Some speculation on the origin of glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11-23

AUTHORS

Matthew R. Quigley, Christopher Post, Garth Ehrlich

ABSTRACT

Glioblastoma, the most common primary brain tumor, is also the most deadly, with median survival of about one year, which is little improved over the last five decades. Its pathogenesis is a vexing problem. Despite extensive basic and clinical scientific research, little is known regarding the cause of this disease, the genetic factors which drive its course, or any strategies which may result in effective treatment. This persistent resistance to understanding suggests to the authors that some of the fundamental assumptions regarding the disease are likely to be flawed, and that a new paradigm must be sought to replace them. This manuscript is a review of some of what is known regarding this disease, and then presents a series of hypotheses which compromise an alternative view of glioblastoma. More... »

PAGES

16-21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10143-006-0048-2

DOI

http://dx.doi.org/10.1007/s10143-006-0048-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018371285

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17123059


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogenes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "420 East North Avenue, Suite 302, 15212, Pittsburgh, PA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA", 
            "420 East North Avenue, Suite 302, 15212, Pittsburgh, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quigley", 
        "givenName": "Matthew R.", 
        "id": "sg:person.015542117302.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015542117302.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.413621.3", 
          "name": [
            "Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Post", 
        "givenName": "Christopher", 
        "id": "sg:person.01016372216.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016372216.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.413621.3", 
          "name": [
            "Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehrlich", 
        "givenName": "Garth", 
        "id": "sg:person.01324252605.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324252605.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1208311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006779418", 
          "https://doi.org/10.1038/sj.onc.1208311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0597-64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006875378", 
          "https://doi.org/10.1038/ng0597-64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01324606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025900919", 
          "https://doi.org/10.1007/bf01324606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006435201961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003407535", 
          "https://doi.org/10.1023/a:1006435201961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-004-0592-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000976130", 
          "https://doi.org/10.1007/s00432-004-0592-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01052928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000308976", 
          "https://doi.org/10.1007/bf01052928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017041687", 
          "https://doi.org/10.1054/bjoc.2000.1612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02571297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043517741", 
          "https://doi.org/10.1007/bf02571297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/351453a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052393971", 
          "https://doi.org/10.1038/351453a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-11-23", 
    "datePublishedReg": "2006-11-23", 
    "description": "Glioblastoma, the most common primary brain tumor, is also the most deadly, with median survival of about one year, which is little improved over the last five decades. Its pathogenesis is a vexing problem. Despite extensive basic and clinical scientific research, little is known regarding the cause of this disease, the genetic factors which drive its course, or any strategies which may result in effective treatment. This persistent resistance to understanding suggests to the authors that some of the fundamental assumptions regarding the disease are likely to be flawed, and that a new paradigm must be sought to replace them. This manuscript is a review of some of what is known regarding this disease, and then presents a series of hypotheses which compromise an alternative view of glioblastoma.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10143-006-0048-2", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1090096", 
        "issn": [
          "0344-5607", 
          "1437-2320"
        ], 
        "name": "Neurosurgical Review", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "keywords": [
      "common primary brain tumor", 
      "origin of glioblastoma", 
      "primary brain tumors", 
      "median survival", 
      "clinical scientific research", 
      "effective treatment", 
      "brain tumors", 
      "disease", 
      "genetic factors", 
      "glioblastoma", 
      "pathogenesis", 
      "tumors", 
      "vexing problem", 
      "survival", 
      "persistent resistance", 
      "treatment", 
      "cause", 
      "review", 
      "years", 
      "course", 
      "factors", 
      "resistance", 
      "hypothesis", 
      "strategies", 
      "manuscript", 
      "decades", 
      "origin", 
      "series", 
      "authors", 
      "new paradigm", 
      "understanding", 
      "research", 
      "paradigm", 
      "speculation", 
      "scientific research", 
      "view", 
      "problem", 
      "series of hypotheses", 
      "alternative view", 
      "assumption", 
      "fundamental assumptions"
    ], 
    "name": "Some speculation on the origin of glioblastoma", 
    "pagination": "16-21", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018371285"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10143-006-0048-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17123059"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10143-006-0048-2", 
      "https://app.dimensions.ai/details/publication/pub.1018371285"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_413.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10143-006-0048-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10143-006-0048-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10143-006-0048-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10143-006-0048-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10143-006-0048-2'


 

This table displays all metadata directly associated to this object as RDF triples.

172 TRIPLES      21 PREDICATES      79 URIs      62 LITERALS      11 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10143-006-0048-2 schema:about N53411af00e95480792fd8dfbbdbe1200
2 N89001d42426241ad9d04e279fefaca94
3 N891152c54d284e06be6c4677d24d08f4
4 N8cceab4aaccf43d29ee26b95b91d70e9
5 anzsrc-for:11
6 anzsrc-for:1108
7 schema:author N08c791e6fab54aa9959cbeb5f24b1de9
8 schema:citation sg:pub.10.1007/bf01052928
9 sg:pub.10.1007/bf01324606
10 sg:pub.10.1007/bf02571297
11 sg:pub.10.1007/s00432-004-0592-5
12 sg:pub.10.1023/a:1006435201961
13 sg:pub.10.1038/351453a0
14 sg:pub.10.1038/ng0597-64
15 sg:pub.10.1038/sj.onc.1208311
16 sg:pub.10.1054/bjoc.2000.1612
17 schema:datePublished 2006-11-23
18 schema:datePublishedReg 2006-11-23
19 schema:description Glioblastoma, the most common primary brain tumor, is also the most deadly, with median survival of about one year, which is little improved over the last five decades. Its pathogenesis is a vexing problem. Despite extensive basic and clinical scientific research, little is known regarding the cause of this disease, the genetic factors which drive its course, or any strategies which may result in effective treatment. This persistent resistance to understanding suggests to the authors that some of the fundamental assumptions regarding the disease are likely to be flawed, and that a new paradigm must be sought to replace them. This manuscript is a review of some of what is known regarding this disease, and then presents a series of hypotheses which compromise an alternative view of glioblastoma.
20 schema:genre article
21 schema:isAccessibleForFree false
22 schema:isPartOf Na37fe2f7ca5a403b985d137592eed1ab
23 Nb25dac320d1d46889c0526a363c2850f
24 sg:journal.1090096
25 schema:keywords alternative view
26 assumption
27 authors
28 brain tumors
29 cause
30 clinical scientific research
31 common primary brain tumor
32 course
33 decades
34 disease
35 effective treatment
36 factors
37 fundamental assumptions
38 genetic factors
39 glioblastoma
40 hypothesis
41 manuscript
42 median survival
43 new paradigm
44 origin
45 origin of glioblastoma
46 paradigm
47 pathogenesis
48 persistent resistance
49 primary brain tumors
50 problem
51 research
52 resistance
53 review
54 scientific research
55 series
56 series of hypotheses
57 speculation
58 strategies
59 survival
60 treatment
61 tumors
62 understanding
63 vexing problem
64 view
65 years
66 schema:name Some speculation on the origin of glioblastoma
67 schema:pagination 16-21
68 schema:productId N0f17e466d94449f4aded175ca701e9e4
69 N5d6720ae5e0341a1b9fefdd9b2d328a1
70 Ncd96a53a92e940eebeab15b31fd2ddce
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018371285
72 https://doi.org/10.1007/s10143-006-0048-2
73 schema:sdDatePublished 2022-08-04T16:55
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N35f5b6093f184b08b457b279fae6a3e7
76 schema:url https://doi.org/10.1007/s10143-006-0048-2
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N08c791e6fab54aa9959cbeb5f24b1de9 rdf:first sg:person.015542117302.21
81 rdf:rest N3aa01530f9914f3b94501e40041675bf
82 N0f17e466d94449f4aded175ca701e9e4 schema:name dimensions_id
83 schema:value pub.1018371285
84 rdf:type schema:PropertyValue
85 N35f5b6093f184b08b457b279fae6a3e7 schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N3aa01530f9914f3b94501e40041675bf rdf:first sg:person.01016372216.81
88 rdf:rest N93fe2112acfe4a61972aa0052e211e6c
89 N53411af00e95480792fd8dfbbdbe1200 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Brain Neoplasms
91 rdf:type schema:DefinedTerm
92 N5d6720ae5e0341a1b9fefdd9b2d328a1 schema:name doi
93 schema:value 10.1007/s10143-006-0048-2
94 rdf:type schema:PropertyValue
95 N89001d42426241ad9d04e279fefaca94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Glioblastoma
97 rdf:type schema:DefinedTerm
98 N891152c54d284e06be6c4677d24d08f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Oncogenes
100 rdf:type schema:DefinedTerm
101 N8cceab4aaccf43d29ee26b95b91d70e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N93fe2112acfe4a61972aa0052e211e6c rdf:first sg:person.01324252605.57
105 rdf:rest rdf:nil
106 Na37fe2f7ca5a403b985d137592eed1ab schema:issueNumber 1
107 rdf:type schema:PublicationIssue
108 Nb25dac320d1d46889c0526a363c2850f schema:volumeNumber 30
109 rdf:type schema:PublicationVolume
110 Ncd96a53a92e940eebeab15b31fd2ddce schema:name pubmed_id
111 schema:value 17123059
112 rdf:type schema:PropertyValue
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical Microbiology
118 rdf:type schema:DefinedTerm
119 sg:journal.1090096 schema:issn 0344-5607
120 1437-2320
121 schema:name Neurosurgical Review
122 schema:publisher Springer Nature
123 rdf:type schema:Periodical
124 sg:person.01016372216.81 schema:affiliation grid-institutes:grid.413621.3
125 schema:familyName Post
126 schema:givenName Christopher
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016372216.81
128 rdf:type schema:Person
129 sg:person.01324252605.57 schema:affiliation grid-institutes:grid.413621.3
130 schema:familyName Ehrlich
131 schema:givenName Garth
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324252605.57
133 rdf:type schema:Person
134 sg:person.015542117302.21 schema:affiliation grid-institutes:None
135 schema:familyName Quigley
136 schema:givenName Matthew R.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015542117302.21
138 rdf:type schema:Person
139 sg:pub.10.1007/bf01052928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000308976
140 https://doi.org/10.1007/bf01052928
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/bf01324606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025900919
143 https://doi.org/10.1007/bf01324606
144 rdf:type schema:CreativeWork
145 sg:pub.10.1007/bf02571297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043517741
146 https://doi.org/10.1007/bf02571297
147 rdf:type schema:CreativeWork
148 sg:pub.10.1007/s00432-004-0592-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000976130
149 https://doi.org/10.1007/s00432-004-0592-5
150 rdf:type schema:CreativeWork
151 sg:pub.10.1023/a:1006435201961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003407535
152 https://doi.org/10.1023/a:1006435201961
153 rdf:type schema:CreativeWork
154 sg:pub.10.1038/351453a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052393971
155 https://doi.org/10.1038/351453a0
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/ng0597-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006875378
158 https://doi.org/10.1038/ng0597-64
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/sj.onc.1208311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006779418
161 https://doi.org/10.1038/sj.onc.1208311
162 rdf:type schema:CreativeWork
163 sg:pub.10.1054/bjoc.2000.1612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017041687
164 https://doi.org/10.1054/bjoc.2000.1612
165 rdf:type schema:CreativeWork
166 grid-institutes:None schema:alternateName 420 East North Avenue, Suite 302, 15212, Pittsburgh, PA, USA
167 schema:name 420 East North Avenue, Suite 302, 15212, Pittsburgh, PA, USA
168 Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA
169 rdf:type schema:Organization
170 grid-institutes:grid.413621.3 schema:alternateName Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA
171 schema:name Division of Neuro-Oncology, Department of Neurosurgery and Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA, USA
172 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...