Clostridium difficile infection: review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-03

AUTHORS

Jacek Czepiel, Mirosław Dróżdż, Hanna Pituch, Ed J. Kuijper, William Perucki, Aleksandra Mielimonka, Sarah Goldman, Dorota Wultańska, Aleksander Garlicki, Grażyna Biesiada

ABSTRACT

Clostridium difficile (C. difficile) is a Gram-positive, spore-forming, anaerobic bacillus, which is widely distributed in the intestinal tract of humans and animals and in the environment. In the last decade, the frequency and severity of C. difficile infection has been increasing worldwide to become one of the most common hospital-acquired infections. Transmission of this pathogen occurs by the fecal-oral route and the most important risk factors include antibiotic therapy, old age, and hospital or nursing home stay. The clinical picture is diverse and ranges from asymptomatic carrier status, through various degrees of diarrhea, to the most severe, life threatening colitis resulting with death. Diagnosis is based on direct detection of C. difficile toxins in feces, most commonly with the use of EIA assay, but no single test is suitable as a stand-alone test confirming CDI. Antibiotics of choice are vancomycin, fidaxomicin, and metronidazole, though metronidazole is considered as inferior. The goal of this review is to update physicians on current scientific knowledge of C. difficile infection, focusing also on fecal microbiota transplantation which is a promising therapy. More... »

PAGES

1211-1221

References to SciGraph publications

  • 2016-04-07. Clostridium difficile infection in NATURE REVIEWS DISEASE PRIMERS
  • 2011-12-20. Fecal microbiota transplantation and emerging applications in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2011-02-04. Advances in pathogenesis, diagnosis and management of CDI in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2012-11. Should We Standardize the 1,700-Year-Old Fecal Microbiota Transplantation? in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-11-22. The Epidemiology of Community-Acquired Clostridium difficile Infection: A Population-Based Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-04-01. Meta-Analysis of Probiotics for the Prevention of Antibiotic Associated Diarrhea and the Treatment of Clostridium difficile Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1007/s10096-019-03539-6

    DOI

    http://dx.doi.org/10.1007/s10096-019-03539-6

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30945014


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