Ontology type: schema:ScholarlyArticle
2021-07-09
AUTHORSKentaro Imamura, Kenshi Yao, Satoshi Nimura, Hiroshi Tanabe, Takao Kanemitsu, Masaki Miyaoka, Yoichiro Ono, Toshiharu Ueki, Akinori Iwashita
ABSTRACTBackground and study aimsGastric adenocarcinoma of fundic-gland type (GA-FG) was first proposed as a new entity of gastric adenocarcinoma in 2010. Subsequently, gastric adenocarcinoma of fundic-gland mucosa type (GA-FGM) was reported as a subtype of gastric adenocarcinoma. This study aimed to investigate the endoscopic findings of GA-FGM and to evaluate the differences between GA-FGM and GA-FG.Patients and methodsThis was a single-center retrospective study. Participants were selected from patients with gastric cancer treated at Fukuoka University Chikushi Hospital, between September 2007 and May 2020. Patients histologically diagnosed with GA-FGM or GA-FG were enrolled, and endoscopic findings were analyzed in detail.ResultsA total of 12 GA-FGM lesions (12 patients) and 14 GA-FG lesions (13 patients) were analyzed. The two lesion types showed similar features: most lesions were of elevated type, located in the upper stomach, and developed in the stomach without Helicobacter pylori infection. On conventional endoscopy using the dye-spraying method, well-demarcated fine granular areas were observed in 7 GA-FGM lesions (58%) but not in any GA-FG lesions, with a significant difference between the two groups (P = 0.001). Magnifying endoscopy with narrow-band imaging (NBI) showed that 11 GA-FGM lesions (92%) met the diagnostic criteria for cancer according to the vessel plus surface classification system, whereas none of the GA-FG lesions met the same criteria (0%, 0/14) (P = 0.001).ConclusionOur results suggest that magnifying endoscopy with NBI is a potentially useful method for the diagnosis of GA-FGM. More... »
PAGES1307-1319
http://scigraph.springernature.com/pub.10.1007/s10120-021-01208-2
DOIhttp://dx.doi.org/10.1007/s10120-021-01208-2
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/34241719
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