Inoculum effect of methicillin-susceptible Staphylococcus aureus against broad-spectrum beta-lactam antibiotics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Kyoung-Ho Song, Sook-In Jung, Shinwon Lee, Sohee Park, Eu Suk Kim, Kyung-Hwa Park, Wan Beom Park, Pyoeng Gyun Choe, Young Keun Kim, Yee Gyung Kwak, Yeon-Sook Kim, Hee-Chang Jang, Sungmin Kiem, Hye-In Kim, Hong Bin Kim, the Korea INfectious Diseases (KIND) study group

ABSTRACT

Scarce information concerning the inoculum effect (InE) of methicillin-susceptible Staphylococcus aureus (MSSA) against broad-spectrum β-lactam antibiotics is available. We investigated the InE of MSSA against ceftriaxone, cefepime, meropenem, ampicillin/sulbactam and piperacillin/tazobactam. The bacteraemic MSSA isolates were collected at ten Korean general hospitals from Sep 2013 to Mar 2015. The InE was defined if MICs of antibiotics at high inoculum (HI, ~5 × 107 CFU/ml) increased beyond the susceptible range compared to those at standard inoculum (SI, ~5 × 105 CFU/ml). All isolates were sequenced for blaZ gene typing. Among 302 MSSA isolates, 254 (84.1%) were positive for blaZ; types A, B, C and D were 13.6%, 26.8%, 43.4% and 0.3%, respectively. Mean HI MICs of all tested antibiotics were significantly increased and increases in HI MIC of piperacillin/tazobactam (HI, 48.14 ± 4.08 vs. SI, 2.04 ± 0.08 mg/L, p < 0.001) and ampicillin/sulbactam (HI, 24.15 ± 1.27 vs. SI, 2.79 ± 0.11 mg/L, p < 0.001) were most prominent. No MSSA isolates exhibited meropenem InE, and few isolates exhibited cefepime (0.3%) and ceftriaxone (2.3%) InE, whereas 43.0% and 65.9% of MSSA isolates exhibited piperacillin/tazobactam and ampicillin/sulbactam InE, respectively. About 93% of type C blaZ versus 45% of non-type C exhibited ampicillin/sulbactam InE (p < 0.001) and 88% of type C blaZ versus 9% of non-type C exhibited piperacillin/tazobactam InE (p < 0.001). A large proportion of MSSA clinical isolates, especially those positive for type C blaZ, showed marked ampicillin/sulbactam InE and piperacillin/tazobactam. More... »

PAGES

67-74

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-018-3392-6

DOI

http://dx.doi.org/10.1007/s10096-018-3392-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107316905

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30269181


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Download the RDF metadata as:  json-ld nt turtle xml License info

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