Interpretation of the Elecsys Toxo IgG avidity results for very low and very high index: study on 741 sera with ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12-19

AUTHORS

H. Fricker-Hidalgo, C. L’Ollivier, C. Bosson, S. Imbert, S. Bailly, C. Dard, R. Piarroux, L. Paris, H. Pelloux

ABSTRACT

Initial results with the Elecsys Toxo IgG Avidity assay showed some potential for interpretation of a very low or very high index result. We aimed to examine these new insights into interpretation using a large panel of serum samples and to define the optimal thresholds. A total of 741 patient serum samples with known date of infection (from a few weeks to more than 9 months after infection), were analysed with the Elecsys Toxo IgG Avidity assay. Values ≥80% (threshold defined by the manufacturer) were reported in 289 sera; 288 sera were sampled more than 4 months after infection. Thus, avidity values ≥80% excluded an infection less than 4 months. Avidity values ≥90% were reported in 112 sera sampled more than 9 months after infection. Thus, avidity values ≥90% excluded infection less than 9 months. Moreover avidity values ≤15% were reported in the 62 sera sampled less than 3 months after infection. Thus avidity values ≤15% excluded infection more than 3 months. More... »

PAGES

847-852

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-016-2870-y

DOI

http://dx.doi.org/10.1007/s10096-016-2870-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052380839

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27995345


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