Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-06-25

AUTHORS

Gotaro Masuda, Akira Tokunaga, Takashi Shirakawa, Akiyoshi Togashi, Teruo Kiyama, Shunji Kato, Norio Matsukura, Hideki Bou, Masanori Watanabe, Takashi Tajiri

ABSTRACT

BackgroundGastric cancers in young adults are thought to be associated with risk factors that include Helicobacter pylori infection and genetic polymorphism. The objective of this study was to elucidate the roles of these risk factors in patients younger than 40 years by analyzing clinicopathological data and H. pylori infection, and using molecular epidemiologic techniques.MethodsClinicopathological features, the presence of H. pylori infection, endoscopic characteristics of gastritis, genetic polymorphism of P4502E1 (CYP2E1), and family history of cancer in patients with gastric cancer treated surgically at Nippon Medical School Hospital from 1991 to 2004 were analyzed, based on our medical database.ResultsGastric cancer in those younger than 40 years was characterized by a predominance of female patients with poorly differentiated adenocarcinoma who had undergone total gastrectomy with extended lymphadenectomy. H. pylori infection had a higher prevalence in patients with gastric cancer than in patients with normal endoscopic results or chronic gastritis, especially in those younger than 40 years (odds ratio, 13.7). Atrophic gastritis, nodular gastritis, and rugal hyperplastic gastritis were observed by endoscopy as H. pylori-associated gastritis. No difference in the incidence of either CYP2E1 genetic polymorphism or a family history of cancer was observed among different age groups.ConclusionGastric cancer in patients younger than 40 years is closely associated with H. pylori infection, but not with genetic characteristics. Eradication therapy for H. pylori and endoscopic examination of H. pylori-positive young adults may be anticipated to be adopted as a strategy for the prevention and/or early detection of cancer. More... »

PAGES

98-103

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10120-007-0414-y

DOI

http://dx.doi.org/10.1007/s10120-007-0414-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040755419

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17577619


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40 schema:description BackgroundGastric cancers in young adults are thought to be associated with risk factors that include Helicobacter pylori infection and genetic polymorphism. The objective of this study was to elucidate the roles of these risk factors in patients younger than 40 years by analyzing clinicopathological data and H. pylori infection, and using molecular epidemiologic techniques.MethodsClinicopathological features, the presence of H. pylori infection, endoscopic characteristics of gastritis, genetic polymorphism of P4502E1 (CYP2E1), and family history of cancer in patients with gastric cancer treated surgically at Nippon Medical School Hospital from 1991 to 2004 were analyzed, based on our medical database.ResultsGastric cancer in those younger than 40 years was characterized by a predominance of female patients with poorly differentiated adenocarcinoma who had undergone total gastrectomy with extended lymphadenectomy. H. pylori infection had a higher prevalence in patients with gastric cancer than in patients with normal endoscopic results or chronic gastritis, especially in those younger than 40 years (odds ratio, 13.7). Atrophic gastritis, nodular gastritis, and rugal hyperplastic gastritis were observed by endoscopy as H. pylori-associated gastritis. No difference in the incidence of either CYP2E1 genetic polymorphism or a family history of cancer was observed among different age groups.ConclusionGastric cancer in patients younger than 40 years is closely associated with H. pylori infection, but not with genetic characteristics. Eradication therapy for H. pylori and endoscopic examination of H. pylori-positive young adults may be anticipated to be adopted as a strategy for the prevention and/or early detection of cancer.
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46 schema:keywords BackgroundGastric cancer
47 CYP2E1
48 CYP2E1 genetic polymorphisms
49 ConclusionGastric cancer
50 H. pylori
51 H. pylori infection
52 H. pylori-associated gastritis
53 Helicobacter pylori infection
54 Medical School Hospital
55 Nippon Medical School Hospital
56 P4502E1
57 School Hospital
58 adenocarcinoma
59 adults
60 age groups
61 atrophic gastritis
62 cancer
63 cancer patients
64 characteristics
65 chronic gastritis
66 clinicopathological data
67 data
68 database
69 detection
70 differences
71 different age groups
72 early detection
73 endoscopic characteristics
74 endoscopic examination
75 endoscopic results
76 endoscopy
77 epidemiologic techniques
78 eradication therapy
79 examination
80 extended lymphadenectomy
81 factors
82 family history
83 female patients
84 gastrectomy
85 gastric cancer
86 gastric cancer patients
87 gastritis
88 genetic characteristics
89 genetic polymorphisms
90 group
91 high prevalence
92 history
93 hospital
94 hyperplastic gastritis
95 incidence
96 infection
97 lymphadenectomy
98 medical databases
99 molecular epidemiologic techniques
100 nodular gastritis
101 normal endoscopic results
102 objective
103 patients
104 polymorphism
105 predominance
106 presence
107 prevalence
108 prevention
109 pylori
110 pylori infection
111 results
112 risk factors
113 role
114 rugal hyperplastic gastritis
115 strategies
116 study
117 technique
118 therapy
119 total gastrectomy
120 years
121 young adults
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