Phase II multicenter trial of docetaxel, epirubicin, and 5-fluorouracil (DEF) in the treatment of advanced gastric cancer: a novel, safe, ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-05

AUTHORS

André M. Murad, Nils G. Skare, Jéferson Vinholes, Sérgio Lago, Ricardo Pecego, Brazilian Gastric Cancer Study Group, Belo Horizonte, MG, Brazil

ABSTRACT

BACKGROUND: This study evaluated the efficacy and safety of docetaxel, epirubicin, and 5-fluorouracil (5-FU) [DEF] as treatment for locally advanced unresectable or metastatic gastric cancer. METHODS: Thirty-seven patients participated in the study (median age, 56 years; range, 22-73 years); Eastern Cooperative Oncology Group performance status [PS], 0-2). Docetaxel 75 mg/m2 IV (day 1), 5-FU 500 mg/m2 IV (days 1-3), and epirubicin 50 mg/m2 IV (day 1) were administered every 3 weeks for six cycles. RESULTS: In total, 20/37 patients (54%) completed six treatment cycles. Thirteen patients (35%; 95% confidence intervals [CI], 20% to 51%) had an objective response; 1 patient (3%) achieved a complete response and 12 patients (32%) achieved partial responses. Stable disease was observed in 7 patients (19%) and progressive disease in 5 patients (14%). Twelve patients (32%) were unevaluable. Clinical benefit (based on PS, weight gain, and analgesic consumption) was observed in 11 patients (30%). Median follow-up was 41 months (range, 26-53 months), median time to progression was 6.6 months (range, 0.5-29.2 months), median overall survival was 10.7 months (range, 7.0-14.6 months), and 1-year survival was 40%. The regimen was well tolerated. Grade 3-4 febrile neutropenia occurred in 8 patients (22%; 6% of cycles) and grade 3-4 neutropenia in 1 patient (1% of cycles). The most frequent grade 3-4 toxicities were alopecia (11% of cycles), diarrhea (4% of cycles) and vomiting (2% of cycles); grade 1-2 asthenia and fatigue occurred in 43% of cycles. CONCLUSION: DEF is effective in the treatment of advanced gastric cancer, and has a good safety profile. More... »

PAGES

99-105

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10120-006-0361-z

DOI

http://dx.doi.org/10.1007/s10120-006-0361-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002334226

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16767365


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Docetaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epirubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taxoids", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais", 
          "id": "https://www.grid.ac/institutes/grid.500232.6", 
          "name": [
            "Oncology Department, Hospital das Clinicas Universidade Federal de Minas Gerais, Rua Piaui 150, 30150-320, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murad", 
        "givenName": "Andr\u00e9 M.", 
        "id": "sg:person.01160627314.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160627314.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Erasto Gaertner", 
          "id": "https://www.grid.ac/institutes/grid.459527.8", 
          "name": [
            "Hospital Erasto Gaertner, Centro de Projetos de Ensino e Pesquisa, Liga Paranaense de Combate ao C\u00e2ncer, Curitiba, PR, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skare", 
        "givenName": "Nils G.", 
        "id": "sg:person.011770272266.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011770272266.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Unidade de Apoio \u00e0 Pesquisa, Porto Alegre, RS, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vinholes", 
        "givenName": "J\u00e9ferson", 
        "id": "sg:person.0602365724.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602365724.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hospital S\u00e3o Lucas \u2014 PUC-RGS, Porto Alegre, RS, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lago", 
        "givenName": "S\u00e9rgio", 
        "id": "sg:person.0670644343.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670644343.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal de Goi\u00e1s", 
          "id": "https://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Hospital das Cl\u00ednicas da UFG, Goi\u00e2nia, GO, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pecego", 
        "givenName": "Ricardo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais", 
          "id": "https://www.grid.ac/institutes/grid.500232.6", 
          "name": [
            "Oncology Department, Hospital das Clinicas Universidade Federal de Minas Gerais, Rua Piaui 150, 30150-320, Belo Horizonte, MG, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brazilian Gastric Cancer Study Group, Belo Horizonte, MG, Brazil", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1994.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008377050", 
          "https://doi.org/10.1038/bjc.1994.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008377050", 
          "https://doi.org/10.1038/bjc.1994.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02993858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010768027", 
          "https://doi.org/10.1007/bf02993858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02993858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010768027", 
          "https://doi.org/10.1007/bf02993858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-200206000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011963622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-200206000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011963622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19961101)78:9<1888::aid-cncr7>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013223002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02074-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013379406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0305-7372(93)90025-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020204712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020520952", 
          "https://doi.org/10.1054/bjoc.2000.1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyf057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027589509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<295::aid-cncr5>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034301343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.9-suppl_2-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044476568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930615)71:12<3813::aid-cncr2820711205>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045322933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/86.14.1086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1985.03350380077025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052251415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.253.14.2061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054145094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008328501128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008342013224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/2.suppl_2.229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059393185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/5.suppl_3.s33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059393431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199808000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199808000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199808000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199912000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199912000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-199912000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060113948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-200008000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060114035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-200008000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060114035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-200008000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060114035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074272175", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327489900600406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074620859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.14.2648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074667554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apm.1965.64.1.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076424426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1992.10.4.541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076951209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077032249", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1991.9.5.827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078050257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a057914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078154101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1994.12.12.2687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082597539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a058686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082685627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.1.261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083031491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083196221", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083300540", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083339874", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-05", 
    "datePublishedReg": "2006-05-01", 
    "description": "BACKGROUND: This study evaluated the efficacy and safety of docetaxel, epirubicin, and 5-fluorouracil (5-FU) [DEF] as treatment for locally advanced unresectable or metastatic gastric cancer.\nMETHODS: Thirty-seven patients participated in the study (median age, 56 years; range, 22-73 years); Eastern Cooperative Oncology Group performance status [PS], 0-2). Docetaxel 75 mg/m2 IV (day 1), 5-FU 500 mg/m2 IV (days 1-3), and epirubicin 50 mg/m2 IV (day 1) were administered every 3 weeks for six cycles.\nRESULTS: In total, 20/37 patients (54%) completed six treatment cycles. Thirteen patients (35%; 95% confidence intervals [CI], 20% to 51%) had an objective response; 1 patient (3%) achieved a complete response and 12 patients (32%) achieved partial responses. Stable disease was observed in 7 patients (19%) and progressive disease in 5 patients (14%). Twelve patients (32%) were unevaluable. Clinical benefit (based on PS, weight gain, and analgesic consumption) was observed in 11 patients (30%). Median follow-up was 41 months (range, 26-53 months), median time to progression was 6.6 months (range, 0.5-29.2 months), median overall survival was 10.7 months (range, 7.0-14.6 months), and 1-year survival was 40%. The regimen was well tolerated. Grade 3-4 febrile neutropenia occurred in 8 patients (22%; 6% of cycles) and grade 3-4 neutropenia in 1 patient (1% of cycles). The most frequent grade 3-4 toxicities were alopecia (11% of cycles), diarrhea (4% of cycles) and vomiting (2% of cycles); grade 1-2 asthenia and fatigue occurred in 43% of cycles.\nCONCLUSION: DEF is effective in the treatment of advanced gastric cancer, and has a good safety profile.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10120-006-0361-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1020959", 
        "issn": [
          "1436-3291", 
          "1436-3305"
        ], 
        "name": "Gastric Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Phase II multicenter trial of docetaxel, epirubicin, and 5-fluorouracil (DEF) in the treatment of advanced gastric cancer: a novel, safe, and active regimen", 
    "pagination": "99-105", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0b1d2d207c1d2e08d3a7eae72304dcfa70f141e01b6deabc7442dd547f468a44"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16767365"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100886238"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10120-006-0361-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002334226"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10120-006-0361-z", 
      "https://app.dimensions.ai/details/publication/pub.1002334226"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13081_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10120-006-0361-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10120-006-0361-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10120-006-0361-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10120-006-0361-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10120-006-0361-z'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      80 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10120-006-0361-z schema:about N0cd9df80c0c443c0841cb7c09bda8c74
2 N3a63bb4189fd4ac4a91b9db9d4e557fb
3 N3f8339614fae4caa83182e8aecb79cb6
4 N42bdeedf083b4b51bfd65f6f0fbf5749
5 N5e64b63eff9546de919aba5dcbe9b56a
6 N63375e4747ce4b538eedeff2bc461c8b
7 N86435bb135174504a2ec16bc85ccd8c7
8 N864c62232694434e8440adc3ef172de0
9 N8eeefb39658b4b4c9bb2ad500f9de5aa
10 Nb26c17cfba89492bb5a9197a843ee245
11 Nb437ca6890844d57bdd9d8c348e44e53
12 Nc19475b5863e4deca77baaef0e5c6b65
13 Ncc44eb6507134434b5838a55e5fb2cc5
14 Nd7d9c562138d492eb7cde483640bf8d3
15 Ne8ba1b809f174ce2b27f339ca2e24525
16 Neff704c20a864fea9f69e1a5b7149f14
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N989c8041365e4406b43431059a84cdbf
20 schema:citation sg:pub.10.1007/bf02993858
21 sg:pub.10.1038/bjc.1994.310
22 sg:pub.10.1054/bjoc.2000.1631
23 https://app.dimensions.ai/details/publication/pub.1074272175
24 https://app.dimensions.ai/details/publication/pub.1077032249
25 https://app.dimensions.ai/details/publication/pub.1083196221
26 https://app.dimensions.ai/details/publication/pub.1083300540
27 https://app.dimensions.ai/details/publication/pub.1083339874
28 https://doi.org/10.1001/jama.1985.03350380077025
29 https://doi.org/10.1001/jama.253.14.2061
30 https://doi.org/10.1002/(sici)1097-0142(19961101)78:9<1888::aid-cncr7>3.0.co;2-b
31 https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<295::aid-cncr5>3.0.co;2-h
32 https://doi.org/10.1002/1097-0142(19930615)71:12<3813::aid-cncr2820711205>3.0.co;2-5
33 https://doi.org/10.1016/0305-7372(93)90025-m
34 https://doi.org/10.1016/s0140-6736(00)02074-2
35 https://doi.org/10.1023/a:1008328501128
36 https://doi.org/10.1023/a:1008342013224
37 https://doi.org/10.1093/annonc/2.suppl_2.229
38 https://doi.org/10.1093/annonc/5.suppl_3.s33
39 https://doi.org/10.1093/jjco/hyf057
40 https://doi.org/10.1093/jnci/86.14.1086
41 https://doi.org/10.1093/oxfordjournals.annonc.a057914
42 https://doi.org/10.1093/oxfordjournals.annonc.a058686
43 https://doi.org/10.1097/00000421-199808000-00021
44 https://doi.org/10.1097/00000421-199912000-00008
45 https://doi.org/10.1097/00000421-200008000-00005
46 https://doi.org/10.1097/00001813-200206000-00008
47 https://doi.org/10.1111/apm.1965.64.1.31
48 https://doi.org/10.1177/107327489900600406
49 https://doi.org/10.1200/jco.1991.9.5.827
50 https://doi.org/10.1200/jco.1992.10.4.541
51 https://doi.org/10.1200/jco.1994.12.12.2687
52 https://doi.org/10.1200/jco.1997.15.1.261
53 https://doi.org/10.1200/jco.2000.18.14.2648
54 https://doi.org/10.1634/theoncologist.9-suppl_2-9
55 schema:datePublished 2006-05
56 schema:datePublishedReg 2006-05-01
57 schema:description BACKGROUND: This study evaluated the efficacy and safety of docetaxel, epirubicin, and 5-fluorouracil (5-FU) [DEF] as treatment for locally advanced unresectable or metastatic gastric cancer. METHODS: Thirty-seven patients participated in the study (median age, 56 years; range, 22-73 years); Eastern Cooperative Oncology Group performance status [PS], 0-2). Docetaxel 75 mg/m2 IV (day 1), 5-FU 500 mg/m2 IV (days 1-3), and epirubicin 50 mg/m2 IV (day 1) were administered every 3 weeks for six cycles. RESULTS: In total, 20/37 patients (54%) completed six treatment cycles. Thirteen patients (35%; 95% confidence intervals [CI], 20% to 51%) had an objective response; 1 patient (3%) achieved a complete response and 12 patients (32%) achieved partial responses. Stable disease was observed in 7 patients (19%) and progressive disease in 5 patients (14%). Twelve patients (32%) were unevaluable. Clinical benefit (based on PS, weight gain, and analgesic consumption) was observed in 11 patients (30%). Median follow-up was 41 months (range, 26-53 months), median time to progression was 6.6 months (range, 0.5-29.2 months), median overall survival was 10.7 months (range, 7.0-14.6 months), and 1-year survival was 40%. The regimen was well tolerated. Grade 3-4 febrile neutropenia occurred in 8 patients (22%; 6% of cycles) and grade 3-4 neutropenia in 1 patient (1% of cycles). The most frequent grade 3-4 toxicities were alopecia (11% of cycles), diarrhea (4% of cycles) and vomiting (2% of cycles); grade 1-2 asthenia and fatigue occurred in 43% of cycles. CONCLUSION: DEF is effective in the treatment of advanced gastric cancer, and has a good safety profile.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N4986cfb89bbb403a98b4dfe38ac8280e
62 N94d19e1726404288a328b50dcf4a6e3e
63 sg:journal.1020959
64 schema:name Phase II multicenter trial of docetaxel, epirubicin, and 5-fluorouracil (DEF) in the treatment of advanced gastric cancer: a novel, safe, and active regimen
65 schema:pagination 99-105
66 schema:productId N515c39451fa647338ce6f79641905afc
67 N61709d8adb94441085c50eaeee7e5dc6
68 N79e861bc405f492aa940722a76fd0058
69 N91120e5b825c4fae92c96a03e9c22dd3
70 Ndbf984306fdf4b779bd68fceba5d432b
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002334226
72 https://doi.org/10.1007/s10120-006-0361-z
73 schema:sdDatePublished 2019-04-11T14:28
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N875be22b71794c41aedff4d837a3ae3a
76 schema:url http://link.springer.com/10.1007/s10120-006-0361-z
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0775ab1b15374f16b45be367071b0957 rdf:first sg:person.0602365724.96
81 rdf:rest N293cef35086c448fbfb4e8946334ebca
82 N0cd9df80c0c443c0841cb7c09bda8c74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Fluorouracil
84 rdf:type schema:DefinedTerm
85 N0fa8a179dce24af9bd01f3641b9a15ff rdf:first N72dd560c15a74c37afcf2e761218cce3
86 rdf:rest Nb70bc757f9c54a8cab19378661376c21
87 N16d60e6d52084567bc57d6b4b787b5dd schema:name Hospital São Lucas — PUC-RGS, Porto Alegre, RS, Brazil
88 rdf:type schema:Organization
89 N293cef35086c448fbfb4e8946334ebca rdf:first sg:person.0670644343.89
90 rdf:rest N0fa8a179dce24af9bd01f3641b9a15ff
91 N3a63bb4189fd4ac4a91b9db9d4e557fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Epirubicin
93 rdf:type schema:DefinedTerm
94 N3f8339614fae4caa83182e8aecb79cb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Stomach Neoplasms
96 rdf:type schema:DefinedTerm
97 N42bdeedf083b4b51bfd65f6f0fbf5749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Adolescent
99 rdf:type schema:DefinedTerm
100 N4986cfb89bbb403a98b4dfe38ac8280e schema:issueNumber 2
101 rdf:type schema:PublicationIssue
102 N515c39451fa647338ce6f79641905afc schema:name dimensions_id
103 schema:value pub.1002334226
104 rdf:type schema:PropertyValue
105 N5e64b63eff9546de919aba5dcbe9b56a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N61709d8adb94441085c50eaeee7e5dc6 schema:name nlm_unique_id
109 schema:value 100886238
110 rdf:type schema:PropertyValue
111 N63375e4747ce4b538eedeff2bc461c8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Male
113 rdf:type schema:DefinedTerm
114 N6ff2be66cb3f4ba0a1ad6db00eadc309 schema:affiliation https://www.grid.ac/institutes/grid.500232.6
115 schema:familyName Brazilian Gastric Cancer Study Group, Belo Horizonte, MG, Brazil
116 rdf:type schema:Person
117 N72dd560c15a74c37afcf2e761218cce3 schema:affiliation https://www.grid.ac/institutes/grid.411195.9
118 schema:familyName Pecego
119 schema:givenName Ricardo
120 rdf:type schema:Person
121 N79e861bc405f492aa940722a76fd0058 schema:name doi
122 schema:value 10.1007/s10120-006-0361-z
123 rdf:type schema:PropertyValue
124 N86435bb135174504a2ec16bc85ccd8c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Antineoplastic Combined Chemotherapy Protocols
126 rdf:type schema:DefinedTerm
127 N864c62232694434e8440adc3ef172de0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Aged
129 rdf:type schema:DefinedTerm
130 N875be22b71794c41aedff4d837a3ae3a schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N8eeefb39658b4b4c9bb2ad500f9de5aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Middle Aged
134 rdf:type schema:DefinedTerm
135 N91120e5b825c4fae92c96a03e9c22dd3 schema:name readcube_id
136 schema:value 0b1d2d207c1d2e08d3a7eae72304dcfa70f141e01b6deabc7442dd547f468a44
137 rdf:type schema:PropertyValue
138 N94d19e1726404288a328b50dcf4a6e3e schema:volumeNumber 9
139 rdf:type schema:PublicationVolume
140 N968a3c792e2044699d3adb6c6a60ad21 rdf:first sg:person.011770272266.57
141 rdf:rest N0775ab1b15374f16b45be367071b0957
142 N989c8041365e4406b43431059a84cdbf rdf:first sg:person.01160627314.03
143 rdf:rest N968a3c792e2044699d3adb6c6a60ad21
144 Nb26c17cfba89492bb5a9197a843ee245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Taxoids
146 rdf:type schema:DefinedTerm
147 Nb437ca6890844d57bdd9d8c348e44e53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Survival Rate
149 rdf:type schema:DefinedTerm
150 Nb70bc757f9c54a8cab19378661376c21 rdf:first N6ff2be66cb3f4ba0a1ad6db00eadc309
151 rdf:rest rdf:nil
152 Nc19475b5863e4deca77baaef0e5c6b65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Adenocarcinoma
154 rdf:type schema:DefinedTerm
155 Ncc44eb6507134434b5838a55e5fb2cc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Docetaxel
157 rdf:type schema:DefinedTerm
158 Nd7d9c562138d492eb7cde483640bf8d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Humans
160 rdf:type schema:DefinedTerm
161 Ndbf984306fdf4b779bd68fceba5d432b schema:name pubmed_id
162 schema:value 16767365
163 rdf:type schema:PropertyValue
164 Ndeb9b128a24e41aba9fe73b4cfd7b586 schema:name Irmandade Santa Casa de Misericórdia de Porto Alegre, Unidade de Apoio à Pesquisa, Porto Alegre, RS, Brazil
165 rdf:type schema:Organization
166 Ne8ba1b809f174ce2b27f339ca2e24525 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Dose-Response Relationship, Drug
168 rdf:type schema:DefinedTerm
169 Neff704c20a864fea9f69e1a5b7149f14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Adult
171 rdf:type schema:DefinedTerm
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
176 schema:name Oncology and Carcinogenesis
177 rdf:type schema:DefinedTerm
178 sg:journal.1020959 schema:issn 1436-3291
179 1436-3305
180 schema:name Gastric Cancer
181 rdf:type schema:Periodical
182 sg:person.01160627314.03 schema:affiliation https://www.grid.ac/institutes/grid.500232.6
183 schema:familyName Murad
184 schema:givenName André M.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160627314.03
186 rdf:type schema:Person
187 sg:person.011770272266.57 schema:affiliation https://www.grid.ac/institutes/grid.459527.8
188 schema:familyName Skare
189 schema:givenName Nils G.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011770272266.57
191 rdf:type schema:Person
192 sg:person.0602365724.96 schema:affiliation Ndeb9b128a24e41aba9fe73b4cfd7b586
193 schema:familyName Vinholes
194 schema:givenName Jéferson
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602365724.96
196 rdf:type schema:Person
197 sg:person.0670644343.89 schema:affiliation N16d60e6d52084567bc57d6b4b787b5dd
198 schema:familyName Lago
199 schema:givenName Sérgio
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670644343.89
201 rdf:type schema:Person
202 sg:pub.10.1007/bf02993858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010768027
203 https://doi.org/10.1007/bf02993858
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/bjc.1994.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008377050
206 https://doi.org/10.1038/bjc.1994.310
207 rdf:type schema:CreativeWork
208 sg:pub.10.1054/bjoc.2000.1631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020520952
209 https://doi.org/10.1054/bjoc.2000.1631
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1074272175 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1077032249 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1083196221 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1083300540 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083339874 schema:CreativeWork
216 https://doi.org/10.1001/jama.1985.03350380077025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052251415
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1001/jama.253.14.2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054145094
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/(sici)1097-0142(19961101)78:9<1888::aid-cncr7>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1013223002
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<295::aid-cncr5>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1034301343
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/1097-0142(19930615)71:12<3813::aid-cncr2820711205>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045322933
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0305-7372(93)90025-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1020204712
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0140-6736(00)02074-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013379406
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1023/a:1008328501128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303192
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1023/a:1008342013224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303302
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1093/annonc/2.suppl_2.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059393185
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/annonc/5.suppl_3.s33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059393431
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/jjco/hyf057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027589509
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/jnci/86.14.1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583436
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/oxfordjournals.annonc.a057914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078154101
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/oxfordjournals.annonc.a058686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082685627
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/00000421-199808000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060113767
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/00000421-199912000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060113948
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1097/00000421-200008000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060114035
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/00001813-200206000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011963622
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/apm.1965.64.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076424426
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1177/107327489900600406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074620859
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1200/jco.1991.9.5.827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078050257
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1200/jco.1992.10.4.541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076951209
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1200/jco.1994.12.12.2687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082597539
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1200/jco.1997.15.1.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083031491
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1200/jco.2000.18.14.2648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074667554
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1634/theoncologist.9-suppl_2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044476568
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.411195.9 schema:alternateName Universidade Federal de Goiás
271 schema:name Hospital das Clínicas da UFG, Goiânia, GO, Brazil
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.459527.8 schema:alternateName Hospital Erasto Gaertner
274 schema:name Hospital Erasto Gaertner, Centro de Projetos de Ensino e Pesquisa, Liga Paranaense de Combate ao Câncer, Curitiba, PR, Brazil
275 rdf:type schema:Organization
276 https://www.grid.ac/institutes/grid.500232.6 schema:alternateName Hospital das Clínicas da Universidade Federal de Minas Gerais
277 schema:name Oncology Department, Hospital das Clinicas Universidade Federal de Minas Gerais, Rua Piaui 150, 30150-320, Belo Horizonte, MG, Brazil
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...