Is preoperative staging enough to guide lymph node dissection in clinically early gastric cancer? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08-01

AUTHORS

Jia Xu, Hui Cao, Jun-Young Yang, Yun-Suhk Suh, Seong-Ho Kong, Se-Hyung Kim, Sang-Gyun Kim, Hyuk-Joon Lee, Woo-Ho Kim, Han-Kwang Yang

ABSTRACT

BackgroundLimited by the accuracy of preoperative staging, some cases of gastric cancer invading the muscularis propria (pT2) are underestimated as early gastric cancer (EGC) in the preoperative assessment. The aim of this present study was to determine prognostic factors and to propose indications for limited lymph node dissection in patients with clinically EGC (cEGC).MethodsPatients of cEGC (n = 2072) who were postoperatively diagnosed as pT1 (cT1pT1, n = 1858) and pT2 (cT1pT2, n = 214) from 2005 to 2009 at Seoul National University Hospital were retrospectively analyzed.ResultsThere was no difference in 5-year survival rate between the cT1pT1 and cT1pT2 group (95.5 % vs. 92.5 %, P = 0.059), and both groups had better overall survival than pT2 patients who were preoperatively diagnosed as locally advanced gastric cancer (cT2-4pT2), whose 5-year survival rate was 78.0 % (P < 0.001). Multivariate analysis indicated lymph node metastasis (LNM) was the independent prognostic factor for cEGC (P < 0.001). In cEGC patients, three preoperative factors, including N stage by multidetector-row computed tomography (MDCT) (P < 0.001), preoperative histological type (P < 0.001), and tumor size (P < 0.001), were associated with LNM by multivariate analysis. Regarding the possibility of LNM, low-risk (4.4 %) and high-risk (17.3 %) groups were developed based on weighted scores of the aforementioned independent three variables. Among 52 patients in the low-risk group, the extension of LNM was limited to the perigastric area.ConclusionsComprehensive evaluation based on MDCT, preoperative histological type, and tumor size is an effective method to predict LNM and guide tailored LN dissection for cEGC. More... »

PAGES

568-578

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10120-015-0512-1

DOI

http://dx.doi.org/10.1007/s10120-015-0512-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005872611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26231352


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Node Excision", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multidetector Computed Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Preoperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Korea", 
            "Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Jia", 
        "id": "sg:person.01342135454.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342135454.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Hui", 
        "id": "sg:person.01115321554.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115321554.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University Hospital, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Jun-Young", 
        "id": "sg:person.0766015756.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766015756.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University Hospital, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suh", 
        "givenName": "Yun-Suhk", 
        "id": "sg:person.010104503132.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010104503132.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Seoul National University Hospital, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kong", 
        "givenName": "Seong-Ho", 
        "id": "sg:person.01043154376.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043154376.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Radiology, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Se-Hyung", 
        "id": "sg:person.01134651464.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134651464.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sang-Gyun", 
        "id": "sg:person.016035435043.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035435043.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Korea", 
            "Department of Surgery, Seoul National University College of Medicine, 101 Daehang-Ro, Jongno-Gu, 110-744, Seoul, Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyuk-Joon", 
        "id": "sg:person.011242043254.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea", 
            "Department of Pathology, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Woo-Ho", 
        "id": "sg:person.016630576674.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Surgery, Seoul National University Hospital, Seoul, Korea", 
            "Department of Surgery, Seoul National University College of Medicine, 101 Daehang-Ro, Jongno-Gu, 110-744, Seoul, Korea", 
            "Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Han-Kwang", 
        "id": "sg:person.015267175234.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267175234.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10120-014-0378-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025516006", 
          "https://doi.org/10.1007/s10120-014-0378-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-011-1684-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022821394", 
          "https://doi.org/10.1007/s11605-011-1684-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-003-0266-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004739989", 
          "https://doi.org/10.1007/s10120-003-0266-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-31629-6_15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002206104", 
          "https://doi.org/10.1007/978-3-642-31629-6_15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00011681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030703112", 
          "https://doi.org/10.1007/pl00011681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-011-1051-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045348820", 
          "https://doi.org/10.1007/s00268-011-1051-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00464-014-3514-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044190428", 
          "https://doi.org/10.1007/s00464-014-3514-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-011-0042-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053291814", 
          "https://doi.org/10.1007/s10120-011-0042-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0404-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024272140", 
          "https://doi.org/10.1245/s10434-009-0404-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-013-3124-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053578299", 
          "https://doi.org/10.1245/s10434-013-3124-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-008-0476-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018920529", 
          "https://doi.org/10.1007/s10120-008-0476-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-008-0492-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015996637", 
          "https://doi.org/10.1007/s10120-008-0492-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-08-01", 
    "datePublishedReg": "2015-08-01", 
    "description": "BackgroundLimited by the accuracy of preoperative staging, some cases of gastric cancer invading the muscularis propria (pT2) are underestimated as early gastric cancer (EGC) in the preoperative assessment. The aim of this present study was to determine prognostic factors and to propose indications for limited lymph node dissection in patients with clinically EGC (cEGC).MethodsPatients of cEGC (n\u00a0=\u00a02072) who were postoperatively diagnosed as pT1 (cT1pT1, n\u00a0=\u00a01858) and pT2 (cT1pT2, n\u00a0=\u00a0214) from 2005 to 2009 at Seoul National University Hospital were retrospectively analyzed.ResultsThere was no difference in 5-year survival rate between the cT1pT1 and cT1pT2 group (95.5\u00a0% vs. 92.5\u00a0%, P\u00a0=\u00a00.059), and both groups had better overall survival than pT2 patients who were preoperatively diagnosed as locally advanced gastric cancer (cT2-4pT2), whose 5-year survival rate was 78.0\u00a0% (P\u00a0<\u00a00.001). Multivariate analysis indicated lymph node metastasis (LNM) was the independent prognostic factor for cEGC (P\u00a0<\u00a00.001). In cEGC patients, three preoperative factors, including N stage by multidetector-row computed tomography (MDCT) (P\u00a0<\u00a00.001), preoperative histological type (P\u00a0<\u00a00.001), and tumor size (P\u00a0<\u00a00.001), were associated with LNM by multivariate analysis. Regarding the possibility of LNM, low-risk (4.4\u00a0%) and high-risk (17.3\u00a0%) groups were developed based on weighted scores of the aforementioned independent three variables. Among 52 patients in the low-risk group, the extension of LNM was limited to the perigastric area.ConclusionsComprehensive evaluation based on MDCT, preoperative histological type, and tumor size is an effective method to predict LNM and guide tailored LN dissection for cEGC.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10120-015-0512-1", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1020959", 
        "issn": [
          "1436-3291", 
          "1436-3305"
        ], 
        "name": "Gastric Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "lymph node metastasis", 
      "early gastric cancer", 
      "lymph node dissection", 
      "gastric cancer", 
      "node dissection", 
      "prognostic factors", 
      "preoperative staging", 
      "histological type", 
      "tumor size", 
      "possibility of LNM", 
      "survival rate", 
      "multivariate analysis", 
      "limited lymph node dissection", 
      "Seoul National University Hospital", 
      "better overall survival", 
      "advanced gastric cancer", 
      "independent prognostic factor", 
      "National University Hospital", 
      "high-risk group", 
      "low-risk group", 
      "LN dissection", 
      "preoperative factors", 
      "overall survival", 
      "pT2 patients", 
      "node metastasis", 
      "preoperative assessment", 
      "perigastric area", 
      "muscularis propria", 
      "University Hospital", 
      "patients", 
      "cEGC", 
      "cancer", 
      "dissection", 
      "staging", 
      "present study", 
      "weighted score", 
      "group", 
      "MethodsPatients", 
      "ResultsThere", 
      "metastasis", 
      "propria", 
      "hospital", 
      "MDCT", 
      "factors", 
      "pT1", 
      "survival", 
      "tomography", 
      "scores", 
      "indications", 
      "rate", 
      "pT2", 
      "aim", 
      "effective method", 
      "assessment", 
      "differences", 
      "cases", 
      "evaluation", 
      "study", 
      "types", 
      "analysis", 
      "stage", 
      "variables", 
      "size", 
      "area", 
      "possibility", 
      "method", 
      "extension", 
      "accuracy"
    ], 
    "name": "Is preoperative staging enough to guide lymph node dissection in clinically early gastric cancer?", 
    "pagination": "568-578", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005872611"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10120-015-0512-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26231352"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10120-015-0512-1", 
      "https://app.dimensions.ai/details/publication/pub.1005872611"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_657.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10120-015-0512-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10120-015-0512-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10120-015-0512-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10120-015-0512-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10120-015-0512-1'


 

This table displays all metadata directly associated to this object as RDF triples.

315 TRIPLES      21 PREDICATES      120 URIs      100 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10120-015-0512-1 schema:about N02390cd82cf74dda8414ed448f16870d
2 N0a498067eb284ce6afc579eb1e8abc6f
3 N1af42861bfe84da1a2c6a0dbf9029c43
4 N1e1ece753dcc4d4695f5bd3613b703af
5 N2729afedfb884ef3b6a43fbf3f773adf
6 N68a0a7c7a7cb4a56ba8343465b45cb7b
7 N6c8ac313e357420088fed35166b73061
8 N73e9f2b436234f0692bc603375de92f2
9 N8b86e06dd2d847069f51650ed6e54812
10 Na39cbfa46b504c3c9725cb918ccd9101
11 Nb131be9435994e1297b947fe82d321bc
12 Nc6bf8cc850bd4fdb8b73a195fa25b170
13 Nd1622e15967942fcbd6e599507aafacc
14 Nd8a824d190814587b867113a7edce02e
15 Nf1090b5052ec4d6caa1c29c7d0c2063f
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author Nbbffb18b7d554494952b9d62a4c4ec62
19 schema:citation sg:pub.10.1007/978-3-642-31629-6_15
20 sg:pub.10.1007/pl00011681
21 sg:pub.10.1007/s00268-011-1051-5
22 sg:pub.10.1007/s00464-014-3514-x
23 sg:pub.10.1007/s10120-003-0266-z
24 sg:pub.10.1007/s10120-008-0476-5
25 sg:pub.10.1007/s10120-008-0492-5
26 sg:pub.10.1007/s10120-011-0042-4
27 sg:pub.10.1007/s10120-014-0378-7
28 sg:pub.10.1007/s11605-011-1684-6
29 sg:pub.10.1245/s10434-009-0404-x
30 sg:pub.10.1245/s10434-013-3124-1
31 schema:datePublished 2015-08-01
32 schema:datePublishedReg 2015-08-01
33 schema:description BackgroundLimited by the accuracy of preoperative staging, some cases of gastric cancer invading the muscularis propria (pT2) are underestimated as early gastric cancer (EGC) in the preoperative assessment. The aim of this present study was to determine prognostic factors and to propose indications for limited lymph node dissection in patients with clinically EGC (cEGC).MethodsPatients of cEGC (n = 2072) who were postoperatively diagnosed as pT1 (cT1pT1, n = 1858) and pT2 (cT1pT2, n = 214) from 2005 to 2009 at Seoul National University Hospital were retrospectively analyzed.ResultsThere was no difference in 5-year survival rate between the cT1pT1 and cT1pT2 group (95.5 % vs. 92.5 %, P = 0.059), and both groups had better overall survival than pT2 patients who were preoperatively diagnosed as locally advanced gastric cancer (cT2-4pT2), whose 5-year survival rate was 78.0 % (P < 0.001). Multivariate analysis indicated lymph node metastasis (LNM) was the independent prognostic factor for cEGC (P < 0.001). In cEGC patients, three preoperative factors, including N stage by multidetector-row computed tomography (MDCT) (P < 0.001), preoperative histological type (P < 0.001), and tumor size (P < 0.001), were associated with LNM by multivariate analysis. Regarding the possibility of LNM, low-risk (4.4 %) and high-risk (17.3 %) groups were developed based on weighted scores of the aforementioned independent three variables. Among 52 patients in the low-risk group, the extension of LNM was limited to the perigastric area.ConclusionsComprehensive evaluation based on MDCT, preoperative histological type, and tumor size is an effective method to predict LNM and guide tailored LN dissection for cEGC.
34 schema:genre article
35 schema:isAccessibleForFree true
36 schema:isPartOf N7f7f80f0e21c42a1abaf31cca51a54b4
37 Nbf6faf88e2784517a6c4041dc18ae2a0
38 sg:journal.1020959
39 schema:keywords LN dissection
40 MDCT
41 MethodsPatients
42 National University Hospital
43 ResultsThere
44 Seoul National University Hospital
45 University Hospital
46 accuracy
47 advanced gastric cancer
48 aim
49 analysis
50 area
51 assessment
52 better overall survival
53 cEGC
54 cancer
55 cases
56 differences
57 dissection
58 early gastric cancer
59 effective method
60 evaluation
61 extension
62 factors
63 gastric cancer
64 group
65 high-risk group
66 histological type
67 hospital
68 independent prognostic factor
69 indications
70 limited lymph node dissection
71 low-risk group
72 lymph node dissection
73 lymph node metastasis
74 metastasis
75 method
76 multivariate analysis
77 muscularis propria
78 node dissection
79 node metastasis
80 overall survival
81 pT1
82 pT2
83 pT2 patients
84 patients
85 perigastric area
86 possibility
87 possibility of LNM
88 preoperative assessment
89 preoperative factors
90 preoperative staging
91 present study
92 prognostic factors
93 propria
94 rate
95 scores
96 size
97 stage
98 staging
99 study
100 survival
101 survival rate
102 tomography
103 tumor size
104 types
105 variables
106 weighted score
107 schema:name Is preoperative staging enough to guide lymph node dissection in clinically early gastric cancer?
108 schema:pagination 568-578
109 schema:productId N3aed9402a67045f5bc47259b3e16f51e
110 N8686810e2cc444d2956ebea6b496e28b
111 Ne82396f2932f440c96b70ecceda3f4cf
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005872611
113 https://doi.org/10.1007/s10120-015-0512-1
114 schema:sdDatePublished 2022-10-01T06:40
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher Nde39fb30f54a42f48f0c1015cbfde1d3
117 schema:url https://doi.org/10.1007/s10120-015-0512-1
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N02390cd82cf74dda8414ed448f16870d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N0a498067eb284ce6afc579eb1e8abc6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Kaplan-Meier Estimate
126 rdf:type schema:DefinedTerm
127 N1af42861bfe84da1a2c6a0dbf9029c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Survival Rate
129 rdf:type schema:DefinedTerm
130 N1e1ece753dcc4d4695f5bd3613b703af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Treatment Outcome
132 rdf:type schema:DefinedTerm
133 N2729afedfb884ef3b6a43fbf3f773adf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Aged
135 rdf:type schema:DefinedTerm
136 N3aed9402a67045f5bc47259b3e16f51e schema:name doi
137 schema:value 10.1007/s10120-015-0512-1
138 rdf:type schema:PropertyValue
139 N4302d68765da4897bee39c6c6f752c43 rdf:first sg:person.01115321554.40
140 rdf:rest Nfd94053a2d6049af8063b4b3229c886d
141 N4b439a81fdb2489cbd5df95bceff268c rdf:first sg:person.010104503132.76
142 rdf:rest N6dff42c845ee443388134eb48a181983
143 N68a0a7c7a7cb4a56ba8343465b45cb7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Lymphatic Metastasis
145 rdf:type schema:DefinedTerm
146 N6c8ac313e357420088fed35166b73061 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Preoperative Care
148 rdf:type schema:DefinedTerm
149 N6dff42c845ee443388134eb48a181983 rdf:first sg:person.01043154376.87
150 rdf:rest N7a572074116e4d3d9e9f94dcb02527b1
151 N73e9f2b436234f0692bc603375de92f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Multidetector Computed Tomography
153 rdf:type schema:DefinedTerm
154 N7a572074116e4d3d9e9f94dcb02527b1 rdf:first sg:person.01134651464.00
155 rdf:rest N94461bdd700e4facba255767c1ea28e3
156 N7f7f80f0e21c42a1abaf31cca51a54b4 schema:issueNumber 2
157 rdf:type schema:PublicationIssue
158 N7f88e825c50f45f987e2496bb190c345 rdf:first sg:person.016630576674.47
159 rdf:rest Ndda6676d33274dc5832366d6f52d4021
160 N8686810e2cc444d2956ebea6b496e28b schema:name pubmed_id
161 schema:value 26231352
162 rdf:type schema:PropertyValue
163 N8b86e06dd2d847069f51650ed6e54812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Female
165 rdf:type schema:DefinedTerm
166 N94461bdd700e4facba255767c1ea28e3 rdf:first sg:person.016035435043.00
167 rdf:rest Nd038e48609a0460480ca42a677e71d7c
168 Na39cbfa46b504c3c9725cb918ccd9101 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Retrospective Studies
170 rdf:type schema:DefinedTerm
171 Nb131be9435994e1297b947fe82d321bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Male
173 rdf:type schema:DefinedTerm
174 Nbbffb18b7d554494952b9d62a4c4ec62 rdf:first sg:person.01342135454.14
175 rdf:rest N4302d68765da4897bee39c6c6f752c43
176 Nbf6faf88e2784517a6c4041dc18ae2a0 schema:volumeNumber 19
177 rdf:type schema:PublicationVolume
178 Nc6bf8cc850bd4fdb8b73a195fa25b170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Prognosis
180 rdf:type schema:DefinedTerm
181 Nd038e48609a0460480ca42a677e71d7c rdf:first sg:person.011242043254.34
182 rdf:rest N7f88e825c50f45f987e2496bb190c345
183 Nd1622e15967942fcbd6e599507aafacc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Middle Aged
185 rdf:type schema:DefinedTerm
186 Nd8a824d190814587b867113a7edce02e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Lymph Node Excision
188 rdf:type schema:DefinedTerm
189 Ndda6676d33274dc5832366d6f52d4021 rdf:first sg:person.015267175234.94
190 rdf:rest rdf:nil
191 Nde39fb30f54a42f48f0c1015cbfde1d3 schema:name Springer Nature - SN SciGraph project
192 rdf:type schema:Organization
193 Ne82396f2932f440c96b70ecceda3f4cf schema:name dimensions_id
194 schema:value pub.1005872611
195 rdf:type schema:PropertyValue
196 Nf1090b5052ec4d6caa1c29c7d0c2063f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Stomach Neoplasms
198 rdf:type schema:DefinedTerm
199 Nfd94053a2d6049af8063b4b3229c886d rdf:first sg:person.0766015756.03
200 rdf:rest N4b439a81fdb2489cbd5df95bceff268c
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
205 schema:name Oncology and Carcinogenesis
206 rdf:type schema:DefinedTerm
207 sg:journal.1020959 schema:issn 1436-3291
208 1436-3305
209 schema:name Gastric Cancer
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.010104503132.76 schema:affiliation grid-institutes:grid.412484.f
213 schema:familyName Suh
214 schema:givenName Yun-Suhk
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010104503132.76
216 rdf:type schema:Person
217 sg:person.01043154376.87 schema:affiliation grid-institutes:grid.412484.f
218 schema:familyName Kong
219 schema:givenName Seong-Ho
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043154376.87
221 rdf:type schema:Person
222 sg:person.01115321554.40 schema:affiliation grid-institutes:grid.16821.3c
223 schema:familyName Cao
224 schema:givenName Hui
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115321554.40
226 rdf:type schema:Person
227 sg:person.011242043254.34 schema:affiliation grid-institutes:grid.31501.36
228 schema:familyName Lee
229 schema:givenName Hyuk-Joon
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34
231 rdf:type schema:Person
232 sg:person.01134651464.00 schema:affiliation grid-institutes:grid.31501.36
233 schema:familyName Kim
234 schema:givenName Se-Hyung
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134651464.00
236 rdf:type schema:Person
237 sg:person.01342135454.14 schema:affiliation grid-institutes:grid.16821.3c
238 schema:familyName Xu
239 schema:givenName Jia
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342135454.14
241 rdf:type schema:Person
242 sg:person.015267175234.94 schema:affiliation grid-institutes:grid.31501.36
243 schema:familyName Yang
244 schema:givenName Han-Kwang
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267175234.94
246 rdf:type schema:Person
247 sg:person.016035435043.00 schema:affiliation grid-institutes:grid.31501.36
248 schema:familyName Kim
249 schema:givenName Sang-Gyun
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035435043.00
251 rdf:type schema:Person
252 sg:person.016630576674.47 schema:affiliation grid-institutes:grid.31501.36
253 schema:familyName Kim
254 schema:givenName Woo-Ho
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47
256 rdf:type schema:Person
257 sg:person.0766015756.03 schema:affiliation grid-institutes:grid.412484.f
258 schema:familyName Yang
259 schema:givenName Jun-Young
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766015756.03
261 rdf:type schema:Person
262 sg:pub.10.1007/978-3-642-31629-6_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002206104
263 https://doi.org/10.1007/978-3-642-31629-6_15
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/pl00011681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030703112
266 https://doi.org/10.1007/pl00011681
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s00268-011-1051-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045348820
269 https://doi.org/10.1007/s00268-011-1051-5
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s00464-014-3514-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044190428
272 https://doi.org/10.1007/s00464-014-3514-x
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s10120-003-0266-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004739989
275 https://doi.org/10.1007/s10120-003-0266-z
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s10120-008-0476-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018920529
278 https://doi.org/10.1007/s10120-008-0476-5
279 rdf:type schema:CreativeWork
280 sg:pub.10.1007/s10120-008-0492-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015996637
281 https://doi.org/10.1007/s10120-008-0492-5
282 rdf:type schema:CreativeWork
283 sg:pub.10.1007/s10120-011-0042-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053291814
284 https://doi.org/10.1007/s10120-011-0042-4
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s10120-014-0378-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025516006
287 https://doi.org/10.1007/s10120-014-0378-7
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s11605-011-1684-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022821394
290 https://doi.org/10.1007/s11605-011-1684-6
291 rdf:type schema:CreativeWork
292 sg:pub.10.1245/s10434-009-0404-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024272140
293 https://doi.org/10.1245/s10434-009-0404-x
294 rdf:type schema:CreativeWork
295 sg:pub.10.1245/s10434-013-3124-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053578299
296 https://doi.org/10.1245/s10434-013-3124-1
297 rdf:type schema:CreativeWork
298 grid-institutes:grid.16821.3c schema:alternateName Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
299 schema:name Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
300 Department of Surgery, Seoul National University Hospital, Seoul, Korea
301 rdf:type schema:Organization
302 grid-institutes:grid.31501.36 schema:alternateName Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
303 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
304 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
305 Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
306 schema:name Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
307 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
308 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
309 Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
310 Department of Surgery, Seoul National University College of Medicine, 101 Daehang-Ro, Jongno-Gu, 110-744, Seoul, Korea
311 Department of Surgery, Seoul National University Hospital, Seoul, Korea
312 rdf:type schema:Organization
313 grid-institutes:grid.412484.f schema:alternateName Department of Surgery, Seoul National University Hospital, Seoul, Korea
314 schema:name Department of Surgery, Seoul National University Hospital, Seoul, Korea
315 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...