The application of physical pretreatment in photodynamic therapy for skin diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-01-06

AUTHORS

Dihui Liu, Shuang Zhao, Jinmao Li, Mingliang Chen, Lisha Wu

ABSTRACT

Photodynamic therapy (PDT) is widely used in skin diseases; the response rate of PDT treatment varies widely. The limited penetration in the tissue of photosensitizers influenced the penetration depth of PDT, which obviously impacts the therapeutic effect. The studies have improved the efficacy of PDT through various pretreatment applications; especially, the physical pretreatment had achieved significant outcomes. We will review the physical pretreatment to optimize the efficacy of PDT in skin diseases by searching the literature on this topic. The types of physical pretreatment commonly used in the clinical practice are discussed: curettage, superficial shaving, laser, surgical resection, plum-blossom needles, and microneedles. Compared with PDT alone, the physical pretreatment before PDT application was generally improved the efficacy and reduced the recurrence, especially in actinic keratoses (AK), Bowen disease (BD), basal cell carcinoma (BCC), and viral warts. The application of the physical pretreatments before PDT may improve the efficacy of PDT in various skin diseases. However, each kind of physical pretreatment has the benefit and shortcoming, and the applicable situation is different. More... »

PAGES

1369-1377

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10103-020-03233-6

DOI

http://dx.doi.org/10.1007/s10103-020-03233-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1134365533

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33404884


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