Characteristics and outcome of varicella-zoster virus central nervous system infections in adults View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-04-28

AUTHORS

A. Le Bot, A. Ballerie, C. Pronier, F. Bénézit, F. Reizine, M. Tas, P. Jégo, M. Revest, Y. Le Tulzo, P. Fillâtre, Pierre Tattevin

ABSTRACT

We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000–2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35–76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10–15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17–3.35] per 10-year increment, P = 0.011). More... »

PAGES

2437-2442

References to SciGraph publications

  • 2015-11-14. Predictors of outcome in HSV encephalitis in JOURNAL OF NEUROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10096-021-04245-y

    DOI

    http://dx.doi.org/10.1007/s10096-021-04245-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1137534678

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33907935


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