Quality of life and nutritional consequences after aboral pouch reconstruction following total gastrectomy for gastric cancer: randomized controlled trial CCG1101 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Yuichi Ito, Takaki Yoshikawa, Michitaka Fujiwara, Hiroshi Kojima, Takanori Matsui, Yoshinari Mochizuki, Haruhiko Cho, Toru Aoyama, Seiji Ito, Kazunari Misawa, Hiroshi Nakayama, Yuki Morioka, Akiharu Ishiyama, Chie Tanaka, Satoshi Morita, Junichi Sakamoto, Yasuhiro Kodera

ABSTRACT

BACKGROUND: Total gastrectomy has detrimental effects on postoperative nutritional status and quality of life (QOL), but it is often unavoidable in the treatment of gastric cancer. Roux-en-Y (RY) is the most common reconstruction method following total gastrectomy. Trials to explore other means of reconstruction have been conducted but have failed to identify a method that is globally accepted. METHODS: Aboral pouch reconstruction (AP), in which an anisoperistaltic jejunal pouch is created in the Y limb of the RY reconstruction, is considered effective and technically feasible. A prospective randomized trial was conducted to compare AP with RY. Gastric cancer patients requiring total gastrectomy for R0 resection were randomly assigned during surgery to receive either RY (n = 51) or AP (n = 49). Postoperative QOL as assessed by the EORTC QLQ-C30 and STO22, body composition, and morbidity were compared between the two reconstruction methods. The physical functioning score of the QLQ-C30 was selected as the primary endpoint. RESULTS: The incidences of postoperative complications were similar between the two groups (29 % in the RY group and 27 % in the AP group). No significant difference was observed in the physical functioning score, and the superiority of AP was demonstrated only for the nausea and vomiting score at 12 months (p = 0.041) and the reflux score at 1 month (p = 0.036). No significant differences were observed in body composition or serum biochemistry. CONCLUSIONS: Although AP was safely implemented, no increased benefits in nutritional or QOL-related parameters were observed for this method over RY within 12 months postoperatively. More... »

PAGES

977-985

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10120-015-0529-5

    DOI

    http://dx.doi.org/10.1007/s10120-015-0529-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045956087

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26272278


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