Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the ... View Full Text


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Article Info

DATE

2022-05-16

AUTHORS

Shamshad Ul Hassan, Eng Guan Chua, Parwinder Kaur, Erwin A. Paz, Chin Yen Tay, Johan C. Greeff, Shimin Liu, Graeme B. Martin

ABSTRACT

Gastrointestinal helminths are a global health issue, for humans as well as domestic animals. Most studies focus on the tissues that are infected with the parasite, but here we studied the ileum, a tissue that is rarely infected by helminths. We tested whether inflammation in the ileum contributes to the development and severity of diarrhoea, by comparing sheep that are susceptible (n = 4) or resistant (n = 4) to the disease. We analyzed the ileum transcriptome using RNASeq sequencing approach and various bioinformatics tools including FastQC, STAR, featureCounts, DESeq2, DAVID, clusterProfiler, Cytoscape (ClusterONE) and EnrichR. We identified 243 differentially expressed genes (DEGs), of which 118 were up-regulated and 125 were down-regulated DEGs in the diarrhoea-susceptible animals compared to the diarrhoea-resistant animals. The resulting DEGs were functionally enriched for biological processes, pathways and gene set enrichment analysis. The up-regulated DEGs suggested that an inflammatory immune response was coupled with genes involved in ‘Th2 immune response’ and ‘anti-inflammatory response’. The down-regulated DEGs were related to ion transport, muscle contraction and pathways preventing inflammation. We conclude that i) susceptibility to helminth-induced diarrhoea involves an inflammatory response at a non-infectious site; ii) down-regulation of pathways preventing inflammation can contribute to the severity of diarrhoea; and iii) genes involved in anti-inflammatory responses can reduce the inflammation and diarrhoea. More... »

PAGES

1-13

References to SciGraph publications

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  • 2012-11-16. Eosinophils: changing perspectives in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2008-12-18. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2020-01-03. Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects in SIGNAL TRANSDUCTION AND TARGETED THERAPY
  • 2015-07-21. Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes in NATURE COMMUNICATIONS
  • 2020-02-26. Pathway paradigms revealed from the genetics of inflammatory bowel disease in NATURE
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  • 2014-04-09. Local cytokine transcription in naïve and previously infected sheep and lambs following challenge with Teladorsagia circumcincta in BMC VETERINARY RESEARCH
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    URI

    http://scigraph.springernature.com/pub.10.1007/s10142-022-00864-6

    DOI

    http://dx.doi.org/10.1007/s10142-022-00864-6

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35576023


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