Risk factors for joint symptoms in postmenopausal Japanese breast cancer patients treated with anastrozole: a prospective multicenter cohort study of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

Chiyomi Egawa, Kouichi Hirokaga, Shintaro Takao, Kazuhiko Yamagami, Masaru Miyashita, Masashi Baba, Shigetoshi Ichii, Muneharu Konishi, Yuichiro Kikawa, Junya Minohata, Toshitaka Okuno, Keisuke Miyauchi, Kazuyuki Wakita, Hirofumi Suwa, Takashi Hashimoto, Masayuki Nishino, Takashi Matsumoto, Toshiharu Hidaka, Yutaka Konishi, Yoko Sakoda, Akihiro Miya, Masao Mitsunobu, Hidefumi Nishikawa, Seishi Kono, Ikuo Kokufu, Isao Sakita, Koushiro Kitatsuji, Koushi Oh, Yasuo Miyoshi

ABSTRACT

BACKGROUND: Endocrine treatment-related adverse events have a strong impact on patients' quality of life and sometimes result in treatment discontinuation. Since joint symptoms are the most frequently recognized side effect of aromatase inhibitors, evaluation of associated risk factors may yield significant findings. PATIENTS AND METHODS: A total of 391 postmenopausal Japanese women with estrogen receptor-positive breast cancer and treated with adjuvant anastrozole were enrolled from 28 centers for assessment of patient-reported outcomes (PROs) in this prospective cohort study (SAVS-JP, UMIN000002455). Patients completed the self-report questionnaire at baseline and after 3, 6, 9, and 12 months of treatment for evaluation of frequency of treatment-related joint symptoms (arthralgia, decrease in range of joint motion, and joint stiffness). RESULTS: We obtained PROs from 362 patients (92.6 %) at baseline and at one or more subsequent points. New or worsening from baseline of joint symptoms were reported by 260 patients (71.8 %). More than 90 % of the symptoms were mild or moderate and nearly 80 % had occurred by 6 months. Multivariate analysis showed that a short time span after menopause [odds ratio (OR) 0.95, 95 % confidence interval (CI) 0.90-0.99; P = 0.02] and adjuvant chemotherapy (OR 2.29, 95 % CI 1.06-4.95; P = 0.03) were significant independent risk factors for joint symptoms. No significant relationships between body mass index (BMI) and joint symptoms were identified. Eighteen patients discontinued treatment during the 1st year and eight of them reported joint symptoms. CONCLUSION: Taking into consideration that PROs may yield higher prevalence rates than physician ratings for symptoms published in pivotal clinical trials, we found that a short time span after menopause and use of adjuvant chemotherapy, but not high BMI, were significantly associated with joint symptoms. These findings might prove useful for counseling before initiating treatment with adjuvant aromatase inhibitors in postmenopausal Japanese women. More... »

PAGES

262-269

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-015-0905-5

DOI

http://dx.doi.org/10.1007/s10147-015-0905-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001322158

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26411314


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ductal, Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Lobular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Joint Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitriles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Outcome Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postmenopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kansai Rosai Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414976.9", 
          "name": [
            "Department of Surgery, Kansai Rosai Hospital, Inaba-so, 3-1-69, 660-8511, Amagasaki, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Egawa", 
        "givenName": "Chiyomi", 
        "id": "sg:person.0754054224.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754054224.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo Prefectural Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.417755.5", 
          "name": [
            "Department of Breast Surgery, Hyogo Cancer Center, Kitaoji-cho, 13-70, 673-8558, Akashi, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirokaga", 
        "givenName": "Kouichi", 
        "id": "sg:person.012465661062.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012465661062.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo Prefectural Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.417755.5", 
          "name": [
            "Department of Breast Surgery, Hyogo Cancer Center, Kitaoji-cho, 13-70, 673-8558, Akashi, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takao", 
        "givenName": "Shintaro", 
        "id": "sg:person.0751370470.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751370470.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shinko Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415766.7", 
          "name": [
            "Department of Breast Surgery, Shinko Hospital, Wakinohama-cho, 1-4-47, Chuo-ku, 651-0072, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamagami", 
        "givenName": "Kazuhiko", 
        "id": "sg:person.0663067774.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663067774.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kohnan Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415430.7", 
          "name": [
            "Department of Surgery, Kohnan Hospital, Kamokogahara, 1-5-16, Higashinada-ku, 658-0064, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyashita", 
        "givenName": "Masaru", 
        "id": "sg:person.0646020706.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646020706.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Itami City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.440094.d", 
          "name": [
            "Department of Surgery, Itami City Hospital, Koyaike, 1-100, 664-8540, Itami, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baba", 
        "givenName": "Masashi", 
        "id": "sg:person.0700054205.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700054205.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rokko Island Konan Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416028.9", 
          "name": [
            "Rokko Island Hospital, Koyochonaka, 2-11, Higashinada-ku, 658-0032, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichii", 
        "givenName": "Shigetoshi", 
        "id": "sg:person.01276425575.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276425575.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo Prefectural Nishinomiya Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413719.9", 
          "name": [
            "Department of Surgery, Hyogo Prefectural Nishinomiya Hospital, Rokutanji-cho, 13-9, 662-0918, Nishinomiya, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konishi", 
        "givenName": "Muneharu", 
        "id": "sg:person.01321156372.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321156372.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kobe City Medical Center West Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415419.c", 
          "name": [
            "Department of Surgery, Kobe City Medical Center West Hospital, Ichiban-cho, 2-4, Nagata-ku, 653-0013, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kikawa", 
        "givenName": "Yuichiro", 
        "id": "sg:person.01320526407.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320526407.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Kobe Kyodo Hospital, Kubo-cho, 2-4-7, Nagata-ku, 653-0041, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minohata", 
        "givenName": "Junya", 
        "id": "sg:person.01251206173.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251206173.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nishi Kobe Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416289.0", 
          "name": [
            "Nishi-kobe Medical Center, Kojidai, 5-7-1, Nishi-ku, 651-2273, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okuno", 
        "givenName": "Toshitaka", 
        "id": "sg:person.0705056724.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705056724.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Miyauchi Clinic, Mukonoso, 4-10-5, 661-0035, Amagasaki, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyauchi", 
        "givenName": "Keisuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Chayamachi Breast Clinic, Chayamachi, 3-1, Kita-ku, 530-0013, Osaka, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wakita", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.016633121325.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016633121325.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hyogo Prefectural Tsukaguchi Hospital, Minamitsukaguchi-cho, 6-8-17, 661-0012, Amagasaki, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suwa", 
        "givenName": "Hirofumi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hashimoto Clinic, Sumiyoshihommachi, 1-7-2, Higashinada-ku, 658-0051, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hashimoto", 
        "givenName": "Takashi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Takarazuka City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416860.d", 
          "name": [
            "Department of Surgery, Takarazuka Municipal Hospital, Kohama, 4-5-1, 665-0827, Takarazuka, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishino", 
        "givenName": "Masayuki", 
        "id": "sg:person.01167371045.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167371045.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kinki Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415371.5", 
          "name": [
            "Department of Surgery, Kinki Central Hospital, Kurumazuka, 3-1, 664-8533, Itami, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Takashi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kobe Century Memorial Hospital, Misaki-cho, 1-9-1, Hyogo-ku, 652-0855, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hidaka", 
        "givenName": "Toshiharu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kobe Urban Breast Clinic, Kumoidori, 4-1-6, Chuo-ku, 651-0096, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konishi", 
        "givenName": "Yutaka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Breast Surgery, Hyogo Prefectural Kakogawa Medical Center, Kanno-cho Kanno, 203, 675-8555, Kakogawa, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakoda", 
        "givenName": "Yoko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuma Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415528.f", 
          "name": [
            "Department of Surgery, Kuma Hospital, Shimoyamatedori, 8-2-35, Chuo-ku, 650-0011, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miya", 
        "givenName": "Akihiro", 
        "id": "sg:person.0637036407.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637036407.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Breast and Endocrine Surgery, Meiwa Hospital, Agenaruo-cho, 4-31, 663-8186, Nishinomiya, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitsunobu", 
        "givenName": "Masao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Nishikawa Clinic, Nishidaimotsu-cho, 12-41, 660-0827, Amagasaki, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishikawa", 
        "givenName": "Hidefumi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kobe University", 
          "id": "https://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Breast and Endocrine Surgery, Kobe University School of Medicine, Kusunoki-cho, 7-5-2, Chuo-ku, 650-0017, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kono", 
        "givenName": "Seishi", 
        "id": "sg:person.01055643576.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055643576.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kokufu Breast Clinic, Nakayamadera, 1-10-6, 665-0861, Takarazuka, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kokufu", 
        "givenName": "Ikuo", 
        "id": "sg:person.0705343752.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705343752.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sakita Clinic, Wajo-cho, 2-35-101, 662-0971, Nishinomiya, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakita", 
        "givenName": "Isao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kitatsuji Clinic, Nishitachibana-cho, 3-1-1, 660-0054, Amagasaki, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitatsuji", 
        "givenName": "Koushiro", 
        "id": "sg:person.010447313241.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010447313241.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kobe Adventist Hospital, Arinodai, 8-4-1, Kita-ku, 651-1321, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Koushi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Division of Breast and Endocrine Surgery, Department of Surgery, Hyogo College of Medicine, Mukogawa-cho, 1-1, 663-8501, Nishinomiya, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyoshi", 
        "givenName": "Yasuo", 
        "id": "sg:person.0775631274.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775631274.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2007.10.7573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002273845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70182-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002955805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-008-0828-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003950605", 
          "https://doi.org/10.1007/s10147-008-0828-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-008-0828-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003950605", 
          "https://doi.org/10.1007/s10147-008-0828-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13697137.2013.819327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005791580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)74803-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009387731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.08.8617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018605357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11606-008-0655-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026470454", 
          "https://doi.org/10.1007/s11606-008-0655-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)17666-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031625479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2325/jbcs.13.284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035409419", 
          "https://doi.org/10.2325/jbcs.13.284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-011-1378-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043654527", 
          "https://doi.org/10.1007/s10549-011-1378-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpainsymman.2012.10.282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044716668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075298818", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04", 
    "datePublishedReg": "2016-04-01", 
    "description": "BACKGROUND: Endocrine treatment-related adverse events have a strong impact on patients' quality of life and sometimes result in treatment discontinuation. Since joint symptoms are the most frequently recognized side effect of aromatase inhibitors, evaluation of associated risk factors may yield significant findings.\nPATIENTS AND METHODS: A total of 391 postmenopausal Japanese women with estrogen receptor-positive breast cancer and treated with adjuvant anastrozole were enrolled from 28 centers for assessment of patient-reported outcomes (PROs) in this prospective cohort study (SAVS-JP, UMIN000002455). Patients completed the self-report questionnaire at baseline and after 3, 6, 9, and 12 months of treatment for evaluation of frequency of treatment-related joint symptoms (arthralgia, decrease in range of joint motion, and joint stiffness).\nRESULTS: We obtained PROs from 362 patients (92.6 %) at baseline and at one or more subsequent points. New or worsening from baseline of joint symptoms were reported by 260 patients (71.8 %). More than 90 % of the symptoms were mild or moderate and nearly 80 % had occurred by 6 months. Multivariate analysis showed that a short time span after menopause [odds ratio (OR) 0.95, 95 % confidence interval (CI) 0.90-0.99; P = 0.02] and adjuvant chemotherapy (OR 2.29, 95 % CI 1.06-4.95; P = 0.03) were significant independent risk factors for joint symptoms. No significant relationships between body mass index (BMI) and joint symptoms were identified. Eighteen patients discontinued treatment during the 1st year and eight of them reported joint symptoms.\nCONCLUSION: Taking into consideration that PROs may yield higher prevalence rates than physician ratings for symptoms published in pivotal clinical trials, we found that a short time span after menopause and use of adjuvant chemotherapy, but not high BMI, were significantly associated with joint symptoms. These findings might prove useful for counseling before initiating treatment with adjuvant aromatase inhibitors in postmenopausal Japanese women.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10147-015-0905-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312225", 
        "issn": [
          "1341-9625", 
          "1437-7772"
        ], 
        "name": "International Journal of Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Risk factors for joint symptoms in postmenopausal Japanese breast cancer patients treated with anastrozole: a prospective multicenter cohort study of patient-reported outcomes", 
    "pagination": "262-269", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "064c3cbe130520ca7c723cd6d13509ed37b3357881fbd73e0674c60c7a939dda"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26411314"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9616295"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10147-015-0905-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001322158"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10147-015-0905-5", 
      "https://app.dimensions.ai/details/publication/pub.1001322158"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000485.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10147-015-0905-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-015-0905-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-015-0905-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-015-0905-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-015-0905-5'


 

This table displays all metadata directly associated to this object as RDF triples.

448 TRIPLES      21 PREDICATES      63 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10147-015-0905-5 schema:about N02b87b3145cb4a1d800176399b9b7321
2 N06e0be2ea4724ff69e12f8cefb5675c4
3 N126b2ac51ff24a31b85486ef3d39f838
4 N14f038db9dc34d70841ba71a28577cae
5 N1c608535e7664c049ea3dcab2d04f9ec
6 N30e7acb7ccc24026897343d749800161
7 N35ad9b18adf648ed87234624e82e1341
8 N3f92a27f5f8a4fdd97f9e806f0272147
9 N455c159f6b644ae89bf7d29dfe6cdc8d
10 N52a1e70ddcc84469bf4a4fe1ef1ecbc4
11 N60d39ab1cd8e45d989f16d0e08bf123b
12 N6218f74b0d164140a30791fb4d7cca25
13 N69971b1b575c42f4852d3210ca201706
14 N774fce86deba4e538eba7a6731d0f992
15 N8e99d18f77ad46c696089f4d9e13ed6d
16 N902785f3b6584fa59997c9debc31347e
17 N932cd0c9c782499b87a2a2d39004954f
18 Nb5b09c3d592d46c3acd1c1c1df29a3d2
19 Nda2edf29cb504d0faf34be4d434418e2
20 Ne56e4235dc5f4f48af03c54fee4b3e58
21 Neec0eece3f984bdba9a493075c68619e
22 Nf0ede38a10d146a7a5e39ff0aefd3558
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N265ee4a15c2c45e49a10dfce705133f7
26 schema:citation sg:pub.10.1007/s10147-008-0828-5
27 sg:pub.10.1007/s10549-011-1378-5
28 sg:pub.10.1007/s11606-008-0655-4
29 sg:pub.10.2325/jbcs.13.284
30 https://app.dimensions.ai/details/publication/pub.1075298818
31 https://doi.org/10.1016/j.jpainsymman.2012.10.282
32 https://doi.org/10.1016/s0140-6736(04)17666-6
33 https://doi.org/10.1016/s0140-6736(05)74803-0
34 https://doi.org/10.1016/s1470-2045(08)70182-7
35 https://doi.org/10.1200/jco.2006.08.8617
36 https://doi.org/10.1200/jco.2007.10.7573
37 https://doi.org/10.3109/13697137.2013.819327
38 schema:datePublished 2016-04
39 schema:datePublishedReg 2016-04-01
40 schema:description BACKGROUND: Endocrine treatment-related adverse events have a strong impact on patients' quality of life and sometimes result in treatment discontinuation. Since joint symptoms are the most frequently recognized side effect of aromatase inhibitors, evaluation of associated risk factors may yield significant findings. PATIENTS AND METHODS: A total of 391 postmenopausal Japanese women with estrogen receptor-positive breast cancer and treated with adjuvant anastrozole were enrolled from 28 centers for assessment of patient-reported outcomes (PROs) in this prospective cohort study (SAVS-JP, UMIN000002455). Patients completed the self-report questionnaire at baseline and after 3, 6, 9, and 12 months of treatment for evaluation of frequency of treatment-related joint symptoms (arthralgia, decrease in range of joint motion, and joint stiffness). RESULTS: We obtained PROs from 362 patients (92.6 %) at baseline and at one or more subsequent points. New or worsening from baseline of joint symptoms were reported by 260 patients (71.8 %). More than 90 % of the symptoms were mild or moderate and nearly 80 % had occurred by 6 months. Multivariate analysis showed that a short time span after menopause [odds ratio (OR) 0.95, 95 % confidence interval (CI) 0.90-0.99; P = 0.02] and adjuvant chemotherapy (OR 2.29, 95 % CI 1.06-4.95; P = 0.03) were significant independent risk factors for joint symptoms. No significant relationships between body mass index (BMI) and joint symptoms were identified. Eighteen patients discontinued treatment during the 1st year and eight of them reported joint symptoms. CONCLUSION: Taking into consideration that PROs may yield higher prevalence rates than physician ratings for symptoms published in pivotal clinical trials, we found that a short time span after menopause and use of adjuvant chemotherapy, but not high BMI, were significantly associated with joint symptoms. These findings might prove useful for counseling before initiating treatment with adjuvant aromatase inhibitors in postmenopausal Japanese women.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N97f8bfb5af6c49918aebf624bb1ef6b9
45 Nb5252e6b693149ae9832bd53e3e0d75e
46 sg:journal.1312225
47 schema:name Risk factors for joint symptoms in postmenopausal Japanese breast cancer patients treated with anastrozole: a prospective multicenter cohort study of patient-reported outcomes
48 schema:pagination 262-269
49 schema:productId N17b7bd892aef431c8ed34de289f93c4b
50 N943cae35fff94a49ac4ebf8d39765b66
51 Nae78d7d2df314652bd1fa34fa3aaa0f5
52 Ncb0d3438ded34573a8cea3fb9516f271
53 Nea335e65f65b45fdbd28ffac2edd1c6d
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001322158
55 https://doi.org/10.1007/s10147-015-0905-5
56 schema:sdDatePublished 2019-04-10T21:30
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N2746fee2ee2746ffa6b25b9faf111b83
59 schema:url http://link.springer.com/10.1007/s10147-015-0905-5
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N02b87b3145cb4a1d800176399b9b7321 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Chemotherapy, Adjuvant
65 rdf:type schema:DefinedTerm
66 N0553fb7a1b1e4fc78a8213d27be9fab3 schema:name Hyogo Prefectural Tsukaguchi Hospital, Minamitsukaguchi-cho, 6-8-17, 661-0012, Amagasaki, Hyogo, Japan
67 rdf:type schema:Organization
68 N06e0be2ea4724ff69e12f8cefb5675c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Surveys and Questionnaires
70 rdf:type schema:DefinedTerm
71 N0e9ba2f76f6e4bb2ae28b941a9bf0bf2 rdf:first sg:person.012465661062.66
72 rdf:rest N1e6756ea8f2e43e480422a6147d2d021
73 N126b2ac51ff24a31b85486ef3d39f838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Nitriles
75 rdf:type schema:DefinedTerm
76 N12e41687a7b946a7b34f1b702aec7886 schema:name Kobe Century Memorial Hospital, Misaki-cho, 1-9-1, Hyogo-ku, 652-0855, Kobe, Hyogo, Japan
77 rdf:type schema:Organization
78 N14f038db9dc34d70841ba71a28577cae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Carcinoma, Lobular
80 rdf:type schema:DefinedTerm
81 N1714dd63e604412e873521c4baae99e7 schema:affiliation Na043bccd50ec4f9a850cd7f50a0c912d
82 schema:familyName Sakoda
83 schema:givenName Yoko
84 rdf:type schema:Person
85 N17b7bd892aef431c8ed34de289f93c4b schema:name doi
86 schema:value 10.1007/s10147-015-0905-5
87 rdf:type schema:PropertyValue
88 N1c608535e7664c049ea3dcab2d04f9ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Adult
90 rdf:type schema:DefinedTerm
91 N1e61b6aab9784c74b361dcea7f42b929 rdf:first Nd0498cd0216d411eb5f9d1f199e19270
92 rdf:rest Ncfccf53b71204b848f6d2cfe2800de35
93 N1e6756ea8f2e43e480422a6147d2d021 rdf:first sg:person.0751370470.68
94 rdf:rest Nd537774fc51540bea783ebe4c97d4b3a
95 N265ee4a15c2c45e49a10dfce705133f7 rdf:first sg:person.0754054224.56
96 rdf:rest N0e9ba2f76f6e4bb2ae28b941a9bf0bf2
97 N26bdeda5e1034b3ca7f22c6845bef492 rdf:first sg:person.0646020706.10
98 rdf:rest Na6e0a3258b984b788ddc574eddb30354
99 N2746fee2ee2746ffa6b25b9faf111b83 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N306f9c58e38640d4a902417117f5d14d rdf:first sg:person.01321156372.82
102 rdf:rest Nde73429c1f014216a44b1a6eb86a4048
103 N30e7acb7ccc24026897343d749800161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aromatase Inhibitors
105 rdf:type schema:DefinedTerm
106 N316b9b28c4384f5c999f401b69b08300 rdf:first sg:person.016633121325.09
107 rdf:rest Nc59691a63f60467bb7fa0782245e6eb8
108 N340815504e904c9c969f78f39b79369d schema:affiliation https://www.grid.ac/institutes/grid.415371.5
109 schema:familyName Matsumoto
110 schema:givenName Takashi
111 rdf:type schema:Person
112 N3465c3f51f7444f0b35bb31b34417ca2 rdf:first sg:person.01167371045.23
113 rdf:rest Nc55240e23efe4a00b7889daa43b98a85
114 N35ad9b18adf648ed87234624e82e1341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N37eb1aab7f034531bb7138149f317d9f rdf:first N83047864df3c46d4907235655e3eed33
118 rdf:rest N58af8b65fd1746a0b8fb7deeabf77b07
119 N3bb975cc81e74acfa7f3e5fde6d11d78 rdf:first N7697c9be6ad34cca83d7d7ec3e2c5b2a
120 rdf:rest N316b9b28c4384f5c999f401b69b08300
121 N3f92a27f5f8a4fdd97f9e806f0272147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Breast Neoplasms
123 rdf:type schema:DefinedTerm
124 N41b97e0bbd15499e9cf2acb78d44021c schema:name Kobe Adventist Hospital, Arinodai, 8-4-1, Kita-ku, 651-1321, Kobe, Hyogo, Japan
125 rdf:type schema:Organization
126 N455c159f6b644ae89bf7d29dfe6cdc8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Risk Factors
128 rdf:type schema:DefinedTerm
129 N4f2e2d9d2b3747828ff8741b058b46cc rdf:first sg:person.0705056724.80
130 rdf:rest N3bb975cc81e74acfa7f3e5fde6d11d78
131 N52a1e70ddcc84469bf4a4fe1ef1ecbc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Postmenopause
133 rdf:type schema:DefinedTerm
134 N56791c8cafb84cdc8b251095324d2ad5 rdf:first N5bca592b96944fd0b057f7f3a5341e15
135 rdf:rest N8f7b36d730e84babbc89bb27f1a57432
136 N58af8b65fd1746a0b8fb7deeabf77b07 rdf:first N9b9f166b17324f61b9f20c34c953967d
137 rdf:rest Nd899cba250ba4c6aa8159fabdf5c6454
138 N5bca592b96944fd0b057f7f3a5341e15 schema:affiliation N41b97e0bbd15499e9cf2acb78d44021c
139 schema:familyName Oh
140 schema:givenName Koushi
141 rdf:type schema:Person
142 N60d39ab1cd8e45d989f16d0e08bf123b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neoplasm Staging
144 rdf:type schema:DefinedTerm
145 N60fb658fd84242df88322f0ae17e4868 schema:affiliation Nd4f5a9e3c8a144ee8c44c1137a82d7bd
146 schema:familyName Konishi
147 schema:givenName Yutaka
148 rdf:type schema:Person
149 N6218f74b0d164140a30791fb4d7cca25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Middle Aged
151 rdf:type schema:DefinedTerm
152 N6319f6e117b34cb49da32e61eb8c1f67 rdf:first Na8671c95f78646c8a9730eba14ea4390
153 rdf:rest Na30980be2bc849fab99a44356b16554b
154 N69971b1b575c42f4852d3210ca201706 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Aged, 80 and over
156 rdf:type schema:DefinedTerm
157 N6d67e08bb2444d24a5427e3d03f7ec7f schema:name Chayamachi Breast Clinic, Chayamachi, 3-1, Kita-ku, 530-0013, Osaka, Osaka, Japan
158 rdf:type schema:Organization
159 N7697c9be6ad34cca83d7d7ec3e2c5b2a schema:affiliation Nd345b336a0234239913e8edeb62c31e1
160 schema:familyName Miyauchi
161 schema:givenName Keisuke
162 rdf:type schema:Person
163 N774fce86deba4e538eba7a6731d0f992 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Carcinoma, Ductal, Breast
165 rdf:type schema:DefinedTerm
166 N7f0e1b2e2807494b960c2ea5afab6020 schema:name Kokufu Breast Clinic, Nakayamadera, 1-10-6, 665-0861, Takarazuka, Hyogo, Japan
167 rdf:type schema:Organization
168 N83047864df3c46d4907235655e3eed33 schema:affiliation N9af395d8792c46e2ae7e7b14883b85cc
169 schema:familyName Mitsunobu
170 schema:givenName Masao
171 rdf:type schema:Person
172 N8e30f87b6c084b7f8bee800afcdab4b7 schema:affiliation N0553fb7a1b1e4fc78a8213d27be9fab3
173 schema:familyName Suwa
174 schema:givenName Hirofumi
175 rdf:type schema:Person
176 N8e99d18f77ad46c696089f4d9e13ed6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Patient Outcome Assessment
178 rdf:type schema:DefinedTerm
179 N8f7b36d730e84babbc89bb27f1a57432 rdf:first sg:person.0775631274.41
180 rdf:rest rdf:nil
181 N902785f3b6584fa59997c9debc31347e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Joint Diseases
183 rdf:type schema:DefinedTerm
184 N90c4ed586a31499a86f7d23b6279fe93 schema:name Sakita Clinic, Wajo-cho, 2-35-101, 662-0971, Nishinomiya, Hyogo, Japan
185 rdf:type schema:Organization
186 N932cd0c9c782499b87a2a2d39004954f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Prospective Studies
188 rdf:type schema:DefinedTerm
189 N943cae35fff94a49ac4ebf8d39765b66 schema:name readcube_id
190 schema:value 064c3cbe130520ca7c723cd6d13509ed37b3357881fbd73e0674c60c7a939dda
191 rdf:type schema:PropertyValue
192 N97f8bfb5af6c49918aebf624bb1ef6b9 schema:issueNumber 2
193 rdf:type schema:PublicationIssue
194 N9af395d8792c46e2ae7e7b14883b85cc schema:name Department of Breast and Endocrine Surgery, Meiwa Hospital, Agenaruo-cho, 4-31, 663-8186, Nishinomiya, Hyogo, Japan
195 rdf:type schema:Organization
196 N9b9f166b17324f61b9f20c34c953967d schema:affiliation Nf3f21556c7d74c58b8462018815d0298
197 schema:familyName Nishikawa
198 schema:givenName Hidefumi
199 rdf:type schema:Person
200 Na043bccd50ec4f9a850cd7f50a0c912d schema:name Department of Breast Surgery, Hyogo Prefectural Kakogawa Medical Center, Kanno-cho Kanno, 203, 675-8555, Kakogawa, Hyogo, Japan
201 rdf:type schema:Organization
202 Na30980be2bc849fab99a44356b16554b rdf:first N60fb658fd84242df88322f0ae17e4868
203 rdf:rest Necf9fb36bd3242fe82615afaad0c55e1
204 Na65426a8e31744d0b39c4d3c006f95c4 rdf:first Nc1ef7a7409f04c81bc7d974a94eef634
205 rdf:rest N3465c3f51f7444f0b35bb31b34417ca2
206 Na6e0a3258b984b788ddc574eddb30354 rdf:first sg:person.0700054205.79
207 rdf:rest Nb13e88cf70e84029a72184262b0765d8
208 Na8671c95f78646c8a9730eba14ea4390 schema:affiliation N12e41687a7b946a7b34f1b702aec7886
209 schema:familyName Hidaka
210 schema:givenName Toshiharu
211 rdf:type schema:Person
212 Nae78d7d2df314652bd1fa34fa3aaa0f5 schema:name nlm_unique_id
213 schema:value 9616295
214 rdf:type schema:PropertyValue
215 Nb13e88cf70e84029a72184262b0765d8 rdf:first sg:person.01276425575.81
216 rdf:rest N306f9c58e38640d4a902417117f5d14d
217 Nb3e9795588e1495e8900b428c6981bfc schema:name Hashimoto Clinic, Sumiyoshihommachi, 1-7-2, Higashinada-ku, 658-0051, Kobe, Hyogo, Japan
218 rdf:type schema:Organization
219 Nb5252e6b693149ae9832bd53e3e0d75e schema:volumeNumber 21
220 rdf:type schema:PublicationVolume
221 Nb5b09c3d592d46c3acd1c1c1df29a3d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Prognosis
223 rdf:type schema:DefinedTerm
224 Nc04742664e054c709ef12f4322bc9ea8 schema:name Department of Surgery, Kobe Kyodo Hospital, Kubo-cho, 2-4-7, Nagata-ku, 653-0041, Kobe, Hyogo, Japan
225 rdf:type schema:Organization
226 Nc1ef7a7409f04c81bc7d974a94eef634 schema:affiliation Nb3e9795588e1495e8900b428c6981bfc
227 schema:familyName Hashimoto
228 schema:givenName Takashi
229 rdf:type schema:Person
230 Nc42a07c346644aca98901d16011bce34 schema:name Kitatsuji Clinic, Nishitachibana-cho, 3-1-1, 660-0054, Amagasaki, Hyogo, Japan
231 rdf:type schema:Organization
232 Nc48fa99acf874fcdb6a21cbf176f5a33 rdf:first sg:person.0637036407.94
233 rdf:rest N37eb1aab7f034531bb7138149f317d9f
234 Nc55240e23efe4a00b7889daa43b98a85 rdf:first N340815504e904c9c969f78f39b79369d
235 rdf:rest N6319f6e117b34cb49da32e61eb8c1f67
236 Nc59691a63f60467bb7fa0782245e6eb8 rdf:first N8e30f87b6c084b7f8bee800afcdab4b7
237 rdf:rest Na65426a8e31744d0b39c4d3c006f95c4
238 Ncb0d3438ded34573a8cea3fb9516f271 schema:name dimensions_id
239 schema:value pub.1001322158
240 rdf:type schema:PropertyValue
241 Ncfccf53b71204b848f6d2cfe2800de35 rdf:first sg:person.010447313241.19
242 rdf:rest N56791c8cafb84cdc8b251095324d2ad5
243 Nd0498cd0216d411eb5f9d1f199e19270 schema:affiliation N90c4ed586a31499a86f7d23b6279fe93
244 schema:familyName Sakita
245 schema:givenName Isao
246 rdf:type schema:Person
247 Nd345b336a0234239913e8edeb62c31e1 schema:name Miyauchi Clinic, Mukonoso, 4-10-5, 661-0035, Amagasaki, Hyogo, Japan
248 rdf:type schema:Organization
249 Nd4f5a9e3c8a144ee8c44c1137a82d7bd schema:name Kobe Urban Breast Clinic, Kumoidori, 4-1-6, Chuo-ku, 651-0096, Kobe, Hyogo, Japan
250 rdf:type schema:Organization
251 Nd537774fc51540bea783ebe4c97d4b3a rdf:first sg:person.0663067774.37
252 rdf:rest N26bdeda5e1034b3ca7f22c6845bef492
253 Nd899cba250ba4c6aa8159fabdf5c6454 rdf:first sg:person.01055643576.49
254 rdf:rest Nfbe14cb66c684f998bf23fc96b77f9ca
255 Nda2edf29cb504d0faf34be4d434418e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Female
257 rdf:type schema:DefinedTerm
258 Nde73429c1f014216a44b1a6eb86a4048 rdf:first sg:person.01320526407.25
259 rdf:rest Nefbf0b2bcc5a4d6eb990df9dc8c139a8
260 Ne56e4235dc5f4f48af03c54fee4b3e58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
261 schema:name Triazoles
262 rdf:type schema:DefinedTerm
263 Nea335e65f65b45fdbd28ffac2edd1c6d schema:name pubmed_id
264 schema:value 26411314
265 rdf:type schema:PropertyValue
266 Necf9fb36bd3242fe82615afaad0c55e1 rdf:first N1714dd63e604412e873521c4baae99e7
267 rdf:rest Nc48fa99acf874fcdb6a21cbf176f5a33
268 Neec0eece3f984bdba9a493075c68619e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
269 schema:name Aged
270 rdf:type schema:DefinedTerm
271 Nefbf0b2bcc5a4d6eb990df9dc8c139a8 rdf:first sg:person.01251206173.66
272 rdf:rest N4f2e2d9d2b3747828ff8741b058b46cc
273 Nf0ede38a10d146a7a5e39ff0aefd3558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
274 schema:name Quality of Life
275 rdf:type schema:DefinedTerm
276 Nf3f21556c7d74c58b8462018815d0298 schema:name Nishikawa Clinic, Nishidaimotsu-cho, 12-41, 660-0827, Amagasaki, Hyogo, Japan
277 rdf:type schema:Organization
278 Nfbe14cb66c684f998bf23fc96b77f9ca rdf:first sg:person.0705343752.58
279 rdf:rest N1e61b6aab9784c74b361dcea7f42b929
280 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
281 schema:name Medical and Health Sciences
282 rdf:type schema:DefinedTerm
283 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
284 schema:name Clinical Sciences
285 rdf:type schema:DefinedTerm
286 sg:journal.1312225 schema:issn 1341-9625
287 1437-7772
288 schema:name International Journal of Clinical Oncology
289 rdf:type schema:Periodical
290 sg:person.010447313241.19 schema:affiliation Nc42a07c346644aca98901d16011bce34
291 schema:familyName Kitatsuji
292 schema:givenName Koushiro
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010447313241.19
294 rdf:type schema:Person
295 sg:person.01055643576.49 schema:affiliation https://www.grid.ac/institutes/grid.31432.37
296 schema:familyName Kono
297 schema:givenName Seishi
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055643576.49
299 rdf:type schema:Person
300 sg:person.01167371045.23 schema:affiliation https://www.grid.ac/institutes/grid.416860.d
301 schema:familyName Nishino
302 schema:givenName Masayuki
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167371045.23
304 rdf:type schema:Person
305 sg:person.012465661062.66 schema:affiliation https://www.grid.ac/institutes/grid.417755.5
306 schema:familyName Hirokaga
307 schema:givenName Kouichi
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012465661062.66
309 rdf:type schema:Person
310 sg:person.01251206173.66 schema:affiliation Nc04742664e054c709ef12f4322bc9ea8
311 schema:familyName Minohata
312 schema:givenName Junya
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251206173.66
314 rdf:type schema:Person
315 sg:person.01276425575.81 schema:affiliation https://www.grid.ac/institutes/grid.416028.9
316 schema:familyName Ichii
317 schema:givenName Shigetoshi
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276425575.81
319 rdf:type schema:Person
320 sg:person.01320526407.25 schema:affiliation https://www.grid.ac/institutes/grid.415419.c
321 schema:familyName Kikawa
322 schema:givenName Yuichiro
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320526407.25
324 rdf:type schema:Person
325 sg:person.01321156372.82 schema:affiliation https://www.grid.ac/institutes/grid.413719.9
326 schema:familyName Konishi
327 schema:givenName Muneharu
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321156372.82
329 rdf:type schema:Person
330 sg:person.016633121325.09 schema:affiliation N6d67e08bb2444d24a5427e3d03f7ec7f
331 schema:familyName Wakita
332 schema:givenName Kazuyuki
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016633121325.09
334 rdf:type schema:Person
335 sg:person.0637036407.94 schema:affiliation https://www.grid.ac/institutes/grid.415528.f
336 schema:familyName Miya
337 schema:givenName Akihiro
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637036407.94
339 rdf:type schema:Person
340 sg:person.0646020706.10 schema:affiliation https://www.grid.ac/institutes/grid.415430.7
341 schema:familyName Miyashita
342 schema:givenName Masaru
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646020706.10
344 rdf:type schema:Person
345 sg:person.0663067774.37 schema:affiliation https://www.grid.ac/institutes/grid.415766.7
346 schema:familyName Yamagami
347 schema:givenName Kazuhiko
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663067774.37
349 rdf:type schema:Person
350 sg:person.0700054205.79 schema:affiliation https://www.grid.ac/institutes/grid.440094.d
351 schema:familyName Baba
352 schema:givenName Masashi
353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700054205.79
354 rdf:type schema:Person
355 sg:person.0705056724.80 schema:affiliation https://www.grid.ac/institutes/grid.416289.0
356 schema:familyName Okuno
357 schema:givenName Toshitaka
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705056724.80
359 rdf:type schema:Person
360 sg:person.0705343752.58 schema:affiliation N7f0e1b2e2807494b960c2ea5afab6020
361 schema:familyName Kokufu
362 schema:givenName Ikuo
363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705343752.58
364 rdf:type schema:Person
365 sg:person.0751370470.68 schema:affiliation https://www.grid.ac/institutes/grid.417755.5
366 schema:familyName Takao
367 schema:givenName Shintaro
368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751370470.68
369 rdf:type schema:Person
370 sg:person.0754054224.56 schema:affiliation https://www.grid.ac/institutes/grid.414976.9
371 schema:familyName Egawa
372 schema:givenName Chiyomi
373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754054224.56
374 rdf:type schema:Person
375 sg:person.0775631274.41 schema:affiliation https://www.grid.ac/institutes/grid.272264.7
376 schema:familyName Miyoshi
377 schema:givenName Yasuo
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775631274.41
379 rdf:type schema:Person
380 sg:pub.10.1007/s10147-008-0828-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003950605
381 https://doi.org/10.1007/s10147-008-0828-5
382 rdf:type schema:CreativeWork
383 sg:pub.10.1007/s10549-011-1378-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043654527
384 https://doi.org/10.1007/s10549-011-1378-5
385 rdf:type schema:CreativeWork
386 sg:pub.10.1007/s11606-008-0655-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026470454
387 https://doi.org/10.1007/s11606-008-0655-4
388 rdf:type schema:CreativeWork
389 sg:pub.10.2325/jbcs.13.284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035409419
390 https://doi.org/10.2325/jbcs.13.284
391 rdf:type schema:CreativeWork
392 https://app.dimensions.ai/details/publication/pub.1075298818 schema:CreativeWork
393 https://doi.org/10.1016/j.jpainsymman.2012.10.282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044716668
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/s0140-6736(04)17666-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031625479
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/s0140-6736(05)74803-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009387731
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1016/s1470-2045(08)70182-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002955805
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1200/jco.2006.08.8617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018605357
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1200/jco.2007.10.7573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002273845
404 rdf:type schema:CreativeWork
405 https://doi.org/10.3109/13697137.2013.819327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005791580
406 rdf:type schema:CreativeWork
407 https://www.grid.ac/institutes/grid.272264.7 schema:alternateName Hyogo College of Medicine
408 schema:name Division of Breast and Endocrine Surgery, Department of Surgery, Hyogo College of Medicine, Mukogawa-cho, 1-1, 663-8501, Nishinomiya, Hyogo, Japan
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.31432.37 schema:alternateName Kobe University
411 schema:name Department of Breast and Endocrine Surgery, Kobe University School of Medicine, Kusunoki-cho, 7-5-2, Chuo-ku, 650-0017, Kobe, Hyogo, Japan
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.413719.9 schema:alternateName Hyogo Prefectural Nishinomiya Hospital
414 schema:name Department of Surgery, Hyogo Prefectural Nishinomiya Hospital, Rokutanji-cho, 13-9, 662-0918, Nishinomiya, Hyogo, Japan
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.414976.9 schema:alternateName Kansai Rosai Hospital
417 schema:name Department of Surgery, Kansai Rosai Hospital, Inaba-so, 3-1-69, 660-8511, Amagasaki, Hyogo, Japan
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.415371.5 schema:alternateName Kinki Central Hospital
420 schema:name Department of Surgery, Kinki Central Hospital, Kurumazuka, 3-1, 664-8533, Itami, Hyogo, Japan
421 rdf:type schema:Organization
422 https://www.grid.ac/institutes/grid.415419.c schema:alternateName Kobe City Medical Center West Hospital
423 schema:name Department of Surgery, Kobe City Medical Center West Hospital, Ichiban-cho, 2-4, Nagata-ku, 653-0013, Kobe, Hyogo, Japan
424 rdf:type schema:Organization
425 https://www.grid.ac/institutes/grid.415430.7 schema:alternateName Kohnan Hospital
426 schema:name Department of Surgery, Kohnan Hospital, Kamokogahara, 1-5-16, Higashinada-ku, 658-0064, Kobe, Hyogo, Japan
427 rdf:type schema:Organization
428 https://www.grid.ac/institutes/grid.415528.f schema:alternateName Kuma Hospital
429 schema:name Department of Surgery, Kuma Hospital, Shimoyamatedori, 8-2-35, Chuo-ku, 650-0011, Kobe, Hyogo, Japan
430 rdf:type schema:Organization
431 https://www.grid.ac/institutes/grid.415766.7 schema:alternateName Shinko Hospital
432 schema:name Department of Breast Surgery, Shinko Hospital, Wakinohama-cho, 1-4-47, Chuo-ku, 651-0072, Kobe, Hyogo, Japan
433 rdf:type schema:Organization
434 https://www.grid.ac/institutes/grid.416028.9 schema:alternateName Rokko Island Konan Hospital
435 schema:name Rokko Island Hospital, Koyochonaka, 2-11, Higashinada-ku, 658-0032, Kobe, Hyogo, Japan
436 rdf:type schema:Organization
437 https://www.grid.ac/institutes/grid.416289.0 schema:alternateName Nishi Kobe Medical Center
438 schema:name Nishi-kobe Medical Center, Kojidai, 5-7-1, Nishi-ku, 651-2273, Kobe, Hyogo, Japan
439 rdf:type schema:Organization
440 https://www.grid.ac/institutes/grid.416860.d schema:alternateName Takarazuka City Hospital
441 schema:name Department of Surgery, Takarazuka Municipal Hospital, Kohama, 4-5-1, 665-0827, Takarazuka, Hyogo, Japan
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.417755.5 schema:alternateName Hyogo Prefectural Cancer Center
444 schema:name Department of Breast Surgery, Hyogo Cancer Center, Kitaoji-cho, 13-70, 673-8558, Akashi, Hyogo, Japan
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.440094.d schema:alternateName Itami City Hospital
447 schema:name Department of Surgery, Itami City Hospital, Koyaike, 1-100, 664-8540, Itami, Hyogo, Japan
448 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...