Rat models of colistin nephrotoxicity: previous experimental researches and future perspectives. View Full Text


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Article Info

DATE

2019-04-04

AUTHORS

Cihan Heybeli, Mehmet Ası Oktan, Zahide Çavdar

ABSTRACT

Colistin is an old antibiotic, which is abandoned decades ago because of high nephrotoxicity rates. However, it is reintroduced to clinical medicine due to lack of newly discovered antibiotics and is still widely used for the treatment of resistant gram-negative infections. Discovering mechanisms to reduce nephrotoxicity risk is of significant importance since exposed patients may have many other factors that alter kidney functions. Several agents were evaluated in animal models of colistin nephrotoxicity as a means to prevent kidney injury. Considerable heterogeneity exists in terms of reporting colistin dosing and experimental designs. This issue leads clinicians to face difficulties in designing studies and sometimes may lead to report dosing strategies inadequately. Here, we present a review according to animal models of colistin nephrotoxicity using data gathered from previous experiments to draw attention on possible complexities that researchers may encounter. More... »

References to SciGraph publications

  • 2011-01. Could nephrotoxicity due to colistin be ameliorated with the use of N-acetylcysteine? in INTENSIVE CARE MEDICINE
  • 2015-07. A review on colistin nephrotoxicity in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2015-12. Colistin for lung infection: an update in JOURNAL OF INTENSIVE CARE
  • 2017-10-24. Modelling diabetic nephropathy in mice in NATURE REVIEWS NEPHROLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s10096-019-03546-7

    DOI

    http://dx.doi.org/10.1007/s10096-019-03546-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113185315

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30949899


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