Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08-22

AUTHORS

P. Fillatre, S. Chevrier, M. Revest, A. Gacouin, S. Jouneau, H. Leroy, F. Robert-Gangneux, S. Minjolle, Y. Le Tulzo, P. Tattevin

ABSTRACT

The purpose of this investigation was to characterize the management and prognosis of severe Pneumocystis jirovecii pneumonia (PJP) in human immunodeficiency virus (HIV)-negative patients. An observational cohort study of HIV-negative adults with PJP documented by bronchoalveolar lavage (BAL) through Gomori-Grocott staining or immunofluorescence, admitted to one intensive care unit (ICU) for acute respiratory failure, was undertaken. From 1990 to 2010, 70 patients (24 females, 46 males) were included, with a mean age of 58.6 ± 18.3 years. The mean Simplified Acute Physiology Score (SAPS)-II was 36.9 ± 20.4. Underlying conditions included hematologic malignancies (n = 21), vasculitis (n = 13), and solid tumors (n = 13). Most patients were receiving systemic corticosteroids (n = 63) and cytotoxic drugs (n = 51). Not a single patient received trimethoprim-sulfamethoxazole as PJP prophylaxis. Endotracheal intubation (ETI) was required in 42 patients (60.0 %), including 38 with acute respiratory distress syndrome (ARDS). In-ICU mortality was 52.9 % overall, reaching 80.9 % and 86.8 %, respectively, for patients who required ETI and for patients with ARDS. In the univariate analysis, in-ICU mortality was associated with SAPS-II (p = 0.0131), ARDS (p < 0.0001), shock (p < 0.0001), and herpes simplex virus (HSV) or cytomegalovirus (CMV) on BAL (p = 0.0031). In the multivariate analysis, only ARDS was associated with in-ICU mortality (odds ratio [OR] 23.4 [4.5-121.9], p < 0.0001). PJP in non-HIV patients remains a serious disease with high in-hospital mortality. Pulmonary co-infection with HSV or CMV may contribute to fatal outcome. More... »

PAGES

189-194

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-012-1730-7

DOI

http://dx.doi.org/10.1007/s10096-012-1730-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032894511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22930407


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchoalveolar Lavage Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coinfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytomegalovirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytomegalovirus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Herpes Simplex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Pneumocystis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simplexvirus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fillatre", 
        "givenName": "P.", 
        "id": "sg:person.01273730565.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273730565.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chevrier", 
        "givenName": "S.", 
        "id": "sg:person.0735742420.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735742420.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France", 
            "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Revest", 
        "givenName": "M.", 
        "id": "sg:person.01126473407.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126473407.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France", 
            "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gacouin", 
        "givenName": "A.", 
        "id": "sg:person.0725601723.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725601723.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IRSET, UMR, INSERM 1085, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.462341.6", 
          "name": [
            "Pneumologie, H\u00f4pital Pontchaillou, 35033 Rennes, France", 
            "IRSET, UMR, INSERM 1085, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jouneau", 
        "givenName": "S.", 
        "id": "sg:person.01120300741.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120300741.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France", 
            "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leroy", 
        "givenName": "H.", 
        "id": "sg:person.01275670201.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275670201.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IRSET, UMR, INSERM 1085, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.462341.6", 
          "name": [
            "Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
            "IRSET, UMR, INSERM 1085, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robert-Gangneux", 
        "givenName": "F.", 
        "id": "sg:person.01073602545.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073602545.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Virologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minjolle", 
        "givenName": "S.", 
        "id": "sg:person.01073741126.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073741126.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France", 
            "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Tulzo", 
        "givenName": "Y.", 
        "id": "sg:person.01272505323.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272505323.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM U835, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "Service des Maladies Infectieuses et de R\u00e9animation M\u00e9dicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France", 
            "CIC INSERM 0203, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France", 
            "INSERM U835, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes 1, IFR140, 35033 Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tattevin", 
        "givenName": "P.", 
        "id": "sg:person.01262110414.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262110414.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc6806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013332005", 
          "https://doi.org/10.1186/cc6806"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-08-22", 
    "datePublishedReg": "2012-08-22", 
    "description": "The purpose of this investigation was to characterize the management and prognosis of severe Pneumocystis jirovecii pneumonia (PJP) in human immunodeficiency virus (HIV)-negative patients. An observational cohort study of HIV-negative adults with PJP documented by bronchoalveolar lavage (BAL) through Gomori-Grocott staining or immunofluorescence, admitted to one intensive care unit (ICU) for acute respiratory failure, was undertaken. From 1990 to 2010, 70 patients (24 females, 46 males) were included, with a mean age of 58.6\u2009\u00b1\u200918.3 years. The mean Simplified Acute Physiology Score (SAPS)-II was 36.9\u2009\u00b1\u200920.4. Underlying conditions included hematologic malignancies (n\u2009=\u200921), vasculitis (n\u2009=\u200913), and solid tumors (n\u2009=\u200913). Most patients were receiving systemic corticosteroids (n\u2009=\u200963) and cytotoxic drugs (n\u2009=\u200951). Not a single patient received trimethoprim-sulfamethoxazole as PJP prophylaxis. Endotracheal intubation (ETI) was required in 42 patients (60.0 %), including 38 with acute respiratory distress syndrome (ARDS). In-ICU mortality was 52.9 % overall, reaching 80.9 % and 86.8 %, respectively, for patients who required ETI and for patients with ARDS. In the univariate analysis, in-ICU mortality was associated with SAPS-II (p\u2009=\u20090.0131), ARDS (p\u2009<\u20090.0001), shock (p\u2009<\u20090.0001), and herpes simplex virus (HSV) or cytomegalovirus (CMV) on BAL (p\u2009=\u20090.0031). In the multivariate analysis, only ARDS was associated with in-ICU mortality (odds ratio [OR] 23.4 [4.5-121.9], p\u2009<\u20090.0001). PJP in non-HIV patients remains a serious disease with high in-hospital mortality. Pulmonary co-infection with HSV or CMV may contribute to fatal outcome.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10096-012-1730-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1093599", 
        "issn": [
          "0934-9723", 
          "1435-4373"
        ], 
        "name": "European Journal of Clinical Microbiology & Infectious Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "keywords": [
      "acute respiratory distress syndrome", 
      "Pneumocystis jirovecii pneumonia", 
      "intensive care unit", 
      "ICU mortality", 
      "bronchoalveolar lavage", 
      "endotracheal intubation", 
      "jirovecii pneumonia", 
      "severe Pneumocystis jirovecii pneumonia", 
      "HIV-negative adults", 
      "HIV-negative patients", 
      "observational cohort study", 
      "acute respiratory failure", 
      "Acute Physiology Score", 
      "respiratory distress syndrome", 
      "human immunodeficiency virus", 
      "human herpes viruses", 
      "PJP prophylaxis", 
      "systemic corticosteroids", 
      "hospital mortality", 
      "respiratory failure", 
      "Physiology Score", 
      "HIV patients", 
      "negative patients", 
      "cohort study", 
      "most patients", 
      "distress syndrome", 
      "SAPS II", 
      "care unit", 
      "immunodeficiency virus", 
      "mean age", 
      "fatal outcome", 
      "underlying condition", 
      "hematologic malignancies", 
      "univariate analysis", 
      "single patient", 
      "herpes virus", 
      "patients", 
      "simplex virus", 
      "solid tumors", 
      "cytotoxic drugs", 
      "multivariate analysis", 
      "mortality", 
      "cytomegalovirus", 
      "pneumonia", 
      "serious disease", 
      "virus", 
      "vasculitis", 
      "corticosteroids", 
      "prophylaxis", 
      "intubation", 
      "lavage", 
      "prognosis", 
      "malignancy", 
      "syndrome", 
      "tumors", 
      "disease", 
      "drugs", 
      "immunofluorescence", 
      "HSV", 
      "staining", 
      "adults", 
      "age", 
      "outcomes", 
      "scores", 
      "failure", 
      "years", 
      "management", 
      "study", 
      "shock", 
      "analysis", 
      "purpose", 
      "units", 
      "investigation", 
      "means", 
      "conditions", 
      "Gomori-Grocott staining"
    ], 
    "name": "Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia", 
    "pagination": "189-194", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032894511"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10096-012-1730-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22930407"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10096-012-1730-7", 
      "https://app.dimensions.ai/details/publication/pub.1032894511"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_577.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10096-012-1730-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10096-012-1730-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10096-012-1730-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10096-012-1730-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10096-012-1730-7'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      22 PREDICATES      118 URIs      108 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10096-012-1730-7 schema:about N1dd189aa7c4b4500ba9dc18055e6e2c4
2 N3dea86b1be14493f8de43a79d71e9c02
3 N5d5896397e6e4b989d6cb5f662de9780
4 N6278435bd70f40bdbe43874761b16195
5 N72bee5187ea349a2a4bb4efa2e8bd89a
6 N761815fa14944f5896b654dece5b5c84
7 N91be1af178bc4d2da176d6b718debf6c
8 Nb6407a5a86c44124b1e3b4603a41e7b5
9 Nb8be6e5d45014c07bfe8e0713ec5432b
10 Nc587b96ce65e49c5b04b2b0d4cd118b9
11 Ne4909cce326f418cb51ceb79882820c1
12 Ne7edb710831e4955b9d002002d317561
13 Nf5a5dfa931be4ab8986f86273d830d61
14 Nf7a2564d6dd14ddd96c9c93a63f0c655
15 anzsrc-for:11
16 anzsrc-for:1103
17 anzsrc-for:1108
18 schema:author Nb89ced6ec166463f8b5ad88373c56c5f
19 schema:citation sg:pub.10.1186/cc6806
20 schema:datePublished 2012-08-22
21 schema:datePublishedReg 2012-08-22
22 schema:description The purpose of this investigation was to characterize the management and prognosis of severe Pneumocystis jirovecii pneumonia (PJP) in human immunodeficiency virus (HIV)-negative patients. An observational cohort study of HIV-negative adults with PJP documented by bronchoalveolar lavage (BAL) through Gomori-Grocott staining or immunofluorescence, admitted to one intensive care unit (ICU) for acute respiratory failure, was undertaken. From 1990 to 2010, 70 patients (24 females, 46 males) were included, with a mean age of 58.6 ± 18.3 years. The mean Simplified Acute Physiology Score (SAPS)-II was 36.9 ± 20.4. Underlying conditions included hematologic malignancies (n = 21), vasculitis (n = 13), and solid tumors (n = 13). Most patients were receiving systemic corticosteroids (n = 63) and cytotoxic drugs (n = 51). Not a single patient received trimethoprim-sulfamethoxazole as PJP prophylaxis. Endotracheal intubation (ETI) was required in 42 patients (60.0 %), including 38 with acute respiratory distress syndrome (ARDS). In-ICU mortality was 52.9 % overall, reaching 80.9 % and 86.8 %, respectively, for patients who required ETI and for patients with ARDS. In the univariate analysis, in-ICU mortality was associated with SAPS-II (p = 0.0131), ARDS (p < 0.0001), shock (p < 0.0001), and herpes simplex virus (HSV) or cytomegalovirus (CMV) on BAL (p = 0.0031). In the multivariate analysis, only ARDS was associated with in-ICU mortality (odds ratio [OR] 23.4 [4.5-121.9], p < 0.0001). PJP in non-HIV patients remains a serious disease with high in-hospital mortality. Pulmonary co-infection with HSV or CMV may contribute to fatal outcome.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree true
26 schema:isPartOf N4b84b5ff2c27414fad8aa250765e206a
27 Ne2f9e63466134580b35b49a53e388dae
28 sg:journal.1093599
29 schema:keywords Acute Physiology Score
30 Gomori-Grocott staining
31 HIV patients
32 HIV-negative adults
33 HIV-negative patients
34 HSV
35 ICU mortality
36 PJP prophylaxis
37 Physiology Score
38 Pneumocystis jirovecii pneumonia
39 SAPS II
40 acute respiratory distress syndrome
41 acute respiratory failure
42 adults
43 age
44 analysis
45 bronchoalveolar lavage
46 care unit
47 cohort study
48 conditions
49 corticosteroids
50 cytomegalovirus
51 cytotoxic drugs
52 disease
53 distress syndrome
54 drugs
55 endotracheal intubation
56 failure
57 fatal outcome
58 hematologic malignancies
59 herpes virus
60 hospital mortality
61 human herpes viruses
62 human immunodeficiency virus
63 immunodeficiency virus
64 immunofluorescence
65 intensive care unit
66 intubation
67 investigation
68 jirovecii pneumonia
69 lavage
70 malignancy
71 management
72 mean age
73 means
74 mortality
75 most patients
76 multivariate analysis
77 negative patients
78 observational cohort study
79 outcomes
80 patients
81 pneumonia
82 prognosis
83 prophylaxis
84 purpose
85 respiratory distress syndrome
86 respiratory failure
87 scores
88 serious disease
89 severe Pneumocystis jirovecii pneumonia
90 shock
91 simplex virus
92 single patient
93 solid tumors
94 staining
95 study
96 syndrome
97 systemic corticosteroids
98 tumors
99 underlying condition
100 units
101 univariate analysis
102 vasculitis
103 virus
104 years
105 schema:name Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia
106 schema:pagination 189-194
107 schema:productId N75542edddbf9406dbea92a6531f75972
108 Nd55d7a209e154946a13765996879d0dd
109 Nf9718fd73c934c2d9ddd601d7ab7c264
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032894511
111 https://doi.org/10.1007/s10096-012-1730-7
112 schema:sdDatePublished 2022-01-01T18:27
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N0cd33cc0f7804510b41afc778ff1ddfd
115 schema:url https://doi.org/10.1007/s10096-012-1730-7
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N0cd33cc0f7804510b41afc778ff1ddfd schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 N1dd189aa7c4b4500ba9dc18055e6e2c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Aged
123 rdf:type schema:DefinedTerm
124 N1e1ff260c1d64abbacb67150dca75d56 rdf:first sg:person.0725601723.28
125 rdf:rest Ne9707fea574646febe4379606483c432
126 N3276790dbb974371be64088e789e2db8 rdf:first sg:person.01275670201.83
127 rdf:rest N3383bcd202da4d4a8cadf08a7c96fc79
128 N3383bcd202da4d4a8cadf08a7c96fc79 rdf:first sg:person.01073602545.66
129 rdf:rest Na140784f0955414fa0ed1a232dbb6558
130 N3dea86b1be14493f8de43a79d71e9c02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N4b84b5ff2c27414fad8aa250765e206a schema:volumeNumber 32
134 rdf:type schema:PublicationVolume
135 N5d5896397e6e4b989d6cb5f662de9780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cytomegalovirus
137 rdf:type schema:DefinedTerm
138 N6278435bd70f40bdbe43874761b16195 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Bronchoalveolar Lavage Fluid
140 rdf:type schema:DefinedTerm
141 N72bee5187ea349a2a4bb4efa2e8bd89a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Simplexvirus
143 rdf:type schema:DefinedTerm
144 N75542edddbf9406dbea92a6531f75972 schema:name doi
145 schema:value 10.1007/s10096-012-1730-7
146 rdf:type schema:PropertyValue
147 N761815fa14944f5896b654dece5b5c84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Retrospective Studies
149 rdf:type schema:DefinedTerm
150 N91be1af178bc4d2da176d6b718debf6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cohort Studies
152 rdf:type schema:DefinedTerm
153 Na140784f0955414fa0ed1a232dbb6558 rdf:first sg:person.01073741126.36
154 rdf:rest Nf509e0eeafd44bb89a6a5beb1a77f9ef
155 Nb6407a5a86c44124b1e3b4603a41e7b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Herpes Simplex
157 rdf:type schema:DefinedTerm
158 Nb89ced6ec166463f8b5ad88373c56c5f rdf:first sg:person.01273730565.40
159 rdf:rest Ne18664d248134f559154f722286d0330
160 Nb8be6e5d45014c07bfe8e0713ec5432b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Pneumonia, Pneumocystis
162 rdf:type schema:DefinedTerm
163 Nc587b96ce65e49c5b04b2b0d4cd118b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Middle Aged
165 rdf:type schema:DefinedTerm
166 Nd55d7a209e154946a13765996879d0dd schema:name dimensions_id
167 schema:value pub.1032894511
168 rdf:type schema:PropertyValue
169 Ndc8092a6ffdf472197664c3d7a2895e0 rdf:first sg:person.01262110414.63
170 rdf:rest rdf:nil
171 Ne18664d248134f559154f722286d0330 rdf:first sg:person.0735742420.05
172 rdf:rest Nf37dd5d5c3434c8cb5a159551ca3bf67
173 Ne2f9e63466134580b35b49a53e388dae schema:issueNumber 2
174 rdf:type schema:PublicationIssue
175 Ne4909cce326f418cb51ceb79882820c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cytomegalovirus Infections
177 rdf:type schema:DefinedTerm
178 Ne7edb710831e4955b9d002002d317561 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Coinfection
180 rdf:type schema:DefinedTerm
181 Ne9707fea574646febe4379606483c432 rdf:first sg:person.01120300741.68
182 rdf:rest N3276790dbb974371be64088e789e2db8
183 Nf37dd5d5c3434c8cb5a159551ca3bf67 rdf:first sg:person.01126473407.04
184 rdf:rest N1e1ff260c1d64abbacb67150dca75d56
185 Nf509e0eeafd44bb89a6a5beb1a77f9ef rdf:first sg:person.01272505323.78
186 rdf:rest Ndc8092a6ffdf472197664c3d7a2895e0
187 Nf5a5dfa931be4ab8986f86273d830d61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Male
189 rdf:type schema:DefinedTerm
190 Nf7a2564d6dd14ddd96c9c93a63f0c655 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Female
192 rdf:type schema:DefinedTerm
193 Nf9718fd73c934c2d9ddd601d7ab7c264 schema:name pubmed_id
194 schema:value 22930407
195 rdf:type schema:PropertyValue
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
200 schema:name Clinical Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical Microbiology
204 rdf:type schema:DefinedTerm
205 sg:journal.1093599 schema:issn 0934-9723
206 1435-4373
207 schema:name European Journal of Clinical Microbiology & Infectious Diseases
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01073602545.66 schema:affiliation grid-institutes:grid.462341.6
211 schema:familyName Robert-Gangneux
212 schema:givenName F.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073602545.66
214 rdf:type schema:Person
215 sg:person.01073741126.36 schema:affiliation grid-institutes:grid.410368.8
216 schema:familyName Minjolle
217 schema:givenName S.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073741126.36
219 rdf:type schema:Person
220 sg:person.01120300741.68 schema:affiliation grid-institutes:grid.462341.6
221 schema:familyName Jouneau
222 schema:givenName S.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120300741.68
224 rdf:type schema:Person
225 sg:person.01126473407.04 schema:affiliation grid-institutes:grid.410368.8
226 schema:familyName Revest
227 schema:givenName M.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126473407.04
229 rdf:type schema:Person
230 sg:person.01262110414.63 schema:affiliation grid-institutes:grid.410368.8
231 schema:familyName Tattevin
232 schema:givenName P.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262110414.63
234 rdf:type schema:Person
235 sg:person.01272505323.78 schema:affiliation grid-institutes:grid.410368.8
236 schema:familyName Le Tulzo
237 schema:givenName Y.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272505323.78
239 rdf:type schema:Person
240 sg:person.01273730565.40 schema:affiliation grid-institutes:grid.414271.5
241 schema:familyName Fillatre
242 schema:givenName P.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273730565.40
244 rdf:type schema:Person
245 sg:person.01275670201.83 schema:affiliation grid-institutes:grid.410368.8
246 schema:familyName Leroy
247 schema:givenName H.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275670201.83
249 rdf:type schema:Person
250 sg:person.0725601723.28 schema:affiliation grid-institutes:grid.410368.8
251 schema:familyName Gacouin
252 schema:givenName A.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725601723.28
254 rdf:type schema:Person
255 sg:person.0735742420.05 schema:affiliation grid-institutes:grid.410368.8
256 schema:familyName Chevrier
257 schema:givenName S.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735742420.05
259 rdf:type schema:Person
260 sg:pub.10.1186/cc6806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013332005
261 https://doi.org/10.1186/cc6806
262 rdf:type schema:CreativeWork
263 grid-institutes:grid.410368.8 schema:alternateName CIC INSERM 0203, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
264 INSERM U835, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
265 Parasitologie-Mycologie, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
266 Virologie, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
267 schema:name CIC INSERM 0203, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
268 INSERM U835, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
269 Parasitologie-Mycologie, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
270 Service des Maladies Infectieuses et de Réanimation Médicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
271 Virologie, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
272 rdf:type schema:Organization
273 grid-institutes:grid.414271.5 schema:alternateName Service des Maladies Infectieuses et de Réanimation Médicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
274 schema:name Service des Maladies Infectieuses et de Réanimation Médicale, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes Cedex, France
275 rdf:type schema:Organization
276 grid-institutes:grid.462341.6 schema:alternateName IRSET, UMR, INSERM 1085, Université de Rennes 1, IFR140, 35033 Rennes, France
277 schema:name IRSET, UMR, INSERM 1085, Université de Rennes 1, IFR140, 35033 Rennes, France
278 Parasitologie-Mycologie, Faculté de Médecine, Université de Rennes 1, IFR140, 35033 Rennes, France
279 Pneumologie, Hôpital Pontchaillou, 35033 Rennes, France
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...