Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy: ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Sadamoto Zenda, Mitsuhiko Kawashima, Satoko Arahira, Ryosuke Kohno, Teiji Nishio, Makoto Tahara, Ryuichi Hayashi, Tetsuo Akimoto

ABSTRACT

BACKGROUND: Although several reports have shown that proton beam therapy (PBT) offers promise for patients with skull base cancer, little is known about the frequency of late toxicity in clinical practice when PBT is used for these patients. Here, we conducted a retrospective analysis to clarify the late toxicity profile of PBT in patients with malignancies of the nasal cavity, para-nasal sinuses, or involving the skull base. METHODS: Entry to this retrospective study was restricted to patients with (1) malignant tumors of the nasal cavity, para-nasal sinuses, or involving the skull base; (2) definitive or postoperative PBT (>50 GyE) from January 1999 through December 2008; and (3) more than 1 year of follow-up. Late toxicities were graded according to the common terminology criteria for adverse events v4.0 (CTCAE v4.0). RESULTS: From January 1999 through December 2008, 90 patients satisfied all criteria. Median observation period was 57.5 months (range, 12.4-162.7 months), median time to onset of grade 2 or greater late toxicity except cataract was 39.2 months (range, 2.7-99.8 months), and 3 patients had toxicities that occurred more than 5 years after PBT. Grade 3 late toxicities occurred in 17 patients (19%), with 19 events, and grade 4 late toxicities in 6 patients (7%), with 6 events (encephalomyelitis infection 2, optic nerve disorder 4). CONCLUSIONS: In conclusion, the late toxicity profile of PBT in patients with malignancy involving the nasal cavity, para-nasal sinuses, or skull base malignancy was partly clarified. Because late toxicity can still occur at 5 years after treatment, long-term follow-up is necessary. More... »

PAGES

447-454

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-014-0737-8

DOI

http://dx.doi.org/10.1007/s10147-014-0737-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048001100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25135461


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasal Cavity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nose Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paranasal Sinus Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proton Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skull Base Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zenda", 
        "givenName": "Sadamoto", 
        "id": "sg:person.01001456272.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001456272.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawashima", 
        "givenName": "Mitsuhiko", 
        "id": "sg:person.01115704672.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115704672.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arahira", 
        "givenName": "Satoko", 
        "id": "sg:person.01336670536.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336670536.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohno", 
        "givenName": "Ryosuke", 
        "id": "sg:person.01200452236.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200452236.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishio", 
        "givenName": "Teiji", 
        "id": "sg:person.0705523136.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705523136.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Head and Neck Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tahara", 
        "givenName": "Makoto", 
        "id": "sg:person.01116615002.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116615002.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Ryuichi", 
        "id": "sg:person.01030202360.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030202360.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center Hospital East", 
          "id": "https://www.grid.ac/institutes/grid.497282.2", 
          "name": [
            "Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akimoto", 
        "givenName": "Tetsuo", 
        "id": "sg:person.0707321522.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707321522.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.07.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000634273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.50.11.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004107068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.04.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004885164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2003.09.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005498492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20011215)92:12<3012::aid-cncr10131>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011870614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70290-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012239121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024097299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(00)00594-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030469918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031676615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2011.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031703462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(63)90387-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031981117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.12.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035873636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(80)90175-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040231977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-7-85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044712145", 
          "https://doi.org/10.1186/1748-717x-7-85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2008.01.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051474358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(81)90443-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052412908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0031-1275636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057238249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/55/12/018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059028201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/55/12/018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059028201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1042-3680(18)30085-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074729399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.15.3547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074857568"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "BACKGROUND: Although several reports have shown that proton beam therapy (PBT) offers promise for patients with skull base cancer, little is known about the frequency of late toxicity in clinical practice when PBT is used for these patients. Here, we conducted a retrospective analysis to clarify the late toxicity profile of PBT in patients with malignancies of the nasal cavity, para-nasal sinuses, or involving the skull base.\nMETHODS: Entry to this retrospective study was restricted to patients with (1) malignant tumors of the nasal cavity, para-nasal sinuses, or involving the skull base; (2) definitive or postoperative PBT (>50 GyE) from January 1999 through December 2008; and (3) more than 1 year of follow-up. Late toxicities were graded according to the common terminology criteria for adverse events v4.0 (CTCAE v4.0).\nRESULTS: From January 1999 through December 2008, 90 patients satisfied all criteria. Median observation period was 57.5 months (range, 12.4-162.7 months), median time to onset of grade 2 or greater late toxicity except cataract was 39.2 months (range, 2.7-99.8 months), and 3 patients had toxicities that occurred more than 5 years after PBT. Grade 3 late toxicities occurred in 17 patients (19%), with 19 events, and grade 4 late toxicities in 6 patients (7%), with 6 events (encephalomyelitis infection 2, optic nerve disorder 4).\nCONCLUSIONS: In conclusion, the late toxicity profile of PBT in patients with malignancy involving the nasal cavity, para-nasal sinuses, or skull base malignancy was partly clarified. Because late toxicity can still occur at 5 years after treatment, long-term follow-up is necessary.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10147-014-0737-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1312225", 
        "issn": [
          "1341-9625", 
          "1437-7772"
        ], 
        "name": "International Journal of Clinical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy: importance of long-term follow-up", 
    "pagination": "447-454", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e4aaef37f7c6d476ae5330669fc5c01fad610dcd702b5a22287b7f5b1874362f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25135461"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9616295"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10147-014-0737-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048001100"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10147-014-0737-8", 
      "https://app.dimensions.ai/details/publication/pub.1048001100"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000491.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10147-014-0737-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-014-0737-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-014-0737-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-014-0737-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-014-0737-8'


 

This table displays all metadata directly associated to this object as RDF triples.

245 TRIPLES      21 PREDICATES      65 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10147-014-0737-8 schema:about N0cc4ce8fc6f647e49a37acff4f79400d
2 N39375729a6a14cab80447a474ff48de2
3 N3977d47fff0b4e5a984ef915664d20c6
4 N54ae69da48c5415780408706042044de
5 N5b42cdc0acad480fa4749ba96801c5fa
6 N6fb77afc0e834af68936f04579dd90d0
7 N8a3f2e77c32e49d19d0f12ab614d11fe
8 N9baa13d850d742a6b578f17d5474618a
9 Na062864cc5c04b428c40314a4cf4c7fb
10 Na6e97b01f15144afafd9b0927e9d3d7e
11 Nac6228556c9b484d968b06acbffd29e0
12 Nb3132c6784dc4ea7bbf358181d486ba1
13 Nc35e903826584dd8a4b0f58d8819e9bc
14 Nd5139bf8313146aa8c8ba68f278826b1
15 Ne7976b82635f4d5e9c4506b2bec5fc71
16 Nff72edf30bf941eb84154ef60d6f5906
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Ndffbd35f22a1471783a8d766870f54c1
20 schema:citation sg:pub.10.1186/1748-717x-7-85
21 https://doi.org/10.1002/1097-0142(20011215)92:12<3012::aid-cncr10131>3.0.co;2-e
22 https://doi.org/10.1016/0002-9610(63)90387-8
23 https://doi.org/10.1016/0360-3016(80)90175-3
24 https://doi.org/10.1016/0360-3016(81)90443-0
25 https://doi.org/10.1016/j.ijrobp.2003.09.101
26 https://doi.org/10.1016/j.ijrobp.2006.09.023
27 https://doi.org/10.1016/j.ijrobp.2006.12.071
28 https://doi.org/10.1016/j.ijrobp.2007.04.044
29 https://doi.org/10.1016/j.ijrobp.2008.01.038
30 https://doi.org/10.1016/j.ijrobp.2008.07.040
31 https://doi.org/10.1016/j.ijrobp.2010.08.009
32 https://doi.org/10.1016/j.radonc.2011.12.013
33 https://doi.org/10.1016/s0360-3016(00)00594-0
34 https://doi.org/10.1016/s1042-3680(18)30085-8
35 https://doi.org/10.1016/s1470-2045(10)70290-4
36 https://doi.org/10.1055/s-0031-1275636
37 https://doi.org/10.1088/0031-9155/55/12/018
38 https://doi.org/10.1136/jnnp.50.11.1407
39 https://doi.org/10.1200/jco.2001.19.15.3547
40 schema:datePublished 2015-06
41 schema:datePublishedReg 2015-06-01
42 schema:description BACKGROUND: Although several reports have shown that proton beam therapy (PBT) offers promise for patients with skull base cancer, little is known about the frequency of late toxicity in clinical practice when PBT is used for these patients. Here, we conducted a retrospective analysis to clarify the late toxicity profile of PBT in patients with malignancies of the nasal cavity, para-nasal sinuses, or involving the skull base. METHODS: Entry to this retrospective study was restricted to patients with (1) malignant tumors of the nasal cavity, para-nasal sinuses, or involving the skull base; (2) definitive or postoperative PBT (>50 GyE) from January 1999 through December 2008; and (3) more than 1 year of follow-up. Late toxicities were graded according to the common terminology criteria for adverse events v4.0 (CTCAE v4.0). RESULTS: From January 1999 through December 2008, 90 patients satisfied all criteria. Median observation period was 57.5 months (range, 12.4-162.7 months), median time to onset of grade 2 or greater late toxicity except cataract was 39.2 months (range, 2.7-99.8 months), and 3 patients had toxicities that occurred more than 5 years after PBT. Grade 3 late toxicities occurred in 17 patients (19%), with 19 events, and grade 4 late toxicities in 6 patients (7%), with 6 events (encephalomyelitis infection 2, optic nerve disorder 4). CONCLUSIONS: In conclusion, the late toxicity profile of PBT in patients with malignancy involving the nasal cavity, para-nasal sinuses, or skull base malignancy was partly clarified. Because late toxicity can still occur at 5 years after treatment, long-term follow-up is necessary.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N96483e3f1ca64733b0dbb216e5642f06
47 Nff95b9060a9940a5b50bcf3da0d841b5
48 sg:journal.1312225
49 schema:name Late toxicity of proton beam therapy for patients with the nasal cavity, para-nasal sinuses, or involving the skull base malignancy: importance of long-term follow-up
50 schema:pagination 447-454
51 schema:productId N27ae6172797344609279b9a595c1481b
52 N368eb43002334ce7a042925c7a71ef2f
53 Na230c14e1a1f45568c3d3c52d0107f18
54 Nc2156f634a4544d6adfee6d3f7e76246
55 Nc46e0ba9c9894a0e85a3812ae2769184
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048001100
57 https://doi.org/10.1007/s10147-014-0737-8
58 schema:sdDatePublished 2019-04-10T20:42
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N0b9b161982e445aaafb085711e3c24e8
61 schema:url http://link.springer.com/10.1007/s10147-014-0737-8
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N08ed74e7980d47b8bee873554ce6e0e3 rdf:first sg:person.0705523136.42
66 rdf:rest Nb34284a367d24cdfa7a1b3c57d2f303a
67 N0b9b161982e445aaafb085711e3c24e8 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N0cc4ce8fc6f647e49a37acff4f79400d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Nasal Cavity
71 rdf:type schema:DefinedTerm
72 N27ae6172797344609279b9a595c1481b schema:name readcube_id
73 schema:value e4aaef37f7c6d476ae5330669fc5c01fad610dcd702b5a22287b7f5b1874362f
74 rdf:type schema:PropertyValue
75 N2a2bb140d72c442aa51f9445e0a42267 rdf:first sg:person.01030202360.97
76 rdf:rest N6d190666b6e04f828bb068afc62e29a6
77 N368eb43002334ce7a042925c7a71ef2f schema:name doi
78 schema:value 10.1007/s10147-014-0737-8
79 rdf:type schema:PropertyValue
80 N39375729a6a14cab80447a474ff48de2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Proton Therapy
82 rdf:type schema:DefinedTerm
83 N3977d47fff0b4e5a984ef915664d20c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Follow-Up Studies
85 rdf:type schema:DefinedTerm
86 N3dd3eee1adbc4fb1bcb8e58668ef8737 rdf:first sg:person.01115704672.51
87 rdf:rest N53860606baed45a0b71df1f7b5adf6ea
88 N53860606baed45a0b71df1f7b5adf6ea rdf:first sg:person.01336670536.27
89 rdf:rest Nad9e8373022f4f948d2f591232ce4a1b
90 N54ae69da48c5415780408706042044de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Nose Neoplasms
92 rdf:type schema:DefinedTerm
93 N5b42cdc0acad480fa4749ba96801c5fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Paranasal Sinus Neoplasms
95 rdf:type schema:DefinedTerm
96 N6d190666b6e04f828bb068afc62e29a6 rdf:first sg:person.0707321522.51
97 rdf:rest rdf:nil
98 N6fb77afc0e834af68936f04579dd90d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Adult
100 rdf:type schema:DefinedTerm
101 N8a3f2e77c32e49d19d0f12ab614d11fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Aged, 80 and over
103 rdf:type schema:DefinedTerm
104 N96483e3f1ca64733b0dbb216e5642f06 schema:issueNumber 3
105 rdf:type schema:PublicationIssue
106 N9baa13d850d742a6b578f17d5474618a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Aged
108 rdf:type schema:DefinedTerm
109 Na062864cc5c04b428c40314a4cf4c7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Humans
111 rdf:type schema:DefinedTerm
112 Na230c14e1a1f45568c3d3c52d0107f18 schema:name dimensions_id
113 schema:value pub.1048001100
114 rdf:type schema:PropertyValue
115 Na6e97b01f15144afafd9b0927e9d3d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Retrospective Studies
117 rdf:type schema:DefinedTerm
118 Nac6228556c9b484d968b06acbffd29e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 Nad9e8373022f4f948d2f591232ce4a1b rdf:first sg:person.01200452236.21
122 rdf:rest N08ed74e7980d47b8bee873554ce6e0e3
123 Nb3132c6784dc4ea7bbf358181d486ba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Middle Aged
125 rdf:type schema:DefinedTerm
126 Nb34284a367d24cdfa7a1b3c57d2f303a rdf:first sg:person.01116615002.44
127 rdf:rest N2a2bb140d72c442aa51f9445e0a42267
128 Nc2156f634a4544d6adfee6d3f7e76246 schema:name pubmed_id
129 schema:value 25135461
130 rdf:type schema:PropertyValue
131 Nc35e903826584dd8a4b0f58d8819e9bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Young Adult
133 rdf:type schema:DefinedTerm
134 Nc46e0ba9c9894a0e85a3812ae2769184 schema:name nlm_unique_id
135 schema:value 9616295
136 rdf:type schema:PropertyValue
137 Nd5139bf8313146aa8c8ba68f278826b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Adolescent
139 rdf:type schema:DefinedTerm
140 Ndffbd35f22a1471783a8d766870f54c1 rdf:first sg:person.01001456272.05
141 rdf:rest N3dd3eee1adbc4fb1bcb8e58668ef8737
142 Ne7976b82635f4d5e9c4506b2bec5fc71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 Nff72edf30bf941eb84154ef60d6f5906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Skull Base Neoplasms
147 rdf:type schema:DefinedTerm
148 Nff95b9060a9940a5b50bcf3da0d841b5 schema:volumeNumber 20
149 rdf:type schema:PublicationVolume
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
154 schema:name Clinical Sciences
155 rdf:type schema:DefinedTerm
156 sg:journal.1312225 schema:issn 1341-9625
157 1437-7772
158 schema:name International Journal of Clinical Oncology
159 rdf:type schema:Periodical
160 sg:person.01001456272.05 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
161 schema:familyName Zenda
162 schema:givenName Sadamoto
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001456272.05
164 rdf:type schema:Person
165 sg:person.01030202360.97 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
166 schema:familyName Hayashi
167 schema:givenName Ryuichi
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030202360.97
169 rdf:type schema:Person
170 sg:person.01115704672.51 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
171 schema:familyName Kawashima
172 schema:givenName Mitsuhiko
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115704672.51
174 rdf:type schema:Person
175 sg:person.01116615002.44 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
176 schema:familyName Tahara
177 schema:givenName Makoto
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116615002.44
179 rdf:type schema:Person
180 sg:person.01200452236.21 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
181 schema:familyName Kohno
182 schema:givenName Ryosuke
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200452236.21
184 rdf:type schema:Person
185 sg:person.01336670536.27 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
186 schema:familyName Arahira
187 schema:givenName Satoko
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336670536.27
189 rdf:type schema:Person
190 sg:person.0705523136.42 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
191 schema:familyName Nishio
192 schema:givenName Teiji
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705523136.42
194 rdf:type schema:Person
195 sg:person.0707321522.51 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
196 schema:familyName Akimoto
197 schema:givenName Tetsuo
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707321522.51
199 rdf:type schema:Person
200 sg:pub.10.1186/1748-717x-7-85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044712145
201 https://doi.org/10.1186/1748-717x-7-85
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/1097-0142(20011215)92:12<3012::aid-cncr10131>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1011870614
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/0002-9610(63)90387-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031981117
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0360-3016(80)90175-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040231977
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0360-3016(81)90443-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052412908
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.ijrobp.2003.09.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005498492
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.ijrobp.2006.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031676615
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.ijrobp.2006.12.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035873636
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.ijrobp.2007.04.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004885164
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ijrobp.2008.01.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051474358
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ijrobp.2008.07.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000634273
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.ijrobp.2010.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024097299
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.radonc.2011.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031703462
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0360-3016(00)00594-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030469918
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s1042-3680(18)30085-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074729399
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1470-2045(10)70290-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012239121
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1055/s-0031-1275636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057238249
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1088/0031-9155/55/12/018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059028201
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1136/jnnp.50.11.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004107068
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1200/jco.2001.19.15.3547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074857568
240 rdf:type schema:CreativeWork
241 https://www.grid.ac/institutes/grid.497282.2 schema:alternateName National Cancer Center Hospital East
242 schema:name Division of Head and Neck Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan
243 Division of Head and Neck Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan
244 Division of Radiation Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan
245 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...