Lysophosphatidylcholine as a prognostic marker in community-acquired pneumonia requiring hospitalization: a pilot study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-30

AUTHORS

W. H. Cho, H. J. Yeo, S. H. Yoon, S. E. Lee, D. S. Jeon, Y. S. Kim, S. J. Lee, E. J. Jo, J. H. Mok, M. H. Kim, K. U. Kim, K. Lee, H. K. Park, M. K. Lee

ABSTRACT

Clinical prediction indicators such as the pneumonia severity index (PSI) and CURB-65 score are useful, but they are complex and often not followed. Therefore, biomarkers that improve hospital outcome predictions are emerging. This study evaluated the prognostic value of a new sepsis biomarker, serum lysophosphatidylcholine (LPC) concentrations, in community-acquired pneumonia (CAP) patients. We prospectively collected blood samples from emergency department CAP patients on days 1 and 7 (post-admission) and analyzed their plasma LPC concentrations. We retrospectively reviewed patient medical records and analyzed correlations between plasma LPC concentrations and clinical parameters and hospital outcomes. A total of 56 CAP patients were included in this study; 24 (42.9 %) required intubation and 15 (26.8 %) died. The mean LPC concentrations on days 1 (p = 0.015) and 7 (p = 0.002) of hospitalization were significantly lower in the non-survivors. Day 1 LPC concentrations were inversely correlated with the PSI (ρ = −269) and CURB-65 scores (ρ = −386). For predicting hospital mortality, the day 1 LPC concentration was comparable with the CURB-65 or PSI scores. Day 1 LPC cut-off levels <29.6 μmol/L were associated with hospital CAP outcomes, including the need for mechanical ventilation, vasopressors, intensive care unit admission, and hospital mortality. Additionally, day 7 LPC concentrations were correlated with in-hospital mortality. Initial serum LPC concentrations predicted hospital outcomes in CAP patients requiring hospitalization. These values were correlated with prognostic markers, such as the PSI and CURB-65 scores. Additionally, follow-up LPC measurements predicted the clinical course of CAP patients. More... »

PAGES

309-315

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-014-2234-4

DOI

http://dx.doi.org/10.1007/s10096-014-2234-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011284981

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25172637


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30 schema:description Clinical prediction indicators such as the pneumonia severity index (PSI) and CURB-65 score are useful, but they are complex and often not followed. Therefore, biomarkers that improve hospital outcome predictions are emerging. This study evaluated the prognostic value of a new sepsis biomarker, serum lysophosphatidylcholine (LPC) concentrations, in community-acquired pneumonia (CAP) patients. We prospectively collected blood samples from emergency department CAP patients on days 1 and 7 (post-admission) and analyzed their plasma LPC concentrations. We retrospectively reviewed patient medical records and analyzed correlations between plasma LPC concentrations and clinical parameters and hospital outcomes. A total of 56 CAP patients were included in this study; 24 (42.9 %) required intubation and 15 (26.8 %) died. The mean LPC concentrations on days 1 (p = 0.015) and 7 (p = 0.002) of hospitalization were significantly lower in the non-survivors. Day 1 LPC concentrations were inversely correlated with the PSI (ρ = −269) and CURB-65 scores (ρ = −386). For predicting hospital mortality, the day 1 LPC concentration was comparable with the CURB-65 or PSI scores. Day 1 LPC cut-off levels <29.6 μmol/L were associated with hospital CAP outcomes, including the need for mechanical ventilation, vasopressors, intensive care unit admission, and hospital mortality. Additionally, day 7 LPC concentrations were correlated with in-hospital mortality. Initial serum LPC concentrations predicted hospital outcomes in CAP patients requiring hospitalization. These values were correlated with prognostic markers, such as the PSI and CURB-65 scores. Additionally, follow-up LPC measurements predicted the clinical course of CAP patients.
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38 CAP patients
39 CURB-65
40 CURB-65 score
41 Clinical prediction indicators
42 Day 1 LPC concentrations
43 Day 1 LPC cut
44 Initial serum LPC concentrations
45 LPC concentration
46 LPC cut
47 LPC measurements
48 PSI score
49 Severity Index
50 admission
51 biomarkers
52 blood samples
53 care unit admission
54 clinical course
55 clinical parameters
56 community-acquired pneumonia
57 community-acquired pneumonia patients
58 concentration
59 correlation
60 course
61 cut
62 day 1
63 day 7 LPC concentrations
64 department CAP patients
65 emergency department CAP patients
66 hospital CAP outcomes
67 hospital mortality
68 hospital outcome predictions
69 hospital outcomes
70 hospitalization
71 index
72 indicators
73 intensive care unit admission
74 intubation
75 levels
76 lysophosphatidylcholine
77 lysophosphatidylcholine concentration
78 markers
79 mean LPC concentrations
80 measurements
81 mechanical ventilation
82 medical records
83 mortality
84 need
85 new sepsis biomarker
86 outcome prediction
87 outcomes
88 parameters
89 patients
90 patients' medical records
91 pilot study
92 plasma LPC concentrations
93 pneumonia
94 pneumonia patients
95 pneumonia severity index
96 prediction
97 prediction indicators
98 prognostic marker
99 prognostic value
100 records
101 samples
102 scores
103 sepsis biomarkers
104 serum LPC concentrations
105 serum lysophosphatidylcholine (LPC) concentrations
106 study
107 total
108 unit admission
109 values
110 vasopressors
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