Development of hypertension within 2 weeks of initiation of sorafenib for advanced hepatocellular carcinoma is a predictor of efficacy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04-18

AUTHORS

Noriyuki Akutsu, Shigeru Sasaki, Hideyasu Takagi, Masayo Motoya, Masahiro Shitani, Mai Igarashi, Daisuke Hirayama, Hideki Wakasugi, Hiroyuki Yamamoto, Hiroyuki Kaneto, Kazuhiko Yonezawa, Atsushi Yawata, Takeya Adachi, Yasuo Hamamoto, Yasuhisa Shinomura

ABSTRACT

BackgroundSorafenib is an agent that inhibits vascular endothelial growth factor and is associated with onset or worsening of hypertension in some patients. We conducted a retrospective analysis of whether the development of hypertension during sorafenib treatment of advanced hepatocellular carcinoma could be a predictor of anti-cancer efficacy.MethodsThe study included 38 patients with advanced hepatocellular carcinoma who had received sorafenib for at least 1 month between January 2010 and December 2012. A retrospective analysis of the efficacy of sorafenib was conducted by dividing the patients into two groups—a hypertension group, presenting with grade 2 or higher hypertension according to the Common Terminology Criteria for Adverse Events (CTCTE) version 4.0; and a non-hypertension group, which included all other patients. This study evaluated the occurrence of hypertension within 2 weeks of initiation of therapy in order to avoid any treatment duration bias. Images were evaluated using the modified Response Evaluation Criteria in Solid Tumors. The response rate, time to progression, and overall survival were assessed.ResultsTwenty-two patients (58 %) developed grade 2 or higher hypertension within 2 weeks of initiation of therapy. The response rate was significantly higher in the hypertension group. Median time to progression was 153 days in the hypertension group versus 50.5 days in the non-hypertension group, which was significantly longer in the hypertension group. Moreover, median overall survival was 1,329 days in the hypertension group versus 302 days in the non-hypertension group, which was significantly longer in the hypertension group.ConclusionsHypertension within 2 weeks of initiation of therapy may be a predictor of the anti-cancer efficacy of sorafenib when used for the treatment of advanced hepatocellular carcinoma. More... »

PAGES

105-110

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-014-0691-5

DOI

http://dx.doi.org/10.1007/s10147-014-0691-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051226834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24744262


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26 schema:description BackgroundSorafenib is an agent that inhibits vascular endothelial growth factor and is associated with onset or worsening of hypertension in some patients. We conducted a retrospective analysis of whether the development of hypertension during sorafenib treatment of advanced hepatocellular carcinoma could be a predictor of anti-cancer efficacy.MethodsThe study included 38 patients with advanced hepatocellular carcinoma who had received sorafenib for at least 1 month between January 2010 and December 2012. A retrospective analysis of the efficacy of sorafenib was conducted by dividing the patients into two groups—a hypertension group, presenting with grade 2 or higher hypertension according to the Common Terminology Criteria for Adverse Events (CTCTE) version 4.0; and a non-hypertension group, which included all other patients. This study evaluated the occurrence of hypertension within 2 weeks of initiation of therapy in order to avoid any treatment duration bias. Images were evaluated using the modified Response Evaluation Criteria in Solid Tumors. The response rate, time to progression, and overall survival were assessed.ResultsTwenty-two patients (58 %) developed grade 2 or higher hypertension within 2 weeks of initiation of therapy. The response rate was significantly higher in the hypertension group. Median time to progression was 153 days in the hypertension group versus 50.5 days in the non-hypertension group, which was significantly longer in the hypertension group. Moreover, median overall survival was 1,329 days in the hypertension group versus 302 days in the non-hypertension group, which was significantly longer in the hypertension group.ConclusionsHypertension within 2 weeks of initiation of therapy may be a predictor of the anti-cancer efficacy of sorafenib when used for the treatment of advanced hepatocellular carcinoma.
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33 BackgroundSorafenib
34 Common Terminology Criteria
35 ConclusionsHypertension
36 MethodsThe study
37 Response Evaluation Criteria
38 ResultsTwenty-two patients
39 Terminology Criteria
40 advanced hepatocellular carcinoma
41 agents
42 analysis
43 anti-cancer efficacy
44 bias
45 carcinoma
46 criteria
47 days
48 development
49 development of hypertension
50 duration bias
51 efficacy
52 efficacy of sorafenib
53 endothelial growth factor
54 evaluation criteria
55 factors
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57 group
58 growth factor
59 hepatocellular carcinoma
60 higher hypertension
61 hypertension
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63 images
64 initiation
65 median overall survival
66 median time
67 months
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69 occurrence
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71 onset
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74 patients
75 predictors
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