Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

M. D. Georgitsi, V. Vitoros, C. Panou, I. Tsangaris, E. Aimoniotou, N. K. Gatselis, E. Chasou, G. Kouliatsis, K. Leventogiannis, D. Velissaris, E. Belesiotou, O. Dioritou-Aggaliadou, E. Giannitsioti, M. G. Netea, E. J. Giamarellos-Bourboulis, G. Giannikopoulos, Z. Alexiou, N. Voloudakis, A. Koutsoukou, on behalf of the Hellenic Sepsis Study Group

ABSTRACT

Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. More... »

PAGES

563-570

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-015-2571-y

DOI

http://dx.doi.org/10.1007/s10096-015-2571-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019914676

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26768584


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    "description": "Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n\u2009=\u2009146), community-acquired pneumonia (CAP, n\u2009=\u2009109), intra-abdominal infections (IAI, n\u2009=\u2009119), and primary bacteremia (BSI, n\u2009=\u2009105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24\u00a0h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. ", 
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