Assessment of linezolid prescriptions in three French hospitals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01-26

AUTHORS

C. Dentan, E. Forestier, M. Roustit, S. Boisset, S. Chanoine, O. Epaulard, P. Pavese

ABSTRACT

The use of linezolid to treat gram-positive cocci infections is increasing in France. Linezolid is approved in pneumonia and complicated skin and soft tissue infections. Overuse and misuse of linezolid can favor the emergence and spreading of linezolid-resistant strains. We aimed to assess the appropriateness of linezolid use in French hospitals. This is a multicenter, retrospective study conducted in three tertiary care hospitals. Appropriateness of linezolid indications and adequacy (composite score concerning dosage, route of administration and blood monitoring) were assessed. Over a three-month period, all prescriptions of linezolid were extracted and analyzed by two independent infectious disease experts. Among the 81 initial prescriptions that were evaluated, indication was appropriate in 48% of cases. Among those, 51% complied with international guidelines. Fifty-seven percent of the prescriptions were adequate regarding dosage, route of administration and blood monitoring. Overall, 23% of prescriptions combined both appropriateness and adequacy. The most frequent reasons for inappropriateness were the possibility of choosing narrower-spectrum antibiotics and the empirical use of linezolid in severe sepsis or septic shock. Initial treatment was the most frequently appropriate in bone and joint infection cases (p = 0.001). Our study shows that even if modalities of use were mostly correct, appropriateness of linezolid indications is low. Educational programs are mandatory to improve practices, as well as clinical studies to better assess the efficacy and safety of linezolid in clinical situations other than pneumonia or complicated skin and soft tissue infections. More... »

PAGES

1133-1141

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-017-2900-4

DOI

http://dx.doi.org/10.1007/s10096-017-2900-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1074221584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28127641


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Utilization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "France", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guideline Adherence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linezolid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prescriptions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tertiary Care Centers", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dentan", 
        "givenName": "C.", 
        "id": "sg:person.01227052335.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227052335.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier M\u00e9tropole Savoie, Chamb\u00e9ry, France", 
          "id": "http://www.grid.ac/institutes/grid.418064.f", 
          "name": [
            "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier M\u00e9tropole Savoie, Chamb\u00e9ry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forestier", 
        "givenName": "E.", 
        "id": "sg:person.01344041665.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344041665.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmacologie, Universit\u00e9 Grenoble Alpes; P\u00f4le Recherche, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Pharmacologie, Universit\u00e9 Grenoble Alpes; P\u00f4le Recherche, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roustit", 
        "givenName": "M.", 
        "id": "sg:person.01225611327.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611327.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire TIMC-IMAG, UMR 5525 CNRS, Universit\u00e9 Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Laboratoire de Bact\u00e9riologie-Hygi\u00e8ne, Institut de Biologie et de Pathologie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", 
            "Laboratoire TIMC-IMAG, UMR 5525 CNRS, Universit\u00e9 Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boisset", 
        "givenName": "S.", 
        "id": "sg:person.01074116263.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074116263.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Institute of Advanced Biosciences (IAB), Centre de Recherche UGA \u2013 INSERM U1209 \u2013 CNRS UMR 5309, Universit\u00e9 Grenoble Alpes, Grenoble, France", 
            "P\u00f4le Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chanoine", 
        "givenName": "S.", 
        "id": "sg:person.01035441127.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035441127.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epaulard", 
        "givenName": "O.", 
        "id": "sg:person.0576007606.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576007606.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pavese", 
        "givenName": "P.", 
        "id": "sg:person.01002527145.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002527145.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.2165/00003088-200443130-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015038530", 
          "https://doi.org/10.2165/00003088-200443130-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc13996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039630305", 
          "https://doi.org/10.1186/cc13996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-006-0221-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033283481", 
          "https://doi.org/10.1007/s10096-006-0221-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-012-2769-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031148336", 
          "https://doi.org/10.1007/s00134-012-2769-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2047-783x-15-12-571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039219649", 
          "https://doi.org/10.1186/2047-783x-15-12-571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2047-783x-15-12-533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039402390", 
          "https://doi.org/10.1186/2047-783x-15-12-533"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01-26", 
    "datePublishedReg": "2017-01-26", 
    "description": "The use of linezolid to treat gram-positive cocci infections is increasing in France. Linezolid is approved in pneumonia and complicated skin and soft tissue infections. Overuse and misuse of linezolid can favor the emergence and spreading of linezolid-resistant strains. We aimed to assess the appropriateness of linezolid use in French hospitals. This is a multicenter, retrospective study conducted in three tertiary care hospitals. Appropriateness of linezolid indications and adequacy (composite score concerning dosage, route of administration and blood monitoring) were assessed. Over a three-month period, all prescriptions of linezolid were extracted and analyzed by two independent infectious disease experts. Among the 81 initial prescriptions that were evaluated, indication was appropriate in 48% of cases. Among those, 51% complied with international guidelines. Fifty-seven percent of the prescriptions were adequate regarding dosage, route of administration and blood monitoring. Overall, 23% of prescriptions combined both appropriateness and adequacy. The most frequent reasons for inappropriateness were the possibility of choosing narrower-spectrum antibiotics and the empirical use of linezolid in severe sepsis or septic shock. Initial treatment was the most frequently appropriate in bone and joint infection cases (p = 0.001). Our study shows that even if modalities of use were mostly correct, appropriateness of linezolid indications is low. Educational programs are mandatory to improve practices, as well as clinical studies to better assess the efficacy and safety of linezolid in clinical situations other than pneumonia or complicated skin and soft tissue infections.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10096-017-2900-4", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093599", 
        "issn": [
          "0934-9723", 
          "1435-4373"
        ], 
        "name": "European Journal of Clinical Microbiology & Infectious Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "keywords": [
      "soft tissue infections", 
      "complicated skin", 
      "tissue infections", 
      "French hospitals", 
      "positive cocci infections", 
      "safety of linezolid", 
      "use of linezolid", 
      "tertiary care hospital", 
      "infectious disease experts", 
      "route of administration", 
      "narrow-spectrum antibiotics", 
      "linezolid-resistant strains", 
      "linezolid use", 
      "linezolid prescriptions", 
      "severe sepsis", 
      "initial prescription", 
      "care hospital", 
      "septic shock", 
      "initial treatment", 
      "retrospective study", 
      "clinical studies", 
      "blood monitoring", 
      "frequent reason", 
      "infection cases", 
      "disease experts", 
      "three-month period", 
      "linezolid", 
      "international guidelines", 
      "clinical situations", 
      "hospital", 
      "empirical use", 
      "modalities of use", 
      "infection", 
      "prescription", 
      "pneumonia", 
      "indications", 
      "skin", 
      "educational programs", 
      "multicenter", 
      "sepsis", 
      "appropriateness", 
      "administration", 
      "study", 
      "efficacy", 
      "antibiotics", 
      "treatment", 
      "modalities", 
      "bone", 
      "cases", 
      "overuse", 
      "use", 
      "dosage", 
      "adequacy", 
      "guidelines", 
      "safety", 
      "percent", 
      "misuse", 
      "assessment", 
      "period", 
      "shock", 
      "inappropriateness", 
      "strains", 
      "monitoring", 
      "program", 
      "practice", 
      "reasons", 
      "experts", 
      "route", 
      "possibility", 
      "emergence", 
      "France", 
      "situation", 
      "spreading"
    ], 
    "name": "Assessment of linezolid prescriptions in three French hospitals", 
    "pagination": "1133-1141", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1074221584"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10096-017-2900-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28127641"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10096-017-2900-4", 
      "https://app.dimensions.ai/details/publication/pub.1074221584"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_731.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10096-017-2900-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10096-017-2900-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10096-017-2900-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10096-017-2900-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10096-017-2900-4'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      118 URIs      103 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10096-017-2900-4 schema:about N013a9ccaa59d4391ab176583c924104c
2 N384974cb1eb74a34a44e3ad3e88cc60a
3 N7fe900ccbe714bc4bff59236075b1232
4 N870e690286ab4d128cc6634ba5d96f7d
5 N8b4100d2e62349d69ca7e386eaa21a1d
6 Nac8ddaa8ae204ebeb5164a148def4e2b
7 Nb3777b8e5be547028358b3cef4d0b3ab
8 Nd6ea15d67dc44f7d85aa137f640c35e5
9 Ndc6d0059f62f4e388b31badd39914043
10 Ne990cd58d52f43399c5b1ed62c69cadd
11 Nedd2f7c827f24c59a5624b9e23bbef72
12 Nf0b1cc6f374a45938079cac09f45d2e0
13 Nf8cab0f9766844eaab691be35eb8661b
14 anzsrc-for:11
15 anzsrc-for:1103
16 anzsrc-for:1117
17 schema:author Nf8624f5f94934c5eab9e24fe344ad1c5
18 schema:citation sg:pub.10.1007/s00134-012-2769-8
19 sg:pub.10.1007/s10096-006-0221-0
20 sg:pub.10.1186/2047-783x-15-12-533
21 sg:pub.10.1186/2047-783x-15-12-571
22 sg:pub.10.1186/cc13996
23 sg:pub.10.2165/00003088-200443130-00005
24 schema:datePublished 2017-01-26
25 schema:datePublishedReg 2017-01-26
26 schema:description The use of linezolid to treat gram-positive cocci infections is increasing in France. Linezolid is approved in pneumonia and complicated skin and soft tissue infections. Overuse and misuse of linezolid can favor the emergence and spreading of linezolid-resistant strains. We aimed to assess the appropriateness of linezolid use in French hospitals. This is a multicenter, retrospective study conducted in three tertiary care hospitals. Appropriateness of linezolid indications and adequacy (composite score concerning dosage, route of administration and blood monitoring) were assessed. Over a three-month period, all prescriptions of linezolid were extracted and analyzed by two independent infectious disease experts. Among the 81 initial prescriptions that were evaluated, indication was appropriate in 48% of cases. Among those, 51% complied with international guidelines. Fifty-seven percent of the prescriptions were adequate regarding dosage, route of administration and blood monitoring. Overall, 23% of prescriptions combined both appropriateness and adequacy. The most frequent reasons for inappropriateness were the possibility of choosing narrower-spectrum antibiotics and the empirical use of linezolid in severe sepsis or septic shock. Initial treatment was the most frequently appropriate in bone and joint infection cases (p = 0.001). Our study shows that even if modalities of use were mostly correct, appropriateness of linezolid indications is low. Educational programs are mandatory to improve practices, as well as clinical studies to better assess the efficacy and safety of linezolid in clinical situations other than pneumonia or complicated skin and soft tissue infections.
27 schema:genre article
28 schema:isAccessibleForFree false
29 schema:isPartOf N05af3ab27e3c4635bf318d74558611aa
30 N6fe531397a40435e97b1fc5a7d8fafb1
31 sg:journal.1093599
32 schema:keywords France
33 French hospitals
34 adequacy
35 administration
36 antibiotics
37 appropriateness
38 assessment
39 blood monitoring
40 bone
41 care hospital
42 cases
43 clinical situations
44 clinical studies
45 complicated skin
46 disease experts
47 dosage
48 educational programs
49 efficacy
50 emergence
51 empirical use
52 experts
53 frequent reason
54 guidelines
55 hospital
56 inappropriateness
57 indications
58 infection
59 infection cases
60 infectious disease experts
61 initial prescription
62 initial treatment
63 international guidelines
64 linezolid
65 linezolid prescriptions
66 linezolid use
67 linezolid-resistant strains
68 misuse
69 modalities
70 modalities of use
71 monitoring
72 multicenter
73 narrow-spectrum antibiotics
74 overuse
75 percent
76 period
77 pneumonia
78 positive cocci infections
79 possibility
80 practice
81 prescription
82 program
83 reasons
84 retrospective study
85 route
86 route of administration
87 safety
88 safety of linezolid
89 sepsis
90 septic shock
91 severe sepsis
92 shock
93 situation
94 skin
95 soft tissue infections
96 spreading
97 strains
98 study
99 tertiary care hospital
100 three-month period
101 tissue infections
102 treatment
103 use
104 use of linezolid
105 schema:name Assessment of linezolid prescriptions in three French hospitals
106 schema:pagination 1133-1141
107 schema:productId N183188cabc9c43adbd32fd64d3e8d1fd
108 N94ff1bba72434dc1b2fadf55892f0919
109 N977635accdb945f6a98db33c88f4b311
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074221584
111 https://doi.org/10.1007/s10096-017-2900-4
112 schema:sdDatePublished 2022-10-01T06:43
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N4fb7d763d1e6471f86f2ab29b426e297
115 schema:url https://doi.org/10.1007/s10096-017-2900-4
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N013a9ccaa59d4391ab176583c924104c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Middle Aged
121 rdf:type schema:DefinedTerm
122 N05af3ab27e3c4635bf318d74558611aa schema:volumeNumber 36
123 rdf:type schema:PublicationVolume
124 N183188cabc9c43adbd32fd64d3e8d1fd schema:name dimensions_id
125 schema:value pub.1074221584
126 rdf:type schema:PropertyValue
127 N1c2c3490a2a245979debe763c00df451 rdf:first sg:person.01002527145.42
128 rdf:rest rdf:nil
129 N24489dae8d4a4954b5ac74ab84ee7551 rdf:first sg:person.01074116263.56
130 rdf:rest Nde71e46ee38141d99b6492fe8c8c759a
131 N384974cb1eb74a34a44e3ad3e88cc60a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged
133 rdf:type schema:DefinedTerm
134 N4fb7d763d1e6471f86f2ab29b426e297 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 N6fe531397a40435e97b1fc5a7d8fafb1 schema:issueNumber 7
137 rdf:type schema:PublicationIssue
138 N7292b7c025354f5ba9ebaf999ca8cf99 rdf:first sg:person.0576007606.12
139 rdf:rest N1c2c3490a2a245979debe763c00df451
140 N7ab84e090b194131ae40b06d10cc33c2 rdf:first sg:person.01225611327.59
141 rdf:rest N24489dae8d4a4954b5ac74ab84ee7551
142 N7fe900ccbe714bc4bff59236075b1232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 N870e690286ab4d128cc6634ba5d96f7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Prescriptions
147 rdf:type schema:DefinedTerm
148 N8b4100d2e62349d69ca7e386eaa21a1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Linezolid
150 rdf:type schema:DefinedTerm
151 N94ff1bba72434dc1b2fadf55892f0919 schema:name pubmed_id
152 schema:value 28127641
153 rdf:type schema:PropertyValue
154 N977635accdb945f6a98db33c88f4b311 schema:name doi
155 schema:value 10.1007/s10096-017-2900-4
156 rdf:type schema:PropertyValue
157 Nac8ddaa8ae204ebeb5164a148def4e2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Tertiary Care Centers
159 rdf:type schema:DefinedTerm
160 Nb3777b8e5be547028358b3cef4d0b3ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name France
162 rdf:type schema:DefinedTerm
163 Nd6ea15d67dc44f7d85aa137f640c35e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Anti-Bacterial Agents
165 rdf:type schema:DefinedTerm
166 Ndc6d0059f62f4e388b31badd39914043 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Guideline Adherence
168 rdf:type schema:DefinedTerm
169 Nde71e46ee38141d99b6492fe8c8c759a rdf:first sg:person.01035441127.34
170 rdf:rest N7292b7c025354f5ba9ebaf999ca8cf99
171 Ne990cd58d52f43399c5b1ed62c69cadd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 Nebcfebe849074f8a8d359661e3a0baf4 rdf:first sg:person.01344041665.54
175 rdf:rest N7ab84e090b194131ae40b06d10cc33c2
176 Nedd2f7c827f24c59a5624b9e23bbef72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Male
178 rdf:type schema:DefinedTerm
179 Nf0b1cc6f374a45938079cac09f45d2e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Retrospective Studies
181 rdf:type schema:DefinedTerm
182 Nf8624f5f94934c5eab9e24fe344ad1c5 rdf:first sg:person.01227052335.19
183 rdf:rest Nebcfebe849074f8a8d359661e3a0baf4
184 Nf8cab0f9766844eaab691be35eb8661b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Drug Utilization
186 rdf:type schema:DefinedTerm
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
191 schema:name Clinical Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
194 schema:name Public Health and Health Services
195 rdf:type schema:DefinedTerm
196 sg:journal.1093599 schema:issn 0934-9723
197 1435-4373
198 schema:name European Journal of Clinical Microbiology & Infectious Diseases
199 schema:publisher Springer Nature
200 rdf:type schema:Periodical
201 sg:person.01002527145.42 schema:affiliation grid-institutes:grid.450307.5
202 schema:familyName Pavese
203 schema:givenName P.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002527145.42
205 rdf:type schema:Person
206 sg:person.01035441127.34 schema:affiliation grid-institutes:grid.450307.5
207 schema:familyName Chanoine
208 schema:givenName S.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035441127.34
210 rdf:type schema:Person
211 sg:person.01074116263.56 schema:affiliation grid-institutes:grid.450307.5
212 schema:familyName Boisset
213 schema:givenName S.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074116263.56
215 rdf:type schema:Person
216 sg:person.01225611327.59 schema:affiliation grid-institutes:grid.450307.5
217 schema:familyName Roustit
218 schema:givenName M.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225611327.59
220 rdf:type schema:Person
221 sg:person.01227052335.19 schema:affiliation grid-institutes:grid.450307.5
222 schema:familyName Dentan
223 schema:givenName C.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227052335.19
225 rdf:type schema:Person
226 sg:person.01344041665.54 schema:affiliation grid-institutes:grid.418064.f
227 schema:familyName Forestier
228 schema:givenName E.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344041665.54
230 rdf:type schema:Person
231 sg:person.0576007606.12 schema:affiliation grid-institutes:grid.450307.5
232 schema:familyName Epaulard
233 schema:givenName O.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576007606.12
235 rdf:type schema:Person
236 sg:pub.10.1007/s00134-012-2769-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031148336
237 https://doi.org/10.1007/s00134-012-2769-8
238 rdf:type schema:CreativeWork
239 sg:pub.10.1007/s10096-006-0221-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033283481
240 https://doi.org/10.1007/s10096-006-0221-0
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/2047-783x-15-12-533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039402390
243 https://doi.org/10.1186/2047-783x-15-12-533
244 rdf:type schema:CreativeWork
245 sg:pub.10.1186/2047-783x-15-12-571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039219649
246 https://doi.org/10.1186/2047-783x-15-12-571
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/cc13996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039630305
249 https://doi.org/10.1186/cc13996
250 rdf:type schema:CreativeWork
251 sg:pub.10.2165/00003088-200443130-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015038530
252 https://doi.org/10.2165/00003088-200443130-00005
253 rdf:type schema:CreativeWork
254 grid-institutes:grid.418064.f schema:alternateName Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Métropole Savoie, Chambéry, France
255 schema:name Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Métropole Savoie, Chambéry, France
256 rdf:type schema:Organization
257 grid-institutes:grid.450307.5 schema:alternateName Laboratoire TIMC-IMAG, UMR 5525 CNRS, Université Grenoble Alpes, Grenoble, France
258 Pharmacologie, Université Grenoble Alpes; Pôle Recherche, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
259 Pôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
260 Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
261 schema:name Institute of Advanced Biosciences (IAB), Centre de Recherche UGA – INSERM U1209 – CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France
262 Laboratoire TIMC-IMAG, UMR 5525 CNRS, Université Grenoble Alpes, Grenoble, France
263 Laboratoire de Bactériologie-Hygiène, Institut de Biologie et de Pathologie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
264 Pharmacologie, Université Grenoble Alpes; Pôle Recherche, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
265 Pôle Pharmacie, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
266 Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...