Comparative Genomic and Transcriptomic Analyses Revealed Twenty-Six Candidate Genes Involved in the Air-Breathing Development and Function of the Bighead Catfish ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-10-28

AUTHORS

Xiaoli Ma, Baofeng Su, Max Bangs, Veronica Alston, Nathan J. C. Backenstose, Rhoda Mae Simora, Wenwen Wang, De Xing, Shangjia Li, Zhi Ye, Anthony G. Moss, Thuy-Yen Duong, Xu Wang, Rex A. Dunham

ABSTRACT

The bighead catfish (Clarias macrocephalus) and channel catfish (Ictalurus punctatus) are freshwater species in the Siluriformes order. C. macrocephalus has both gills and modified gill structures serving as an air-breathing organ (ABO), while I. punctatus does not possess such an organ, and cannot breathe in air, providing an excellent model for studying the molecular basis of ABO development in teleost fish. To investigate the critical time window for the development of air-breathing function, seven development stages were selected based on hypoxia challenge results, and RNA-seq was performed upon C. macrocephalus to compare with the non-air-breathing I. punctatus. Five-hundred million reads were generated and 25,239 expressed genes were annotated in C. macrocephalus. Among those, 8675 genes were differentially expressed across developmental stages. Comparative genomic analysis identified 1458 C. macrocephalus specific genes, which were absent in I. punctatus. Gene network and protein-protein interaction analyses identified 26 key hub genes involved in the air-breathing function. Three top candidate genes, mb, ngb, hbae, are mainly associated with oxygen carrying, oxygen binding, and heme binding activities. Our study provides a rich data set for exploring the genomic basis of air-breathing function in C. macrocephalus and offers insights into the adaption to hypoxic environments. More... »

PAGES

90-105

References to SciGraph publications

  • 2010-10-21. Changes of globin expression in the Japanese medaka (Oryzias latipes) in response to acute and chronic hypoxia in JOURNAL OF COMPARATIVE PHYSIOLOGY B
  • 2013-07-11. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis in NATURE PROTOCOLS
  • 2015-08-06. OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy in GENOME BIOLOGY
  • 2018-01-22. Testicular germ line cell identification, isolation, and transplantation in two North American catfish species in FISH PHYSIOLOGY AND BIOCHEMISTRY
  • 2011-08-04. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome in BMC BIOINFORMATICS
  • 2007-08-17. Functional ureogenesis and adaptation to ammonia metabolism in Indian freshwater air-breathing catfishes in FISH PHYSIOLOGY AND BIOCHEMISTRY
  • 2007-08-14. Genetic Structure of Different Populations of Walking Catfish (Clarias batrachus L.) in Bangladesh in BIOCHEMICAL GENETICS
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2016-06-02. The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts in NATURE COMMUNICATIONS
  • 2016-08-22. Developmental transcriptome analysis and identification of genes involved in formation of intestinal air-breathing function of Dojo loach, Misgurnus anguillicaudatus in SCIENTIFIC REPORTS
  • 2011-05-26. Ontogeny of globin expression in zebrafish (Danio rerio) in JOURNAL OF COMPARATIVE PHYSIOLOGY B
  • 1979-08. The survival of habitat desiccation by air breathing clariid catfishes in ENVIRONMENTAL BIOLOGY OF FISHES
  • 2018-12-20. Genome sequence of walking catfish (Clarias batrachus) provides insights into terrestrial adaptation in BMC GENOMICS
  • 2017-02-13. Molecular evolution of globin genes in Gymnotiform electric fishes: relation to hypoxia tolerance in BMC ECOLOGY AND EVOLUTION
  • 2017-02-08. De Novo Transcriptome Characterization and Growth-Related Gene Expression Profiling of Diploid and Triploid Bighead Catfish (Clarias macrocephalus Günther, 1864) in MARINE BIOTECHNOLOGY
  • 2011-04-22. Cardiorespiratory responses to hypoxia in the African catfish, Clarias gariepinus (Burchell 1822), an air-breathing fish in JOURNAL OF COMPARATIVE PHYSIOLOGY B
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10126-020-10005-4

    DOI

    http://dx.doi.org/10.1007/s10126-020-10005-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132134384

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33113010


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/05", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Environmental Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/07", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Agricultural and Veterinary Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Technology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptation, Physiological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Catfishes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gills", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoxia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxygen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, RNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ma", 
            "givenName": "Xiaoli", 
            "id": "sg:person.014555412257.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014555412257.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su", 
            "givenName": "Baofeng", 
            "id": "sg:person.01112761467.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112761467.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biological Science, Florida State University, 32304, Tallahassee, FL, USA", 
              "id": "http://www.grid.ac/institutes/grid.255986.5", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
                "Department of Biological Science, Florida State University, 32304, Tallahassee, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bangs", 
            "givenName": "Max", 
            "id": "sg:person.012045266536.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012045266536.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alston", 
            "givenName": "Veronica", 
            "id": "sg:person.014751701173.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014751701173.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biological Sciences, University at Buffalo, 14260, Buffalo, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.273335.3", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
                "Department of Biological Sciences, University at Buffalo, 14260, Buffalo, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Backenstose", 
            "givenName": "Nathan J. C.", 
            "id": "sg:person.011540052643.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011540052643.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Fisheries and Ocean Sciences, University of the Philippines Visayas, Miagao, 5023, Iloilo, Philippines", 
              "id": "http://www.grid.ac/institutes/grid.449735.8", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
                "College of Fisheries and Ocean Sciences, University of the Philippines Visayas, Miagao, 5023, Iloilo, Philippines"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Simora", 
            "givenName": "Rhoda Mae", 
            "id": "sg:person.01035624003.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035624003.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Wenwen", 
            "id": "sg:person.014564127650.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014564127650.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xing", 
            "givenName": "De", 
            "id": "sg:person.011234531773.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011234531773.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Shangjia", 
            "id": "sg:person.014220461513.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014220461513.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, University of Washington, 98195, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
                "Department of Biochemistry, University of Washington, 98195, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ye", 
            "givenName": "Zhi", 
            "id": "sg:person.01076312441.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076312441.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biological Sciences, Auburn University, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/grid.252546.2", 
              "name": [
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
                "Department of Biological Sciences, Auburn University, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moss", 
            "givenName": "Anthony G.", 
            "id": "sg:person.01233570203.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233570203.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Aquaculture and Fisheries, Can Tho University, 94000, Can Tho City, Vietnam", 
              "id": "http://www.grid.ac/institutes/grid.25488.33", 
              "name": [
                "College of Aquaculture and Fisheries, Can Tho University, 94000, Can Tho City, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duong", 
            "givenName": "Thuy-Yen", 
            "id": "sg:person.0577223046.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577223046.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "HudsonAlpha Institute for Biotechnology, 35806, Huntsville, AL, USA", 
              "id": "http://www.grid.ac/institutes/grid.417691.c", 
              "name": [
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
                "Department of Pathobiology, Auburn University, 36849, Auburn, AL, USA", 
                "HudsonAlpha Institute for Biotechnology, 35806, Huntsville, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Xu", 
            "id": "sg:person.0632050341.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632050341.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA", 
                "Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dunham", 
            "givenName": "Rex A.", 
            "id": "sg:person.01117775636.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117775636.17"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10695-018-0467-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100559761", 
              "https://doi.org/10.1007/s10695-018-0467-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12862-017-0893-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083812249", 
              "https://doi.org/10.1186/s12862-017-0893-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00360-011-0577-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005930057", 
              "https://doi.org/10.1007/s00360-011-0577-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004141571", 
              "https://doi.org/10.1038/ncomms11757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-018-5355-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110812388", 
              "https://doi.org/10.1186/s12864-018-5355-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep31845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043590027", 
              "https://doi.org/10.1038/srep31845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021902674", 
              "https://doi.org/10.1186/1471-2105-12-323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00360-011-0588-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000624048", 
              "https://doi.org/10.1007/s00360-011-0588-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10126-017-9730-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083736083", 
              "https://doi.org/10.1007/s10126-017-9730-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00360-010-0518-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020626591", 
              "https://doi.org/10.1007/s00360-010-0518-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0721-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026229827", 
              "https://doi.org/10.1186/s13059-015-0721-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10528-007-9102-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050983193", 
              "https://doi.org/10.1007/s10528-007-9102-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10695-007-9172-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047820463", 
              "https://doi.org/10.1007/s10695-007-9172-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051115056", 
              "https://doi.org/10.1038/nprot.2013.084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00005484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024313871", 
              "https://doi.org/10.1007/bf00005484"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-10-28", 
        "datePublishedReg": "2020-10-28", 
        "description": "The bighead catfish (Clarias macrocephalus) and channel catfish (Ictalurus punctatus) are freshwater species in the Siluriformes order. C. macrocephalus has both gills and modified gill structures serving as an air-breathing organ (ABO), while I. punctatus does not possess such an organ, and cannot breathe in air, providing an excellent model for studying the molecular basis of ABO development in teleost fish. To investigate the critical time window for the development of air-breathing function, seven development stages were selected based on hypoxia challenge results, and RNA-seq was performed upon C. macrocephalus to compare with the non-air-breathing I. punctatus. Five-hundred million reads were generated and 25,239 expressed genes were annotated in C. macrocephalus. Among those, 8675 genes were differentially expressed across developmental stages. Comparative genomic analysis identified 1458 C. macrocephalus specific genes, which were absent in I. punctatus. Gene network and protein-protein interaction analyses identified 26 key hub genes involved in the air-breathing function. Three top candidate genes, mb, ngb, hbae, are mainly associated with oxygen carrying, oxygen binding, and heme binding activities. Our study provides a rich data set for exploring the genomic basis of air-breathing function in C. macrocephalus and offers insights into the adaption to hypoxic environments.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10126-020-10005-4", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8828998", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8674701", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1021527", 
            "issn": [
              "1436-2228", 
              "1432-1408"
            ], 
            "name": "Marine Biotechnology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "keywords": [
          "air-breathing function", 
          "air-breathing organ", 
          "I. punctatus", 
          "C. macrocephalus", 
          "candidate genes", 
          "protein-protein interaction analysis", 
          "comparative genomic analysis", 
          "freshwater species", 
          "key hub genes", 
          "top candidate genes", 
          "genomic basis", 
          "comparative genomics", 
          "gene networks", 
          "genomic analysis", 
          "transcriptomic analysis", 
          "RNA-seq", 
          "hub genes", 
          "teleost fish", 
          "Siluriformes order", 
          "molecular basis", 
          "specific genes", 
          "bighead catfish", 
          "genes", 
          "excellent model", 
          "developmental stages", 
          "gill structure", 
          "binding activity", 
          "Clarias macrocephalus", 
          "macrocephalus", 
          "channel catfish", 
          "punctatus", 
          "hypoxic environment", 
          "oxygen binding", 
          "oxygen carrying", 
          "catfish", 
          "interaction analysis", 
          "development stages", 
          "critical time window", 
          "genomics", 
          "species", 
          "fish", 
          "reads", 
          "HbAE", 
          "gills", 
          "organs", 
          "function", 
          "binding", 
          "Ngb", 
          "MB", 
          "development", 
          "stage", 
          "insights", 
          "basis", 
          "analysis", 
          "activity", 
          "adaption", 
          "environment", 
          "structure", 
          "study", 
          "challenge results", 
          "data", 
          "results", 
          "network", 
          "carrying", 
          "time window", 
          "order", 
          "model", 
          "window", 
          "rich data", 
          "air"
        ], 
        "name": "Comparative Genomic and Transcriptomic Analyses Revealed Twenty-Six Candidate Genes Involved in the Air-Breathing Development and Function of the Bighead Catfish Clarias macrocephalus", 
        "pagination": "90-105", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1132134384"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10126-020-10005-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33113010"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10126-020-10005-4", 
          "https://app.dimensions.ai/details/publication/pub.1132134384"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_844.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10126-020-10005-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10126-020-10005-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10126-020-10005-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10126-020-10005-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10126-020-10005-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    367 TRIPLES      21 PREDICATES      122 URIs      97 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10126-020-10005-4 schema:about N101d52e1223a4302be7d28510a0d7f85
    2 N17e8635fb0eb47f38cd9310fdfc4647d
    3 N1941c0772e1848c09a4efb7e8cbe1d4e
    4 N35a0cbd5b0ce4ed1910a4c00b0279202
    5 N71bd51a8006a46fa846f8693726b023a
    6 N8a8fc6ea5370410dbe0ceeeac095d9da
    7 Nab9107d8f6164d10945411c9b09b19a7
    8 Nb2dcab6fa1ea4780aedbf13fda434644
    9 Ne1a07e87afed4953b1dd98854b5ea1f4
    10 Ne5d2b1279e5741c8b235bc680481d38f
    11 anzsrc-for:05
    12 anzsrc-for:07
    13 anzsrc-for:10
    14 schema:author N400180b3dd194e3380f7fda9816d524d
    15 schema:citation sg:pub.10.1007/bf00005484
    16 sg:pub.10.1007/s00360-010-0518-2
    17 sg:pub.10.1007/s00360-011-0577-z
    18 sg:pub.10.1007/s00360-011-0588-9
    19 sg:pub.10.1007/s10126-017-9730-3
    20 sg:pub.10.1007/s10528-007-9102-1
    21 sg:pub.10.1007/s10695-007-9172-3
    22 sg:pub.10.1007/s10695-018-0467-3
    23 sg:pub.10.1038/ncomms11757
    24 sg:pub.10.1038/nprot.2013.084
    25 sg:pub.10.1038/srep31845
    26 sg:pub.10.1186/1471-2105-12-323
    27 sg:pub.10.1186/s12862-017-0893-3
    28 sg:pub.10.1186/s12864-018-5355-9
    29 sg:pub.10.1186/s13059-014-0550-8
    30 sg:pub.10.1186/s13059-015-0721-2
    31 schema:datePublished 2020-10-28
    32 schema:datePublishedReg 2020-10-28
    33 schema:description The bighead catfish (Clarias macrocephalus) and channel catfish (Ictalurus punctatus) are freshwater species in the Siluriformes order. C. macrocephalus has both gills and modified gill structures serving as an air-breathing organ (ABO), while I. punctatus does not possess such an organ, and cannot breathe in air, providing an excellent model for studying the molecular basis of ABO development in teleost fish. To investigate the critical time window for the development of air-breathing function, seven development stages were selected based on hypoxia challenge results, and RNA-seq was performed upon C. macrocephalus to compare with the non-air-breathing I. punctatus. Five-hundred million reads were generated and 25,239 expressed genes were annotated in C. macrocephalus. Among those, 8675 genes were differentially expressed across developmental stages. Comparative genomic analysis identified 1458 C. macrocephalus specific genes, which were absent in I. punctatus. Gene network and protein-protein interaction analyses identified 26 key hub genes involved in the air-breathing function. Three top candidate genes, mb, ngb, hbae, are mainly associated with oxygen carrying, oxygen binding, and heme binding activities. Our study provides a rich data set for exploring the genomic basis of air-breathing function in C. macrocephalus and offers insights into the adaption to hypoxic environments.
    34 schema:genre article
    35 schema:isAccessibleForFree false
    36 schema:isPartOf N890f22d73ec24f8ea676c2c71462e172
    37 Nced9af1d4f3842989d0acc2229795ac2
    38 sg:journal.1021527
    39 schema:keywords C. macrocephalus
    40 Clarias macrocephalus
    41 HbAE
    42 I. punctatus
    43 MB
    44 Ngb
    45 RNA-seq
    46 Siluriformes order
    47 activity
    48 adaption
    49 air
    50 air-breathing function
    51 air-breathing organ
    52 analysis
    53 basis
    54 bighead catfish
    55 binding
    56 binding activity
    57 candidate genes
    58 carrying
    59 catfish
    60 challenge results
    61 channel catfish
    62 comparative genomic analysis
    63 comparative genomics
    64 critical time window
    65 data
    66 development
    67 development stages
    68 developmental stages
    69 environment
    70 excellent model
    71 fish
    72 freshwater species
    73 function
    74 gene networks
    75 genes
    76 genomic analysis
    77 genomic basis
    78 genomics
    79 gill structure
    80 gills
    81 hub genes
    82 hypoxic environment
    83 insights
    84 interaction analysis
    85 key hub genes
    86 macrocephalus
    87 model
    88 molecular basis
    89 network
    90 order
    91 organs
    92 oxygen binding
    93 oxygen carrying
    94 protein-protein interaction analysis
    95 punctatus
    96 reads
    97 results
    98 rich data
    99 species
    100 specific genes
    101 stage
    102 structure
    103 study
    104 teleost fish
    105 time window
    106 top candidate genes
    107 transcriptomic analysis
    108 window
    109 schema:name Comparative Genomic and Transcriptomic Analyses Revealed Twenty-Six Candidate Genes Involved in the Air-Breathing Development and Function of the Bighead Catfish Clarias macrocephalus
    110 schema:pagination 90-105
    111 schema:productId N82185806d0d94b33896a3f3633748661
    112 Nad1b1e96eea14c3494ba5981f1a83da8
    113 Ne9e9edc99994422bbfaf761ea794b606
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132134384
    115 https://doi.org/10.1007/s10126-020-10005-4
    116 schema:sdDatePublished 2022-12-01T06:40
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher N9296d7632b17448ab83a917d6c26b58b
    119 schema:url https://doi.org/10.1007/s10126-020-10005-4
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N101d52e1223a4302be7d28510a0d7f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Hypoxia
    125 rdf:type schema:DefinedTerm
    126 N17e8635fb0eb47f38cd9310fdfc4647d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Catfishes
    128 rdf:type schema:DefinedTerm
    129 N1941c0772e1848c09a4efb7e8cbe1d4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Gene Expression Profiling
    131 rdf:type schema:DefinedTerm
    132 N23842d3f33ce4bb4b044f844dea105f4 rdf:first sg:person.014564127650.03
    133 rdf:rest N284374b41af94f8ab6256989fb2386de
    134 N284374b41af94f8ab6256989fb2386de rdf:first sg:person.011234531773.75
    135 rdf:rest Nb6fd9413fb67483c927c34024280b3cb
    136 N35a0cbd5b0ce4ed1910a4c00b0279202 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Adaptation, Physiological
    138 rdf:type schema:DefinedTerm
    139 N400180b3dd194e3380f7fda9816d524d rdf:first sg:person.014555412257.55
    140 rdf:rest N744f90cd54ed4b93b20266c6dfd56c01
    141 N59c36c333f3e4f1cab7105d162d0763e rdf:first sg:person.014751701173.23
    142 rdf:rest Na4453b06ccb3438ab94bfb0ef0feaabf
    143 N668b29e5af4f4e08aa1c285e12ba460f rdf:first sg:person.01035624003.38
    144 rdf:rest N23842d3f33ce4bb4b044f844dea105f4
    145 N71bd51a8006a46fa846f8693726b023a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Gills
    147 rdf:type schema:DefinedTerm
    148 N744f90cd54ed4b93b20266c6dfd56c01 rdf:first sg:person.01112761467.14
    149 rdf:rest Na784d8440d51493fba40635f070f03d9
    150 N82185806d0d94b33896a3f3633748661 schema:name pubmed_id
    151 schema:value 33113010
    152 rdf:type schema:PropertyValue
    153 N890f22d73ec24f8ea676c2c71462e172 schema:issueNumber 1
    154 rdf:type schema:PublicationIssue
    155 N8a8fc6ea5370410dbe0ceeeac095d9da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Respiration
    157 rdf:type schema:DefinedTerm
    158 N9296d7632b17448ab83a917d6c26b58b schema:name Springer Nature - SN SciGraph project
    159 rdf:type schema:Organization
    160 Na4453b06ccb3438ab94bfb0ef0feaabf rdf:first sg:person.011540052643.91
    161 rdf:rest N668b29e5af4f4e08aa1c285e12ba460f
    162 Na784d8440d51493fba40635f070f03d9 rdf:first sg:person.012045266536.21
    163 rdf:rest N59c36c333f3e4f1cab7105d162d0763e
    164 Nab9107d8f6164d10945411c9b09b19a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Oxygen
    166 rdf:type schema:DefinedTerm
    167 Nad1b1e96eea14c3494ba5981f1a83da8 schema:name doi
    168 schema:value 10.1007/s10126-020-10005-4
    169 rdf:type schema:PropertyValue
    170 Nb2dcab6fa1ea4780aedbf13fda434644 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Sequence Analysis, RNA
    172 rdf:type schema:DefinedTerm
    173 Nb6fd9413fb67483c927c34024280b3cb rdf:first sg:person.014220461513.03
    174 rdf:rest Ne8c5fe332f984037a40fa97f01c6043c
    175 Nc6569c6e71bf4ab48a1d58883b8c4481 rdf:first sg:person.01233570203.09
    176 rdf:rest Nd292fa152ac443988c7bc6b0795ad8d6
    177 Nced9af1d4f3842989d0acc2229795ac2 schema:volumeNumber 23
    178 rdf:type schema:PublicationVolume
    179 Nd292fa152ac443988c7bc6b0795ad8d6 rdf:first sg:person.0577223046.87
    180 rdf:rest Ne01ec15b1b244ce4aa8a460a20d63b80
    181 Ne01ec15b1b244ce4aa8a460a20d63b80 rdf:first sg:person.0632050341.19
    182 rdf:rest Nfac5f5dbd71d42e39915e0afe956c61e
    183 Ne1a07e87afed4953b1dd98854b5ea1f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Genomics
    185 rdf:type schema:DefinedTerm
    186 Ne5d2b1279e5741c8b235bc680481d38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Animals
    188 rdf:type schema:DefinedTerm
    189 Ne8c5fe332f984037a40fa97f01c6043c rdf:first sg:person.01076312441.61
    190 rdf:rest Nc6569c6e71bf4ab48a1d58883b8c4481
    191 Ne9e9edc99994422bbfaf761ea794b606 schema:name dimensions_id
    192 schema:value pub.1132134384
    193 rdf:type schema:PropertyValue
    194 Nfac5f5dbd71d42e39915e0afe956c61e rdf:first sg:person.01117775636.17
    195 rdf:rest rdf:nil
    196 anzsrc-for:05 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Environmental Sciences
    198 rdf:type schema:DefinedTerm
    199 anzsrc-for:07 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Agricultural and Veterinary Sciences
    201 rdf:type schema:DefinedTerm
    202 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Technology
    204 rdf:type schema:DefinedTerm
    205 sg:grant.8674701 http://pending.schema.org/fundedItem sg:pub.10.1007/s10126-020-10005-4
    206 rdf:type schema:MonetaryGrant
    207 sg:grant.8828998 http://pending.schema.org/fundedItem sg:pub.10.1007/s10126-020-10005-4
    208 rdf:type schema:MonetaryGrant
    209 sg:journal.1021527 schema:issn 1432-1408
    210 1436-2228
    211 schema:name Marine Biotechnology
    212 schema:publisher Springer Nature
    213 rdf:type schema:Periodical
    214 sg:person.01035624003.38 schema:affiliation grid-institutes:grid.449735.8
    215 schema:familyName Simora
    216 schema:givenName Rhoda Mae
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035624003.38
    218 rdf:type schema:Person
    219 sg:person.01076312441.61 schema:affiliation grid-institutes:grid.34477.33
    220 schema:familyName Ye
    221 schema:givenName Zhi
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076312441.61
    223 rdf:type schema:Person
    224 sg:person.01112761467.14 schema:affiliation grid-institutes:None
    225 schema:familyName Su
    226 schema:givenName Baofeng
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112761467.14
    228 rdf:type schema:Person
    229 sg:person.01117775636.17 schema:affiliation grid-institutes:None
    230 schema:familyName Dunham
    231 schema:givenName Rex A.
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117775636.17
    233 rdf:type schema:Person
    234 sg:person.011234531773.75 schema:affiliation grid-institutes:None
    235 schema:familyName Xing
    236 schema:givenName De
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011234531773.75
    238 rdf:type schema:Person
    239 sg:person.011540052643.91 schema:affiliation grid-institutes:grid.273335.3
    240 schema:familyName Backenstose
    241 schema:givenName Nathan J. C.
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011540052643.91
    243 rdf:type schema:Person
    244 sg:person.012045266536.21 schema:affiliation grid-institutes:grid.255986.5
    245 schema:familyName Bangs
    246 schema:givenName Max
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012045266536.21
    248 rdf:type schema:Person
    249 sg:person.01233570203.09 schema:affiliation grid-institutes:grid.252546.2
    250 schema:familyName Moss
    251 schema:givenName Anthony G.
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233570203.09
    253 rdf:type schema:Person
    254 sg:person.014220461513.03 schema:affiliation grid-institutes:None
    255 schema:familyName Li
    256 schema:givenName Shangjia
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014220461513.03
    258 rdf:type schema:Person
    259 sg:person.014555412257.55 schema:affiliation grid-institutes:None
    260 schema:familyName Ma
    261 schema:givenName Xiaoli
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014555412257.55
    263 rdf:type schema:Person
    264 sg:person.014564127650.03 schema:affiliation grid-institutes:None
    265 schema:familyName Wang
    266 schema:givenName Wenwen
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014564127650.03
    268 rdf:type schema:Person
    269 sg:person.014751701173.23 schema:affiliation grid-institutes:None
    270 schema:familyName Alston
    271 schema:givenName Veronica
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014751701173.23
    273 rdf:type schema:Person
    274 sg:person.0577223046.87 schema:affiliation grid-institutes:grid.25488.33
    275 schema:familyName Duong
    276 schema:givenName Thuy-Yen
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577223046.87
    278 rdf:type schema:Person
    279 sg:person.0632050341.19 schema:affiliation grid-institutes:grid.417691.c
    280 schema:familyName Wang
    281 schema:givenName Xu
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632050341.19
    283 rdf:type schema:Person
    284 sg:pub.10.1007/bf00005484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024313871
    285 https://doi.org/10.1007/bf00005484
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s00360-010-0518-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626591
    288 https://doi.org/10.1007/s00360-010-0518-2
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s00360-011-0577-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005930057
    291 https://doi.org/10.1007/s00360-011-0577-z
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s00360-011-0588-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000624048
    294 https://doi.org/10.1007/s00360-011-0588-9
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s10126-017-9730-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083736083
    297 https://doi.org/10.1007/s10126-017-9730-3
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1007/s10528-007-9102-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050983193
    300 https://doi.org/10.1007/s10528-007-9102-1
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1007/s10695-007-9172-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047820463
    303 https://doi.org/10.1007/s10695-007-9172-3
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s10695-018-0467-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100559761
    306 https://doi.org/10.1007/s10695-018-0467-3
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/ncomms11757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004141571
    309 https://doi.org/10.1038/ncomms11757
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nprot.2013.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051115056
    312 https://doi.org/10.1038/nprot.2013.084
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/srep31845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043590027
    315 https://doi.org/10.1038/srep31845
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1186/1471-2105-12-323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021902674
    318 https://doi.org/10.1186/1471-2105-12-323
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1186/s12862-017-0893-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083812249
    321 https://doi.org/10.1186/s12862-017-0893-3
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1186/s12864-018-5355-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110812388
    324 https://doi.org/10.1186/s12864-018-5355-9
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    327 https://doi.org/10.1186/s13059-014-0550-8
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1186/s13059-015-0721-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026229827
    330 https://doi.org/10.1186/s13059-015-0721-2
    331 rdf:type schema:CreativeWork
    332 grid-institutes:None schema:alternateName Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    333 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    334 School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA
    335 rdf:type schema:Organization
    336 grid-institutes:grid.252546.2 schema:alternateName Department of Biological Sciences, Auburn University, 36849, Auburn, AL, USA
    337 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    338 Department of Biological Sciences, Auburn University, 36849, Auburn, AL, USA
    339 rdf:type schema:Organization
    340 grid-institutes:grid.25488.33 schema:alternateName College of Aquaculture and Fisheries, Can Tho University, 94000, Can Tho City, Vietnam
    341 schema:name College of Aquaculture and Fisheries, Can Tho University, 94000, Can Tho City, Vietnam
    342 rdf:type schema:Organization
    343 grid-institutes:grid.255986.5 schema:alternateName Department of Biological Science, Florida State University, 32304, Tallahassee, FL, USA
    344 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    345 Department of Biological Science, Florida State University, 32304, Tallahassee, FL, USA
    346 School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA
    347 rdf:type schema:Organization
    348 grid-institutes:grid.273335.3 schema:alternateName Department of Biological Sciences, University at Buffalo, 14260, Buffalo, NY, USA
    349 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    350 Department of Biological Sciences, University at Buffalo, 14260, Buffalo, NY, USA
    351 School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA
    352 rdf:type schema:Organization
    353 grid-institutes:grid.34477.33 schema:alternateName Department of Biochemistry, University of Washington, 98195, Seattle, WA, USA
    354 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    355 Department of Biochemistry, University of Washington, 98195, Seattle, WA, USA
    356 School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA
    357 rdf:type schema:Organization
    358 grid-institutes:grid.417691.c schema:alternateName HudsonAlpha Institute for Biotechnology, 35806, Huntsville, AL, USA
    359 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    360 Department of Pathobiology, Auburn University, 36849, Auburn, AL, USA
    361 HudsonAlpha Institute for Biotechnology, 35806, Huntsville, AL, USA
    362 rdf:type schema:Organization
    363 grid-institutes:grid.449735.8 schema:alternateName College of Fisheries and Ocean Sciences, University of the Philippines Visayas, Miagao, 5023, Iloilo, Philippines
    364 schema:name Alabama Agricultural Experiment Station, 36849, Auburn, AL, USA
    365 College of Fisheries and Ocean Sciences, University of the Philippines Visayas, Miagao, 5023, Iloilo, Philippines
    366 School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, 36849, Auburn, AL, USA
    367 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...