Feasibility of the imatinib stop study in the Japanese clinical setting: delightedly overcome CML expert stop TKI trial (DOMEST Trial) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-12

AUTHORS

Shin Fujisawa, Yasunori Ueda, Kensuke Usuki, Hajime Kobayashi, Eisei Kondo, Noriko Doki, Takafumi Nakao, Yoshinobu Kanda, Nobuharu Kosugi, Hiroshi Kosugi, Takashi Kumagai, Hiroshi Harada, Masato Shikami, Yasuhiro Maeda, Toru Sakura, Koiti Inokuchi, Akio Saito, Yuichiro Nawa, Masahiro Ogasawara, Junji Nishida, Takeshi Kondo, Chikashi Yoshida, Hiroyuki Kuroda, Yoko Tabe, Yoshinobu Maeda, Kenji Imajo, Kensuke Kojima, Satoshi Morita, Sho Komukai, Atsushi Kawaguchi, Junichi Sakamoto, Shinya Kimura

ABSTRACT

BackgroundTreatment-free remission (TFR), the ability to maintain a molecular response (MR), occurs in approximately 50% of patients with chronic myelogenous leukemia (CML) treated with tyrosine kinase inhibitors (TKIs).MethodsA multicenter phase 2 trial (Delightedly Overcome CML Expert Stop TKI Trial: DOMEST Trial) was conducted to test the safety and efficacy of discontinuing imatinib. Patients with CML with a sustained MR of 4.0 or MR4.0-equivalent for at least 2 years and confirmed MR4.0 at the beginning of the study were enrolled. In the TFR phase, the international scale (IS) was regularly monitored by IS-PCR testing. Molecular recurrence was defined as the loss of MR4.0. Recurrent patients were immediately treated with dasatinib or other TKIs including imatinib.ResultsOf 110 enrolled patients, 99 were evaluable. The median time from diagnosis to discontinuation of imatinib was 103 months, and the median duration of imatinib therapy was 100 months. Molecular recurrence-free survival rates were 69.6%, 68.6% and 64.3% at 6, 12, and 24 months, respectively. After discontinuation of imatinib therapy, 26 patients showed molecular recurrence, and 25 re-achieved deep MR after dasatinib treatment. Molecular response MR4.0 was achieved in 23 patients within 6 months and 25 patients within 12 months. Multivariate analysis revealed that a longer time from diagnosis to discontinuation of imatinib therapy (p = 0.0002) and long duration of imatinib therapy (p = 0.0029) predicted a favorable prognosis.ConclusionsThis DOMEST Trial showed the feasibility of TKI discontinuation in a Japanese clinical setting. More... »

PAGES

445-453

Journal

Author Affiliations

  • Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan
  • Department of Hematology, NTT Medical Center, Tokyo, Japan
  • Department of Hematology, Obihiro Kosei Hospital, Obihiro, Japan
  • Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Osaka City General Hospital, Osaka, Japan
  • Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
  • Department of Hematology, Numazu City Hospital, Numazu, Japan
  • Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan
  • Department of Hematology, Ome Municipal General Hospital, Ome, Japan
  • Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan
  • Department of Hematology, Daiyukai General Hospital, Ichinomiya, Japan
  • Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan
  • Department of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan
  • Department of Hematology, Nippon Medical School, Tokyo, Japan
  • Department of Hematology, Fujioka General Hospital, Fujioka, Japan
  • Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
  • Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
  • Department of Hematology, National Hospital Organization Mito Medical Center, Mito, Japan
  • Department of Gastroenterology and Hematology/Clinical Oncology, Steel Muroran Memorial Hospital, Muroran, Japan
  • Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
  • Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
  • Department of Internal Medicine, Okayama Municipal Hospital, Okayama, Japan
  • Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
  • Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
  • Tokai Central Hospital, Kakamigahara, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2

    DOI

    http://dx.doi.org/10.1007/s10147-018-1368-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1109819873

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30421023


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dasatinib", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imatinib Mesylate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myelogenous, Chronic, BCR-ABL Positive", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Withholding Treatment", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413045.7", 
              "name": [
                "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujisawa", 
            "givenName": "Shin", 
            "id": "sg:person.01145377314.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415565.6", 
              "name": [
                "Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ueda", 
            "givenName": "Yasunori", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, NTT Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414992.3", 
              "name": [
                "Department of Hematology, NTT Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Usuki", 
            "givenName": "Kensuke", 
            "id": "sg:person.0724116206.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Obihiro Kosei Hospital, Obihiro, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416691.d", 
              "name": [
                "Department of Hematology, Obihiro Kosei Hospital, Obihiro, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Hajime", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kondo", 
            "givenName": "Eisei", 
            "id": "sg:person.014450312452.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014450312452.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doki", 
            "givenName": "Noriko", 
            "id": "sg:person.01240752436.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Osaka City General Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416948.6", 
              "name": [
                "Department of Hematology, Osaka City General Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakao", 
            "givenName": "Takafumi", 
            "id": "sg:person.0655045363.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655045363.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416093.9", 
              "name": [
                "Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Yoshinobu", 
            "id": "sg:person.0617055140.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Numazu City Hospital, Numazu, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416627.0", 
              "name": [
                "Department of Hematology, Numazu City Hospital, Numazu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kosugi", 
            "givenName": "Nobuharu", 
            "id": "sg:person.01110574032.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110574032.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416762.0", 
              "name": [
                "Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kosugi", 
            "givenName": "Hiroshi", 
            "id": "sg:person.0716070516.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716070516.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Ome Municipal General Hospital, Ome, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416773.0", 
              "name": [
                "Department of Hematology, Ome Municipal General Hospital, Ome, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumagai", 
            "givenName": "Takashi", 
            "id": "sg:person.0677442365.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677442365.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412808.7", 
              "name": [
                "Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harada", 
            "givenName": "Hiroshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Daiyukai General Hospital, Ichinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413416.5", 
              "name": [
                "Department of Hematology, Daiyukai General Hospital, Ichinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shikami", 
            "givenName": "Masato", 
            "id": "sg:person.01212043506.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212043506.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.471868.4", 
              "name": [
                "Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maeda", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.014613660432.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014613660432.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416616.2", 
              "name": [
                "Department of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakura", 
            "givenName": "Toru", 
            "id": "sg:person.0620232746.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620232746.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Nippon Medical School, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410821.e", 
              "name": [
                "Department of Hematology, Nippon Medical School, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Inokuchi", 
            "givenName": "Koiti", 
            "id": "sg:person.015546543462.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546543462.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Fujioka General Hospital, Fujioka, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Fujioka General Hospital, Fujioka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Akio", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414413.7", 
              "name": [
                "Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nawa", 
            "givenName": "Yuichiro", 
            "id": "sg:person.01235232263.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235232263.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415262.6", 
              "name": [
                "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogasawara", 
            "givenName": "Masahiro", 
            "id": "sg:person.01066317125.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066317125.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416093.9", 
              "name": [
                "Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishida", 
            "givenName": "Junji", 
            "id": "sg:person.01370167773.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370167773.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412167.7", 
              "name": [
                "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kondo", 
            "givenName": "Takeshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Mito Medical Center, Mito, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410845.c", 
              "name": [
                "Department of Hematology, National Hospital Organization Mito Medical Center, Mito, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Chikashi", 
            "id": "sg:person.01277156611.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277156611.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hematology/Clinical Oncology, Steel Muroran Memorial Hospital, Muroran, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Gastroenterology and Hematology/Clinical Oncology, Steel Muroran Memorial Hospital, Muroran, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuroda", 
            "givenName": "Hiroyuki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tabe", 
            "givenName": "Yoko", 
            "id": "sg:person.01130154025.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130154025.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412342.2", 
              "name": [
                "Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maeda", 
            "givenName": "Yoshinobu", 
            "id": "sg:person.011371440332.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011371440332.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Okayama Municipal Hospital, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Internal Medicine, Okayama Municipal Hospital, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Imajo", 
            "givenName": "Kenji", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412339.e", 
              "name": [
                "Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kojima", 
            "givenName": "Kensuke", 
            "id": "sg:person.016662733302.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016662733302.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morita", 
            "givenName": "Satoshi", 
            "id": "sg:person.01177506722.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177506722.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Komukai", 
            "givenName": "Sho", 
            "id": "sg:person.07743051405.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07743051405.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawaguchi", 
            "givenName": "Atsushi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokai Central Hospital, Kakamigahara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.460103.0", 
              "name": [
                "Tokai Central Hospital, Kakamigahara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakamoto", 
            "givenName": "Junichi", 
            "id": "sg:person.0673305153.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673305153.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412339.e", 
              "name": [
                "Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Shinya", 
            "id": "sg:person.016704032752.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704032752.24"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12185-017-2334-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091831187", 
              "https://doi.org/10.1007/s12185-017-2334-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2009.46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012226579", 
              "https://doi.org/10.1038/leu.2009.46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2016.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022073613", 
              "https://doi.org/10.1038/leu.2016.115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10147-011-0328-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002300629", 
              "https://doi.org/10.1007/s10147-011-0328-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2016.360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009666759", 
              "https://doi.org/10.1038/leu.2016.360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2016.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041273297", 
              "https://doi.org/10.1038/leu.2016.5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-11-12", 
        "datePublishedReg": "2018-11-12", 
        "description": "BackgroundTreatment-free remission (TFR), the ability to maintain a molecular response (MR), occurs in approximately 50% of patients with chronic myelogenous leukemia (CML) treated with tyrosine kinase inhibitors (TKIs).MethodsA multicenter phase 2 trial (Delightedly Overcome CML Expert Stop TKI Trial: DOMEST Trial) was conducted to test the safety and efficacy of discontinuing imatinib. Patients with CML with a sustained MR of 4.0 or MR4.0-equivalent for at least 2\u00a0years and confirmed MR4.0\u00a0at the beginning of the study were enrolled. In the TFR phase, the international scale (IS) was regularly monitored by IS-PCR testing. Molecular recurrence was defined as the loss of MR4.0. Recurrent patients were immediately treated with dasatinib or other TKIs including imatinib.ResultsOf 110 enrolled patients, 99 were evaluable. The median time from diagnosis to discontinuation of imatinib was 103 months, and the median duration of imatinib therapy was 100 months. Molecular recurrence-free survival rates were 69.6%, 68.6% and 64.3% at 6, 12, and 24 months, respectively. After discontinuation of imatinib therapy, 26 patients showed molecular recurrence, and 25 re-achieved deep MR after dasatinib treatment. Molecular response MR4.0 was achieved in 23 patients within 6 months and 25 patients within 12 months. Multivariate analysis revealed that a longer time from diagnosis to discontinuation of imatinib therapy (p\u2009=\u20090.0002) and long duration of imatinib therapy (p\u2009=\u20090.0029) predicted a favorable prognosis.ConclusionsThis DOMEST Trial showed the feasibility of TKI discontinuation in a Japanese clinical setting.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10147-018-1368-2", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6835426", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6835406", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1312225", 
            "issn": [
              "1341-9625", 
              "1437-7772"
            ], 
            "name": "International Journal of Clinical Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "24"
          }
        ], 
        "keywords": [
          "tyrosine kinase inhibitors", 
          "chronic myelogenous leukemia", 
          "imatinib therapy", 
          "Japanese clinical settings", 
          "molecular recurrence", 
          "multicenter phase 2 trial", 
          "recurrence-free survival rates", 
          "clinical setting", 
          "phase 2 trial", 
          "deep molecular response", 
          "discontinuation of imatinib", 
          "molecular response", 
          "TFR phase", 
          "CML experts", 
          "TKI discontinuation", 
          "median duration", 
          "favorable prognosis", 
          "recurrent patients", 
          "median time", 
          "dasatinib treatment", 
          "myelogenous leukemia", 
          "MR4.0", 
          "patients", 
          "discontinuation", 
          "survival rate", 
          "multivariate analysis", 
          "therapy", 
          "imatinib", 
          "kinase inhibitors", 
          "STOP study", 
          "months", 
          "longer duration", 
          "trials", 
          "recurrence", 
          "diagnosis", 
          "duration", 
          "remission", 
          "prognosis", 
          "leukemia", 
          "dasatinib", 
          "setting", 
          "efficacy", 
          "treatment", 
          "inhibitors", 
          "study", 
          "safety", 
          "years", 
          "response", 
          "testing", 
          "long time", 
          "feasibility", 
          "time", 
          "rate", 
          "loss", 
          "international scale", 
          "ability", 
          "scale", 
          "analysis", 
          "experts", 
          "beginning", 
          "phase"
        ], 
        "name": "Feasibility of the imatinib stop study in the Japanese clinical setting: delightedly overcome CML expert stop TKI trial (DOMEST Trial)", 
        "pagination": "445-453", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1109819873"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10147-018-1368-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30421023"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10147-018-1368-2", 
          "https://app.dimensions.ai/details/publication/pub.1109819873"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:34", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_787.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10147-018-1368-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-018-1368-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    512 TRIPLES      22 PREDICATES      110 URIs      96 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10147-018-1368-2 schema:about N0d456003144d4d0286994dfbea0313a0
    2 N3e49325ce1854541a1b105c8e9a1632e
    3 N43efbc3f3b0f4e76ae44c03785ca361b
    4 N61e55ce48364477aa7ac2f3724d006c1
    5 N6fea40959cfa4e57b92461d0e9083e3b
    6 N74452e56475b4a88a51e0571e11a878a
    7 N7a5de04005174e32a716307b6e9c1e29
    8 N7e3982126692453993a806022db4fb8c
    9 N87d7a1ff0a3f42f89ee0f9137179b3f1
    10 N8d73970d0b0d44a3bc4566deeb397223
    11 Na8ae3c1efee04c0fafbd0381cb97b543
    12 Nb3621ba1da0a4541900a402206ca3530
    13 Nbc9ad47b610a455880f73a20c98c9a89
    14 Nbecd5a2ecb464787844d56431a5c57e7
    15 Nd9775bf51c924588bf97d439f19dbdca
    16 Nef1e527901c74be6acb509c809cc23f1
    17 Nf45e118dd35b45ee8ff671813968b513
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author N41defe12490e464597fadd5f3b35524e
    21 schema:citation sg:pub.10.1007/s10147-011-0328-x
    22 sg:pub.10.1007/s12185-017-2334-x
    23 sg:pub.10.1038/leu.2009.46
    24 sg:pub.10.1038/leu.2016.115
    25 sg:pub.10.1038/leu.2016.360
    26 sg:pub.10.1038/leu.2016.5
    27 schema:datePublished 2018-11-12
    28 schema:datePublishedReg 2018-11-12
    29 schema:description BackgroundTreatment-free remission (TFR), the ability to maintain a molecular response (MR), occurs in approximately 50% of patients with chronic myelogenous leukemia (CML) treated with tyrosine kinase inhibitors (TKIs).MethodsA multicenter phase 2 trial (Delightedly Overcome CML Expert Stop TKI Trial: DOMEST Trial) was conducted to test the safety and efficacy of discontinuing imatinib. Patients with CML with a sustained MR of 4.0 or MR4.0-equivalent for at least 2 years and confirmed MR4.0 at the beginning of the study were enrolled. In the TFR phase, the international scale (IS) was regularly monitored by IS-PCR testing. Molecular recurrence was defined as the loss of MR4.0. Recurrent patients were immediately treated with dasatinib or other TKIs including imatinib.ResultsOf 110 enrolled patients, 99 were evaluable. The median time from diagnosis to discontinuation of imatinib was 103 months, and the median duration of imatinib therapy was 100 months. Molecular recurrence-free survival rates were 69.6%, 68.6% and 64.3% at 6, 12, and 24 months, respectively. After discontinuation of imatinib therapy, 26 patients showed molecular recurrence, and 25 re-achieved deep MR after dasatinib treatment. Molecular response MR4.0 was achieved in 23 patients within 6 months and 25 patients within 12 months. Multivariate analysis revealed that a longer time from diagnosis to discontinuation of imatinib therapy (p = 0.0002) and long duration of imatinib therapy (p = 0.0029) predicted a favorable prognosis.ConclusionsThis DOMEST Trial showed the feasibility of TKI discontinuation in a Japanese clinical setting.
    30 schema:genre article
    31 schema:inLanguage en
    32 schema:isAccessibleForFree true
    33 schema:isPartOf N223024826d0040489b0e54f862f706ee
    34 N323f4b2d5fd94344a12ab2d12491e22a
    35 sg:journal.1312225
    36 schema:keywords CML experts
    37 Japanese clinical settings
    38 MR4.0
    39 STOP study
    40 TFR phase
    41 TKI discontinuation
    42 ability
    43 analysis
    44 beginning
    45 chronic myelogenous leukemia
    46 clinical setting
    47 dasatinib
    48 dasatinib treatment
    49 deep molecular response
    50 diagnosis
    51 discontinuation
    52 discontinuation of imatinib
    53 duration
    54 efficacy
    55 experts
    56 favorable prognosis
    57 feasibility
    58 imatinib
    59 imatinib therapy
    60 inhibitors
    61 international scale
    62 kinase inhibitors
    63 leukemia
    64 long time
    65 longer duration
    66 loss
    67 median duration
    68 median time
    69 molecular recurrence
    70 molecular response
    71 months
    72 multicenter phase 2 trial
    73 multivariate analysis
    74 myelogenous leukemia
    75 patients
    76 phase
    77 phase 2 trial
    78 prognosis
    79 rate
    80 recurrence
    81 recurrence-free survival rates
    82 recurrent patients
    83 remission
    84 response
    85 safety
    86 scale
    87 setting
    88 study
    89 survival rate
    90 testing
    91 therapy
    92 time
    93 treatment
    94 trials
    95 tyrosine kinase inhibitors
    96 years
    97 schema:name Feasibility of the imatinib stop study in the Japanese clinical setting: delightedly overcome CML expert stop TKI trial (DOMEST Trial)
    98 schema:pagination 445-453
    99 schema:productId N14482d7b0e184ef0a2bb66c5a06a3262
    100 N3d2b8325df5643bcb95e91c7b2188dda
    101 Na8041322e1f54f709357bda03218a309
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109819873
    103 https://doi.org/10.1007/s10147-018-1368-2
    104 schema:sdDatePublished 2022-05-20T07:34
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher N513124170e324ab484fd2d19adae4e3c
    107 schema:url https://doi.org/10.1007/s10147-018-1368-2
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N0aa6e23cca67492abd3ee1c8104ca11d rdf:first N3d94f4e7791c4894b4e352228df73bb9
    112 rdf:rest N6860ce507f0148e3b0fffdd0db5c54c5
    113 N0ae5f79739984a87a56500fd71500ec2 rdf:first sg:person.01370167773.75
    114 rdf:rest N2e0c9439eaeb4d54a53d35a06d8e3ac2
    115 N0bde9e58d27f4fb9b453fa200ee2dbe5 rdf:first sg:person.0655045363.48
    116 rdf:rest N66c8533c9d8f4ff3a1dc96e482dbb23c
    117 N0d456003144d4d0286994dfbea0313a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    119 rdf:type schema:DefinedTerm
    120 N14482d7b0e184ef0a2bb66c5a06a3262 schema:name doi
    121 schema:value 10.1007/s10147-018-1368-2
    122 rdf:type schema:PropertyValue
    123 N19591ce0149a47df852c024fdf3de08e rdf:first N9353e3d015bc4468ba4474560e721fb6
    124 rdf:rest N8a83ba88e99a4a81b99443650ac12f24
    125 N1e424a89e8f54cd09eb0708eca75c813 rdf:first sg:person.01235232263.62
    126 rdf:rest Ndbda9765e2e74ba6bef3a111422751eb
    127 N223024826d0040489b0e54f862f706ee schema:volumeNumber 24
    128 rdf:type schema:PublicationVolume
    129 N2e0c9439eaeb4d54a53d35a06d8e3ac2 rdf:first N9ec02e78dab6424cb20964a1426b7c3a
    130 rdf:rest N902cab21d0e44a7ea0e5226aa2ec6dfd
    131 N2e7bf7a0a78c4304b87ff49cff1e479f rdf:first sg:person.014613660432.11
    132 rdf:rest N5f887e4b86414e19a4ca303450b696aa
    133 N323f4b2d5fd94344a12ab2d12491e22a schema:issueNumber 4
    134 rdf:type schema:PublicationIssue
    135 N32ad15af0bef4674944fe606554dc6d5 rdf:first sg:person.01177506722.07
    136 rdf:rest N8865fdd8040440ba911ba9b9cea0febb
    137 N3d2b8325df5643bcb95e91c7b2188dda schema:name pubmed_id
    138 schema:value 30421023
    139 rdf:type schema:PropertyValue
    140 N3d94f4e7791c4894b4e352228df73bb9 schema:affiliation grid-institutes:grid.415565.6
    141 schema:familyName Ueda
    142 schema:givenName Yasunori
    143 rdf:type schema:Person
    144 N3e49325ce1854541a1b105c8e9a1632e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Protein Kinase Inhibitors
    146 rdf:type schema:DefinedTerm
    147 N3fa07b454bd44f20bbb753ae770d0e9d schema:affiliation grid-institutes:None
    148 schema:familyName Kuroda
    149 schema:givenName Hiroyuki
    150 rdf:type schema:Person
    151 N41defe12490e464597fadd5f3b35524e rdf:first sg:person.01145377314.06
    152 rdf:rest N0aa6e23cca67492abd3ee1c8104ca11d
    153 N43efbc3f3b0f4e76ae44c03785ca361b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Imatinib Mesylate
    155 rdf:type schema:DefinedTerm
    156 N46abd6e2f8314623b426e8ac8a18335e rdf:first N4c1aca2e172a463eb92a6439921bf847
    157 rdf:rest N1e424a89e8f54cd09eb0708eca75c813
    158 N47cf1de11b1d4a9b980c03c949d27b6c rdf:first N894d8494f57b46cda475b138afe43eda
    159 rdf:rest N63c593f7518c464a90b04ba9e047e7af
    160 N483b8864cd96434991e5da5172281c7c rdf:first sg:person.0677442365.54
    161 rdf:rest Nd117b301546340e3a9433cc41e74e32f
    162 N4c1aca2e172a463eb92a6439921bf847 schema:affiliation grid-institutes:None
    163 schema:familyName Saito
    164 schema:givenName Akio
    165 rdf:type schema:Person
    166 N513124170e324ab484fd2d19adae4e3c schema:name Springer Nature - SN SciGraph project
    167 rdf:type schema:Organization
    168 N5f887e4b86414e19a4ca303450b696aa rdf:first sg:person.0620232746.38
    169 rdf:rest Nef7b4e681fb546dfa587c3cc4e8df5fd
    170 N61e55ce48364477aa7ac2f3724d006c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Dasatinib
    172 rdf:type schema:DefinedTerm
    173 N63c593f7518c464a90b04ba9e047e7af rdf:first sg:person.016662733302.12
    174 rdf:rest N32ad15af0bef4674944fe606554dc6d5
    175 N66c8533c9d8f4ff3a1dc96e482dbb23c rdf:first sg:person.0617055140.49
    176 rdf:rest Nbc48f677c8e546a398b9f1620c1062c5
    177 N6860ce507f0148e3b0fffdd0db5c54c5 rdf:first sg:person.0724116206.23
    178 rdf:rest N6dfcdd0b21154859a1eb0e5253bd14ed
    179 N6a7ecaa5be3041b58cb729e533d86d3e rdf:first N3fa07b454bd44f20bbb753ae770d0e9d
    180 rdf:rest Nd477ba1519324827a934d1a25908e037
    181 N6dfcdd0b21154859a1eb0e5253bd14ed rdf:first Na2e92ca6a5124ccf8ef009e3d2bae0db
    182 rdf:rest Nd76329fb4dde473d8b7ec058da390446
    183 N6fea40959cfa4e57b92461d0e9083e3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Japan
    185 rdf:type schema:DefinedTerm
    186 N74452e56475b4a88a51e0571e11a878a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Antineoplastic Agents
    188 rdf:type schema:DefinedTerm
    189 N7a5de04005174e32a716307b6e9c1e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Male
    191 rdf:type schema:DefinedTerm
    192 N7e3982126692453993a806022db4fb8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Female
    194 rdf:type schema:DefinedTerm
    195 N87d7a1ff0a3f42f89ee0f9137179b3f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Neoplasm Recurrence, Local
    197 rdf:type schema:DefinedTerm
    198 N8865fdd8040440ba911ba9b9cea0febb rdf:first sg:person.07743051405.19
    199 rdf:rest N19591ce0149a47df852c024fdf3de08e
    200 N894d8494f57b46cda475b138afe43eda schema:affiliation grid-institutes:None
    201 schema:familyName Imajo
    202 schema:givenName Kenji
    203 rdf:type schema:Person
    204 N8a83ba88e99a4a81b99443650ac12f24 rdf:first sg:person.0673305153.34
    205 rdf:rest Nc929046a5e3248eaa0d8cee294e89a2b
    206 N8d73970d0b0d44a3bc4566deeb397223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Adult
    208 rdf:type schema:DefinedTerm
    209 N902cab21d0e44a7ea0e5226aa2ec6dfd rdf:first sg:person.01277156611.63
    210 rdf:rest N6a7ecaa5be3041b58cb729e533d86d3e
    211 N9353e3d015bc4468ba4474560e721fb6 schema:affiliation grid-institutes:grid.136593.b
    212 schema:familyName Kawaguchi
    213 schema:givenName Atsushi
    214 rdf:type schema:Person
    215 N9ec02e78dab6424cb20964a1426b7c3a schema:affiliation grid-institutes:grid.412167.7
    216 schema:familyName Kondo
    217 schema:givenName Takeshi
    218 rdf:type schema:Person
    219 Na2e92ca6a5124ccf8ef009e3d2bae0db schema:affiliation grid-institutes:grid.416691.d
    220 schema:familyName Kobayashi
    221 schema:givenName Hajime
    222 rdf:type schema:Person
    223 Na8041322e1f54f709357bda03218a309 schema:name dimensions_id
    224 schema:value pub.1109819873
    225 rdf:type schema:PropertyValue
    226 Na8ae3c1efee04c0fafbd0381cb97b543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Middle Aged
    228 rdf:type schema:DefinedTerm
    229 Nae07559995da46b281a0d008d4c5a335 rdf:first sg:person.0716070516.48
    230 rdf:rest N483b8864cd96434991e5da5172281c7c
    231 Nb3621ba1da0a4541900a402206ca3530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Aged
    233 rdf:type schema:DefinedTerm
    234 Nb5e1453685c34aaa81b10c578231fcf6 schema:affiliation grid-institutes:grid.412808.7
    235 schema:familyName Harada
    236 schema:givenName Hiroshi
    237 rdf:type schema:Person
    238 Nbc48f677c8e546a398b9f1620c1062c5 rdf:first sg:person.01110574032.09
    239 rdf:rest Nae07559995da46b281a0d008d4c5a335
    240 Nbc9ad47b610a455880f73a20c98c9a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Humans
    242 rdf:type schema:DefinedTerm
    243 Nbecd5a2ecb464787844d56431a5c57e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    244 schema:name Time Factors
    245 rdf:type schema:DefinedTerm
    246 Nc929046a5e3248eaa0d8cee294e89a2b rdf:first sg:person.016704032752.24
    247 rdf:rest rdf:nil
    248 Nd117b301546340e3a9433cc41e74e32f rdf:first Nb5e1453685c34aaa81b10c578231fcf6
    249 rdf:rest Ned47c33e7df34d97bf8b6f757c6e2052
    250 Nd477ba1519324827a934d1a25908e037 rdf:first sg:person.01130154025.08
    251 rdf:rest Nebd6d275e3ff40b7b1507662a56f870b
    252 Nd76329fb4dde473d8b7ec058da390446 rdf:first sg:person.014450312452.43
    253 rdf:rest Ne80e10bf3fee445bb2761de8814961a6
    254 Nd9775bf51c924588bf97d439f19dbdca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name Aged, 80 and over
    256 rdf:type schema:DefinedTerm
    257 Ndbda9765e2e74ba6bef3a111422751eb rdf:first sg:person.01066317125.91
    258 rdf:rest N0ae5f79739984a87a56500fd71500ec2
    259 Ne80e10bf3fee445bb2761de8814961a6 rdf:first sg:person.01240752436.35
    260 rdf:rest N0bde9e58d27f4fb9b453fa200ee2dbe5
    261 Nebd6d275e3ff40b7b1507662a56f870b rdf:first sg:person.011371440332.50
    262 rdf:rest N47cf1de11b1d4a9b980c03c949d27b6c
    263 Ned47c33e7df34d97bf8b6f757c6e2052 rdf:first sg:person.01212043506.30
    264 rdf:rest N2e7bf7a0a78c4304b87ff49cff1e479f
    265 Nef1e527901c74be6acb509c809cc23f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    266 schema:name Withholding Treatment
    267 rdf:type schema:DefinedTerm
    268 Nef7b4e681fb546dfa587c3cc4e8df5fd rdf:first sg:person.015546543462.29
    269 rdf:rest N46abd6e2f8314623b426e8ac8a18335e
    270 Nf45e118dd35b45ee8ff671813968b513 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    271 schema:name Treatment Outcome
    272 rdf:type schema:DefinedTerm
    273 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    274 schema:name Medical and Health Sciences
    275 rdf:type schema:DefinedTerm
    276 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    277 schema:name Oncology and Carcinogenesis
    278 rdf:type schema:DefinedTerm
    279 sg:grant.6835406 http://pending.schema.org/fundedItem sg:pub.10.1007/s10147-018-1368-2
    280 rdf:type schema:MonetaryGrant
    281 sg:grant.6835426 http://pending.schema.org/fundedItem sg:pub.10.1007/s10147-018-1368-2
    282 rdf:type schema:MonetaryGrant
    283 sg:journal.1312225 schema:issn 1341-9625
    284 1437-7772
    285 schema:name International Journal of Clinical Oncology
    286 schema:publisher Springer Nature
    287 rdf:type schema:Periodical
    288 sg:person.01066317125.91 schema:affiliation grid-institutes:grid.415262.6
    289 schema:familyName Ogasawara
    290 schema:givenName Masahiro
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066317125.91
    292 rdf:type schema:Person
    293 sg:person.01110574032.09 schema:affiliation grid-institutes:grid.416627.0
    294 schema:familyName Kosugi
    295 schema:givenName Nobuharu
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110574032.09
    297 rdf:type schema:Person
    298 sg:person.01130154025.08 schema:affiliation grid-institutes:grid.258269.2
    299 schema:familyName Tabe
    300 schema:givenName Yoko
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130154025.08
    302 rdf:type schema:Person
    303 sg:person.011371440332.50 schema:affiliation grid-institutes:grid.412342.2
    304 schema:familyName Maeda
    305 schema:givenName Yoshinobu
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011371440332.50
    307 rdf:type schema:Person
    308 sg:person.01145377314.06 schema:affiliation grid-institutes:grid.413045.7
    309 schema:familyName Fujisawa
    310 schema:givenName Shin
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06
    312 rdf:type schema:Person
    313 sg:person.01177506722.07 schema:affiliation grid-institutes:grid.258799.8
    314 schema:familyName Morita
    315 schema:givenName Satoshi
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177506722.07
    317 rdf:type schema:Person
    318 sg:person.01212043506.30 schema:affiliation grid-institutes:grid.413416.5
    319 schema:familyName Shikami
    320 schema:givenName Masato
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212043506.30
    322 rdf:type schema:Person
    323 sg:person.01235232263.62 schema:affiliation grid-institutes:grid.414413.7
    324 schema:familyName Nawa
    325 schema:givenName Yuichiro
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235232263.62
    327 rdf:type schema:Person
    328 sg:person.01240752436.35 schema:affiliation grid-institutes:grid.415479.a
    329 schema:familyName Doki
    330 schema:givenName Noriko
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35
    332 rdf:type schema:Person
    333 sg:person.01277156611.63 schema:affiliation grid-institutes:grid.410845.c
    334 schema:familyName Yoshida
    335 schema:givenName Chikashi
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277156611.63
    337 rdf:type schema:Person
    338 sg:person.01370167773.75 schema:affiliation grid-institutes:grid.416093.9
    339 schema:familyName Nishida
    340 schema:givenName Junji
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370167773.75
    342 rdf:type schema:Person
    343 sg:person.014450312452.43 schema:affiliation grid-institutes:grid.261356.5
    344 schema:familyName Kondo
    345 schema:givenName Eisei
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014450312452.43
    347 rdf:type schema:Person
    348 sg:person.014613660432.11 schema:affiliation grid-institutes:grid.471868.4
    349 schema:familyName Maeda
    350 schema:givenName Yasuhiro
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014613660432.11
    352 rdf:type schema:Person
    353 sg:person.015546543462.29 schema:affiliation grid-institutes:grid.410821.e
    354 schema:familyName Inokuchi
    355 schema:givenName Koiti
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546543462.29
    357 rdf:type schema:Person
    358 sg:person.016662733302.12 schema:affiliation grid-institutes:grid.412339.e
    359 schema:familyName Kojima
    360 schema:givenName Kensuke
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016662733302.12
    362 rdf:type schema:Person
    363 sg:person.016704032752.24 schema:affiliation grid-institutes:grid.412339.e
    364 schema:familyName Kimura
    365 schema:givenName Shinya
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016704032752.24
    367 rdf:type schema:Person
    368 sg:person.0617055140.49 schema:affiliation grid-institutes:grid.416093.9
    369 schema:familyName Kanda
    370 schema:givenName Yoshinobu
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49
    372 rdf:type schema:Person
    373 sg:person.0620232746.38 schema:affiliation grid-institutes:grid.416616.2
    374 schema:familyName Sakura
    375 schema:givenName Toru
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620232746.38
    377 rdf:type schema:Person
    378 sg:person.0655045363.48 schema:affiliation grid-institutes:grid.416948.6
    379 schema:familyName Nakao
    380 schema:givenName Takafumi
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655045363.48
    382 rdf:type schema:Person
    383 sg:person.0673305153.34 schema:affiliation grid-institutes:grid.460103.0
    384 schema:familyName Sakamoto
    385 schema:givenName Junichi
    386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673305153.34
    387 rdf:type schema:Person
    388 sg:person.0677442365.54 schema:affiliation grid-institutes:grid.416773.0
    389 schema:familyName Kumagai
    390 schema:givenName Takashi
    391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677442365.54
    392 rdf:type schema:Person
    393 sg:person.0716070516.48 schema:affiliation grid-institutes:grid.416762.0
    394 schema:familyName Kosugi
    395 schema:givenName Hiroshi
    396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716070516.48
    397 rdf:type schema:Person
    398 sg:person.0724116206.23 schema:affiliation grid-institutes:grid.414992.3
    399 schema:familyName Usuki
    400 schema:givenName Kensuke
    401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23
    402 rdf:type schema:Person
    403 sg:person.07743051405.19 schema:affiliation grid-institutes:grid.136593.b
    404 schema:familyName Komukai
    405 schema:givenName Sho
    406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07743051405.19
    407 rdf:type schema:Person
    408 sg:pub.10.1007/s10147-011-0328-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002300629
    409 https://doi.org/10.1007/s10147-011-0328-x
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1007/s12185-017-2334-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1091831187
    412 https://doi.org/10.1007/s12185-017-2334-x
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1038/leu.2009.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012226579
    415 https://doi.org/10.1038/leu.2009.46
    416 rdf:type schema:CreativeWork
    417 sg:pub.10.1038/leu.2016.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073613
    418 https://doi.org/10.1038/leu.2016.115
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1038/leu.2016.360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009666759
    421 https://doi.org/10.1038/leu.2016.360
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/leu.2016.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041273297
    424 https://doi.org/10.1038/leu.2016.5
    425 rdf:type schema:CreativeWork
    426 grid-institutes:None schema:alternateName Department of Gastroenterology and Hematology/Clinical Oncology, Steel Muroran Memorial Hospital, Muroran, Japan
    427 Department of Hematology, Fujioka General Hospital, Fujioka, Japan
    428 Department of Internal Medicine, Okayama Municipal Hospital, Okayama, Japan
    429 schema:name Department of Gastroenterology and Hematology/Clinical Oncology, Steel Muroran Memorial Hospital, Muroran, Japan
    430 Department of Hematology, Fujioka General Hospital, Fujioka, Japan
    431 Department of Internal Medicine, Okayama Municipal Hospital, Okayama, Japan
    432 rdf:type schema:Organization
    433 grid-institutes:grid.136593.b schema:alternateName Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    434 schema:name Division of Biomedical Statistics, Department of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    435 rdf:type schema:Organization
    436 grid-institutes:grid.258269.2 schema:alternateName Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
    437 schema:name Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
    438 rdf:type schema:Organization
    439 grid-institutes:grid.258799.8 schema:alternateName Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    440 schema:name Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    441 rdf:type schema:Organization
    442 grid-institutes:grid.261356.5 schema:alternateName Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    443 schema:name Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    444 rdf:type schema:Organization
    445 grid-institutes:grid.410821.e schema:alternateName Department of Hematology, Nippon Medical School, Tokyo, Japan
    446 schema:name Department of Hematology, Nippon Medical School, Tokyo, Japan
    447 rdf:type schema:Organization
    448 grid-institutes:grid.410845.c schema:alternateName Department of Hematology, National Hospital Organization Mito Medical Center, Mito, Japan
    449 schema:name Department of Hematology, National Hospital Organization Mito Medical Center, Mito, Japan
    450 rdf:type schema:Organization
    451 grid-institutes:grid.412167.7 schema:alternateName Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
    452 schema:name Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
    453 rdf:type schema:Organization
    454 grid-institutes:grid.412339.e schema:alternateName Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    455 schema:name Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    456 rdf:type schema:Organization
    457 grid-institutes:grid.412342.2 schema:alternateName Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
    458 schema:name Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
    459 rdf:type schema:Organization
    460 grid-institutes:grid.412808.7 schema:alternateName Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan
    461 schema:name Division of Hematology, Department of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan
    462 rdf:type schema:Organization
    463 grid-institutes:grid.413045.7 schema:alternateName Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    464 schema:name Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    465 rdf:type schema:Organization
    466 grid-institutes:grid.413416.5 schema:alternateName Department of Hematology, Daiyukai General Hospital, Ichinomiya, Japan
    467 schema:name Department of Hematology, Daiyukai General Hospital, Ichinomiya, Japan
    468 rdf:type schema:Organization
    469 grid-institutes:grid.414413.7 schema:alternateName Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan
    470 schema:name Department of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan
    471 rdf:type schema:Organization
    472 grid-institutes:grid.414992.3 schema:alternateName Department of Hematology, NTT Medical Center, Tokyo, Japan
    473 schema:name Department of Hematology, NTT Medical Center, Tokyo, Japan
    474 rdf:type schema:Organization
    475 grid-institutes:grid.415262.6 schema:alternateName Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
    476 schema:name Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
    477 rdf:type schema:Organization
    478 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    479 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    480 rdf:type schema:Organization
    481 grid-institutes:grid.415565.6 schema:alternateName Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan
    482 schema:name Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan
    483 rdf:type schema:Organization
    484 grid-institutes:grid.416093.9 schema:alternateName Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    485 Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    486 schema:name Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    487 Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    488 rdf:type schema:Organization
    489 grid-institutes:grid.416616.2 schema:alternateName Department of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan
    490 schema:name Department of Hematology, Saiseikai Maebashi Hospital, Maebashi, Japan
    491 rdf:type schema:Organization
    492 grid-institutes:grid.416627.0 schema:alternateName Department of Hematology, Numazu City Hospital, Numazu, Japan
    493 schema:name Department of Hematology, Numazu City Hospital, Numazu, Japan
    494 rdf:type schema:Organization
    495 grid-institutes:grid.416691.d schema:alternateName Department of Hematology, Obihiro Kosei Hospital, Obihiro, Japan
    496 schema:name Department of Hematology, Obihiro Kosei Hospital, Obihiro, Japan
    497 rdf:type schema:Organization
    498 grid-institutes:grid.416762.0 schema:alternateName Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan
    499 schema:name Department of Hematology, Ogaki Municipal Hospital, Ogaki, Japan
    500 rdf:type schema:Organization
    501 grid-institutes:grid.416773.0 schema:alternateName Department of Hematology, Ome Municipal General Hospital, Ome, Japan
    502 schema:name Department of Hematology, Ome Municipal General Hospital, Ome, Japan
    503 rdf:type schema:Organization
    504 grid-institutes:grid.416948.6 schema:alternateName Department of Hematology, Osaka City General Hospital, Osaka, Japan
    505 schema:name Department of Hematology, Osaka City General Hospital, Osaka, Japan
    506 rdf:type schema:Organization
    507 grid-institutes:grid.460103.0 schema:alternateName Tokai Central Hospital, Kakamigahara, Japan
    508 schema:name Tokai Central Hospital, Kakamigahara, Japan
    509 rdf:type schema:Organization
    510 grid-institutes:grid.471868.4 schema:alternateName Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan
    511 schema:name Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan
    512 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...