journal of Clinical Oncology",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "24"
}
],
"name": "Feasibility of the imatinib stop study in the Japanese clinical setting: delightedly overcome CML expert stop TKI trial (DOMEST Trial)",
"pagination": "445-453",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"5c05139f69de57850fdc43d076f7f5987fc598c5f62f320a2b200a83465bd72e"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30421023"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9616295"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10147-018-1368-2"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1109819873"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10147-018-1368-2",
"https://app.dimensions.ai/details/publication/pub.1109819873"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:18",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78947_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs10147-018-1368-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'
This table displays all metadata directly associated to this object as RDF triples.
441 TRIPLES
21 PREDICATES
54 URIs
21 LITERALS
9 BLANK NODES