Sustained high serum caspase-3 concentrations and mortality in septic patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-08

AUTHORS

L. Lorente, M. M. Martín, A. Pérez-Cejas, A. F. González-Rivero, R. O. López, J. Ferreres, J. Solé-Violán, L. Labarta, C. Díaz, S. Palmero, A. Jiménez

ABSTRACT

Caspase-3 is the main executor of the apoptotic process. Higher serum caspase-3 concentrations in non-survivor compared to survivor septic patients have been found. The objectives of this work (with the increase of sample size to 308 patients, and the determination of serum caspase-3 concentrations also on days 4 and 8 of diagnosis of severe sepsis) were to know whether an association between serum caspase-3 concentrationss during the first week, degree of apoptosis, sepsis severity, and sepsis mortality exists. We collected serum samples of 308 patients with severe sepsis from eight intensive care units on days 1, 4 and 8 to measure concentrations of caspase-3 and caspase-cleaved cytokeratin (CCCK)-18 (to assess degree of apoptosis). End point was 30-day mortality. We found higher serum concentrations of caspase-3 and CCCK-18 in non-survivors compared to survivors on days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001). We found an association between serum caspase-3 concentrations on days 1, 4 and 8 of severe sepsis diagnosis and serum CCCK-18 concentrations (p < 0.001), SOFA (p < 0.001), serum acid lactic concentrations (p < 0.001), and 30-day sepsis mortality (p < 0.001). The new findings of this work were that an association between serum caspase-3 concentrations during the first week, apoptosis degree, sepsis severity, and sepsis mortality exists. More... »

PAGES

281-288

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-017-3129-y

DOI

http://dx.doi.org/10.1007/s10096-017-3129-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092591268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29119350


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31 schema:description Caspase-3 is the main executor of the apoptotic process. Higher serum caspase-3 concentrations in non-survivor compared to survivor septic patients have been found. The objectives of this work (with the increase of sample size to 308 patients, and the determination of serum caspase-3 concentrations also on days 4 and 8 of diagnosis of severe sepsis) were to know whether an association between serum caspase-3 concentrationss during the first week, degree of apoptosis, sepsis severity, and sepsis mortality exists. We collected serum samples of 308 patients with severe sepsis from eight intensive care units on days 1, 4 and 8 to measure concentrations of caspase-3 and caspase-cleaved cytokeratin (CCCK)-18 (to assess degree of apoptosis). End point was 30-day mortality. We found higher serum concentrations of caspase-3 and CCCK-18 in non-survivors compared to survivors on days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001). We found an association between serum caspase-3 concentrations on days 1, 4 and 8 of severe sepsis diagnosis and serum CCCK-18 concentrations (p < 0.001), SOFA (p < 0.001), serum acid lactic concentrations (p < 0.001), and 30-day sepsis mortality (p < 0.001). The new findings of this work were that an association between serum caspase-3 concentrations during the first week, apoptosis degree, sepsis severity, and sepsis mortality exists.
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38 SOFA
39 apoptosis
40 apoptosis degree
41 apoptotic process
42 association
43 care unit
44 caspase-3
45 caspase-3 concentrations
46 concentration
47 cytokeratin
48 day 1
49 degree
50 degree of apoptosis
51 diagnosis
52 end point
53 executor
54 findings
55 first week
56 higher serum concentrations
57 intensive care unit
58 lactic concentration
59 main executor
60 mortality
61 new findings
62 objective
63 patients
64 point
65 process
66 samples
67 sepsis
68 sepsis diagnosis
69 sepsis mortality
70 sepsis severity
71 septic patients
72 serum concentrations
73 serum samples
74 severe sepsis
75 severe sepsis diagnosis
76 severity
77 survivors
78 units
79 weeks
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