Tumorigenic mechanisms of estrogen and Helicobacter pylori cytotoxin-associated gene A in estrogen receptor α-positive diffuse-type gastric adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-04-07

AUTHORS

Seungkyung Kang, Miree Park, Jung Yeon Cho, Su jin Ahn, Changhwan Yoon, Sang Gyun Kim, Soo-Jeong Cho

ABSTRACT

BackgroundDiffuse-type gastric cancer (DGC), for which Helicobacter pylori infection is a causal factor, is associated with poor prognosis among young women, possibly due to female hormones such as estrogen. We aimed to identify the carcinogenesis induced by estrogen and H. pylori in DGC.MethodsWe screened and selected estrogen receptor alpha (ERα)-positive (MKN45) and ERα-negative (SNU5) DGC cell lines. H. pylori strain 60190 and its isogenic mutant strain lacking cytotoxin-associated gene A (60190ΔCagA) were used to infect MKN45 cells. And the cytotoxin-related gene A (CagA) cDNA which was cloned into pSP65-SR-HA (cagA-pSP65SRa) vector was used to transfect MKN45 cells. Tumor samples were used for DGC organoid culture.ResultsIn MKN45 cells, we found that estradiol promotes epithelial–mesenchymal transition (EMT) and stemness phenotypes via HOTAIR expression. These effects were further enhanced by the addition of CagA secreted by H. pylori but were reversed by co-treatment with fulvestrant (ICI 182,780), a selective ER degrader. We also validated the effect of estrogen on DGC organoids. ERα expression was associated with tumor invasion and HOTAIR expression in DGC patients with overt H. pylori infection.ConclusionsThese findings may explain the rapid DGC progression in young women with physiologically high levels of estrogen and suggest that fulvestrant with ovarian function suppression could serve as a tumor-suppressive agent in premenopausal patients with DGC. More... »

PAGES

678-696

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10120-022-01290-0

DOI

http://dx.doi.org/10.1007/s10120-022-01290-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146948039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35391613


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Receptor alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fulvestrant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter pylori", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Seungkyung", 
        "id": "sg:person.016566170020.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016566170020.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Miree", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Jung Yeon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Su jin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Columbia University Irving Medical Center, 630 W. 168th St, 10032, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Surgery, Columbia University Irving Medical Center, 630 W. 168th St, 10032, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Changhwan", 
        "id": "sg:person.0636244265.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636244265.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sang Gyun", 
        "id": "sg:person.016035435043.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035435043.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Soo-Jeong", 
        "id": "sg:person.0641563624.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641563624.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bjc.6990497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043768337", 
          "https://doi.org/10.1038/sj.bjc.6990497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-018-0826-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103632706", 
          "https://doi.org/10.1007/s10120-018-0826-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1031-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034136408", 
          "https://doi.org/10.1245/s10434-010-1031-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-013-0670-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030465300", 
          "https://doi.org/10.1007/s12032-013-0670-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11894-017-0575-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090832727", 
          "https://doi.org/10.1007/s11894-017-0575-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-3127-9_31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036249089", 
          "https://doi.org/10.1007/978-1-4939-3127-9_31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40164-018-0116-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107112030", 
          "https://doi.org/10.1186/s40164-018-0116-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-04-07", 
    "datePublishedReg": "2022-04-07", 
    "description": "BackgroundDiffuse-type gastric cancer (DGC), for which Helicobacter pylori infection is a causal factor, is associated with poor prognosis among young women, possibly due to female hormones such as estrogen. We aimed to identify the carcinogenesis induced by estrogen and H. pylori in DGC.MethodsWe screened and selected estrogen receptor alpha (ER\u03b1)-positive (MKN45) and ER\u03b1-negative (SNU5) DGC cell lines. H. pylori strain 60190 and its isogenic mutant strain lacking cytotoxin-associated gene A (60190\u0394CagA) were used to infect MKN45 cells. And the cytotoxin-related gene A (CagA) cDNA which was cloned into pSP65-SR-HA (cagA-pSP65SRa) vector was used to transfect MKN45 cells. Tumor samples were used for DGC organoid culture.ResultsIn MKN45 cells, we found that estradiol promotes epithelial\u2013mesenchymal transition (EMT) and stemness phenotypes via HOTAIR expression. These effects were further enhanced by the addition of CagA secreted by H. pylori but were reversed by co-treatment with fulvestrant (ICI 182,780), a selective ER degrader. We also validated the effect of estrogen on DGC organoids. ER\u03b1 expression was associated with tumor invasion and HOTAIR expression in DGC patients with overt H. pylori infection.ConclusionsThese findings may explain the rapid DGC progression in young women with physiologically high levels of estrogen and suggest that fulvestrant with ovarian function suppression could serve as a tumor-suppressive agent in premenopausal patients with DGC.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10120-022-01290-0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1020959", 
        "issn": [
          "1436-3291", 
          "1436-3305"
        ], 
        "name": "Gastric Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "keywords": [
      "epithelial-mesenchymal transition", 
      "pylori infection", 
      "MKN45 cells", 
      "HOTAIR expression", 
      "H. pylori", 
      "cytotoxin-associated gene A", 
      "young women", 
      "diffuse-type gastric adenocarcinoma", 
      "ovarian function suppression", 
      "H. pylori strain 60190", 
      "Helicobacter pylori infection", 
      "H. pylori infection", 
      "effects of estrogen", 
      "cytotoxin-associated gene", 
      "selective ER degrader", 
      "estrogen receptor alpha", 
      "estrogen receptor \u03b1", 
      "tumor-suppressive agent", 
      "premenopausal patients", 
      "ER\u03b1 expression", 
      "poor prognosis", 
      "gastric adenocarcinoma", 
      "female hormones", 
      "ER degraders", 
      "gastric cancer", 
      "DGC patients", 
      "receptor alpha", 
      "isogenic mutant strains", 
      "receptor \u03b1", 
      "estrogen", 
      "tumor invasion", 
      "tumor samples", 
      "stemness phenotype", 
      "ConclusionsThese findings", 
      "strain 60190", 
      "HA vector", 
      "tumorigenic mechanisms", 
      "patients", 
      "cell lines", 
      "organoid cultures", 
      "infection", 
      "pylori", 
      "women", 
      "gene A", 
      "cells", 
      "expression", 
      "causal factors", 
      "high levels", 
      "fulvestrant", 
      "adenocarcinoma", 
      "prognosis", 
      "estradiol", 
      "cancer", 
      "MethodsWe", 
      "CagA", 
      "hormone", 
      "progression", 
      "carcinogenesis", 
      "A cDNA", 
      "invasion", 
      "DGC", 
      "alpha", 
      "organoids", 
      "phenotype", 
      "effect", 
      "suppression", 
      "agents", 
      "findings", 
      "factors", 
      "levels", 
      "mutant strain", 
      "genes", 
      "strains", 
      "culture", 
      "cDNA", 
      "mechanism", 
      "samples", 
      "addition", 
      "lines", 
      "vector", 
      "degraders", 
      "transition"
    ], 
    "name": "Tumorigenic mechanisms of estrogen and Helicobacter pylori cytotoxin-associated gene A in estrogen receptor \u03b1-positive diffuse-type gastric adenocarcinoma", 
    "pagination": "678-696", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1146948039"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10120-022-01290-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35391613"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10120-022-01290-0", 
      "https://app.dimensions.ai/details/publication/pub.1146948039"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_930.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10120-022-01290-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10120-022-01290-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10120-022-01290-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10120-022-01290-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10120-022-01290-0'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      127 URIs      111 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10120-022-01290-0 schema:about N11172ae7bd7e40f889921c920113f014
2 N23b6e46947bb44e59f57bd39640e26fb
3 N39b1cb900f2f4a04b46a28df740ae30b
4 N43a4887cc7c74eb8a772009463e95ba1
5 N5aa803ed7afc418b8030108e583b968b
6 N72c905c3dec64585a9e79e6991654b65
7 N7aa41f39a33147ad9effb895ae38a0b1
8 N94a7779480974c4cb4cf58b0b8511fd6
9 Na3420d56b9b34b58bcf9445af9e98147
10 Nb5d794b0ee0c4142b15d9b8cbc0b2339
11 Ndfe6878942b34364aa269b3031943804
12 Nebdf8cd43b92435dad0e2130e6d373cb
13 anzsrc-for:11
14 anzsrc-for:1103
15 anzsrc-for:1112
16 schema:author Nac4ea8c52d554aa49d4f6e2dd9c9ceed
17 schema:citation sg:pub.10.1007/978-1-4939-3127-9_31
18 sg:pub.10.1007/s10120-018-0826-x
19 sg:pub.10.1007/s11894-017-0575-8
20 sg:pub.10.1007/s12032-013-0670-0
21 sg:pub.10.1038/sj.bjc.6990497
22 sg:pub.10.1186/s40164-018-0116-7
23 sg:pub.10.1245/s10434-010-1031-2
24 schema:datePublished 2022-04-07
25 schema:datePublishedReg 2022-04-07
26 schema:description BackgroundDiffuse-type gastric cancer (DGC), for which Helicobacter pylori infection is a causal factor, is associated with poor prognosis among young women, possibly due to female hormones such as estrogen. We aimed to identify the carcinogenesis induced by estrogen and H. pylori in DGC.MethodsWe screened and selected estrogen receptor alpha (ERα)-positive (MKN45) and ERα-negative (SNU5) DGC cell lines. H. pylori strain 60190 and its isogenic mutant strain lacking cytotoxin-associated gene A (60190ΔCagA) were used to infect MKN45 cells. And the cytotoxin-related gene A (CagA) cDNA which was cloned into pSP65-SR-HA (cagA-pSP65SRa) vector was used to transfect MKN45 cells. Tumor samples were used for DGC organoid culture.ResultsIn MKN45 cells, we found that estradiol promotes epithelial–mesenchymal transition (EMT) and stemness phenotypes via HOTAIR expression. These effects were further enhanced by the addition of CagA secreted by H. pylori but were reversed by co-treatment with fulvestrant (ICI 182,780), a selective ER degrader. We also validated the effect of estrogen on DGC organoids. ERα expression was associated with tumor invasion and HOTAIR expression in DGC patients with overt H. pylori infection.ConclusionsThese findings may explain the rapid DGC progression in young women with physiologically high levels of estrogen and suggest that fulvestrant with ovarian function suppression could serve as a tumor-suppressive agent in premenopausal patients with DGC.
27 schema:genre article
28 schema:isAccessibleForFree false
29 schema:isPartOf N55107083780d4cde9983c73f3772c4c5
30 N8457c730b65e4d3c88d5c874e4a3e92f
31 sg:journal.1020959
32 schema:keywords A cDNA
33 CagA
34 ConclusionsThese findings
35 DGC
36 DGC patients
37 ER degraders
38 ERα expression
39 H. pylori
40 H. pylori infection
41 H. pylori strain 60190
42 HA vector
43 HOTAIR expression
44 Helicobacter pylori infection
45 MKN45 cells
46 MethodsWe
47 addition
48 adenocarcinoma
49 agents
50 alpha
51 cDNA
52 cancer
53 carcinogenesis
54 causal factors
55 cell lines
56 cells
57 culture
58 cytotoxin-associated gene
59 cytotoxin-associated gene A
60 degraders
61 diffuse-type gastric adenocarcinoma
62 effect
63 effects of estrogen
64 epithelial-mesenchymal transition
65 estradiol
66 estrogen
67 estrogen receptor alpha
68 estrogen receptor α
69 expression
70 factors
71 female hormones
72 findings
73 fulvestrant
74 gastric adenocarcinoma
75 gastric cancer
76 gene A
77 genes
78 high levels
79 hormone
80 infection
81 invasion
82 isogenic mutant strains
83 levels
84 lines
85 mechanism
86 mutant strain
87 organoid cultures
88 organoids
89 ovarian function suppression
90 patients
91 phenotype
92 poor prognosis
93 premenopausal patients
94 prognosis
95 progression
96 pylori
97 pylori infection
98 receptor alpha
99 receptor α
100 samples
101 selective ER degrader
102 stemness phenotype
103 strain 60190
104 strains
105 suppression
106 transition
107 tumor invasion
108 tumor samples
109 tumor-suppressive agent
110 tumorigenic mechanisms
111 vector
112 women
113 young women
114 schema:name Tumorigenic mechanisms of estrogen and Helicobacter pylori cytotoxin-associated gene A in estrogen receptor α-positive diffuse-type gastric adenocarcinoma
115 schema:pagination 678-696
116 schema:productId N21ed678c1f0e4df18f6b9bbef1d4c003
117 Nbfe86b30634248b4acbd0e6a4f2f07cf
118 Nd598edfa66204850a026c7a811722f04
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1146948039
120 https://doi.org/10.1007/s10120-022-01290-0
121 schema:sdDatePublished 2022-10-01T06:50
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N1549c39bdc0a4bcdbbed136584a92901
124 schema:url https://doi.org/10.1007/s10120-022-01290-0
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N0bab457fe6784d89aac7c4c1a0d9b648 schema:affiliation grid-institutes:grid.31501.36
129 schema:familyName Ahn
130 schema:givenName Su jin
131 rdf:type schema:Person
132 N11172ae7bd7e40f889921c920113f014 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Fulvestrant
134 rdf:type schema:DefinedTerm
135 N1549c39bdc0a4bcdbbed136584a92901 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N21ed678c1f0e4df18f6b9bbef1d4c003 schema:name dimensions_id
138 schema:value pub.1146948039
139 rdf:type schema:PropertyValue
140 N21ef98a521084c5c9d328e446a2ba717 schema:affiliation grid-institutes:grid.412484.f
141 schema:familyName Park
142 schema:givenName Miree
143 rdf:type schema:Person
144 N23b6e46947bb44e59f57bd39640e26fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 N304be1bfdf644814b4095e8019b49e68 rdf:first sg:person.0641563624.14
148 rdf:rest rdf:nil
149 N39b1cb900f2f4a04b46a28df740ae30b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Estrogens
151 rdf:type schema:DefinedTerm
152 N43a4887cc7c74eb8a772009463e95ba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Estrogen Receptor alpha
154 rdf:type schema:DefinedTerm
155 N55107083780d4cde9983c73f3772c4c5 schema:issueNumber 4
156 rdf:type schema:PublicationIssue
157 N5aa803ed7afc418b8030108e583b968b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Bacterial Proteins
159 rdf:type schema:DefinedTerm
160 N6832060da7de418592ad24ebc613411e schema:affiliation grid-institutes:grid.412484.f
161 schema:familyName Cho
162 schema:givenName Jung Yeon
163 rdf:type schema:Person
164 N68e0092a64f7416b974cfdcfafe37000 rdf:first sg:person.0636244265.58
165 rdf:rest Nf299787f1db44a4a82bdc8f8e8bf5c1b
166 N72c905c3dec64585a9e79e6991654b65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Adenocarcinoma
168 rdf:type schema:DefinedTerm
169 N7aa41f39a33147ad9effb895ae38a0b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Cytotoxins
171 rdf:type schema:DefinedTerm
172 N8457c730b65e4d3c88d5c874e4a3e92f schema:volumeNumber 25
173 rdf:type schema:PublicationVolume
174 N94a7779480974c4cb4cf58b0b8511fd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Helicobacter Infections
176 rdf:type schema:DefinedTerm
177 Na3420d56b9b34b58bcf9445af9e98147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Humans
179 rdf:type schema:DefinedTerm
180 Nac4ea8c52d554aa49d4f6e2dd9c9ceed rdf:first sg:person.016566170020.38
181 rdf:rest Nceb946dba60242e894e3cf3d02610e32
182 Nb5d794b0ee0c4142b15d9b8cbc0b2339 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Stomach Neoplasms
184 rdf:type schema:DefinedTerm
185 Nbfe86b30634248b4acbd0e6a4f2f07cf schema:name pubmed_id
186 schema:value 35391613
187 rdf:type schema:PropertyValue
188 Nceb946dba60242e894e3cf3d02610e32 rdf:first N21ef98a521084c5c9d328e446a2ba717
189 rdf:rest Nf7cf3752365b4122b3e396e38f62f375
190 Nd379a53f8d5449e5b66dd7dd7361c6d0 rdf:first N0bab457fe6784d89aac7c4c1a0d9b648
191 rdf:rest N68e0092a64f7416b974cfdcfafe37000
192 Nd598edfa66204850a026c7a811722f04 schema:name doi
193 schema:value 10.1007/s10120-022-01290-0
194 rdf:type schema:PropertyValue
195 Ndfe6878942b34364aa269b3031943804 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Antigens, Bacterial
197 rdf:type schema:DefinedTerm
198 Nebdf8cd43b92435dad0e2130e6d373cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Helicobacter pylori
200 rdf:type schema:DefinedTerm
201 Nf299787f1db44a4a82bdc8f8e8bf5c1b rdf:first sg:person.016035435043.00
202 rdf:rest N304be1bfdf644814b4095e8019b49e68
203 Nf7cf3752365b4122b3e396e38f62f375 rdf:first N6832060da7de418592ad24ebc613411e
204 rdf:rest Nd379a53f8d5449e5b66dd7dd7361c6d0
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
209 schema:name Clinical Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:journal.1020959 schema:issn 1436-3291
215 1436-3305
216 schema:name Gastric Cancer
217 schema:publisher Springer Nature
218 rdf:type schema:Periodical
219 sg:person.016035435043.00 schema:affiliation grid-institutes:grid.31501.36
220 schema:familyName Kim
221 schema:givenName Sang Gyun
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035435043.00
223 rdf:type schema:Person
224 sg:person.016566170020.38 schema:affiliation grid-institutes:grid.31501.36
225 schema:familyName Kang
226 schema:givenName Seungkyung
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016566170020.38
228 rdf:type schema:Person
229 sg:person.0636244265.58 schema:affiliation grid-institutes:grid.21729.3f
230 schema:familyName Yoon
231 schema:givenName Changhwan
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636244265.58
233 rdf:type schema:Person
234 sg:person.0641563624.14 schema:affiliation grid-institutes:grid.31501.36
235 schema:familyName Cho
236 schema:givenName Soo-Jeong
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641563624.14
238 rdf:type schema:Person
239 sg:pub.10.1007/978-1-4939-3127-9_31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036249089
240 https://doi.org/10.1007/978-1-4939-3127-9_31
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/s10120-018-0826-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103632706
243 https://doi.org/10.1007/s10120-018-0826-x
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/s11894-017-0575-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090832727
246 https://doi.org/10.1007/s11894-017-0575-8
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s12032-013-0670-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030465300
249 https://doi.org/10.1007/s12032-013-0670-0
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/sj.bjc.6990497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043768337
252 https://doi.org/10.1038/sj.bjc.6990497
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/s40164-018-0116-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107112030
255 https://doi.org/10.1186/s40164-018-0116-7
256 rdf:type schema:CreativeWork
257 sg:pub.10.1245/s10434-010-1031-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034136408
258 https://doi.org/10.1245/s10434-010-1031-2
259 rdf:type schema:CreativeWork
260 grid-institutes:grid.21729.3f schema:alternateName Department of Surgery, Columbia University Irving Medical Center, 630 W. 168th St, 10032, New York, NY, USA
261 schema:name Department of Surgery, Columbia University Irving Medical Center, 630 W. 168th St, 10032, New York, NY, USA
262 rdf:type schema:Organization
263 grid-institutes:grid.31501.36 schema:alternateName Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
264 Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
265 schema:name Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
266 Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
267 rdf:type schema:Organization
268 grid-institutes:grid.412484.f schema:alternateName Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
269 schema:name Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...