Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer View Full Text


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Article Info

DATE

2016-09-24

AUTHORS

Yeonjoo Choi, Jin Won Kim, Kyung Han Nam, Song-Hee Han, Ji-Won Kim, Sang-Hoon Ahn, Do Joong Park, Keun-Wook Lee, Hye Seung Lee, Hyung-Ho Kim

ABSTRACT

BackgroundThe neutrophil–lymphocyte ratio (NLR) and the prognostic nutritional index (PNI) are markers of systemic inflammation known to be useful prognostic indicators of malignancy. However, little evidence has defined the influence of inflammation on the tumor microenvironment.MethodsTwo hundred eighty-eight patients who underwent curative surgery for gastric cancer were included. Preoperative peripheral blood samples were used to analyze the NLR and PNI. The optimal cutoff levels for the NLR and PNI were defined by receiver operating characteristic curve analysis for survival (NLR = 2.7, PNI = 47.7). The densities of specific immune cells (CD3+, CD4+, CD8+) within the tumor microenvironment were measured in tumor microarrays by immunohistochemical analysis.ResultsTwo hundred thirty-five patients (81.6 %) had a low NLR and 53 patients (18.4 %) had a high NLR. One hundred seventeen patients (40.6 %) had a low PNI and 171 patients (59.4 %) had a high PNI. CD3+ and CD8+ immune cell density were not associated with the NLR and PNI. However, in the high-NLR group compared with the low-NLR group, CD4+ immune cell density was significantly decreased (P < 0.001). Similarly, the density of CD4+ immune cells was also significantly decreased in the low-PNI group compared with the high-PNI group (P = 0.007). A high NLR and a low PNI were correlated with worse overall survival in multivariate analysis (P = 0.028 and P = 0.002 respectively).ConclusionsThe NLR and PNI are associated with the density of CD4+ immune cells in the tumor microenvironment, which leads to prognostic values of systemic inflammation in gastric cancer. More... »

PAGES

602-611

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    http://scigraph.springernature.com/pub.10.1007/s10120-016-0642-0

    DOI

    http://dx.doi.org/10.1007/s10120-016-0642-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003537299

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27665104


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