Risk factors for nonalcoholic fatty liver disease after gastrectomy for gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-09-25

AUTHORS

Keita Kouzu, Hironori Tsujimoto, Makoto Nishikawa, Manabu Harada, Takao Sugihara, Hiromi Nagata, Shuichi Hiraki, Yoshihisa Yaguchi, Risa Takahata, Shinsuke Nomura, Nozomi Ito, Yusuke Ishibashi, Yujiro Itazaki, Satoshi Tsuchiya, Kazuo Hase, Yoji Kishi, Hideki Ueno

ABSTRACT

BackgroundNonalcoholic fatty liver disease (NAFLD) refers to hepatic steatosis caused by something other than alcoholic liver injury, and often occurs after gastrointestinal surgeries such as pancreatoduodenectomy and gastrectomy. This study aimed to identify the risk factors for NAFLD after gastrectomy for gastric cancer.MethodsA total of 721 patients who underwent gastrectomy for gastric cancer and plane abdominal computed tomography (CT) preoperatively and 1 year after surgery were included in this study. NAFLD was defined as having a mean hepatic CT attenuation value of < 40 Hounsfield units. We retrospectively examined the relationship between the onset of NAFLD and clinicopathological findings to identify the risk factors associated with the development of NAFLD after gastrectomy.ResultsThe incidence of postoperative NAFLD was 4.85% (35/721). The univariate analysis identified the following factors as being significantly associated with the incidence of NAFLD: age, preoperative BMI ≥ 25 kg/m2, tumor depth of pT3 ≤, lymph node metastasis grade of pN2 ≤, cholecystectomy, D2 lymphadenectomy, adjuvant chemotherapy, high preoperative cholinesterase serum level, and low grade of preoperative FIB-4 index. Adjuvant chemotherapy (p < 0.001) and high preoperative cholinesterase serum level (p = 0.021) were identified as independent risk factors for NAFLD 1 year after gastrectomy.ConclusionOur study showed that adjuvant chemotherapy with S-1 and high level of serum cholinesterase were considered as the risk factors for NAFLD occurring after gastrectomy for gastric cancer. More... »

PAGES

356-362

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10120-019-01009-8

DOI

http://dx.doi.org/10.1007/s10120-019-01009-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121254518

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31555950


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27 schema:description BackgroundNonalcoholic fatty liver disease (NAFLD) refers to hepatic steatosis caused by something other than alcoholic liver injury, and often occurs after gastrointestinal surgeries such as pancreatoduodenectomy and gastrectomy. This study aimed to identify the risk factors for NAFLD after gastrectomy for gastric cancer.MethodsA total of 721 patients who underwent gastrectomy for gastric cancer and plane abdominal computed tomography (CT) preoperatively and 1 year after surgery were included in this study. NAFLD was defined as having a mean hepatic CT attenuation value of < 40 Hounsfield units. We retrospectively examined the relationship between the onset of NAFLD and clinicopathological findings to identify the risk factors associated with the development of NAFLD after gastrectomy.ResultsThe incidence of postoperative NAFLD was 4.85% (35/721). The univariate analysis identified the following factors as being significantly associated with the incidence of NAFLD: age, preoperative BMI ≥ 25 kg/m2, tumor depth of pT3 ≤, lymph node metastasis grade of pN2 ≤, cholecystectomy, D2 lymphadenectomy, adjuvant chemotherapy, high preoperative cholinesterase serum level, and low grade of preoperative FIB-4 index. Adjuvant chemotherapy (p < 0.001) and high preoperative cholinesterase serum level (p = 0.021) were identified as independent risk factors for NAFLD 1 year after gastrectomy.ConclusionOur study showed that adjuvant chemotherapy with S-1 and high level of serum cholinesterase were considered as the risk factors for NAFLD occurring after gastrectomy for gastric cancer.
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36 BackgroundNonalcoholic fatty liver disease
37 CT attenuation values
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39 D2 lymphadenectomy
40 FIB-4 index
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42 NAFLD
43 NAFLD 1 year
44 adjuvant chemotherapy
45 age
46 alcoholic liver injury
47 analysis
48 attenuation values
49 cancer
50 chemotherapy
51 cholecystectomy
52 cholinesterase
53 cholinesterase serum level
54 clinicopathological findings
55 depth
56 development
57 development of NAFLD
58 disease
59 factors
60 fatty liver disease
61 findings
62 gastrectomy
63 gastric cancer
64 gastrointestinal surgery
65 grade
66 hepatic CT attenuation value
67 hepatic steatosis
68 high levels
69 high preoperative cholinesterase serum level
70 incidence
71 incidence of NAFLD
72 independent risk factor
73 index
74 injury
75 levels
76 liver disease
77 liver injury
78 low grade
79 lymph node metastasis grade
80 lymphadenectomy
81 m2
82 mean hepatic CT attenuation value
83 metastasis grade
84 node metastasis grade
85 nonalcoholic fatty liver disease
86 onset
87 onset of NAFLD
88 pN2
89 pT3
90 pancreatoduodenectomy
91 patients
92 plane abdominal
93 postoperative NAFLD
94 preoperative BMI
95 preoperative FIB-4 index
96 preoperative cholinesterase serum level
97 relationship
98 risk factors
99 serum cholinesterase
100 serum levels
101 steatosis
102 study
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104 tomography
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107 units
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