Comparison of clinical and laboratory characteristics during two major paediatric meningitis outbreaks of echovirus 30 and other non-polio enteroviruses in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-13

AUTHORS

H. Rudolph, R. Prieto Dernbach, M. Walka, P. Rey-Hinterkopf, V. Melichar, E. Muschiol, S. Schweitzer-Krantz, J. W. Richter, C. Weiss, S. Böttcher, S. Diedrich, H. Schroten, T. Tenenbaum

ABSTRACT

Viral meningitis is mainly caused by non-polio enteroviruses (NPEV). Large-scale data on the clinical characteristics between different outbreaks within the same region are lacking. This study aimed to analyse a possible influence of the circulating NPEV genotype on the disease outcome of affected children. A retrospective cohort study analysing two major outbreaks of NPEV meningitis in Germany in 2008 and 2013 was conducted in cooperation with the National Reference Centre for Poliomyelitis and Enteroviruses (NRC PE) and five German children’s hospitals. A total of 196 patients with laboratory-confirmed NPEV meningitis were enrolled. In 2008, children with NPEV meningitis had significantly higher fever and showed more behavioural changes and less back pain. To better define typical findings in echovirus 30 (E-30) meningitis, patients were split into the following three groups: E-30 positive patients, patients with “Non E-30” infection and patients with “Untyped” NPEV infection. E-30 positive patients were significantly older and their disease course was more acute, with early admission to but also early discharge from hospital. E-30 positive patients showed a significantly higher rate of headache and meningism, and a lower rate of diarrhoea and clinically defined septicaemia when compared to the others. Regarding laboratory testing, E-30 positive patients presented with significantly elevated peripheral blood neutrophil counts when compared to patients with “Non E-30” or “Untyped” NPEV infection. In conclusion, E-30 meningitis in children shows a characteristic pattern of clinical features. To further characterise NPEV strains worldwide, continuous surveillance and typing of NPEV strains causing central nervous system disease is warranted. More... »

PAGES

1651-1660

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-017-2979-7

DOI

http://dx.doi.org/10.1007/s10096-017-2979-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084807214

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28409290


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29 schema:description Viral meningitis is mainly caused by non-polio enteroviruses (NPEV). Large-scale data on the clinical characteristics between different outbreaks within the same region are lacking. This study aimed to analyse a possible influence of the circulating NPEV genotype on the disease outcome of affected children. A retrospective cohort study analysing two major outbreaks of NPEV meningitis in Germany in 2008 and 2013 was conducted in cooperation with the National Reference Centre for Poliomyelitis and Enteroviruses (NRC PE) and five German children’s hospitals. A total of 196 patients with laboratory-confirmed NPEV meningitis were enrolled. In 2008, children with NPEV meningitis had significantly higher fever and showed more behavioural changes and less back pain. To better define typical findings in echovirus 30 (E-30) meningitis, patients were split into the following three groups: E-30 positive patients, patients with “Non E-30” infection and patients with “Untyped” NPEV infection. E-30 positive patients were significantly older and their disease course was more acute, with early admission to but also early discharge from hospital. E-30 positive patients showed a significantly higher rate of headache and meningism, and a lower rate of diarrhoea and clinically defined septicaemia when compared to the others. Regarding laboratory testing, E-30 positive patients presented with significantly elevated peripheral blood neutrophil counts when compared to patients with “Non E-30” or “Untyped” NPEV infection. In conclusion, E-30 meningitis in children shows a characteristic pattern of clinical features. To further characterise NPEV strains worldwide, continuous surveillance and typing of NPEV strains causing central nervous system disease is warranted.
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36 German children’s hospitals
37 Germany
38 NPEV infections
39 National Reference Center
40 admission
41 analyse
42 back pain
43 behavioral changes
44 blood neutrophils
45 center
46 central nervous system disease
47 changes
48 characteristic pattern
49 characteristics
50 children
51 clinical characteristics
52 clinical features
53 cohort study
54 comparison
55 conclusion
56 continuous surveillance
57 cooperation
58 course
59 data
60 diarrhea
61 different outbreaks
62 discharge
63 disease
64 disease course
65 disease outcome
66 early admission
67 early discharge
68 echovirus 30
69 echovirus 30 meningitis
70 elevated peripheral blood neutrophil
71 enteroviruses
72 features
73 fever
74 findings
75 genotypes
76 group
77 headache
78 high fever
79 high rate
80 hospital
81 infection
82 influence
83 laboratory characteristics
84 laboratory testing
85 large-scale data
86 lower rates
87 major outbreaks
88 meningism
89 meningitis
90 meningitis outbreak
91 more behavioural changes
92 nervous system diseases
93 neutrophils
94 non e
95 non-polio enteroviruses
96 outbreak
97 outcomes
98 pain
99 patients
100 patterns
101 peripheral blood neutrophils
102 poliomyelitis
103 positive patients
104 possible influence
105 rate
106 reference center
107 region
108 retrospective cohort study
109 same region
110 septicaemia
111 strains
112 study
113 surveillance
114 system diseases
115 testing
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117 typical findings
118 typing
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