ANGPTL4 regulates the osteogenic differentiation of periodontal ligament stem cells View Full Text


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Article Info

DATE

2022-07-13

AUTHORS

Lingli Xu, Chengze Wang, Yongzheng Li, Ying Wang, Baiping Fu, Guoli Yang

ABSTRACT

The molecular mechanism of mechanical force regulating the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) has not been clearly elucidated. In this study, two mRNA-seqs, GSE106887 and GSE109167, which contained several samples of PDLSCs under mechanical force, were downloaded from Gene Expression Omnibus. Differential expression analysis was firstly taken between GSE106887 and GSE109167, then the common 84 up-regulated genes and 26 down-regulated genes were selected. Function enrichment analysis was used to identify the key genes and pathways in PDLSCs subjected to the tension and compression force. PDLSCs were isolated from human periodontal ligament tissues. The effects of ANGPTL4 knockdown with shRNA on the osteogenic differentiation of PDLSCs were studied in vitro. Then, the orthodontic tooth movement (OTM) rat model was used to study the expression of HIF-1α and ANGPTL4 in alveolar bone remodeling in vivo. ANGPTL4 and the HIF-1 pathway were identified in PDLSCs subjected to the tension and compression force. alizarin red staining, alcian blue staining, and oil red O staining verified that PDLSCs had the ability of osteogenic, chondrogenic, and adipogenic differentiation, respectively. Verification experiment revealed that the expression of ANGPTL4 in PDLSCs significantly increased when cultured under osteogenic medium in vitro. While ANGPTL4 was knocked down by shRNA, the levels of ALPL, RUNX2, and OCN decreased significantly, as well as the protein levels of COL1A1, ALPL, RUNX2, and OCN. During the OTM, the expression of HIF-1α and ANGPTL4 in periodontal ligament cells increased on the tension and compression sides. We concluded the positive relationship between ANGPTL4 and osteogenic differentiation of PDLSCs. More... »

PAGES

1-13

References to SciGraph publications

  • 2013-11-06. Cellular response to orthodontically-induced short-term hypoxia in dental pulp cells in CELL AND TISSUE RESEARCH
  • 2010-11-13. CD10-bearing fibroblasts may inhibit skin inflammation by down-modulating substance P in ARCHIVES OF DERMATOLOGICAL RESEARCH
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  • 2017-06-24. CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ in JOURNAL OF MOLECULAR HISTOLOGY
  • 2017-12-02. Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation in BMC GENOMIC DATA
  • 2019-03. Hypoxia Induces Hypoxia-Inducible Factor 1α and Potential HIF-Responsive Gene Expression in Uterine Leiomyoma in REPRODUCTIVE SCIENCES
  • 2011-04-20. Hypoxia inducible factor-1α directly induces the expression of receptor activator of nuclear factor-κB ligand in periodontal ligament fibroblasts in MOLECULES AND CELLS
  • 2019-10-07. Intermittent compressive force promotes osteogenic differentiation in human periodontal ligament cells by regulating the transforming growth factor-β pathway in CELL DEATH & DISEASE
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2020-09-15. EZH2 reduction is an essential mechanoresponse for the maintenance of super-enhancer polarization against compressive stress in human periodontal ligament stem cells in CELL DEATH & DISEASE
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