Photobiomodulation-induced analgesia in experimental temporomandibular disorder involves central inhibition of fractalkine. View Full Text


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Article Info

DATE

2019-04-10

AUTHORS

João Ignácio Ferrara-Jr, Everton Tiago de Souza, Adriano Cardozo Franciosi, Elaine Flamia Toniolo, Camila Squarzoni Dale

ABSTRACT

Temporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the temporomandibular joint, and associated structures. Despite their high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not yet well understood. Treatments for TMD pain relief and control should be minimally invasive, reversible, and conservative. Photobiomodulation (PBM) is a promising option once it is known to inhibit inflammatory response and to relief painful symptoms. Herein, the effects of PBM (660 nm, 30 mW, 16 J/cm2, 0.2 cm2, 15 s in a continuous frequency) on the pain sensitivity of rats submitted to an experimental model of TMD induced by CFA was evaluated. Experimental TMD was induced in rats by the injection of complete Freund's adjuvant (CFA) injection into the masseter muscle. Nociceptive behavior was evaluated by electronic von Frey before CFA and after 1 h, 3 h, 6 h, and 24 h and 7, 14, and 21 days after PBM treatment. Inflammatory infiltrate was evaluated by histology of the masseter muscle and fractalkine expression was evaluated by immunohistochemistry of the trigeminal ganglia. PBM reversed the mechanical hypersensitivity of the animals by inhibiting the local inflammatory response, observed by the decrease of the inflammatory infiltrate in the masseter muscle of rats and by a central inhibition of fractalkine observed in the trigeminal ganglion. These data provide new insights into the mechanisms involved in the effects of photobiomodulation therapy emphasizing its therapeutic potential in the treatment of TMD. More... »

References to SciGraph publications

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  • Journal

    TITLE

    Lasers in Medical Science

    ISSUE

    N/A

    VOLUME

    N/A

    Author Affiliations

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10103-019-02785-6

    DOI

    http://dx.doi.org/10.1007/s10103-019-02785-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113329003

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30969378


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        "description": "Temporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the temporomandibular joint, and associated structures. Despite their high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not yet well understood. Treatments for TMD pain relief and control should be minimally invasive, reversible, and conservative. Photobiomodulation (PBM) is a promising option once it is known to inhibit inflammatory response and to relief painful symptoms. Herein, the effects of PBM (660\u00a0nm, 30\u00a0mW, 16\u00a0J/cm2, 0.2\u00a0cm2, 15\u00a0s in a continuous frequency) on the pain sensitivity of rats submitted to an experimental model of TMD induced by CFA was evaluated. Experimental TMD was induced in rats by the injection of complete Freund's adjuvant (CFA) injection into the masseter muscle. Nociceptive behavior was evaluated by electronic von Frey before CFA and after 1\u00a0h, 3\u00a0h, 6\u00a0h, and 24\u00a0h and 7, 14, and 21\u00a0days after PBM treatment. Inflammatory infiltrate was evaluated by histology of the masseter muscle and fractalkine expression was evaluated by immunohistochemistry of the trigeminal ganglia. PBM reversed the mechanical hypersensitivity of the animals by inhibiting the local inflammatory response, observed by the decrease of the inflammatory infiltrate in the masseter muscle of rats and by a central inhibition of fractalkine observed in the trigeminal ganglion. These data provide new insights into the mechanisms involved in the effects of photobiomodulation therapy emphasizing its therapeutic potential in the treatment of TMD.", 
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