Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12-21

AUTHORS

Tomoko Seya, Noritake Tanaka, Kimiyoshi Yokoi, Noriyuki Ishikawa, Koji Horiba, Yoshikazu Kanazawa, Takeshi Yamada, Michihiro Koizumi, Seiichi Shinji, Hirotake Okazaki, Yoshiharu Ohaki, Toshiyuki Ishiwata, Zenya Naito, Takashi Tajiri

ABSTRACT

Here we report the case of a patient with advanced gastric cancer with esophageal invasion who was treated with chemotherapy using S-1 and cisplatin (CDDP) preoperatively. The patient was a 72-year-old woman who was diagnosed with advanced gastric cancer (T3N2M0) with esophageal invasion. S-1 was orally administered at 80 mg/day (60 mg/m2 per day) on days 1–14 and CDDP was infused at 80 mg/day (60 mg/m2 per day) on day 8, followed by a 1-week rest. Marked reductions in the sizes of the primary tumor and metastatic lymph nodes around the stomach were observed after two cycles of the therapy. Adverse reactions occurring during the therapy were only grade 2 gastrointestinal disorder and grade 1 leukocytopenia. Radiological and endoscopic examinations before surgery showed that a partial response (PR) had been achieved. The patient underwent curative surgery consisting of total gastrectomy, D2 lymph node dissection, and splenectomy. Her postoperative course was uneventful, without surgical complications. No gastric cancer cells were detected in the primary lesion or lymph nodes by immunohistochemical staining with cytokeratin, confirming a histological complete response (CR). As Epstein-Barr virus-encoded small RNA (EBER) had been detected by in-situ hybridization in the gastric cancer cells of a biopsy specimen, this tumor was diagnosed as an Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC), which was effectively treated with S-1 and cisplatin chemotherapy. More... »

PAGES

472-477

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10147-007-0682-x

DOI

http://dx.doi.org/10.1007/s10147-007-0682-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009288096

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18071868


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26 schema:description Here we report the case of a patient with advanced gastric cancer with esophageal invasion who was treated with chemotherapy using S-1 and cisplatin (CDDP) preoperatively. The patient was a 72-year-old woman who was diagnosed with advanced gastric cancer (T3N2M0) with esophageal invasion. S-1 was orally administered at 80 mg/day (60 mg/m2 per day) on days 1–14 and CDDP was infused at 80 mg/day (60 mg/m2 per day) on day 8, followed by a 1-week rest. Marked reductions in the sizes of the primary tumor and metastatic lymph nodes around the stomach were observed after two cycles of the therapy. Adverse reactions occurring during the therapy were only grade 2 gastrointestinal disorder and grade 1 leukocytopenia. Radiological and endoscopic examinations before surgery showed that a partial response (PR) had been achieved. The patient underwent curative surgery consisting of total gastrectomy, D2 lymph node dissection, and splenectomy. Her postoperative course was uneventful, without surgical complications. No gastric cancer cells were detected in the primary lesion or lymph nodes by immunohistochemical staining with cytokeratin, confirming a histological complete response (CR). As Epstein-Barr virus-encoded small RNA (EBER) had been detected by in-situ hybridization in the gastric cancer cells of a biopsy specimen, this tumor was diagnosed as an Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC), which was effectively treated with S-1 and cisplatin chemotherapy.
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33 D2 lymph node dissection
34 Epstein-Barr virus
35 Epstein-Barr virus infection
36 Epstein-Barr virus-encoded small RNA
37 RNA
38 advanced gastric cancer
39 adverse reactions
40 biopsy specimen
41 cancer
42 cancer cells
43 carcinoma
44 cases
45 cells
46 chemotherapy
47 cisplatin
48 cisplatin chemotherapy
49 complete response
50 complications
51 course
52 curative surgery
53 cycle
54 cytokeratin
55 day 1
56 day 8
57 days
58 disorders
59 dissection
60 endoscopic examination
61 esophageal invasion
62 examination
63 gastrectomy
64 gastric cancer
65 gastric cancer cells
66 gastric carcinoma
67 gastrointestinal disorders
68 histological complete response
69 hybridization
70 immunohistochemical staining
71 infection
72 invasion
73 lesions
74 leukocytopenia
75 lymph node dissection
76 lymph nodes
77 marked reduction
78 metastatic lymph nodes
79 node dissection
80 nodes
81 partial response
82 patients
83 postoperative course
84 preoperative chemotherapy
85 primary lesion
86 primary tumor
87 reaction
88 reduction
89 response
90 rest
91 situ hybridization
92 size
93 small RNAs
94 specimen
95 splenectomy
96 staining
97 stomach
98 surgery
99 surgical complications
100 therapy
101 total gastrectomy
102 tumors
103 virus
104 virus infection
105 women
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