Leiomyosarcoma: investigation of prognostic factors for risk-stratification model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06-28

AUTHORS

Hyun Ju Kim, Yong Jin Cho, Soo Hee Kim, Sun Young Rha, Joong Bae Ahn, Woo Ick Yang, Young Han Lee, Jin-Suck Suh, Jae Kyung Roh, Kyung Sik Kim, Young Deuk Choi, Kyoo-Ho Shin, Hyo Song Kim

ABSTRACT

BackgroundWe performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors.MethodsBetween 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed.ResultsOf the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n = 25), pelvis (n = 40), thoracic cavity (n = 11), intra-abdomen (n = 19), retroperitoneum (n = 23), and head/neck (n = 11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n = 42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n = 87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0 years, P = 0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P = 0.027). Independent prognostic factors for survival were primary site (P = 0.041, hazard ratio (HR) 1.7; 95 % CI 1.2–2.8), tumor size (P = 0.038, HR 1.9; 95 % CI 1.13–3.38), margin status (P = 0.019, HR 2.1; 95 % CI 1.13–3.88), and histology grade (P = 0.01, HR 3.59; 95 % CI 1.64–7.87). We identified four different risk groups with different survival outcome: group 1 (n = 8), no adverse factors; groups 2 (n = 37) and 3 (n = 61) with one and two adverse factors, and group 4 (n = 23) with 3 or 4 adverse factors.ConclusionPrimary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination. More... »

PAGES

1226-1232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-015-0847-y

DOI

http://dx.doi.org/10.1007/s10147-015-0847-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028900637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26123311


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    "description": "BackgroundWe performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors.MethodsBetween 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed.ResultsOf the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n\u00a0=\u00a025), pelvis (n\u00a0=\u00a040), thoracic cavity (n\u00a0=\u00a011), intra-abdomen (n\u00a0=\u00a019), retroperitoneum (n\u00a0=\u00a023), and head/neck (n\u00a0=\u00a011). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n\u00a0=\u00a042) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n\u00a0=\u00a087). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0\u00a0years, P\u00a0=\u00a00.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P\u00a0=\u00a00.027). Independent prognostic factors for survival were primary site (P\u00a0=\u00a00.041, hazard ratio (HR) 1.7; 95\u00a0% CI 1.2\u20132.8), tumor size (P\u00a0=\u00a00.038, HR 1.9; \u00a095\u00a0% CI\u00a0\u00a01.13\u20133.38), margin status (P\u00a0=\u00a00.019, HR 2.1; 95\u00a0% CI\u00a01.13\u20133.88), and histology grade (P\u00a0=\u00a00.01, HR 3.59; 95\u00a0% CI 1.64\u20137.87). We identified four different risk groups with different survival outcome: group 1 (n\u00a0=\u00a08), no adverse factors; groups 2 (n\u00a0=\u00a037) and 3 (n\u00a0=\u00a061) with one and two adverse factors, and group 4 (n\u00a0=\u00a023) with 3 or 4 adverse factors.ConclusionPrimary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination.", 
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28 schema:description BackgroundWe performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors.MethodsBetween 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed.ResultsOf the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n = 25), pelvis (n = 40), thoracic cavity (n = 11), intra-abdomen (n = 19), retroperitoneum (n = 23), and head/neck (n = 11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n = 42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n = 87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0 years, P = 0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P = 0.027). Independent prognostic factors for survival were primary site (P = 0.041, hazard ratio (HR) 1.7; 95 % CI 1.2–2.8), tumor size (P = 0.038, HR 1.9;  95 % CI  1.13–3.38), margin status (P = 0.019, HR 2.1; 95 % CI 1.13–3.88), and histology grade (P = 0.01, HR 3.59; 95 % CI 1.64–7.87). We identified four different risk groups with different survival outcome: group 1 (n = 8), no adverse factors; groups 2 (n = 37) and 3 (n = 61) with one and two adverse factors, and group 4 (n = 23) with 3 or 4 adverse factors.ConclusionPrimary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination.
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35 schema:keywords BackgroundWe
36 MethodsBetween 1988
37 ResultsOf
38 abdominal group
39 adverse factors
40 anatomic location
41 better prognostic discrimination
42 categories
43 cavity
44 clinical features
45 curative intent
46 different risk groups
47 different survival outcomes
48 discrimination
49 distinct groups
50 distinctive clinical features
51 distribution
52 extremities
53 factors
54 features
55 grade
56 group
57 group 1
58 group 2
59 group 4
60 head/neck
61 histology grade
62 histology subtype
63 independent prognostic factor
64 intent
65 investigation
66 leiomyosarcoma
67 leiomyosarcoma patients
68 location
69 margin
70 margin status
71 model
72 neck
73 outcomes
74 overall survival
75 patients
76 pelvis
77 primary site
78 prognosis
79 prognostic discrimination
80 prognostic factors
81 prognostic model
82 resection
83 resection margins
84 retroperitoneum
85 risk groups
86 risk stratification model
87 sites
88 size
89 status
90 study
91 subtypes
92 surgical resection
93 survival
94 survival outcomes
95 thoracic cavity
96 tumor size
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