Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-25

AUTHORS

Takahiro Takazono, Tomomi Saijo, Nobuyuki Ashizawa, Kazuhiro Oshima, Keitaro Nishimura, Masato Tashiro, Kazuko Yamamoto, Yoshifumi Imamura, Taiga Miyazaki, Katsunori Yanagihara, Hiroshi Mukae, Koichi Izumikawa, Donald C. Sheppard

ABSTRACT

There have been conflicting reports of false positive galactomannan assay results in patients with systemic cryptococcosis. We sought to determine the frequency of GM positivity in patients with pulmonary cryptococcosis and confirm the source of this cross-reactivity in vitro. We conducted a retrospective study to elucidate the rate of galactomannan (GM) false positivity and cause in a cohort of 29 patients with pulmonary cryptococcal disease. The production of GM cross-reacting substances by clinical isolates and laboratory isolates of C. neoformans was tested in vitro. The mean serum GM index (Platelia Aspergillus) in patients with pulmonary cryptococcosis was 1.06, with 16 (55.2%) of patients having values above the positive cutoff value of 0.5. GM index values significantly decreased after treatment of cryptococcosis. There was no significant correlation between galactomannan and cryptococcal glucuronoxylomannan antigen (Eiken Latex test) results. Culture supernatants from clinical isolates and wild-type C. neoformans did not react in the GM assay; however, growth in the presence of 6% sodium chloride induced the production of cross-reacting GM antigens in culture supernatants from clinical isolates, wild type and a glucuronoxylomannan-deficient mutant of C. neoformans, but not in culture supernatants from a galactoxylomannan-deficient strain. Our results support the cross-reactivity of cryptococcal galactoxylomannan with the serum GM assay in vitro and in patients with pulmonary cryptococcal infection. More... »

PAGES

735-741

References to SciGraph publications

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URI

http://scigraph.springernature.com/pub.10.1007/s10096-019-03469-3

DOI

http://dx.doi.org/10.1007/s10096-019-03469-3

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30684164


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69 positive galactomannan
70 positive results
71 positivity
72 presence
73 production
74 pulmonary cryptococcal disease
75 pulmonary cryptococcal infection
76 pulmonary cryptococcosis
77 pulmonary cryptococcosis patients
78 rate
79 report
80 results
81 retrospective study
82 serum GM
83 significant correlation
84 sodium chloride
85 source
86 strains
87 study
88 substances
89 supernatant
90 systemic cryptococcosis
91 treatment
92 treatment of cryptococcosis
93 types
94 values
95 wild type
96 wild-type C. neoformans
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