Raman spectroscopic study of the repair of surgical bone defects grafted or not with biphasic synthetic micro-granular HA + β-calcium ... View Full Text


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Article Info

DATE

2014-11

AUTHORS

Luiz Guilherme P. Soares, Aparecida Maria C. Marques, Milena G. Guarda, Jouber Mateus S. Aciole, Aline S. Andrade, Antonio Luiz B. Pinheiro, Landulfo Silveira

ABSTRACT

The handling of bone losses due to different etiologic factors is difficult and many techniques are aim to improve repair, including a wide range of biomaterials and, recently, photobioengineering. This work aimed to assess, through Raman spectroscopy, the level of bone mineralization using the intensities of the Raman peaks of both inorganic (~960, ~1,070, and 1,077 cm(-1)) and organic (~1,454 and ~1,666 cm(-1)) contents of bone tissue. Forty rats were divided into four groups each subdivided into two subgroups according to the time of sacrifice (15 and 30 days). Surgical bone defects were made on the femur of each animal with a trephine drill. On animals of group clot, the defect was filled only by blood clot, on group LED, the defect filled with the clot was further irradiated. On animals of groups biomaterial and LED + biomaterial, the defect was filled by biomaterial and the last one was further irradiated (λ850 ± 10 nm, 150 mW, Φ ~ 0.5 cm(2), 20 J/cm(2)-session, 140 J/cm(2)-treatment) at 48-h intervals and repeated for 2 weeks. At both 15th and 30th days following sacrifice, samples were taken and analyzed by Raman spectroscopy. At the end of the experimental time, the intensity of hydroxyapatite (HA) (~960 cm(-1)) were higher on group LED + biomaterial and the peaks of both organic content (~1,454 and ~1,666 cm(-1)) and transitional HA (~1,070 and ~1,077 cm(-1)) were lower on the same group. It is concluded that the use of LED phototherapy associated to biomaterial was effective in improving bone healing on bone defects as a result of the increasing deposition of HA measured by Raman spectroscopy. More... »

PAGES

1927-1936

References to SciGraph publications

  • 1998-12. MicroRaman Spectral Study of the PO4 and CO3 Vibrational Modes in Synthetic and Biological Apatites in CALCIFIED TISSUE INTERNATIONAL
  • 2011-08. Raman Assessment of Bone Quality in CLINICAL ORTHOPAEDICS AND RELATED RESEARCH®
  • 2009-03. Bone repair following bone grafting hydroxyapatite guided bone regeneration and infra-red laser photobiomodulation: a histological study in a rodent model in LASERS IN MEDICAL SCIENCE
  • 2008-07. Effect of IR laser photobiomodulation on the repair of bone defects grafted with organic bovine bone in LASERS IN MEDICAL SCIENCE
  • 2007-07. Carbonate Assignment and Calibration in the Raman Spectrum of Apatite in CALCIFIED TISSUE INTERNATIONAL
  • 2013-02. The efficacy of the use of IR laser phototherapy associated to biphasic ceramic graft and guided bone regeneration on surgical fractures treated with miniplates: a Raman spectral study on rabbits in LASERS IN MEDICAL SCIENCE
  • 2012-09. Does LED phototherapy influence the repair of bone defects grafted with MTA, bone morphogenetic proteins, and guided bone regeneration? A description of the repair process on rodents in LASERS IN MEDICAL SCIENCE
  • 2012-09. Effects of LED phototherapy on bone defects grafted with MTA, bone morphogenetic proteins and guided bone regeneration: a Raman spectroscopic study in LASERS IN MEDICAL SCIENCE
  • 2014-09. Raman study of the repair of surgical bone defects grafted with biphasic synthetic microgranular HA + β-calcium triphosphate and irradiated or not with λ780 nm laser in LASERS IN MEDICAL SCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10103-014-1601-9

    DOI

    http://dx.doi.org/10.1007/s10103-014-1601-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010906734

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25027176


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