Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-02

AUTHORS

Masanori Terashima, Yoshiaki Iwasaki, Junki Mizusawa, Hiroshi Katayama, Kenichi Nakamura, Hitoshi Katai, Takaki Yoshikawa, Yuichi Ito, Masahide Kaji, Yutaka Kimura, Motohiro Hirao, Makoto Yamada, Akira Kurita, Masakazu Takagi, Narikazu Boku, Takeshi Sano, Mitsuru Sasako,

ABSTRACT

BackgroundThe prognosis of patients with linitis plastica (type 4) and large (≥ 8 cm) ulcero-invasive-type (type 3) gastric cancer is extremely poor, even after extended surgery and adjuvant chemotherapy. Given the promising results of our previous phase II study evaluating neoadjuvant chemotherapy (NAC) with S-1 plus cisplatin (JCOG0210), we performed a phase III study to confirm the efficacy of NAC in these patients, with the safety and surgical results are presented here.MethodsEligible patients were randomized to gastrectomy plus adjuvant chemotherapy with S-1 (Arm A) or NAC followed by gastrectomy + adjuvant chemotherapy (Arm B). The primary endpoint was the overall survival (OS). This trial is registered at the UMIN Clinical Trials Registry as C000000279.ResultsFrom February 2007 to July 2013, 300 patients were randomized (Arm A 149, Arm B 151). NAC was completed in 133 patients (88%). Major grade 3/4 adverse events during NAC were neutropenia (29.3%), nausea (5.4%), diarrhea (4.8%), and fatigue (2.7%). Gastrectomy was performed in 147 patients (99%) in Arm A and 139 patients (92%) in Arm B. The operation time was significantly shorter in Arm B than in Arm A (median 255 vs. 240 min, respectively; p = 0.024). There were no significant differences in Grade 2–4 morbidity and mortality (25.2% and 1.3% in Arm A and 15.8% and 0.7% in Arm B, respectively).ConclusionsNAC for type 4 and large type 3 gastric cancer followed by D2 gastrectomy can be safely performed without increasing the morbidity or mortality. More... »

PAGES

1044-1052

Journal

TITLE

Gastric Cancer

ISSUE

5

VOLUME

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10120-019-00941-z

DOI

http://dx.doi.org/10.1007/s10120-019-00941-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112504584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30827001


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxonic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tegafur", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Gastric Surgery, Shizuoka Cancer Center, 1007 Monagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Nagaizumi, Shizuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415797.9", 
          "name": [
            "Division of Gastric Surgery, Shizuoka Cancer Center, 1007 Monagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Nagaizumi, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terashima", 
        "givenName": "Masanori", 
        "id": "sg:person.0771235105.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771235105.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwasaki", 
        "givenName": "Yoshiaki", 
        "id": "sg:person.0601444523.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601444523.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizusawa", 
        "givenName": "Junki", 
        "id": "sg:person.0575526511.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575526511.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katayama", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0753572034.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753572034.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Kenichi", 
        "id": "sg:person.0703432342.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703432342.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katai", 
        "givenName": "Hitoshi", 
        "id": "sg:person.0745061127.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745061127.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414944.8", 
          "name": [
            "Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshikawa", 
        "givenName": "Takaki", 
        "id": "sg:person.01023410054.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023410054.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Yuichi", 
        "id": "sg:person.01206115531.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206115531.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417235.6", 
          "name": [
            "Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaji", 
        "givenName": "Masahide", 
        "id": "sg:person.015636156754.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015636156754.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Sakai City Hospital, Sakai, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Surgery, Sakai City Hospital, Sakai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Yutaka", 
        "id": "sg:person.0731365376.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731365376.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416803.8", 
          "name": [
            "Department of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirao", 
        "givenName": "Motohiro", 
        "id": "sg:person.01361741512.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361741512.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Gifu Municipal Hospital, Gifu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415535.3", 
          "name": [
            "Department of Surgery, Gifu Municipal Hospital, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Makoto", 
        "id": "sg:person.014333213121.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333213121.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415740.3", 
          "name": [
            "Department of Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurita", 
        "givenName": "Akira", 
        "id": "sg:person.01204671744.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204671744.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Shizuoka General Hospital, Shizuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415804.c", 
          "name": [
            "Department of Surgery, Shizuoka General Hospital, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takagi", 
        "givenName": "Masakazu", 
        "id": "sg:person.01272760453.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272760453.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boku", 
        "givenName": "Narikazu", 
        "id": "sg:person.01267664726.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267664726.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sano", 
        "givenName": "Takeshi", 
        "id": "sg:person.013151517662.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151517662.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Hyogo College of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Surgery, Hyogo College of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasako", 
        "givenName": "Mitsuru", 
        "id": "sg:person.01315641163.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315641163.21"
        ], 
        "type": "Person"
      }, 
      {}
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12029-014-9680-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005956666", 
          "https://doi.org/10.1007/s12029-014-9680-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-008-0496-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034224299", 
          "https://doi.org/10.1007/s10120-008-0496-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11864-017-0510-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092710044", 
          "https://doi.org/10.1007/s11864-017-0510-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-016-0619-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023846778", 
          "https://doi.org/10.1007/s10120-016-0619-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-016-0622-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005167644", 
          "https://doi.org/10.1007/s10120-016-0622-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00011681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030703112", 
          "https://doi.org/10.1007/pl00011681"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-02", 
    "datePublishedReg": "2019-03-02", 
    "description": "BackgroundThe prognosis of patients with linitis plastica (type 4) and large (\u2265\u20098\u00a0cm) ulcero-invasive-type (type 3) gastric cancer is extremely poor, even after extended surgery and adjuvant chemotherapy. Given the promising results of our previous phase II study evaluating neoadjuvant chemotherapy (NAC) with S-1 plus cisplatin (JCOG0210), we performed a phase III study to confirm the efficacy of NAC in these patients, with the safety and surgical results are presented here.MethodsEligible patients were randomized to gastrectomy plus adjuvant chemotherapy with S-1 (Arm A) or NAC followed by gastrectomy\u2009+\u2009adjuvant chemotherapy (Arm B). The primary endpoint was the overall survival (OS). This trial is registered at the UMIN Clinical Trials Registry as C000000279.ResultsFrom February 2007 to July 2013, 300 patients were randomized (Arm A 149, Arm B 151). NAC was completed in 133 patients (88%). Major grade 3/4 adverse events during NAC were neutropenia (29.3%), nausea (5.4%), diarrhea (4.8%), and fatigue (2.7%). Gastrectomy was performed in 147 patients (99%) in Arm A and 139 patients (92%) in Arm B. The operation time was significantly shorter in Arm B than in Arm A (median 255 vs. 240\u00a0min, respectively; p\u2009=\u20090.024). There were no significant differences in Grade 2\u20134 morbidity and mortality (25.2% and 1.3% in Arm A and 15.8% and 0.7% in Arm B, respectively).ConclusionsNAC for type 4 and large type 3 gastric cancer followed by D2 gastrectomy can be safely performed without increasing the morbidity or mortality.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10120-019-00941-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.9338988", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5920971", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9339130", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1020959", 
        "issn": [
          "1436-3291", 
          "1436-3305"
        ], 
        "name": "Gastric Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "large type 3 gastric cancer", 
      "type 3 gastric cancer", 
      "neoadjuvant chemotherapy", 
      "adjuvant chemotherapy", 
      "gastric cancer", 
      "overall survival", 
      "arm A", 
      "surgical results", 
      "major grade 3/4 adverse events", 
      "Japan Clinical Oncology Group Study", 
      "previous phase II study", 
      "efficacy of NAC", 
      "UMIN Clinical Trials Registry", 
      "grade 3/4 adverse events", 
      "randomized phase III trial", 
      "phase II study", 
      "phase III study", 
      "phase III trials", 
      "prognosis of patients", 
      "Clinical Trials Registry", 
      "short-term safety", 
      "type 4", 
      "type gastric cancer", 
      "MethodsEligible patients", 
      "D2 gastrectomy", 
      "extended surgery", 
      "II study", 
      "III study", 
      "primary endpoint", 
      "arm B.", 
      "III trials", 
      "linitis plastica", 
      "Trials Registry", 
      "adverse events", 
      "arm B", 
      "gastrectomy", 
      "patients", 
      "grade 2", 
      "chemotherapy", 
      "group study", 
      "cancer", 
      "operation time", 
      "morbidity", 
      "significant differences", 
      "mortality", 
      "cisplatin", 
      "trials", 
      "safety", 
      "neutropenia", 
      "nausea", 
      "plastica", 
      "prognosis", 
      "surgery", 
      "diarrhea", 
      "ConclusionsNAC", 
      "registry", 
      "study", 
      "endpoint", 
      "efficacy", 
      "survival", 
      "promising results", 
      "B.", 
      "fatigue", 
      "differences", 
      "results", 
      "events", 
      "time", 
      "Clinical Oncology Group Study", 
      "Oncology Group Study"
    ], 
    "name": "Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer, the short-term safety and surgical results: Japan Clinical Oncology Group Study (JCOG0501)", 
    "pagination": "1044-1052", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112504584"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10120-019-00941-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30827001"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10120-019-00941-z", 
      "https://app.dimensions.ai/details/publication/pub.1112504584"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_793.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10120-019-00941-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10120-019-00941-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10120-019-00941-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10120-019-00941-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10120-019-00941-z'


 

This table displays all metadata directly associated to this object as RDF triples.

399 TRIPLES      22 PREDICATES      122 URIs      107 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10120-019-00941-z schema:about N15fa5a24cf734dd3b256bf5e01d1822d
2 N3e3139f87a8f4fc49c58bf2b83c4a978
3 N4faff54724654cc1924fc0db6dcedd2c
4 N51fb750b7e7c45338496b99fdae3067d
5 N53a3c72c52c94a8ca68f5b16efc313f6
6 N5e555d8dda4b4c839964f5e4067b77c5
7 N5e97b81170884553bfd83cf66afca093
8 N623c0f8f6f024ccbb8909f989f4bcd59
9 N65228c246da34bd8a5a9fa5281037be5
10 N6b2cdcae629941fc9c5b44eb33b21137
11 N838ad456ca654c6192f93352b1e8191b
12 N93180c62066f495eabeaa70752f7f2a8
13 Na517898b68954c53b3c1622dcaf517ad
14 Na8b039cfdf3c43a4a61d54636d933c3b
15 Nb06ed19efe9541a9bf15f5a14052543f
16 Nb4f53a53353942afbb9cb8e9c4bbcec5
17 Nb8b50d3abd364f0783dc645f3cc84142
18 Nbba662695b914f19bf86c5e6ce727d12
19 Ndfad8832b60f471eaec4f8b092544d86
20 Nef5bd2e3d02c49d6bc31a0f421b9189d
21 anzsrc-for:11
22 anzsrc-for:1103
23 anzsrc-for:1112
24 schema:author Na5966aa1b4b94f6eb1299b609d93f40c
25 schema:citation sg:pub.10.1007/pl00011681
26 sg:pub.10.1007/s10120-008-0496-1
27 sg:pub.10.1007/s10120-016-0619-z
28 sg:pub.10.1007/s10120-016-0622-4
29 sg:pub.10.1007/s11864-017-0510-0
30 sg:pub.10.1007/s12029-014-9680-1
31 schema:datePublished 2019-03-02
32 schema:datePublishedReg 2019-03-02
33 schema:description BackgroundThe prognosis of patients with linitis plastica (type 4) and large (≥ 8 cm) ulcero-invasive-type (type 3) gastric cancer is extremely poor, even after extended surgery and adjuvant chemotherapy. Given the promising results of our previous phase II study evaluating neoadjuvant chemotherapy (NAC) with S-1 plus cisplatin (JCOG0210), we performed a phase III study to confirm the efficacy of NAC in these patients, with the safety and surgical results are presented here.MethodsEligible patients were randomized to gastrectomy plus adjuvant chemotherapy with S-1 (Arm A) or NAC followed by gastrectomy + adjuvant chemotherapy (Arm B). The primary endpoint was the overall survival (OS). This trial is registered at the UMIN Clinical Trials Registry as C000000279.ResultsFrom February 2007 to July 2013, 300 patients were randomized (Arm A 149, Arm B 151). NAC was completed in 133 patients (88%). Major grade 3/4 adverse events during NAC were neutropenia (29.3%), nausea (5.4%), diarrhea (4.8%), and fatigue (2.7%). Gastrectomy was performed in 147 patients (99%) in Arm A and 139 patients (92%) in Arm B. The operation time was significantly shorter in Arm B than in Arm A (median 255 vs. 240 min, respectively; p = 0.024). There were no significant differences in Grade 2–4 morbidity and mortality (25.2% and 1.3% in Arm A and 15.8% and 0.7% in Arm B, respectively).ConclusionsNAC for type 4 and large type 3 gastric cancer followed by D2 gastrectomy can be safely performed without increasing the morbidity or mortality.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N7da1aa2825af47109f0a2fef76297edc
38 Nac32501506704512a4d44090fa853b0a
39 sg:journal.1020959
40 schema:keywords B.
41 Clinical Oncology Group Study
42 Clinical Trials Registry
43 ConclusionsNAC
44 D2 gastrectomy
45 II study
46 III study
47 III trials
48 Japan Clinical Oncology Group Study
49 MethodsEligible patients
50 Oncology Group Study
51 Trials Registry
52 UMIN Clinical Trials Registry
53 adjuvant chemotherapy
54 adverse events
55 arm A
56 arm B
57 arm B.
58 cancer
59 chemotherapy
60 cisplatin
61 diarrhea
62 differences
63 efficacy
64 efficacy of NAC
65 endpoint
66 events
67 extended surgery
68 fatigue
69 gastrectomy
70 gastric cancer
71 grade 2
72 grade 3/4 adverse events
73 group study
74 large type 3 gastric cancer
75 linitis plastica
76 major grade 3/4 adverse events
77 morbidity
78 mortality
79 nausea
80 neoadjuvant chemotherapy
81 neutropenia
82 operation time
83 overall survival
84 patients
85 phase II study
86 phase III study
87 phase III trials
88 plastica
89 previous phase II study
90 primary endpoint
91 prognosis
92 prognosis of patients
93 promising results
94 randomized phase III trial
95 registry
96 results
97 safety
98 short-term safety
99 significant differences
100 study
101 surgery
102 surgical results
103 survival
104 time
105 trials
106 type 3 gastric cancer
107 type 4
108 type gastric cancer
109 schema:name Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer, the short-term safety and surgical results: Japan Clinical Oncology Group Study (JCOG0501)
110 schema:pagination 1044-1052
111 schema:productId N5bc9d50511204d18aa7b230bf65806ca
112 N9d11b98340b646ca88589fb271d60522
113 Nd9f96e204cc345f59a5ab089253f8fb5
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112504584
115 https://doi.org/10.1007/s10120-019-00941-z
116 schema:sdDatePublished 2022-01-01T18:47
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N16a2a0816f8d4dc78342fb2b6e924a1b
119 schema:url https://doi.org/10.1007/s10120-019-00941-z
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N00575582006f4fb5a0a95caabeeac668 rdf:first sg:person.01361741512.76
124 rdf:rest N87867099bc5a454aba45739217d8133d
125 N0432b9cac4624475a040fb51f618438e rdf:first sg:person.01206115531.87
126 rdf:rest N6b0446d3c8ee46bf9dda0360348b94b0
127 N050607b44be0465e9f0d25e5a7268acc rdf:first sg:person.0575526511.11
128 rdf:rest N254e4d7328844bf79e7f6f37a52c5b62
129 N083acf99184440f59b11f491b440c935 rdf:first sg:person.0703432342.22
130 rdf:rest N0d519093eb90433680c60540cbb20f0b
131 N0d519093eb90433680c60540cbb20f0b rdf:first sg:person.0745061127.00
132 rdf:rest N17cd118d8b124b50a1c55960d47b8427
133 N15fa5a24cf734dd3b256bf5e01d1822d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Gastrectomy
135 rdf:type schema:DefinedTerm
136 N16a2a0816f8d4dc78342fb2b6e924a1b schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N17cd118d8b124b50a1c55960d47b8427 rdf:first sg:person.01023410054.33
139 rdf:rest N0432b9cac4624475a040fb51f618438e
140 N1f132e561c02469296b71f411b3b111c rdf:first sg:person.01315641163.21
141 rdf:rest Ne3f16c8de5b94259816c122906f22824
142 N254e4d7328844bf79e7f6f37a52c5b62 rdf:first sg:person.0753572034.36
143 rdf:rest N083acf99184440f59b11f491b440c935
144 N31d504d6062b4deaa12aefd38ded8c30 rdf:first sg:person.0731365376.99
145 rdf:rest N00575582006f4fb5a0a95caabeeac668
146 N3e3139f87a8f4fc49c58bf2b83c4a978 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Aged
148 rdf:type schema:DefinedTerm
149 N4faff54724654cc1924fc0db6dcedd2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Follow-Up Studies
151 rdf:type schema:DefinedTerm
152 N51fb750b7e7c45338496b99fdae3067d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Middle Aged
154 rdf:type schema:DefinedTerm
155 N53a3c72c52c94a8ca68f5b16efc313f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Drug Combinations
157 rdf:type schema:DefinedTerm
158 N5bc9d50511204d18aa7b230bf65806ca schema:name dimensions_id
159 schema:value pub.1112504584
160 rdf:type schema:PropertyValue
161 N5e555d8dda4b4c839964f5e4067b77c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Peritoneal Neoplasms
163 rdf:type schema:DefinedTerm
164 N5e97b81170884553bfd83cf66afca093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Stomach Neoplasms
166 rdf:type schema:DefinedTerm
167 N623c0f8f6f024ccbb8909f989f4bcd59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Tegafur
169 rdf:type schema:DefinedTerm
170 N6286c439584a4e2cbc1c757fcbfc3ec4 rdf:first sg:person.0601444523.47
171 rdf:rest N050607b44be0465e9f0d25e5a7268acc
172 N65228c246da34bd8a5a9fa5281037be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Neoplasm Staging
174 rdf:type schema:DefinedTerm
175 N6b0446d3c8ee46bf9dda0360348b94b0 rdf:first sg:person.015636156754.75
176 rdf:rest N31d504d6062b4deaa12aefd38ded8c30
177 N6b2cdcae629941fc9c5b44eb33b21137 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 N7da1aa2825af47109f0a2fef76297edc schema:volumeNumber 22
181 rdf:type schema:PublicationVolume
182 N838ad456ca654c6192f93352b1e8191b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Neoadjuvant Therapy
184 rdf:type schema:DefinedTerm
185 N87867099bc5a454aba45739217d8133d rdf:first sg:person.014333213121.69
186 rdf:rest Nc11a4d124403460b8a5623b5030d5f0d
187 N93180c62066f495eabeaa70752f7f2a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Humans
189 rdf:type schema:DefinedTerm
190 N9d11b98340b646ca88589fb271d60522 schema:name pubmed_id
191 schema:value 30827001
192 rdf:type schema:PropertyValue
193 Na517898b68954c53b3c1622dcaf517ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Adult
195 rdf:type schema:DefinedTerm
196 Na5966aa1b4b94f6eb1299b609d93f40c rdf:first sg:person.0771235105.50
197 rdf:rest N6286c439584a4e2cbc1c757fcbfc3ec4
198 Na8b039cfdf3c43a4a61d54636d933c3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Young Adult
200 rdf:type schema:DefinedTerm
201 Nac32501506704512a4d44090fa853b0a schema:issueNumber 5
202 rdf:type schema:PublicationIssue
203 Nb06ed19efe9541a9bf15f5a14052543f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Cisplatin
205 rdf:type schema:DefinedTerm
206 Nb4f53a53353942afbb9cb8e9c4bbcec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Antineoplastic Combined Chemotherapy Protocols
208 rdf:type schema:DefinedTerm
209 Nb8b50d3abd364f0783dc645f3cc84142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Combined Modality Therapy
211 rdf:type schema:DefinedTerm
212 Nbba662695b914f19bf86c5e6ce727d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Male
214 rdf:type schema:DefinedTerm
215 Nc11a4d124403460b8a5623b5030d5f0d rdf:first sg:person.01204671744.44
216 rdf:rest Nc72b671049f84071b716d580cdb59e25
217 Nc72b671049f84071b716d580cdb59e25 rdf:first sg:person.01272760453.72
218 rdf:rest Nd08d3fc201f045cdabde54ffa42d9777
219 Nd08d3fc201f045cdabde54ffa42d9777 rdf:first sg:person.01267664726.29
220 rdf:rest Nd5624a86b46d44998d80c98cea5e9952
221 Nd5624a86b46d44998d80c98cea5e9952 rdf:first sg:person.013151517662.47
222 rdf:rest N1f132e561c02469296b71f411b3b111c
223 Nd9f96e204cc345f59a5ab089253f8fb5 schema:name doi
224 schema:value 10.1007/s10120-019-00941-z
225 rdf:type schema:PropertyValue
226 Ndfad8832b60f471eaec4f8b092544d86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Survival Rate
228 rdf:type schema:DefinedTerm
229 Ne3f16c8de5b94259816c122906f22824 rdf:first N369d83a62bc94a92bb075bae2f641065
230 rdf:rest rdf:nil
231 Nef5bd2e3d02c49d6bc31a0f421b9189d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Oxonic Acid
233 rdf:type schema:DefinedTerm
234 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
235 schema:name Medical and Health Sciences
236 rdf:type schema:DefinedTerm
237 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
238 schema:name Clinical Sciences
239 rdf:type schema:DefinedTerm
240 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
241 schema:name Oncology and Carcinogenesis
242 rdf:type schema:DefinedTerm
243 sg:grant.5920971 http://pending.schema.org/fundedItem sg:pub.10.1007/s10120-019-00941-z
244 rdf:type schema:MonetaryGrant
245 sg:grant.9338988 http://pending.schema.org/fundedItem sg:pub.10.1007/s10120-019-00941-z
246 rdf:type schema:MonetaryGrant
247 sg:grant.9339130 http://pending.schema.org/fundedItem sg:pub.10.1007/s10120-019-00941-z
248 rdf:type schema:MonetaryGrant
249 sg:journal.1020959 schema:issn 1436-3291
250 1436-3305
251 schema:name Gastric Cancer
252 schema:publisher Springer Nature
253 rdf:type schema:Periodical
254 sg:person.01023410054.33 schema:affiliation grid-institutes:grid.414944.8
255 schema:familyName Yoshikawa
256 schema:givenName Takaki
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023410054.33
258 rdf:type schema:Person
259 sg:person.01204671744.44 schema:affiliation grid-institutes:grid.415740.3
260 schema:familyName Kurita
261 schema:givenName Akira
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204671744.44
263 rdf:type schema:Person
264 sg:person.01206115531.87 schema:affiliation grid-institutes:grid.410800.d
265 schema:familyName Ito
266 schema:givenName Yuichi
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206115531.87
268 rdf:type schema:Person
269 sg:person.01267664726.29 schema:affiliation grid-institutes:grid.272242.3
270 schema:familyName Boku
271 schema:givenName Narikazu
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267664726.29
273 rdf:type schema:Person
274 sg:person.01272760453.72 schema:affiliation grid-institutes:grid.415804.c
275 schema:familyName Takagi
276 schema:givenName Masakazu
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272760453.72
278 rdf:type schema:Person
279 sg:person.013151517662.47 schema:affiliation grid-institutes:grid.410807.a
280 schema:familyName Sano
281 schema:givenName Takeshi
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151517662.47
283 rdf:type schema:Person
284 sg:person.01315641163.21 schema:affiliation grid-institutes:grid.272264.7
285 schema:familyName Sasako
286 schema:givenName Mitsuru
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315641163.21
288 rdf:type schema:Person
289 sg:person.01361741512.76 schema:affiliation grid-institutes:grid.416803.8
290 schema:familyName Hirao
291 schema:givenName Motohiro
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361741512.76
293 rdf:type schema:Person
294 sg:person.014333213121.69 schema:affiliation grid-institutes:grid.415535.3
295 schema:familyName Yamada
296 schema:givenName Makoto
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333213121.69
298 rdf:type schema:Person
299 sg:person.015636156754.75 schema:affiliation grid-institutes:grid.417235.6
300 schema:familyName Kaji
301 schema:givenName Masahide
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015636156754.75
303 rdf:type schema:Person
304 sg:person.0575526511.11 schema:affiliation grid-institutes:grid.272242.3
305 schema:familyName Mizusawa
306 schema:givenName Junki
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575526511.11
308 rdf:type schema:Person
309 sg:person.0601444523.47 schema:affiliation grid-institutes:grid.415479.a
310 schema:familyName Iwasaki
311 schema:givenName Yoshiaki
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601444523.47
313 rdf:type schema:Person
314 sg:person.0703432342.22 schema:affiliation grid-institutes:grid.272242.3
315 schema:familyName Nakamura
316 schema:givenName Kenichi
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703432342.22
318 rdf:type schema:Person
319 sg:person.0731365376.99 schema:affiliation grid-institutes:None
320 schema:familyName Kimura
321 schema:givenName Yutaka
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731365376.99
323 rdf:type schema:Person
324 sg:person.0745061127.00 schema:affiliation grid-institutes:grid.272242.3
325 schema:familyName Katai
326 schema:givenName Hitoshi
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745061127.00
328 rdf:type schema:Person
329 sg:person.0753572034.36 schema:affiliation grid-institutes:grid.272242.3
330 schema:familyName Katayama
331 schema:givenName Hiroshi
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753572034.36
333 rdf:type schema:Person
334 sg:person.0771235105.50 schema:affiliation grid-institutes:grid.415797.9
335 schema:familyName Terashima
336 schema:givenName Masanori
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771235105.50
338 rdf:type schema:Person
339 sg:pub.10.1007/pl00011681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030703112
340 https://doi.org/10.1007/pl00011681
341 rdf:type schema:CreativeWork
342 sg:pub.10.1007/s10120-008-0496-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034224299
343 https://doi.org/10.1007/s10120-008-0496-1
344 rdf:type schema:CreativeWork
345 sg:pub.10.1007/s10120-016-0619-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023846778
346 https://doi.org/10.1007/s10120-016-0619-z
347 rdf:type schema:CreativeWork
348 sg:pub.10.1007/s10120-016-0622-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005167644
349 https://doi.org/10.1007/s10120-016-0622-4
350 rdf:type schema:CreativeWork
351 sg:pub.10.1007/s11864-017-0510-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092710044
352 https://doi.org/10.1007/s11864-017-0510-0
353 rdf:type schema:CreativeWork
354 sg:pub.10.1007/s12029-014-9680-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005956666
355 https://doi.org/10.1007/s12029-014-9680-1
356 rdf:type schema:CreativeWork
357 grid-institutes:None schema:alternateName Department of Surgery, Sakai City Hospital, Sakai, Japan
358 schema:name Department of Surgery, Sakai City Hospital, Sakai, Japan
359 rdf:type schema:Organization
360 grid-institutes:grid.272242.3 schema:alternateName Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan
361 Department of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
362 JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan
363 schema:name Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan
364 Department of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
365 JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan
366 rdf:type schema:Organization
367 grid-institutes:grid.272264.7 schema:alternateName Department of Surgery, Hyogo College of Medicine, Kobe, Japan
368 schema:name Department of Surgery, Hyogo College of Medicine, Kobe, Japan
369 rdf:type schema:Organization
370 grid-institutes:grid.410800.d schema:alternateName Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
371 schema:name Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
372 rdf:type schema:Organization
373 grid-institutes:grid.410807.a schema:alternateName Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
374 schema:name Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
375 rdf:type schema:Organization
376 grid-institutes:grid.414944.8 schema:alternateName Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
377 schema:name Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan
378 rdf:type schema:Organization
379 grid-institutes:grid.415479.a schema:alternateName Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
380 schema:name Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
381 rdf:type schema:Organization
382 grid-institutes:grid.415535.3 schema:alternateName Department of Surgery, Gifu Municipal Hospital, Gifu, Japan
383 schema:name Department of Surgery, Gifu Municipal Hospital, Gifu, Japan
384 rdf:type schema:Organization
385 grid-institutes:grid.415740.3 schema:alternateName Department of Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
386 schema:name Department of Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
387 rdf:type schema:Organization
388 grid-institutes:grid.415797.9 schema:alternateName Division of Gastric Surgery, Shizuoka Cancer Center, 1007 Monagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Nagaizumi, Shizuoka, Japan
389 schema:name Division of Gastric Surgery, Shizuoka Cancer Center, 1007 Monagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Nagaizumi, Shizuoka, Japan
390 rdf:type schema:Organization
391 grid-institutes:grid.415804.c schema:alternateName Department of Surgery, Shizuoka General Hospital, Shizuoka, Japan
392 schema:name Department of Surgery, Shizuoka General Hospital, Shizuoka, Japan
393 rdf:type schema:Organization
394 grid-institutes:grid.416803.8 schema:alternateName Department of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan
395 schema:name Department of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan
396 rdf:type schema:Organization
397 grid-institutes:grid.417235.6 schema:alternateName Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan
398 schema:name Department of Surgery, Toyama Prefectural Central Hospital, Toyama, Japan
399 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...