Dermabrasion combined with photodynamic therapy: a new option for the treatment of non-melanoma skin cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-08

AUTHORS

Nianzhou Yu, Xi Luo, Tianhong Wei, Qian Zhang, Jing Yu, Lisha Wu, Juan Su, Mingliang Chen, Kai Huang, Fangfang Li, Yang Xie, Fang Fang, Liang Zhang, Renliang He, Xiang Chen, Shuang Zhao, WenBo Bu

ABSTRACT

Non-melanoma skin cancer (NMSC) is the most common malignancy. Photodynamic therapy (PDT) is effective for the treatment of certain NMSCs. However, the clinical response rates of some NMSCs to single PDT are still far from ideal. The reason may be that PDT has shown limited efficacy in managing thicker NMSCs. To explore the efficacy and safety of dermabrasion combined with PDT (D-PDT) for the treatment of NMSCs. This was a retrospective, single-arm, multi-centre study. In total, 172 tumours from 40 patients were treated with D-PDT during the study period. The mean follow-up period was 40 months (range 15–110 months). D-PDT was performed with 633-nm red light at 80 m W/cm2 after lesion dermabrasion and 4 h of photosensitizer exposure. Six nodular basal cell carcinomas (nBCCs) from 6 patients, 9 squamous cell carcinomas (SCCs) from 9 patients, 17 Bowen diseases (BDs) from 10 patients and 140 actinic keratoses (AKs) from 15 patients treated with D-PDT were examined in this study. Only two patients with three AKs experienced recurrence over 12 months. The mean final follow-up periods of patients with AKs, BDs, nBCCs and SCCs were 30, 33, 45 and 60 months, respectively. Thirty-four of the 40 patients treated with D-PDT reported excellent or good cosmetic results. The mean Dermatology Life Quality Index (DLQI) scores of the patients improved significantly after treatment (estimated MD 9.72 [95% CI 8.69 to 10.75]; p < 0.001). D-PDT is a safe, cosmetic and effective treatment that could be a new candidate therapeutic for NMSC. More... »

PAGES

1255-1263

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10103-021-03381-3

DOI

http://dx.doi.org/10.1007/s10103-021-03381-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140280362

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34365550


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16 schema:description Non-melanoma skin cancer (NMSC) is the most common malignancy. Photodynamic therapy (PDT) is effective for the treatment of certain NMSCs. However, the clinical response rates of some NMSCs to single PDT are still far from ideal. The reason may be that PDT has shown limited efficacy in managing thicker NMSCs. To explore the efficacy and safety of dermabrasion combined with PDT (D-PDT) for the treatment of NMSCs. This was a retrospective, single-arm, multi-centre study. In total, 172 tumours from 40 patients were treated with D-PDT during the study period. The mean follow-up period was 40 months (range 15–110 months). D-PDT was performed with 633-nm red light at 80 m W/cm2 after lesion dermabrasion and 4 h of photosensitizer exposure. Six nodular basal cell carcinomas (nBCCs) from 6 patients, 9 squamous cell carcinomas (SCCs) from 9 patients, 17 Bowen diseases (BDs) from 10 patients and 140 actinic keratoses (AKs) from 15 patients treated with D-PDT were examined in this study. Only two patients with three AKs experienced recurrence over 12 months. The mean final follow-up periods of patients with AKs, BDs, nBCCs and SCCs were 30, 33, 45 and 60 months, respectively. Thirty-four of the 40 patients treated with D-PDT reported excellent or good cosmetic results. The mean Dermatology Life Quality Index (DLQI) scores of the patients improved significantly after treatment (estimated MD 9.72 [95% CI 8.69 to 10.75]; p < 0.001). D-PDT is a safe, cosmetic and effective treatment that could be a new candidate therapeutic for NMSC.
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22 schema:keywords Bowen's disease
23 D-PDT
24 Dermatology Life Quality Index scores
25 Life Quality Index scores
26 Quality Index scores
27 actinic keratoses
28 basal cell carcinoma
29 cancer
30 candidates
31 carcinoma
32 cell carcinoma
33 certain non-melanoma skin cancers
34 clinical response rate
35 cm2
36 common malignancy
37 cosmetic results
38 dermabrasion
39 disease
40 effective treatment
41 efficacy
42 exposure
43 final follow
44 follow
45 good cosmetic results
46 ideal
47 index score
48 keratoses
49 light
50 limited efficacy
51 malignancy
52 mean Dermatology Life Quality Index (DLQI) score
53 mean final follow
54 mean follow
55 months
56 multi-center study
57 new candidates
58 new options
59 nodular basal cell carcinoma
60 non-melanoma skin cancer
61 options
62 patients
63 period
64 period of patients
65 photodynamic therapy
66 rate
67 reasons
68 recurrence
69 red light
70 response rate
71 results
72 safety
73 scores
74 single photodynamic therapy
75 skin cancer
76 squamous cell carcinoma
77 study
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79 therapy
80 treatment
81 treatment of NMSC
82 tumors
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