Multicenter phase II study of modified FOLFOX6 as neoadjuvant chemotherapy for patients with unresectable liver-only metastases from colorectal cancer in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04

AUTHORS

Takao Takahashi, Yoshihisa Shibata, Yuichiro Tojima, Kenji Tsuboi, Eiji Sakamoto, Katsuyuki Kunieda, Hiroshi Matsuoka, Kazuyoshi Suzumura, Mikinori Sato, Tatsushi Naganuma, Junichi Sakamoto, Satoshi Morita, Ken Kondo

ABSTRACT

BACKGROUND: Neoadjuvant chemotherapy for unresectable colorectal liver metastases can reduce tumor size, which sometimes leads to curative resection. The aim of the present study was to identify and describe patients with initially unresectable liver-only metastases from colorectal cancer who obtained sufficient chemotherapeutic benefit that eventually lead to the removal of the metastatic diseases in the liver. METHODS: A phase II multicenter cooperative study was conducted in 38 medical institutions using modified FOLFOX6 (mFOLFOX6) as neoadjuvant chemotherapy from January 2008 to June 2009. Patients with liver-only metastases from colorectal cancer that was deemed not optimally resectable by liver surgeons received mFOLFOX6 as preoperative neoadjuvant chemotherapy for 6-8 cycles. Patients were reassessed for resectability after 6 cycles of mFOLFOX6. Surgery was carried out 3-6 weeks after chemotherapy. The primary endpoint was the rate of macroscopic curative surgery including liver resection. RESULTS: 36 patients (23 male/13 female, ECOG performance status 0-1) were enrolled. The median age of the patients was 62.5 years; 78% (28 patients) had 5 or more metastatic tumors, and 50% (18 patients) had metastatic tumors over 5 cm diameter. The mFOLFOX6 regimen was safety administered resulting in 18 partial responses (50%), 12 stable disease, and 4 progressive disease. There was no grade 3/4 neurotoxicity. Fourteen patients (38.9%) underwent surgery (R0: 13; R1: 1). Of these, thirteen patients (36.1%) underwent R0 surgery. CONCLUSIONS: Our data suggest that mFOLFOX6 has a high response rate in patients with liver-only metastases from colorectal cancer, allowing for R0 resection of liver metastases in a proportion of patients initially not judged to be optimally resectable. More... »

PAGES

335-342

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-012-0382-z

DOI

http://dx.doi.org/10.1007/s10147-012-0382-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007423928

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22383023


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10147-012-0382-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10147-012-0382-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10147-012-0382-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10147-012-0382-z'


 

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318 https://www.grid.ac/institutes/grid.415536.0 schema:alternateName Gifu Prefectural General Medical Center
319 schema:name Department of Surgery, Gifu Prefectural General Medical Center, Gifu, Japan
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.417192.8 schema:alternateName Tosei General Hospital
322 schema:name Department of Surgery, Tosei General Hospital, Seto, Japan
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.417241.5 schema:alternateName Toyohashi Municipal Hospital
325 schema:name Department of Surgery, Toyohashi Municipal Hospital, Toyohashi, Japan
326 rdf:type schema:Organization
 




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